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Clarithromycin

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Helicobacter pylori

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Abstract

Clarithromycin is a macrolide antimicrobial agent that is the main component of Helicobacter pylori (H. pylori) eradication therapy. Therefore, clarithromycin resistance is the most influential factor to determine either the success or the failure of the antibiotic therapy. Recently, clarithromycin resistance has rapidly increased, which leads to H. pylori eradication failure. Clarithromycin resistance mechanisms depend on 23S rRNA gene mutations, and A2143G point mutation is the most critical factor for the determination of resistance. Thus, the pretreatment determination of clarithromycin resistance leads to the increment of successful eradication. Also, genetic epidemiology studies on resistance mutations contribute to the development of rapid molecular diagnostic tests for better H. pylori treatment. Therefore, studies to overcome resistance mechanism should be continued.

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Authors and Affiliations

  1. Department of Internal Medicine and Liver Research Institute, Seoul National University College of Medicine, 101 Daehak-ro, Jongno-gu, Seoul, 03080, South Korea

    Jung Won Lee MD

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  1. Jung Won Lee MD
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Correspondence to Jung Won Lee MD .

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Editors and Affiliations

  1. Seoul National University, Bundang Hospital, Seongnam-si, Gyeonggi-do, Korea (Republic of)

    Nayoung Kim

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© 2016 Springer Science+Business Media Singapore

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Lee, J.W. (2016). Clarithromycin. In: Kim, N. (eds) Helicobacter pylori. Springer, Singapore. https://doi.org/10.1007/978-981-287-706-2_36

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  • DOI: https://doi.org/10.1007/978-981-287-706-2_36

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  • Publisher Name: Springer, Singapore

  • Print ISBN: 978-981-287-705-5

  • Online ISBN: 978-981-287-706-2

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