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Ocular Circulation

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Abstract

Blood supply of the eye

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References

  1. Riva CE, Alm A, Pournaras CJ. Ocular circulation. In: Levin LA, Nilsson SFE, Ver Hoeve J, Wu SM, editors. Adler’s physiology of the eye. 11th ed. Philadelphia: Saunders/Elsevier; 2011.

    Google Scholar 

  2. Hayreh SS. Orbital vascular anatomy. Eye. 2006;20:1130–44.

    Article  CAS  PubMed  Google Scholar 

  3. Kocabiyik N, Yalcin B, Ozan H. The morphometric analysis of the central retinal artery. Ophthal Physiol Opt. 2005;25:375–8.

    Article  Google Scholar 

  4. Resch H, Brela B, Resch-Wolfslehner C, Vass C. Position of retinal blood vessels correlates with retinal nerve fibre layer thickness profiles as measured with GDx VCC and ECC. Br J Ophthalmol. 2011;95:680–4.

    Article  PubMed Central  PubMed  Google Scholar 

  5. Hood DC, Fortune B, Arthur SN, et al. Blood vessel contributions to retinal nerve fiber layer thickness profiles measured with optical coherence tomography. J Glaucoma. 2008;17:519–28.

    Article  PubMed Central  PubMed  Google Scholar 

  6. Zhang Y, Stone J. Role of astrocytes in the control of developing retinal vessels. Invest Ophthalmol Vis Sci. 1997;38:1653–66.

    CAS  PubMed  Google Scholar 

  7. Pournaras CJ, Rungger-Brandle E, Riva CE, Hardarson SH, Stefansson E. Regulation of retinal blood flow in health and disease. Prog Retin Eye Res. 2008;27:284–330.

    Article  CAS  PubMed  Google Scholar 

  8. Nickla DL, Wallman J. The multifunctional choroid. Prog Retin Eye Res. 2010;29:144–68.

    Article  PubMed Central  PubMed  Google Scholar 

  9. Justice Jr J, Lehmann RP. Cilioretinal arteries. A study based on review of stereo fundus photographs and fluorescein angiographic findings. Arch Ophthalmol. 1976;94:1355–8.

    Article  PubMed  Google Scholar 

  10. Wang RK, An L, Francis P, Wilson DJ. Depth-resolved imaging of capillary networks in retina and choroid using ultrahigh sensitive optical microangiography. Opt Lett. 2010;35:1467–9.

    Article  PubMed Central  PubMed  Google Scholar 

  11. Henkind P. Radial peripapillary capillaries of the retina. I. Anatomy: human and comparative. Br J Ophthalmol. 1967;51:115–23.

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  12. Witkin AJ, Alshareef RA, Rezeq SS, et al. Comparative analysis of the retinal microvasculature visualized with fluorescein angiography and the retinal function imager. Am J Ophthalmol. 2012;154:901–7 e2.

    Article  PubMed  Google Scholar 

  13. Nelson DA, Burgansky-Eliash Z, Barash H, et al. High-resolution wide-field imaging of perfused capillaries without the use of contrast agent. Clin Ophthalmol. 2011;5:1095–106.

    PubMed Central  PubMed  Google Scholar 

  14. Wilcox LM, Keough EM, Connolly RJ, Hotte CE. The contribution of blood flow by the anterior ciliary arteries to the anterior segment in the primate eye. Exp Eye Res. 1980;30:167–74.

    Article  CAS  PubMed  Google Scholar 

  15. Song Y, Song YJ, Ko MK. A study of the vascular network of the iris using flat preparation. Korean J Ophthalmol. 2009;23:296–300.

    Article  PubMed Central  PubMed  Google Scholar 

  16. Hayreh SS. Posterior ciliary artery circulation in health and disease: the Weisenfeld lecture. Invest Ophthalmol Vis Sci. 2004;45:749–57, 58.

    Article  PubMed  Google Scholar 

  17. Hirata Y, Nishiwaki H. The choroidal circulation assessed by laser-targeted angiography. Prog Retin Eye Res. 2006;25:129–47.

    Article  PubMed  Google Scholar 

  18. Kiryu J, Shahidi M, Mori MT, Ogura Y, Asrani S, Zeimer R. Noninvasive visualization of the choriocapillaris and its dynamic filling. Invest Ophthalmol Vis Sci. 1994;35:3724–31.

