Abstract
Radiation and chemotherapy are common and mainstay treatments for cancer patients. But they are also usually associated with some toxicity and side effects in most of the patients. Ganoderma (Lingzhi) is considered as a major kind of complementary/alternative medicine and used to prevent the adverse effects caused by radiation and chemotherapy. This chapter reviewed the protective effects of Ganoderma (Lingzhi) on radiation and chemotherapy, including the preventive effects on myelosuppression, intestinal injury, nephrotoxicity, cardiovascular toxicity, and other side effects. Both basic researches and clinical studies of Ganoderma (Lingzhi) in preventing side effects induced by radiation and chemotherapy were reviewed.
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References
Kovac AL (2003) Benefits and risks of newer treatments for chemotherapy -induced and postoperative nausea and vomiting. Drug Safety 26(4):227–259
Cui JJ, Yuan JF, Zhang ZQ (2010) Anti-oxidation activity of the crude polysaccharides isolated from Polygonum Cillinerve (Nakai) Ohwi in immunosuppressed mice. J Ethnopharmacol 132(2):512–517
Mujic A, Grdovic N, Mujić I, Mihailović M, Živković J, Poznanović G, Vidaković M (2011) Anti-oxidative effects of phenolic extracts from chestnut leaves, catkins and spiny burs in streptozotocin-treated rat pancreatic beta-cells. Food Chem 125(3):841–849
Devipriya N, Nagarajan AR, Sudheer M, Menon VP (2008) Quercetin ameliorates gamma radiation-induced DNA damage and biochemical changes in human peripheral blood lymphocytes. Mutat Res 654(1):1–7
Tagliaferri M, Cohen I, Tripathy D (2001) Complementary and alternative medicine in early stage breast cancer. Semin Oncol 28(1):121–134
Lindequist U, Niedermeyer THJ, Julich WD (2005) The pharmacological potential of mushrooms. eCAM 2(3):285–299
Wasser SP (2002) Medicinal mushrooms as a source of antitumor and immunomodulating polysaccharides. Appl Microbiol Biotechnol 60(3):258–274
Zaidman BZ, Yassin M, Mahajna J, Wasser SP (2005) Medicinal mushroom. modulators of molecular targets as cancer therapeutics. Appl Microbiol Biotechnol 67(4):453–464
Sheena N, Lakshmi B, Janardhanan KK (2005) Therapeutic potential of Ganoderma lucidum (Fr.) P. Karst. Nat Prod Rad 4(5):382
Pillai TG, Salvi VP, Maurya DK, Nair CKK, Janardhanan KK (2006) Prevention of radiation-induced damages by aqueous extract of Ganoderma lucidum occurring in southern parts of India. Curr Sci 91(3):341
Mego M, Holec V, Drgona L, Hainova K, Ciernikova S, Zajac V (2013) Probiotic bacteria in cancer patients undergoing chemotherapy and radiation therapy. Complement Ther Med 21(6):712–723
Soccol CR, Bissoqui LY, Rodrigues C, Rubel R, Sella SR, Leifa F, de Souza VL, Soccol VT (2016) Pharmacological properties of biocompounds from spores of the Lingzhi or Reishi medicinal mushroom Ganoderma lucidum (Agaricomycetes): a review. Int J Med Mushrooms 18(9):757–767
Richardson MA, Sanders T, Palmer JL, Greisinger A, Singletary SE (2000) Complementary/alternative medicine use in a comprehensive cancer center and the implications for oncology. J Clin Oncol 18(13):2505–2514
Lin ZB, Zhang HN (2004) Anti-tumor and immunoregulatory activities of Ganoderma lucidum and its possible mechanisms. Acta Pharmacol Sin 25(11):1387–1395
Cao Y, Xu X, Liu S, Huang L, Gu J (2018) Ganoderma: a cancer immunotherapy review. Front Pharmacol 9:1217
Lin ZB, Zhang ZL, Lin HR, Wu YC, Ruan Y, Cong Z, Cai ZJ (1980) Preliminary study on the anti-radiation effects of Ganoderma lucidum. Sci Bull (Ke Xue Tong Bao) 4:187–184
Ahlmann M, Hempel G (2016) The effect of cyclophosphamide on the immune system: implications for clinical cancer therapy. Cancer Chemother Pharmacol 78(4):661–671
