Abstract
Upconversion nanoparticles (UCNPs) are ideal fluorescent probes for biomedical applications owing to their good characteristics, including superior photostability, deep light penetration, low background auto-fluorescence and good biocompatibility. This chapter focuses on the recent developments of UCNPs in bioimaging and tumor therapy applications, as well as gives an analysis of the advantages of UCNPs over the conventional fluorescent materials and the biocompatibility and toxicity of UCNPs. Finally, the chapter discuss the challenges in the development of UCNPs in biomedical application.
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References
Abdul Jalil R, Zhang Y. Biocompatibility of silica coated NaYF(4) upconversion fluorescent nanocrystals. Biomaterials. 2008;29(30):4122–4128.
Bae YM, Park YI, Nam SH, Kim JH, Lee K, Kim HM, Yoo B, Choi JS, Lee KT, Hyeon T, Suh YD. Endocytosis, intracellular transport, and exocytosis of lanthanide-doped upconverting nanoparticles in single living cells. Biomaterials. 2012;33(35):9080–9086.
Barreto JA, O’Malley W, Kubeil M, Graham B, Stephan H, Spiccia L. Nanomaterials: applications in cancer imaging and therapy. Adv Mater. 2011;23(12):H18–H40.
Chatterjee DK, Yong Z. Upconverting nanoparticles as nanotransducers for photodynamic therapy in cancer cells. Nanomedicine (Lond). 2008;3(1):73–82.
Cheng L, Yang K, Li Y, Zeng X, Shao M, Lee ST, Liu Z. Multifunctional nanoparticles for upconversion luminescence/MR multimodal imaging and magnetically targeted photothermal therapy. Biomaterials. 2012;33(7):2215–2222.
Doane TL, Burda C. The unique role of nanoparticles in nanomedicine: imaging, drug delivery and therapy. Chem Soc Rev. 2012;41(7):2885–2911.
Dong B, Xu S, Sun J, Bi S, Li D, Bai X, Wang Y, Wang L, Song H. Multifunctional NaYF4: Yb3+, Er3+@Ag core/shell nanocomposites: integration of upconversion imaging and photothermal therapy. J Mater Chem. 2011;21(17):6193.
Idris NM, Gnanasammandhan MK, Zhang J, Ho PC, Mahendran R, Zhang Y. In vivo photodynamic therapy using upconversion nanoparticles as remote-controlled nanotransducers. Nat Med. 2012;18(10):1580–1585.
Jayakumar MK, Idris NM, Zhang Y. Remote activation of biomolecules in deep tissues using near-infrared-to-UV upconversion nanotransducers. Proc Natl Acad Sci USA. 2012;109(22):8483–8488.
Li Z, Zhang Y, Shuter B, Muhammad Idris N. Hybrid lanthanide nanoparticles with paramagnetic shell coated on upconversion fluorescent nanocrystals. Langmuir. 2009;25(20):12015–12018.
Lim SF, Riehn R, Ryu WS, Khanarian N, Tung CK, Tank D, Austin RH. In vivo and scanning electron microscopy imaging of up-converting nanophosphors in Caenorhabditis elegans. Nano Lett. 2006;6(2):169–174.
Lim ME, Lee YL, Zhang Y, Chu JJ. Photodynamic inactivation of viruses using upconversion nanoparticles. Biomaterials. 2012;33(6):1912–1920.
Liu Q, Sun Y, Li C, Zhou J, Yang T, Zhang X, Yi T, Wu D, Li F. 18F-Labeled magnetic-upconversion nanophosphors via rare-earth cation-assisted ligand assembly. ACS Nano. 2011;5(4):3146–3157.
Liu Z, Pu F, Huang S, Yuan Q, Ren J, Qu X. Long-circulating Gd(2)O(3):Yb(3+), Er(3+) up-conversion nanoprobes as high-performance contrast agents for multi-modality imaging. Biomaterials. 2013;34(6):1712–1721.
Nyk M, Kumar R, Ohulchanskyy TY, Bergey EJ, Prasad PN. High contrast in vitro and in vivo photoluminescence bioimaging using near infrared to near infrared up-conversion in Tm3+ and Yb3+ doped fluoride nanophosphors. Nano Lett. 2008;8(11):3834–3838.
Park YI, Kim JH, Lee KT, Jeon K-S, Na HB, Yu JH, Kim HM, Lee N, Choi SH, Baik S-I, Kim H, Park SP, Park B-J, Kim YW, Lee SH, Yoon S-Y, Song IC, Moon WK, Suh YD, Hyeon T. Nonblinking and nonbleaching upconverting nanoparticles as an optical imaging nanoprobe and T1 magnetic resonance imaging contrast agent. Adv Mater. 2009;21(44):4467–4471.