    CAS  PubMed  Google Scholar 

  19. Hayreh SS. In vivo choroidal circulation and its watershed zones. Eye. 1990;4(Pt 2):273–89.

    Article  PubMed  Google Scholar 

  20. Hayreh SS. The 1994 Von Sallman Lecture. The optic nerve head circulation in health and disease. Exp Eye Res. 1995;61:259–72.

    Article  CAS  PubMed  Google Scholar 

  21. Hayreh SS. The blood supply of the optic nerve head and the evaluation of it – myth and reality. Prog Retin Eye Res. 2001;20:563–93.

    Article  CAS  PubMed  Google Scholar 

  22. Olver JM, Spalton DJ, McCartney AC. Microvascular study of the retrolaminar optic nerve in man: the possible significance in anterior ischaemic optic neuropathy. Eye. 1990;4(Pt 1):7–24.

    Article  PubMed  Google Scholar 

  23. Tso MO, Shih CY, McLean IW. Is there a blood–brain barrier at the optic nerve head? Arch Ophthalmol. 1975;93:815–25.

    Article  CAS  PubMed  Google Scholar 

  24. Onda E, Cioffi GA, Bacon DR, Van Buskirk EM. Microvasculature of the human optic nerve. Am J Ophthalmol. 1995;120:92–102.

    Article  CAS  PubMed  Google Scholar 

  25. Lu M, Adamis AP. The retinal microvasculature. In: Shepro D, editor. Microvascular research. New York: Elsevier; 2006.

    Google Scholar 

  26. Pries AR, Kuebler WM. Normal endothelium. Handb Exp Pharmacol. 2006;1–40.

    Google Scholar 

  27. Bill A, Tornquist P, Alm A. Permeability of the intraocular blood vessels. Trans Ophthalmol Soc U K. 1980;100:332–6.

    CAS  PubMed  Google Scholar 

  28. Erickson KK, Sundstrom JM, Antonetti DA. Vascular permeability in ocular disease and the role of tight junctions. Angiogenesis. 2007;10:103–17.

    Article  PubMed  Google Scholar 

  29. Tornquist P, Alm A, Bill A. Permeability of ocular vessels and transport across the blood-retinal-barrier. Eye. 1990;4(Pt 2):303–9.

    Article  PubMed  Google Scholar 

  30. Cunha-Vaz JG. The blood-ocular barriers: past, present, and future. Doc Ophthalmol. 1997;93:149–57.

    Article  CAS  PubMed  Google Scholar 

  31. Hosoya K, Yamamoto A, Akanuma S, Tachikawa M. Lipophilicity and transporter influence on blood-retinal barrier permeability: a comparison with blood–brain barrier permeability. Pharm Res. 2010;27:2715–24.

    Article  CAS  PubMed  Google Scholar 

  32. Hanrahan F, Humphries P, Campbell M. RNAi-mediated barrier modulation: synergies of the brain and eye. Ther Deliv. 2010;1:587–94.

    Article  CAS  PubMed  Google Scholar 

  33. Choi YK, Kim KW. Blood-neural barrier: its diversity and coordinated cell-to-cell communication. BMB Rep. 2008;41:345–52.

    Article  CAS  PubMed  Google Scholar 

  34. Bill A. The blood-aqueous barrier. Trans Ophthalmol Soc U K. 1986;105(Pt 2):149–55.

    PubMed  Google Scholar 

  35. Raviola G, Raviola E. Intercellular junctions in the ciliary epithelium. Invest Ophthalmol Vis Sci. 1978;17:958–81.

    CAS  PubMed  Google Scholar 

  36. Civan MM, Macknight AD. The ins and outs of aqueous humour secretion. Exp Eye Res. 2004;78:625–31.

    Article  CAS  PubMed  Google Scholar 

  37. Saari M. Ultrastructure of the microvessels of the iris in mammals with special reference to their permeability. Albrecht Von Graefes Arch Klin Exp Ophthalmol. 1975;194:87–93.

    Article  CAS  PubMed  Google Scholar 

  38. Kaur C, Foulds WS, Ling EA. Blood-retinal barrier in hypoxic ischaemic conditions: basic concepts, clinical features and management. Prog Retin Eye Res. 2008;27:622–47.

    Article  CAS  PubMed  Google Scholar 

  39. Frank RN, Turczyn TJ, Das A. Pericyte coverage of retinal and cerebral capillaries. Invest Ophthalmol Vis Sci. 1990;31:999–1007.

