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Gastric Cancer: First Relatives of Gastric Cancer

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Helicobacter pylori

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Abstract

Family history is an important risk factor of gastric cancer and can be seen from 10 % to 15 % of gastric cancer patients. This factor is partially explained by genetic and environmental factors, and family history is also related to familial clustering of Helicobacter pylori (H. pylori) infection. This factor is notable because an immediate family history on gastric cancer itself increases gastric cancer genesis by two to three times, and this genesis increases by 5.88 times if H. pylori infection is also present. Along with family history as a risk factor, some of gastric cancer types with high genetic dependence can be classified as germline CDHI mutation-related hereditary diffuse gastric cancer of which was found to be 0.3–3.1 % in Korea and Japan. Although family history increases gastric cancer genesis, this factor is beneficial for the cancer prognosis. These subjects do frequent health screenings because of their immediate family history and follow good health-related behaviors, and the patients often show microsatellite instability (MSI) and mismatch repair proteins, which are related to good prognosis. H. pylori eradication is the most important priority for immediate family members, who are less than 40s, especially in 20s and 30s, of gastric cancer patients. This early H. pylori eradication is helpful to avoid future intestinal metaplasia and to restrict synergistic effect of H. pylori infection and the immediate family history.

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  1. Department of Internal Medicine, Seoul National University College of Medicine, Seoul National University Bundang Hospital, 82 Gumi-ro 173 beon-gil, Bundang-gu, Seongnam, Gyeonggi-do, 13620, South Korea

    Nayoung Kim MD, PhD & Yoon Jin Choi

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Correspondence to Nayoung Kim MD, PhD .

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  1. Seoul National University, Bundang Hospital, Seongnam-si, Gyeonggi-do, Korea (Republic of)

    Nayoung Kim

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Kim, N., Choi, Y.J. (2016). Gastric Cancer: First Relatives of Gastric Cancer. In: Kim, N. (eds) Helicobacter pylori. Springer, Singapore. https://doi.org/10.1007/978-981-287-706-2_27

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  • DOI: https://doi.org/10.1007/978-981-287-706-2_27

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