Abstract
Bilateral cadaveric lung transplantation (CLT) is the most common procedure for pulmonary arterial hypertension (PAH) according to the report from International Society for Heart and Lung Transplantation. The 5-year survival after CLT is approximately 50 %, and pulmonary hypertension (PH) is known to be a significant risk factor of early death after lung transplantation.
Because of severe shortage of cadaveric lungs in Japan, living-donor lobar lung transplantation (LDLLT) is often the only realistic option for very sick PAH patients especially for children.
Between 1998 and 2015, lung transplantation has been performed in 464 patients at nine lung transplant centers in Japan. Among these, the author and his colleagues have performed 184 lung transplants including 111 LDLLTs and 73 CLTs. Thirty-five of them (19 %) were diagnosed with PH. Twenty-four patients received LDLLT and 11 patients received CLT. The 5-year survival rate was 81.2 % for PH patients (n = 35) and was 72.2 % for non-PH patients (n = 149).
Lung transplantation is a viable treatment in patients with PAH who failed to respond medical treatment.
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Date, H. (2017). Lung Transplantation. In: Fukumoto, Y. (eds) Diagnosis and Treatment of Pulmonary Hypertension. Springer, Singapore. https://doi.org/10.1007/978-981-287-840-3_13
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DOI: https://doi.org/10.1007/978-981-287-840-3_13
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