Abstract
Ganoderma lucidum (G. lucidum, Lingzhi), a kind of mushroom with various bioactivities, is recently revealed to improve skin quality and treat skin diseases. Traditionally, polysaccharides and ganoderic acids have been reported as the major functional metabolites of Ganoderma possessing antioxidant and anti-inflammatory functions. Based on our research and other studies, Ganoderma extracts, such as Ganoderma polysaccharides, have been used in promoting skin wound healing, mitigating postburn infection, and preventing skin flap ischemia-reperfusion injury. Ganoderma extracts have also been used in skin care, because of their roles in skin photoaging and skin whitening. Meanwhile, the anti-inflammatory effect of Ganoderma in atopic dermatitis and cutaneous sarcoidosis is also elaborated in this chapter. Finally, the potential use of Ganoderma in skin carcinoma is introduced. In brief, the dermoprotective effect of Ganoderma will be summarized in this chapter.
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References
Webb R (2019) Skin integrity and infection prevention: ideas to action. J Wound Care 28:S3
Bonifant H, Holloway S (2019) A review of the effects of ageing on skin integrity and wound healing. Br J Community Nurs 24:S28–S33
Kiya K, Kubo T (2019) Neurovascular interactions in skin wound healing. Neurochem Int 125:144–150
Song Y, Wu C, Zhang X, Bian W, Liu N, Yin S, Yang M, Luo M, Tang J, Yang X (2019) A short peptide potentially promotes the healing of skin wound. Biosci Rep 39:BSR20181734
Shu X, Shu S, Tang S, Yang L, Liu D, Li K, Dong Z, Ma Z, Zhu Z, Din J (2018) Efficiency of stem cell based therapy in the treatment of diabetic foot ulcer: a meta-analysis. Endocr J 65:403–413
Jeffcoate WJ, Vileikyte L, Boyko EJ, Armstrong DG, Boulton AJM (2018) Current challenges and opportunities in the prevention and management of diabetic foot ulcers. Diabetes Care 41:645–652
Tie L, Yang HQ, An Y, Liu SQ, Han J, Xu Y, Hu M, Li WD, Chen AF, Lin ZB, Li XJ (2012) Ganoderma lucidum polysaccharide accelerates refractory wound healing by inhibition of mitochondrial oxidative stress in type 1 diabetes. Cell Physiol Biochem 29:583–594
Hu F, Yan Y, Wang CW, Liu Y, Wang JJ, Zhou F, Zeng QH, Zhou X, Chen J, Wang AJ, Zhou JD (2019) Article effect and mechanism of Ganoderma lucidum polysaccharides on human fibroblasts and skin wound healing in mice. Chin J Integr Med 25:203–209
Li S, Wu H (2011) Clinical effect of Ganadoma Lucidum on diabetic foot. J Hainan Med Univ 17:1333–1334
Kim HS, Sun X, Lee JH, Kim HW, Fu X, Leong KW (2018) Advanced drug delivery systems and artificial skin grafts for skin wound healing. Adv Drug Deliv Rev. https://doi.org/10.1016/j.addr.2014.12.014
Czajkowska-Kosnik A, Szekalska M, Winnicka K (2019) Nanostructured lipid carriers: a potential use for skin drug delivery systems. Pharmacol Rep 71:156–166
Shinde UA, Parmar SJ, Easwaran S (2019) Metronidazole-loaded nanostructured lipid carriers to improve skin deposition and retention in the treatment of rosacea. Drug Dev Ind Pharm 45:1–13. https://doi.org/10.1080/03639045.2019.1569026
Cepas V, Lopez Y, Munoz E, Rolo D, Ardanuy C, Marti S, Xercavins M, Horcajada JP, Bosch J, Soto SM (2019) Relationship between biofilm formation and antimicrobial resistance in gram-negative Bacteria. Microb Drug Resist 25:72–79
Saleh MM, Abbas HA, Askoura MM (2019) Repositioning secnidazole as a novel virulence factors attenuating agent in Pseudomonas aeruginosa. Microb Pathog 127:31–38
El Zawawy NA, Ali SS (2016) Anti-proteolytic activity of Ganoderma lucidum methanol extract against Pseudomonas aeruginosa. J Infect Dev Ctries 10:1020–1024
Sun BK, Siprashvili Z, Khavari PA (2014) Advances in skin grafting and treatment of cutaneous wounds. Science 346:941–945
Su CH, Sun CS, Juan SW, Hu CH, Ke WT, Sheu MT (1997) Fungal mycelia as the source of chitin and polysaccharides and their applications as skin substitutes. Biomaterials 18:1169–1174
