Abstract
A wide variant of non-tumorous bone lesions may exhibit radiographic and MRI features similar to neoplastic conditions of the bone. The World Health Organization classification includes simple bone cysts, aneurysmal bone cysts, fibrous dysplasia, osteofibrous dysplasia, and Langerhans cell histiocytosis under the category “tumors of undefined neoplastic nature.” These lesions will be discussed in this chapter, along with other miscellaneous lesions such as intraosseous lipoma, liposclerosing myxofibrous tumors, and adamantinoma. Brown tumor is not a true tumor but rather a reparative cellular process which is seen in hyperparathyroidism. However, it has overlapping imaging features with certain primary bone tumors or metastatic diseases and will be illustrated in this chapter.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Suggested Reading
Simple Bone Cyst
Burr BA, Resnick D, Syklawer R, Haghighi P. Fluid-fluid levels in a unicameral bone cyst: CT and MR findings. J Comput Assist Tomogr. 1993;17:134–6.
Lokiec F, Wientroub S. Simple bone cyst: etiology, classification, pathology, and treatment modalities. J Pediatr Orthop B. 1998;7:262–73.
Margau R, Babyn P, Cole W, Smith C, Lee F. MR imaging of simple bone cysts in children: not so simple. Pediatr Radiol. 2000;30:551–7.
Struhl S, Edelson C, Pritzker H, Seimon LP, Dorfman HD. Solitary (unicameral) bone cyst. The fallen fragment sign revisited. Skeletal Radiol. 1989;18:261–5.
Wilkins RM. Unicameral bone cysts. J Am Acad Orthop Surg. 2000;8:217–24.
Aneurysmal Bone Cyst
Beltran J, Simon DC, Levy M, Herman L, Weis L, Mueller CF. Aneurysmal bone cysts: MR imaging at 1.5 T. Radiology. 1986;158:689–90.
Bonakdarpour A, Levy WM, Aegerter E. Primary and secondary aneurysmal bone cyst: a radiological study of 75 cases. Radiology. 1978;126:75–83.
Hudson TM. Fluid levels in aneurysmal bone cysts: a CT feature. AJR Am J Roentgenol. 1984;142:1001–4.
Hudson TM, Hamlin DJ, Fitzsimmons JR. Magnetic resonance imaging of fluid levels in an aneurysmal bone cyst and in anticoagulated human blood. Skelet Radiol. 1985;13:267–70.
Kransdorf MJ, Sweet DE. Aneurysmal bone cyst: concept, controversy, clinical presentation, and imaging. AJR Am J Roentgenol. 1995;164:573–80.
Levy WM, Miller AS, Bonakdarpour A, Aegerter E. Aneurysmal bone cyst secondary to other osseous lesions. Report of 57 cases. Am J Clin Pathol. 1975;63:1–8.
Mahnken AH, Nolte-Ernsting CC, Wildberger JE, et al. Aneurysmal bone cyst: value of MR imaging and conventional radiography. Eur Radiol. 2003;13:1118–24.
Munk PL, Helms CA, Holt RG, Johnston J, Steinbach L, Neumann C. MR imaging of aneurysmal bone cysts. AJR Am J Roentgenol. 1989;153:99–101.
Fibrous Dysplasia
Fitzpatrick KA, Taljanovic MS, Speer DP, et al. Imaging findings of fibrous dysplasia with histopathologic and intraoperative correlation. AJR Am J Roentgenol. 2004;182:1389–98.
Jee WH, Choi KH, Choe BY, Park JM, Shinn KS. Fibrous dysplasia: MR imaging characteristics with radiopathologic correlation. AJR Am J Roentgenol. 1996;167:1523–7.
Kransdorf MJ, Moser Jr RP, Gilkey FW. Fibrous dysplasia. Radiographics. 1990;10:519–37.
Kumar R, Madewell JE, Lindell MM, Swischuk LE. Fibrous lesions of bones. Radiographics. 1990;10:237–56.