Zhu XL, Liu JH, Li WD, Lin ZB (2012) Promotion of myelopoiesis in myelosuppressed mice by Ganoderma lucidum polysaccharides. Front Pharmacol 3:20
Smina TP, Maurya DK, Devasagayam TP, Janardhanan KK (2015) Protection of radiation induced DNA and membrane damages by total triterpenes isolated from Ganoderma lucidum (Fr.) P. Karst. Chem Biol Interact 233:1–7
Smina TP, De S, Devasagayam TP, Adhikari S, Janardhanan KK (2011) Ganoderma lucidum total triterpenes prevent radiation-induced DNA damage and apoptosis in splenic lymphocytes in vitro. Mutat Res 726(2):188–194
Pillai TG, Nair CK, Janardhanan KK (2008) Polysaccharides isolated from Ganoderma lucidum occurring in Southern parts of India, protects radiation induced damages both in vitro and in vivo. Environ Toxicol Pharmacol 26(1):80–85
Pillai TG, Uma DP (2013) Mushroom beta glucan: potential candidate for post irradiation protection. Mutat Res 751(2):109–115
Pillai TG, Maurya DK, Salvi VP, Janardhanan KK, Nair CK (2014) Fungal beta glucan protects radiation induced DNA damage in human lymphocytes. Ann Transl Med 2(2):13
Zhao W, Jiang X, Deng W, Lai Y, Wu M, Zhang Z (2012) Antioxidant activities of Ganoderma lucidum polysaccharides and their role on DNA damage in mice induced by cobalt-60 gamma-irradiation. Food Chem Toxicol 50(2):303–309
Liu GJ, Li J, Chen LL, Jiang ZJ, Liu PQ, Chen JW, Guo LB (2017) The efficacy enhancing and toxicity reducing of Ganoderma lucidum spore oil emulsion to mice undergoing chemotherapy. Electron J Metab Nutr Cancer 4(1):60–66
Chen CH, Fang TH, Xu L, Zhou LL, Jia M (2008) Toxin-attenuating and the efficacy-enhancing effect of Compound Lingzhi Baozi Oil on S180 tumor-bearing mice after chemotherapy. J Nanjing TCM Univ 24(2):127–129
Yu S, Wu S, Liu J, Han C, Wei L (1997) An experimental study on the effects of lingzhi spore on the immune function and 60Co radioresistance in mice. Zhongguo Zhong Yao Za Zhi 22(10):625–626
Kashimoto N, Ishii S, Myojin Y, Ushijima M, Hayama M, Watanabe H (2010) A water-soluble extract from cultured medium of Ganoderma lucidum (Reishi) mycelia attenuates the small intestinal injury induced by anti-cancer drugs. Oncol Lett 1(1):63–64
Kubo N, Myojin Y, Shimamoto F, Kashimoto N, Kyo E, Kamiya K, Watanabe H (2005) Protective effects of a water-soluble extract from cultured medium of Ganoderma lucidum (Rei-shi) mycelia and Agaricus blazei murill against X-irradiation in B6C3F1 mice: Increased small intestinal crypt survival and prolongation of average time to animal death. Int J Mol Med 15(3):401–406
Li CH, Ko JL, Ou CC, Lin WL, Yen CC, Hsu CT, Hsiao YP (2019) The protective role of GMI, an immunomodulatory protein from Ganoderma microsporum, on 5-fluorouracil-induced oral and intestinal Mucositis. Integr Cancer Ther 18:1871052227
Chen LH, Lin ZB, Li WD (2011) Ganoderma lucidum polysaccharides reduce methotrexate- induced small intestinal damage in mice via induction of epithelial cell proliferation and migration. Acta Pharmacol Sin 32(12):1505–1512
Husain K, Morris C, Whitworth C, Trammell GL, Rybak LP, Somani SM (1998) Protection by ebselen against cisplatin-induced nephrotoxicity: antioxidant system. Mol Cell Biochem 178(1-2):127–133
Sheena N, Ajith TA, Janardhanan KK (2003) Prevention of nephrotoxicity induced by the anticancer drug cisplatin, using Ganoderma lucidum, a medicinal mushroom occurring in South India. Curr Sci India 85(4):478–482
Pillai TG, John M, Sara TG (2011) Prevention of cisplatin induced nephrotoxicity by terpenes isolated from Ganoderma lucidum occurring in Southern Parts of India. Exp Toxicol Pathol 63(1-2):157–160
