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SIRT6 Activities in DNA Damage Repair and Premature Aging pp 1–59Cite as

Introduction

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Abstract

This chapter first gives a detailed background information on premature aging, laminopathies (a class of premature aging syndromes), and mammalian sirtuins to set the backdrop for introduction of SIRT6. This is followed by a literature survey on sirtuin 6 (SIRT6) and its roles in several biological processes, with a brief review on p53, a master regulatory factor involved in the aging process. This chapter concludes with the hypotheses and overall aims of the study.

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  1. Dana-Farber Cancer Institute, Boston, MA, USA

    Dr. Shrestha Ghosh

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Ghosh, S. (2019). Introduction. In: SIRT6 Activities in DNA Damage Repair and Premature Aging. Springer Theses. Springer, Singapore. https://doi.org/10.1007/978-981-32-9267-3_1

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