Ozaki T, Sugihara M, Nakatsuka Y, Kawai A, Inoue H. Polyostotic fibrous dysplasia. A long-term follow up of 8 patients. Int Orthop. 1996;20:227–32.
Utz JA, Kransdorf MJ, Jelinek JS, Moser Jr RP, Berrey BH. MR appearance of fibrous dysplasia. J Comput Assist Tomogr. 1989;13:845–51.
Osteofibrous Dysplasia
Bethapudi S, Ritchie DA, Macduff E, Straiton J. Imaging in osteofibrous dysplasia, osteofibrous dysplasia-like adamantinoma, and classic adamantinoma. Clin Radiol. 2014;69:200–8.
Jung JY, Jee WH, Hong SH, et al. MR findings of the osteofibrous dysplasia. Korean J Radiol. 2014;15:114–22.
Kahn LB. Adamantinoma, osteofibrous dysplasia and differentiated adamantinoma. Skelet Radiol. 2003;32:245–58.
Khanna M, Delaney D, Tirabosco R, Saifuddin A. Osteofibrous dysplasia, osteofibrous dysplasia-like adamantinoma and adamantinoma: correlation of radiological imaging features with surgical histology and assessment of the use of radiology in contributing to needle biopsy diagnosis. Skelet Radiol. 2008;37:1077–84.
Levine SM, Lambiase RE, Petchprapa CN. Cortical lesions of the tibia: characteristic appearances at conventional radiography. Radiographics. 2003;23:157–77.
Langerhans Cell Histiocytosis
Azouz EM, Saigal G, Rodriguez MM, Podda A. Langerhans’ cell histiocytosis: pathology, imaging and treatment of skeletal involvement. Pediatr Radiol. 2005;35:103–15.
Ghanem I, Tolo VT, D’Ambra P, Malogalowkin MH. Langerhans cell histiocytosis of bone in children and adolescents. J Pediatr Orthop. 2003;23:124–30.
Khung S, Budzik JF, Amzallag-Bellenger E, et al. Skeletal involvement in Langerhans cell histiocytosis. Insights Imaging. 2013;4:569–79.
Meyer JS, Harty MP, Mahboubi S, et al. Langerhans cell histiocytosis: presentation and evolution of radiologic findings with clinical correlation. Radiographics. 1995;15:1135–46.
Stull MA, Kransdorf MJ, Devaney KO. Langerhans cell histiocytosis of bone. Radiographics. 1992;12:801–23.
Song YS, Lee IS, Yi JH, Cho KH, Kim DK, Song JW. Radiologic findings of adult pelvis and appendicular skeletal Langerhans cell histiocytosis in nine patients. Skelet Radiol. 2011;40:1421–6.
Intraosseous Lipoma
Blacksin MF, Ende N, Benevenia J. Magnetic resonance imaging of intraosseous lipomas: a radiologic-pathologic correlation. Skelet Radiol. 1995;24:37–41.
Campbell RS, Grainger AJ, Mangham DC, Beggs I, Teh J, Davies AM. Intraosseous lipoma: report of 35 new cases and a review of the literature. Skelet Radiol. 2003;32:209–22.
Levin MF, Vellet AD, Munk PL, McLean CA. Intraosseous lipoma of the distal femur: MRI appearance. Skelet Radiol. 1996;25:82–4.
Murphey MD, Carroll JF, Flemming DJ, Pope TL, Gannon FH, Kransdorf MJ. From the archives of the AFIP: benign musculoskeletal lipomatous lesions. Radiographics. 2004;24:1433–66.
Propeck T, Bullard MA, Lin J, Doi K, Martel W. Radiologic-pathologic correlation of intraosseous lipomas. AJR Am J Roentgenol. 2000;175:673–8.