Hung WS, Fang CL, Su CH, Lai WF, Chang YC, Tsai YH (2001) Cytotoxicity and immunogenicity of SACCHACHITIN and its mechanism of action on skin wound healing. J Biomed Mater Res 56:93–100
Smith WC, Friedman MA, Goldsmith TH (1992) Retinoids in the lateral eye of Limulus: evidence for a retinal photoisomerase. Vis Neurosci 8:329–336
Hung WS, Lai WF, Leu B, Su CH, Fang CL, Tsai YH (2004) Effect of SACCHACHITIN on keratinocyte proliferation and the expressions of type I collagen and tissue-transglutaminase during skin wound healing. J Biomed Mater Res B Appl Biomater 70:122–129
Chuang CM, Wang HE, Chang CH, Peng CC, Ker YB, Lai JE, Chen KC, Peng RY (2013) Sacchachitin, a novel chitin-polysaccharide conjugate macromolecule present in Ganoderma lucidum: purification, composition, and properties. Pharm Biol 51:84–95
Wang WZ, Baynosa RC, Zamboni WA (2011) Update on ischemia-reperfusion injury for the plastic surgeon: 2011. Plast Reconstr Surg 128:685e–692e
Widgerow AD (2014) Ischemia-reperfusion injury: influencing the microcirculatory and cellular environment. Ann Plast Surg 72:253–260
Ren H, Meng X, Yin J, Sun J, Huang Q, Yin Z (2018) Ganoderma lucidum polysaccharide peptide attenuates skin flap ischemia-reperfusion injury in a Thioredoxin-dependent manner. Plast Reconstr Surg 142:23e–33e
Slominski AT, Zmijewski MA, Plonka PM, Szaflarski JP, Paus R (2018) How UV light touches the brain and endocrine system through skin, and why. Endocrinology 159:1992–2007
McDaniel D, Farris P, Valacchi G (2018) Atmospheric skin aging-contributors and inhibitors. J Cosmet Dermatol 17:124–137
Poon F, Kang S, Chien AL (2015) Mechanisms and treatments of photoaging. Photodermatol Photoimmunol Photomed 31:65–74
Weihermann AC, Lorencini M, Brohem CA, de Carvalho CM (2017) Elastin structure and its involvement in skin photoageing. Int J Cosmet Sci 39:241–247
Bora NS, Mazumder B, Mandal S, Patowary P, Goyary D, Chattopadhyay P, Dwivedi SK (2019) Amelioration of UV radiation-induced photoaging by a combinational sunscreen formulation via aversion of oxidative collagen degradation and promotion of TGF-beta-Smad-mediated collagen production. Eur J Pharm Sci 127:261–275
Lee KS, Shin S, Cho E, Im WK, Jeon SH, Kim Y, Park D, Frechet M, Chajra H, Jung E (2019) nc886, a non-coding RNA, inhibits UVB-induced MMP-9 and COX-2 expression via the PKR pathway in human keratinocytes. Biochem Biophys Res Commun 512:647–652
Zhonghui Z, Xiaowei Z, Fang F (2014) Ganoderma lucidum polysaccharides supplementation attenuates exercise-induced oxidative stress in skeletal muscle of mice. Saudi J Biol Sci 21:119–123
Zeng Q, Zhou F, Lei L, Chen J, Lu J, Zhou J, Cao K, Gao L, Xia F, Ding S, Huang L, Xiang H, Wang J, Xiao Y, Xiao R, Huang J (2017) Ganoderma lucidum polysaccharides protect fibroblasts against UVB-induced photoaging. Mol Med Rep 15:111–116
Lin KW, Chen YT, Yang SC, Wei BL, Hung CF, Lin CN (2013) Xanthine oxidase inhibitory lanostanoids from Ganoderma tsugae. Fitoterapia 89:231–238
Ko HH, Hung CF, Wang JP, Lin CN (2008) Antiinflammatory triterpenoids and steroids from Ganoderma lucidum and G. tsugae. Phytochemistry 69:234–239
Xie Y, Liao W (2006) Ganoderma polysaccharides and H2O2-induced Kerotinocytes oxidative stress. Zhongguo Pi Fu Xing Bing Xue Zha Zhi 20:77–79
Li X, Li J (2013) Ganoderma lucidum polysaccharide prevents oxidation and skin aging. Chin J Tissue Eng Res 17:7272–7277
Sanchez E, Kupfer E, Goedbloed DJ, Nolte AW, Luddecke T, Schulz S, Vences M, Steinfartz S (2018) Morphological and transcriptomic analyses reveal three discrete primary stages of postembryonic development in the common fire salamander, Salamandra salamandra. J Exp Zool B Mol Dev Evol 330:96–108
Pillaiyar T, Manickam M, Namasivayam V (2017) Skin whitening agents: medicinal chemistry perspective of tyrosinase inhibitors. J Enzyme Inhib Med Chem 32:403–425
