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Association of BDNF Levels and Muscoskeletal Problems in Type 2 Diabetes

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Biotechnology and Bioforensics

Part of the book series: SpringerBriefs in Applied Sciences and Technology ((BRIEFSFOMEBI))

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Abstract

Brain Derived neurotrophic factor (BDNF) is very well reported in development of neurons and it plays major role in memory and interpretation. It is evident that BDNF is involved in maintaining the equilibrium of body weight and glucose homeostasis mechanism. Out of 96 Subjects included in this study Plasma BDNF level was found low in the patients with Type 2 Diabetes. We didn’t find positive indications wrt association of BDNF G196A (Val66Met) polymorphism in diabetes or obesity. Type 2 Diabetic patients with the complaint of Joint pains were found to have even lower Plasma BDNF levels as compared to the diabetic patients without any Neurological problems or joint pains. Worsening BDNF Levels may be an alarming factor for type 2 diabetic patients with respect to development of Neurological disorders.

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Funding and Support

This Research was solely funded by Department of Science and Technology, Government of India under IRHPA Scheme vide Lr No. IR/SO/LU/03/2008/1.

Conflict of Interest

Authors didn’t have any conflict of interest in this Research.

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Authors and Affiliations

  1. Jawaharlal Nehru Technological University, Kakinada, Andhra Pradesh, India

    Allam Appa Rao

  2. BioAxis DNA Research Centre (P) Limited, Hyderabad, 500 068, Andhra Pradesh, India

    Amit Kumar, Surendra Babu & Anuradha Parihar

  3. Andhra University, Visakhapatnam, India

    Surendra Babu

  4. Jawaharlal Nehru Technological University, Vijayanagaram, Andhra Pradesh, India

    Subha Senkhula

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  1. Allam Appa Rao
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  2. Amit Kumar
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  4. Anuradha Parihar
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  5. Subha Senkhula
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Correspondence to Allam Appa Rao .

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Rao, A.A., Kumar, A., Babu, S., Parihar, A., Senkhula, S. (2015). Association of BDNF Levels and Muscoskeletal Problems in Type 2 Diabetes. In: Biotechnology and Bioforensics. SpringerBriefs in Applied Sciences and Technology(). Springer, Singapore. https://doi.org/10.1007/978-981-287-050-6_9

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  • DOI: https://doi.org/10.1007/978-981-287-050-6_9

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  • Publisher Name: Springer, Singapore

  • Print ISBN: 978-981-287-049-0

  • Online ISBN: 978-981-287-050-6

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