Reig-Boix V, Guinot-Tormo J, Risent-Martinez F, Aparisi-Rodriguez F, Ferrer-Jimenez R. Computed tomography of intraosseous lipoma of os calcis. Clin Orthop Relat Res. 1987;221:286–91.
Liposclerosing Myxofibrous Tumor
Corsi A, De Maio F, Ippolito E, et al. Monostotic fibrous dysplasia of the proximal femur and liposclerosing myxofibrous tumor: which one is which? J Bone Miner Res. 2006;21:1955–8.
Heim-Hall JM, Williams RP. Liposclerosing myxofibrous tumour: a traumatized variant of fibrous dysplasia? Report of four cases and review of the literature. Histopathology. 2004;45:369–76.
Kransdorf MJ, Murphey MD, Sweet DE. Liposclerosing myxofibrous tumor: a radiologic-pathologic-distinct fibro-osseous lesion of bone with a marked predilection for the intertrochanteric region of the femur. Radiology. 1999;212:693–8.
Murphey MD, Carroll JF, Flemming DJ, Pope TL, Gannon FH, Kransdorf MJ. From the archives of the AFIP: benign musculoskeletal lipomatous lesions. Radiographics. 2004;24:1433–66.
Adamantinoma
Bethapudi S, Ritchie DA, Macduff E, Straiton J. Imaging in osteofibrous dysplasia, osteofibrous dysplasia-like adamantinoma, and classic adamantinoma. Clin Radiol. 2014;69:200–8.
Kahn LB. Adamantinoma, osteofibrous dysplasia and differentiated adamantinoma. Skelet Radiol. 2003;32:245–58.
Khanna M, Delaney D, Tirabosco R, Saifuddin A. Osteofibrous dysplasia, osteofibrous dysplasia-like adamantinoma and adamantinoma: correlation of radiological imaging features with surgical histology and assessment of the use of radiology in contributing to needle biopsy diagnosis. Skelet Radiol. 2008;37:1077–84.
Levine SM, Lambiase RE, Petchprapa CN. Cortical lesions of the tibia: characteristic appearances at conventional radiography. Radiographics. 2003;23:157–77.
Brown Tumor
Chew FS, Huang-Hellinger F. Brown tumor. AJR Am J Roentgenol. 1993;160:752.
Davies AM, Evans N, Mangham DC, Grimer RJ. MR imaging of brown tumour with fluid-fluid levels: a report of three cases. Eur Radiol. 2001;11:1445–9.
Franco M, Bendini JC, Albano L, Barrillon D, Cassuto E, Bracco J. Radiographic follow-up of a phalangeal brown tumor. Joint Bone Spine. 2002;69:506–10.
Hong WS, Sung MS, Chun KA, et al. Emphasis on the MR imaging findings of brown tumor: a report of five cases. Skelet Radiol. 2011;205:205–13.
Hoshi M, Takami M, Kajikawa M, et al. A case of multiple skeletal lesions of brown tumors, mimicking carcinoma metastases. Arch Orthop Trauma Surg. 2008;128:149–54.
Jouan A, Zabraniecki L, Vincent V, Poix E, Fournie B. An unusual presentation of primary hyperparathyroidism: severe hypercalcemia and multiple brown tumors. Joint Bone Spine. 2008;75:209–11.
Author information
Authors and Affiliations
Rights and permissions
Copyright information
© 2017 Springer Science+Business Media Singapore
About this chapter
Cite this chapter
Kang, H.S., Ahn, J.M., Kang, Y. (2017). Other Tumor-Like Lesions and Soft Tissue Type Tumors. In: Oncologic Imaging: Bone Tumors. Springer, Singapore. https://doi.org/10.1007/978-981-287-703-1_8
Download citation
DOI: https://doi.org/10.1007/978-981-287-703-1_8
Publisher Name: Springer, Singapore
Print ISBN: 978-981-287-702-4
Online ISBN: 978-981-287-703-1
eBook Packages: MedicineMedicine (R0)