Chien CC, Tsai ML, Chen CC, Chang SJ, Tseng CH (2008) Effects on tyrosinase activity by the extracts of Ganoderma lucidum and related mushrooms. Mycopathologia 166:117–120
Hsu KD, Cheng KC (2018) From nutraceutical to clinical trial: frontiers in Ganoderma development. Appl Microbiol Biotechnol 102:9037–9051
Hu S, Huang J, Pei S, Ouyang Y, Ding Y, Jiang L, Lu J, Kang L, Huang L, Xiang H, Xiao R, Zeng Q, Chen J (2019) Ganoderma lucidum polysaccharide inhibits UVB-induced melanogenesis by antagonizing cAMP/PKA and ROS/MAPK signaling pathways. J Cell Physiol 234:7330–7340
Hsu KD, Chen HJ, Wang CS, Lum CC, Wu SP, Lin SP, Cheng KC (2016) Extract of Ganoderma formosanum mycelium as a highly potent Tyrosinase inhibitor. Sci Rep 6:32854
Hsu KD, Chan YH, Chen HJ, Lin SP, Cheng KC (2018) Tyrosinase-based TLC autography for anti-melanogenic drug screening. Sci Rep 8:401
Sommer M, Courtney RJ (1991) Differential rates of processing and transport of herpes simplex virus type 1 glycoproteins gB and gC. J Virol 65:520–525
Lin JY, Chen ML, Chiang BL, Lin BF (2006) Ganoderma tsugae supplementation alleviates bronchoalveolar inflammation in an airway sensitization and challenge mouse model. Int Immunopharmacol 6:241–251
Pi CC, Wang HY, Lu CY, Lu FL, Chen CJ (2014) Ganoderma formosanum polysaccharides attenuate Th2 inflammation and airway hyperresponsiveness in a murine model of allergic asthma. Springerplus 3:297
Taofiq O, Rodrigues F, Barros L, Barreiro MF, Ferreira I, Oliveira M (2019) Mushroom ethanolic extracts as cosmeceuticals ingredients: safety and ex vivo skin permeation studies. Food Chem Toxicol 127:228–236
Choi MJ, Kim DY, Kim JS, Kim H, Cho SB (2013) Acute vesiculobullous hand dermatitis and anagen effluvium in Ganoderma lucidum-induced aplastic crisis. Ann Hematol 92:1417–1419
Welsch K, Holstein J, Laurence A, Ghoreschi K (2017) Targeting JAK/STAT signalling in inflammatory skin diseases with small molecule inhibitors. Eur J Immunol 47:1096–1107
Weidinger S, Novak N (2016) Atopic dermatitis. Lancet 387:1109–1122
Son HU, Lee S, Heo JC, Lee SH (2017) The solid-state fermentation of Artemisia capillaris leaves with Ganoderma lucidum enhances the anti-inflammatory effects in a model of atopic dermatitis. Int J Mol Med 39:1233–1241
Llanos O, Hamzeh N (2019) Sarcoidosis. Med Clin North Am 103:527–534
Saylam Kurtipek G, Ataseven A, Kurtipek E, Kucukosmanoglu I, Toksoz MR (2016) Resolution of cutaneous sarcoidosis following topical application of Ganoderma lucidum (Reishi mushroom). Dermatol Ther (Heidelb) 6:105–109
Zapata Laguado MI, Lizarazo Hurtado DV, Bonilla Gomez CE (2019) Neurofibromatosis type 1 - association with breast Cancer, basal cell carcinoma of the skin, and low-grade peripheral nerve sheath sarcoma: case report and literature review. Case Rep Oncol 12:228–234
Hsu SC, Ou CC, Chuang TC, Li JW, Lee YJ, Wang V, Liu JY, Chen CS, Lin SC, Kao MC (2009) Ganoderma tsugae extract inhibits expression of epidermal growth factor receptor and angiogenesis in human epidermoid carcinoma cells: in vitro and in vivo. Cancer Lett 281:108–116
Gu YH, Belury MA (2005) Selective induction of apoptosis in murine skin carcinoma cells (CH72) by an ethanol extract of Lentinula edodes. Cancer Lett 220:21–28
Akihisa T, Nakamura Y, Tagata M, Tokuda H, Yasukawa K, Uchiyama E, Suzuki T, Kimura Y (2007) Anti-inflammatory and anti-tumor-promoting effects of triterpene acids and sterols from the fungus Ganoderma lucidum. Chem Biodivers 4:224–231
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Yin, Z., Yang, B., Ren, H. (2019). Preventive and Therapeutic Effect of Ganoderma (Lingzhi) on Skin Diseases and Care. In: Lin, Z., Yang, B. (eds) Ganoderma and Health. Advances in Experimental Medicine and Biology, vol 1182. Springer, Singapore. https://doi.org/10.1007/978-981-32-9421-9_14
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DOI: https://doi.org/10.1007/978-981-32-9421-9_14
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