Yan YM, Wang XL, Zhou LL, Zhou FJ, Li R, Tian Y, Zuo ZL, Fang P, Chung AC, Hou FF, Cheng YX (2015) Lingzhilactones from Ganoderma lingzhi ameliorate adriamycin-induced nephropathy in mice. J Ethnopharmacol 176:385–393
Octavia Y, Tocchetti CG, Gabrielson KL, Janssens S, Crijns HJ, Moens AL (2012) Doxorubicin- induced cardiomyopathy: from molecular mechanisms to therapeutic strategies. J Mol Cell Cardiol 52(6):1213–1225
Sudheesh NP, Ajith TA, Janardhanan KK (2013) Ganoderma lucidum ameliorate mitochondrial damage in isoproterenol-induced myocardial infarction in rats by enhancing the activities of TCA cycle enzymes and respiratory chain complexes. Int J Cardiol 165(1):117–125
Veena RK, Ajith TA, Janardhanan KK (2018) Lingzhi or Reishi medicinal mushroom, Ganoderma lucidum (Agaricomycetes), prevents Doxorubicin- induced cardiotoxicity in rats. Int J Med Mushrooms 20(8):761–774
Xu F, Li X, Xiao X, Liu LF, Zhang L, Lin PP, Zhang SL, Li QS (2017) Effects of Ganoderma lucidum polysaccharides against doxorubicin-induced cardiotoxicity. Biomed Pharmacother 95:504–512
Kensler TW, Wakabayashi N, Biswal S (2007) Cell survival responses to environmental stresses via the Keap1-Nrf2-ARE pathway. Annu Rev Pharmacol Toxicol 47:89–116
Rajasekaran M, Kalaimagal C (2012) Cardioprotective effect of a medicinal mushroom, Ganoderma lucidum against Adriamycin induced toxicity. Int J Pharmacol 8(4):252–254
Poon KS, Un MK, Low XH, Cheung YT, Yap KY, Chan A (2013) Impact of cancer-related fatigue on chemotherapy-induced nausea and vomiting in Asian cancer patients. Pharmacoepidemiol Drug Saf 22(12):1345–1351
Liu L, Mills PJ, Rissling M, Fiorentino L, Natarajan L, Dimsdale JE, Sadler GR, Parker BA, Ancoli-Israel S (2012) Fatigue and sleep quality are associated with changes in inflammatory markers in breast cancer patients undergoing chemotherapy. Brain Behav Immun 26(5):706–713
Berger AM, Mooney K, Alvarez-Perez A, Breitbart WS, Carpenter KM, Cella D, Cleeland C, Dotan E, Eisenberger MA, Escalante CP, Jacobsen PB, Jankowski C, LeBlanc T, Ligibel JA, Loggers ET, Mandrell B, Murphy BA, Palesh O, Pirl WF, Plaxe SC, Riba MB, Rugo HS, Salvador C, Wagner LI, Wagner-Johnston ND, Zachariah FJ, Bergman MA, Smith C (2015) Cancer-related fatigue, Version 2.2015. J Natl Compr Canc Netw 13(8):1012–1039
Iwase S, Kawaguchi T, Tokoro A, Yamada K, Kanai Y, Matsuda Y, Kashiwaya Y, Okuma K, Inada S, Ariyoshi K, Miyaji T, Azuma K, Ishiki H, Unezaki S, Yamaguchi T (2015) Assessment of cancer-related fatigue, pain, and quality of life in cancer patients at palliative care team referral: a multicenter observational study (JORTC PAL-09). Plos One 10(8):e134022
Bao PP, Lu W, Cui Y, Zheng Y, Gu K, Chen Z, Zheng W, Shu XO (2012) Ginseng and Ganoderma lucidum use after breast cancer diagnosis and quality of life: a report from the Shanghai Breast Cancer Survival Study. Plos One 7(6):e39343
Pan K, Jiang Q, Liu G, Miao X, Zhong D (2013) Optimization extraction of Ganoderma lucidum polysaccharides and its immunity and antioxidant activities. Int J Biol Macromol 55:301–306
Ouyang MZ, Lin LZ, Lv WJ, Zuo Q, Lv Z, Guan JS, Wang ST, Sun LL, Chen HR, Xiao ZW (2016) Effects of the polysaccharides extracted from Ganoderma lucidum on chemotherapy-related fatigue in mice. Int J Biol Macromol 91:905–910
McKenzie E, Zaki P, Raman S, Olson R, McFarlane T, DeAngelis C, Chan S, Pidduck W, Razvi Y, Bushehri A, Chow E (2019) Radiation-induced nausea and vomiting: a comparison between MASCC/ESMO, ASCO, and NCCN antiemetic guidelines. Support Care Cancer 27(3):783–791
Kovac AL (2003) Benefits and risks of newer treatments for chemotherapy-induced and postoperative nausea and vomiting. Drug Saf 26(4):227–259