    CAS  PubMed  Google Scholar 

  40. Bandopadhyay R, Orte C, Lawrenson JG, Reid AR, De Silva S, Allt G. Contractile proteins in pericytes at the blood–brain and blood-retinal barriers. J Neurocytol. 2001;30:35–44.

    Article  CAS  PubMed  Google Scholar 

  41. Puro DG. Physiology and pathobiology of the pericyte-containing retinal microvasculature: new developments. Microcirculation. 2007;14:1–10.

    Article  CAS  PubMed  Google Scholar 

  42. Siemerink MJ, Augustin AJ, Schlingemann RO. Mechanisms of ocular angiogenesis and its molecular mediators. Dev Ophthalmol. 2010;46:4–20.

    Article  CAS  PubMed  Google Scholar 

  43. Rizzolo LJ. Development and role of tight junctions in the retinal pigment epithelium. Int Rev Cytol. 2007;258:195–234.

    Article  CAS  PubMed  Google Scholar 

  44. Hillenkamp J, Hussain AA, Jackson TL, Cunningham JR, Marshall J. The influence of path length and matrix components on ageing characteristics of transport between the choroid and the outer retina. Invest Ophthalmol Vis Sci. 2004;45:1493–8.

    Article  PubMed  Google Scholar 

  45. Miller SS, Hughes BA, Machen TE. Fluid transport across retinal pigment epithelium is inhibited by cyclic AMP. Proc Natl Acad Sci U S A. 1982;79:2111–5.

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  46. Bill A, Sperber G, Ujiie K. Physiology of the choroidal vascular bed. Int Ophthalmol. 1983;6:101–7.

    Article  CAS  PubMed  Google Scholar 

  47. Rose RC, Bode AM. Ocular ascorbate transport and metabolism. Comp Biochem Physiol A Comp Physiol. 1991;100:273–85.

    Article  CAS  PubMed  Google Scholar 

  48. Kur J, Newman EA, Chan-Ling T. Cellular and physiological mechanisms underlying blood flow regulation in the retina and choroid in health and disease. Prog Retin Eye Res. 2012;31:377–406.

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  49. Delaey C, Van De Voorde J. Regulatory mechanisms in the retinal and choroidal circulation. Ophthalmic Res. 2000;32:249–56.

    Article  CAS  PubMed  Google Scholar 

  50. Wang Y, Lu A, Gil-Flamer J, Tan O, Izatt JA, Huang D. Measurement of total blood flow in the normal human retina using Doppler Fourier-domain optical coherence tomography. Br J Ophthalmol. 2009;93:634–7.

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  51. Tornquist P, Alm A. Retinal and choroidal contribution to retinal metabolism in vivo. A study in pigs. Acta Physiol Scand. 1979;106:351–7.

    Article  CAS  PubMed  Google Scholar 

  52. Dumskyj MJ, Eriksen JE, Dore CJ, Kohner EM. Autoregulation in the human retinal circulation: assessment using isometric exercise, laser Doppler velocimetry, and computer-assisted image analysis. Microvasc Res. 1996;51:378–92.

    Article  CAS  PubMed  Google Scholar 

  53. Flammer J, Mozaffarieh M. Autoregulation, a balancing act between supply and demand. Can J Ophthalmol. 2008;43:317–21.

    Article  PubMed  Google Scholar 

  54. Kawarai M, Koss MC. Sympathetic vasodilation in the rat anterior choroid mediated by beta(1)-adrenoceptors. Eur J Pharmacol. 1999;386:227–33.

    Article  CAS  PubMed  Google Scholar 

  55. Lutjen-Drecoll E. Choroidal innervation in primate eyes. Exp Eye Res. 2006;82:357–61.

    Article  PubMed  Google Scholar 

  56. Polak K, Schmetterer L, Riva CE. Influence of flicker frequency on flicker-induced changes of retinal vessel diameter. Invest Ophthalmol Vis Sci. 2002;43:2721–6.

    PubMed  Google Scholar 

  57. Simader C, Lung S, Weigert G, et al. Role of NO in the control of choroidal blood flow during a decrease in ocular perfusion pressure. Invest Ophthalmol Vis Sci. 2009;50:372–7.

    Article  PubMed  Google Scholar 

  58. Glucksberg MR, Dunn R. Direct measurement of retinal microvascular pressures in the live, anesthetized cat. Microvasc Res. 1993;45:158–65.

    Article  CAS  PubMed  Google Scholar 

  59. Caprioli J, Coleman AL. Blood flow in glaucoma D. Blood pressure, perfusion pressure, and glaucoma. Am J Ophthalmol. 2010;149:704–12.

