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Plasmonic Exosome Biosensors for Medical Diagnostics

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Frontiers in Biophotonics for Translational Medicine

Part of the book series: Progress in Optical Science and Photonics ((POSP,volume 3))

Abstract

This chapter provides an overview of plasmonic biosensor technology for the analysis of extracellular lipid vesicles that hold potential to serve as new type of biomarkers. In particular, it discusses detection of exosomes that are secreted to bodily fluids and become of increasing interest in clinical research. Plasmonic biosensor technology is pushed forward to provide new means for their sensitive and specific detection without the need of specialized laboratories. It offers a versatile optical toolbox for probing various biological species by tightly confined electromagnetic field of surface plasmons. These optical waves originate from collective oscillations of electron charge density at metallic thin films and (nano)structures. This chapter gives an introduction to surface plasmon photonics and its use in direct surface plasmon resonance and in fluorescence spectroscopy-based biosensors. It provides a brief summary of current state-of-the-art in exosome biomarker research and discusses current advances in exosome plasmonic biosensors for medical diagnostics of diseases, in particular cancer.

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Acknowledgments

This work was partially supported by Austrian Science Fund (FWF) through the project ACTIPLAS (P244920-N20) and by Austrian Federal Ministry for Transport, Innovation and Technology (GZ BMVIT-612.166/0001-III/I1/2010) via the International Graduate School Bio-Nano-Tech, a joint Ph.D. program of the University of Natural Resources and Life Sciences Vienna (BOKU), the Austrian Institute of Technology (AIT), and the Nanyang Technological University (NTU).

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Authors and Affiliations

  1. BioSensor Technologies, AIT-Austrian Institute of Technology GmbH, Muthgasse 11, 1190, Vienna, Austria

    Agnes T. Reiner, Wolfgang Knoll & Jakub Dostalek

  2. Centre for Biomimetic Sensor Science, School of Materials Science and Engineering, Nanyang Technological University, 50 Nanyang Drive, Singapore, 637553, Singapore

    Agnes T. Reiner & Wolfgang Knoll

  3. Institute of Biomaterials and Bioengineering, Tokyo Medical and Dental University, 2-3-10 Kanda-Surugadai, Chiyoda-ku, Tokyo, 101-0062, Japan

    Koji Toma

  4. Molecular Imaging and NanoBioTechnology, UMR-5248-CBMN CNRS-University of Bordeaux-IPB, Allée Geoffroy Saint-Hilaire, 33600, Pessac, France

    Alain R. Brisson

  5. Department of Obstetrics and Gynecology, Molecular Oncology Group, Medical University of Vienna, Waehringer Guertel 18-20, 1090, Vienna, Austria

    Dietmar Pils

Authors
  1. Agnes T. Reiner
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  2. Koji Toma
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  3. Alain R. Brisson
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  4. Dietmar Pils
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  6. Jakub Dostalek
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Correspondence to Jakub Dostalek .

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Editors and Affiliations

  1. Agency for Science, Technology and Research (A*STAR), Singapore Bioimaging Consortium, Singapore, Singapore

    Malini Olivo

  2. Agency for Science, Technology and Research (A*STAR), Singapore Bioimaging Consortium, Singapore, Singapore

    U. S. Dinish

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Reiner, A.T., Toma, K., Brisson, A.R., Pils, D., Knoll, W., Dostalek, J. (2016). Plasmonic Exosome Biosensors for Medical Diagnostics. In: Olivo, M., Dinish, U. (eds) Frontiers in Biophotonics for Translational Medicine. Progress in Optical Science and Photonics, vol 3. Springer, Singapore. https://doi.org/10.1007/978-981-287-627-0_8

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  • DOI: https://doi.org/10.1007/978-981-287-627-0_8

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  • Publisher Name: Springer, Singapore

  • Print ISBN: 978-981-287-626-3

  • Online ISBN: 978-981-287-627-0

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