Horneber M, van Ackeren G, Fischer F, Kappauf H, Birkmann J (2018) Addressing unmet information needs: results of a clinician-led consultation service about complementary and alternative medicine for cancer patients and their relatives. Integr Cancer Ther 17(4):1172–1182
Wang CZ, Basila D, Aung HH, Mehendale SR, Chang WT, McEntee E, Guan X, Yuan CS (2005) Effects of Ganoderma lucidum extract on chemotherapy-induced nausea and vomiting in a rat model. Am J Chin Med 33(5):807–815
Wang DH, Weng XC (2006) Antitumor activity of extracts of 53. Ganoderma lucidum and their protective effects on damaged HL-7702 cells induced by radiotherapy and chemotherapy. China J Chin Mat Media 31(19):1618–1622
Lin ZB (2011) Multi-target anti-tumor effect of Ganoderma lucidum and its research. Li xuejun editor-in-chief. Multi-target drug research and application. People’s Health Publishing Press, Beijing, pp 479–489
Liang J, Li YR, Wang SW (2002) Effect of radiotherapy combined with a medicine Lingzhi-912 on treatment of esophageal cancer. J Fourth Mil Med Univ 23(3):278–280
Zhuang SR, Chiu HF, Chen SL, Tsai MY, Lee MY, Lee HS, Shen YC, Yan YY, Shane GT, Wang CK (2012) Effects of a Chinese medical herbs complex on cellular immunity and toxicity-related conditions of breast cancer patients. Br J Nutr 107(5):712–714
Zhao FY, Wu Q, Li YM, Wang R (2015) Efficacy of Ganoderma lucidum spore capsule combined with chemotherapy in the treatment of non-small cell lung cancer and its effect on immune function. Chin J Gerontol 35(10):2721–2722
Wang J, Chen ZQ, Li Y, Wang XS, Fei CL, Wang XJ (2016) Clinical effect of compound Ganoderma lucidum spore capsule combined with chemotherapy on non-small cell lung cancer and its effect on immune function. Mod J Integr Tradit Chin West Med 25(24):2673–2675
Yan BK, Wei YJ, Li YQ (1998) Effect of Lao Jun Xian Lingzhi oral liquid combined with chemotherapy on advanced non-small cell lung cancer at stages II and III. Tradit Chin Drug Res Pharmacol 9(2):13–16
Yu Y (2001) Effects of Ganoderma spore powder on peripheral blood cells of cancer patients. J Liao Ning Coll Tradit Chin Med 3(3):173
Sun DJ, Li W, Zhang WG, Wei QL (1999) Clinical observation on the efficacy of Lingzhi Fuzheng capsule in reducing toxicity and enhancing efficacy of radiotherapy and chemotherapy for malignant tumors. J Binzhou Med Univ 22(2):40–42
Qi YF, Li XR, Yan M (1999) Ganoderma spore powder adjuvant chemotherapy for digestive system tumors clinical observation. Chin J Integr Med 19(9):554–555
Kuang JM, Wang JW, Kuang JM (2007) Clinical Observation on the curative effect of broken Ganoderma spore powder combined with chemotherapy for malignant tumor. Shandong Med J 47(21):59–60
Wang YH, Qu ZH, Qin Y (2014) Clinical observation of broken Ganoderma spore powder combined with xeloda and combined with oxaliplatin chemotherapy for advanced colorectal cancer. China Prac Med 9(21):108–109
Lin ND, Su JN, Zhu Z, Gao YH, Gao H, Xie GY, Chen B, Ye XY (2004) Analysis on 66 cases of cancer patients treated by chemotherapy with extract of Ganoderma lucidum. J Pract Tradit Chin Intern Med 18(5):457–454
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Chen, L., Abulizi, A., Li, M. (2019). Protective Effect of Ganoderma (Lingzhi) on Radiation and Chemotherapy. In: Lin, Z., Yang, B. (eds) Ganoderma and Health. Advances in Experimental Medicine and Biology, vol 1182. Springer, Singapore. https://doi.org/10.1007/978-981-32-9421-9_4
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DOI: https://doi.org/10.1007/978-981-32-9421-9_4
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