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Neuroimmune Advance in Depressive Disorder

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Book cover Depressive Disorders: Mechanisms, Measurement and Management

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 1180))

  • The original version of this chapter was revised: The reference Schedlowski et al. 2016 has been replaced with “Walsh et al. (2016)”. The correction to this chapter is available at: https://doi.org/10.1007/978-981-32-9271-0_16

Abstract

Major depressive disorder (MDD) or depression is one of the most highly prevalent, chronic, and recurrent disorders, which is associated with a high burden of disease and substantial impairment in social functions. Both immune molecules and cells have been implicated in the pathophysiology and maintenance of MDD. Findings in animals and MDD patients have suggested that both pro- and anti-inflammatory cytokines are activated in the neuroinflammation which contribute to behavioral symptoms and changes in the course of depression. There is a growing body of evidence to support that neuroinflammation is a mediator for the communication among stress response, neuroendocrine, neurotransmission, neurogenesis, and gut microbiota. These communications have been known as risk factors in the pathogenesis of MDD. In the meantime, accumulating evidence has suggested that some interventions targeting the inflammatory processes may play an important role in the treatment of MDD.

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Change history

  • 08 March 2020

    In the original version of the book, the following belated corrections have been incorporated: “Walsh E, Eisenlohr-Moul T, Baer R (2016) Brief mindfulness training reduces salivary IL-6 and TNF-α in young women with depressive symptomatology. J Consult Clin Psychol 84(10):887–897. https://doi.org/10.1037/ccp0000122” has been replaced instead of “Schedlowski et al. 2016” in the reference list and citation in chapter 4. The chapter and book have been updated with the changes.

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Acknowledgements

We thank Prof. Yiru Fang for many constructive opinions on the writing of this chapter.

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Authors and Affiliations

  1. Department of Psychology, Provincial Hospital Affiliated to Shandong University, Jinan, China

    Guoqing Zhao

  2. Division of Mood Disorders, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China

    Xiaohua Liu

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  1. Guoqing Zhao
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Correspondence to Xiaohua Liu .

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  1. Division of Mood Disorders, Shanghai Mental Health Center, Shanghai, China

    Yiru Fang

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Zhao, G., Liu, X. (2019). Neuroimmune Advance in Depressive Disorder. In: Fang, Y. (eds) Depressive Disorders: Mechanisms, Measurement and Management. Advances in Experimental Medicine and Biology, vol 1180. Springer, Singapore. https://doi.org/10.1007/978-981-32-9271-0_4

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