Abstract
The current therapies for oxidative stress-induced lung diseases are majorly based on the reduction of airway obstruction and improved exacerbations. However, none of the available treatments have been proven to avoid disease progression or reduce mortality. In this context, mesenchymal stem cell (MSC) therapy has become a strong contender for better therapeutic strategies for several pulmonary diseases. MSCs can be readily harvested from various tissues and efficiently propagated and possess strong immunomodulatory/suppressive properties. Animal studies have shown encouraging outcomes with MSC therapy for various lung disorders, like COPD and emphysema. These studies have inspired research groups to understand the mechanisms by which MSCs may bring about their beneficial effects upon transplantation; however, clinical trials have not been as successful. This chapter summarizes and highlights the various aspects of MSC therapy in cellular, preclinical, and clinical settings.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
References
Geiger S, Hirsch D, Hermann FG (2017) Cell therapy for lung disease Eur Respir Rev:26(144)
Chaudhuri R, Thompson MA, Pabelick C, Agrawal A, Prakash YS (2018) Obesity, mitochondrial dysfunction and obstructive lung disease: mechanisms and manifestations of obesity in lung disease. Elsevier. ISBN: 978-0-12-813553-2
Villegas L, Stidham T, Nozik-Grayck E (2014) Oxidative stress and therapeutic development in lung diseases. J Pulmon Respirat Med 4(4):194
Wecht S, Rojas M (2016) Mesenchymal stem cells in the treatment of chronic lung disease. Respirology 21(8):1366–1375
Grippi MA, Elias JA, Fishman JA, Kotloff RM, Pack AI, Senior RM, Siegel MD (eds) (2015) Fishman’s pulmonary diseases and disorders, 5th edn. McGraw-Hill, New York
Antunes MA, Lapa E, Silva JR, Rocco PR (2017) Mesenchymal stromal cell therapy in COPD: from bench to bedside. Int J Chron Obstruct Pulmon Dis 12:3017–3027
Paliwal S, Chaudhuri R, Agrawal A et al (2018) Human tissue-specific MSCs demonstrate differential mitochondria transfer abilities that may determine their regenerative abilities. Stem Cell Res Ther 9(1):298
Silva LHA, Antunes MA, Santos CCD, Weiss DJ, Cruz FF, Rocco PRM (2018) Strategies to improve the therapeutic effects of mesenchymal stromal cells in respiratory diseases. Stem Cell Res Ther 9:45
Li X, Michaeloudes C, Zhang Y et al (2018) Mesenchymal stem cells alleviate oxidative stress–induced mitochondrial dysfunction in the airways. J Allergy Clin Immunol 141(5):1634–1645
Li X, Yue S, Luo Z (2017) Mesenchymal stem cells in idiopathic pulmonary fibrosis. Oncotarget 8(60):102600–102616
Yang SR, Park JR, Kang KS (2015) Reactive oxygen species in mesenchymal stem cell aging: implication to lung diseases. Oxidative Med Cell Longev 486263. 11 pages
Ortiz LA, Gambelli F, McBride C et al (2003) Mesenchymal stem cell engraftment in lung is enhanced in response to bleomycin exposure and ameliorates its fibrotic effects. Proc Natl Acad Sci U S A 100(14):8407–8411
Zhao F, Zhang YF, Liu YG et al (2008) Therapeutic effects of bone marrow-derived mesenchymal stem cells engraftment on bleomycin-induced lung injury in rats. Transplant Proc 40(5):1700–1705
Islam MN, Das SR, Emin MT, Wei M, Sun L, Westphalen K, Rowlands DJ, Quadri SK, Bhattacharya S, Bhattacharya J (2012) Mitochondrial transfer from bone-marrow-derived stromal cells to pulmonary alveoli protects against acute lung injury. Nat Med 18(5):759–765. https://doi.org/10.1038/nm.2736
Ahmad T, Mukherjee S, Pattnaik B et al (2014) Miro1 regulates intercellular mitochondrial transport & enhances mesenchymal stem cell rescue efficacy. EMBO J 33(9):994–1010
Paliwal S, Chaudhuri R, Agrawal A et al (2018) Regenerative abilities of mesenchymal stem cells through mitochondrial transfer. J Biomed Sci 25(1):31
Chuang YC, Liou CW, Shang C, Wang PW, Chuang JH, Tiao MM et al (2017) Mitochondrial transfer from Wharton’s jelly mesenchymal stem cell to MERRF cybrid reduces oxidative stress and improves mitochondrial bioenergetics. Oxidative Med Cell Longev Article ID 5691215, 22 pages
Park WS, Ahn SY, Sung SI et al (2018) Strategies to enhance paracrine potency of transplanted mesenchymal stem cells in intractable neonatal disorders. Pediatr Res 83(1–2):214–222
Fröhlich E, Mercuri A, Wu S et al (2016) Measurements of deposition, lung surface area and lung fluid for simulation of inhaled compounds. Front Pharmacol 7:181
Weiss DJ, Casaburi R, Flannery R et al (2013) A placebo-controlled, randomized trial of mesenchymal stem cells in COPD. Chest 143(6):1590–1598
Barisione EE, Ferretti GG, Ravera SS et al (2012) Dieulafoy’s disease of the bronchus: a possible mistake. Multidiscip Respir Med 7(1):40
Rubio M et al (2017). https://ichgcp.net/clinical-trials-registry/NCT03044431
Zubair AC et al (2017). https://clinicaltrials.gov/ct2/show/NCT02181712
Propis et al (2017). https://ichgcp.net/clinical-trials-registry/NCT02216630
Olson AL et al (2019). https://clinicaltrials.gov/ct2/show/NCT02804945
Glassberg M et al ongoing. https://clinicaltrials.gov/ct2/show/NCT03137199
Anne B-l et al (2012). https://ichgcp.net/clinical-trials-registry/NCT01560689
Chambers D et al(2015). https://clinicaltrials.gov/ct2/show/NCT01385644
Acknowledgement
We thank Rajan Mishra, Stem Cell Facility, AIIMS, New Delhi, for assisting us in arranging the required references and proofreading the manuscript.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2020 Springer Nature Singapore Pte Ltd.
About this chapter
Cite this chapter
Chaudhuri, R., Singh, M., Mohanty, S. (2020). Potential of Mesenchymal Stem Cells in Modulating Oxidative Stress in Management of Lung Diseases. In: Chakraborti, S., Parinandi, N., Ghosh, R., Ganguly, N., Chakraborti, T. (eds) Oxidative Stress in Lung Diseases. Springer, Singapore. https://doi.org/10.1007/978-981-32-9366-3_3
Download citation
DOI: https://doi.org/10.1007/978-981-32-9366-3_3
Published:
Publisher Name: Springer, Singapore
Print ISBN: 978-981-32-9365-6
Online ISBN: 978-981-32-9366-3
eBook Packages: Biomedical and Life SciencesBiomedical and Life Sciences (R0)