Shan J, Budijono SJ, Hu G, Yao N, Kang Y, Ju Y, Prud’homme RK. Pegylated composite nanoparticles containing upconverting phosphors and meso-tetraphenyl porphine (TPP) for photodynamic therapy. Adv Func Mater. 2011;21(13):2488–2495.
Sun Y, Yu M, Liang S, Zhang Y, Li C, Mou T, Yang W, Zhang X, Li B, Huang C, Li F. Fluorine-18 labeled rare-earth nanoparticles for positron emission tomography (PET) imaging of sentinel lymph node. Biomaterials. 2011;32(11):2999–3007.
Tian G, Gu Z, Liu X, Zhou L, Yin W, Yan L, Jin S, Ren W, Xing G, Li S, Zhao Y. Facile fabrication of rare-earth-doped Gd2O3 Hollow spheres with upconversion luminescence, magnetic resonance, and drug delivery properties. J Phys Chem C. 2011;115(48):23790–23796.
Wang C, Cheng L, Liu Z. Drug delivery with upconversion nanoparticles for multi-functional targeted cancer cell imaging and therapy. Biomaterials. 2011a;32(4):1110–1120.
Wang C, Tao H, Cheng L, Liu Z. Near-infrared light induced in vivo photodynamic therapy of cancer based on upconversion nanoparticles. Biomaterials. 2011b;32(26):6145–6154.
Xia A, Gao Y, Zhou J, Li C, Yang T, Wu D, Wu L, Li F. Core-shell NaYF4:Yb3+, Tm3+@FexOy nanocrystals for dual-modality T2-enhanced magnetic resonance and NIR-to-NIR upconversion luminescent imaging of small-animal lymphatic node. Biomaterials. 2011;32(29):7200–7208.
Xia A, Chen M, Gao Y, Wu D, Feng W, Li F. Gd3+ complex-modified NaLuF4-based upconversion nanophosphors for trimodality imaging of NIR-to-NIR upconversion luminescence, X-Ray computed tomography and magnetic resonance. Biomaterials. 2012;33(21):5394–5405.
Xiong LQ, Chen ZG, Yu MX, Li FY, Liu C, Huang CH. Synthesis, characterization, and in vivo targeted imaging of amine-functionalized rare-earth up-converting nanophosphors. Biomaterials. 2009a;30(29):5592–5600.
Xiong L, Chen Z, Tian Q, Cao T, Xu C, Li F. High contrast upconversion luminescence targeted imaging in vivo using peptide-labeled nanophosphors. Anal Chem. 2009b;81(21):8687–8694.
Yan L, Chang Y-N, Zhao L, Gu Z, Liu X, Tian G, Zhou L, Ren W, Jin S, Yin W, Chang H, Xing G, Gao X, Zhao Y. The use of polyethylenimine-modified graphene oxide as a nanocarrier for transferring hydrophobic nanocrystals into water to produce water-dispersible hybrids for use in drug delivery. Carbon. 2013;57:120–129.
Yang T, Sun Y, Liu Q, Feng W, Yang P, Li F. Cubic sub-20 nm NaLuF(4)-based upconversion nanophosphors for high-contrast bioimaging in different animal species. Biomaterials. 2012;33(14):3733–3742.
Yu M, Li F, Chen Z, Hu H, Zhan C, Yang H, Huang C. Laser scanning up-conversion luminescence microscopy for imaging cells labeled with rare-earth nanophosphors. Anal Chem. 2009;81(3):930–935.
Yu XF, Sun Z, Li M, Xiang Y, Wang QQ, Tang F, Wu Y, Cao Z, Li W. Neurotoxin-conjugated upconversion nanoprobes for direct visualization of tumors under near-infrared irradiation. Biomaterials. 2010;31(33):8724–8731.
Zhou J, Yu M, Sun Y, Zhang X, Zhu X, Wu Z, Wu D, Li F. Fluorine-18-labeled Gd3+/Yb3+/Er3+ co-doped NaYF4 nanophosphors for multimodality PET/MR/UCL imaging. Biomaterials. 2011;32(4):1148–1156.
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Zhao, Y. (2019). Application of UCNPs in Bio-imaging and Treatment. In: Yang, R. (eds) Principles and Applications of Up-converting Phosphor Technology. Springer, Singapore. https://doi.org/10.1007/978-981-32-9279-6_17
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DOI: https://doi.org/10.1007/978-981-32-9279-6_17
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