    Article  PubMed  Google Scholar 

  60. Wang L, Grant C, Fortune B, Cioffi GA. Retinal and choroidal vasoreactivity to altered PaCO2 in rat measured with a modified microsphere technique. Exp Eye Res. 2008;86:908–13.

    Article  CAS  PubMed  Google Scholar 

  61. Lange CA, Bainbridge JW. Oxygen sensing in retinal health and disease. Ophthalmologica. 2012;227:115–31.

    Article  CAS  PubMed  Google Scholar 

  62. Yamanishi S, Katsumura K, Kobayashi T, Puro DG. Extracellular lactate as a dynamic vasoactive signal in the rat retinal microvasculature. Am J Physiol Heart Circ Physiol. 2006;290:H925–34.

    Article  CAS  PubMed  Google Scholar 

  63. Wang L, Bill A. Effects of constant and flickering light on retinal metabolism in rabbits. Acta Ophthalmol Scand. 1997;75:227–31.

    Article  CAS  PubMed  Google Scholar 

  64. Polak K, Luksch A, Frank B, Jandrasits K, Polska E, Schmetterer L. Regulation of human retinal blood flow by endothelin-1. Exp Eye Res. 2003;76:633–40.

    Article  CAS  PubMed  Google Scholar 

  65. Steinle JJ, Krizsan-Agbas D, Smith PG. Regional regulation of choroidal blood flow by autonomic innervation in the rat. Am J Physiol Regul Integr Comp Physiol. 2000;279:R202–9.

    CAS  PubMed  Google Scholar 

  66. Movaffaghy A, Chamot SR, Dosso A, Pournaras CJ, Sommerhalder JR, Riva CE. Effect of isometric exercise on choroidal blood flow in type I diabetic patients. Klin Monbl Augenheilkd. 2002;219:299–301.

    Article  PubMed  Google Scholar 

  67. Nilsson SF, Linder J, Bill A. Characteristics of uveal vasodilation produced by facial nerve stimulation in monkeys, cats and rabbits. Exp Eye Res. 1985;40:841–52.

    Article  CAS  PubMed  Google Scholar 

  68. Hayreh SS. Acute retinal arterial occlusive disorders. Prog Retin Eye Res. 2011;30:359–94.

    Article  PubMed Central  PubMed  Google Scholar 

  69. Unger WG. Review: mediation of the ocular response to injury. J Ocul Pharmacol. 1990;6:337–53.

    Article  CAS  PubMed  Google Scholar 

  70. Beltramo E, Porta M. Pericyte loss in diabetic retinopathy: mechanisms and consequences. Curr Med Chem. 2013;20:3218–25.

    Article  CAS  PubMed  Google Scholar 

  71. Schmidl D, Garhofer G, Schmetterer L. The complex interaction between ocular perfusion pressure and ocular blood flow - relevance for glaucoma. Exp Eye Res. 2011;93:141–55.

    Article  CAS  PubMed  Google Scholar 

  72. Weinberger J. Clinical applications of noninvasive carotid artery testing. J Am Coll Cardiol. 1985;5:137–48.

    Article  CAS  PubMed  Google Scholar 

  73. Ferrara N. Role of vascular endothelial growth factor in regulation of physiological angiogenesis. Am J Physiol Cell Physiol. 2001;280:C1358–66.

    CAS  PubMed  Google Scholar 

  74. Miller JW, Le Couter J, Strauss EC, Ferrara N. Vascular endothelial growth factor a in intraocular vascular disease. Ophthalmology. 2013;120:106–14.

    Article  PubMed  Google Scholar 

  75. Wakabayashi T, Oshima Y, Sakaguchi H, et al. Intravitreal bevacizumab to treat iris neovascularization and neovascular glaucoma secondary to ischemic retinal diseases in 41 consecutive cases. Ophthalmology. 2008;115:1571–80, 80e1–3.

    Article  PubMed  Google Scholar 

  76. Kim J, Kim SJ, Chang YS, Park WS. Combined intravitreal bevacizumab injection and zone I sparing laser photocoagulation in patients with zone I retinopathy of prematurity. Retina. 2014;34:77–82.

    Article  CAS  PubMed  Google Scholar 

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Skalicky, S.E. (2016). Ocular Circulation. In: Ocular and Visual Physiology. Springer, Singapore. https://doi.org/10.1007/978-981-287-846-5_11

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  • DOI: https://doi.org/10.1007/978-981-287-846-5_11

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