Skip to main content
SpringerLink
Log in

Predisposition Factors of Type II Diabetes Mellitus and Related Complications

  • Chapter
  • First Online:
Biotechnology and Bioforensics

Part of the book series: SpringerBriefs in Applied Sciences and Technology ((BRIEFSFOMEBI))

  • 1413 Accesses

Abstract

Diabetes mellitus is considered to be one of the leading causes of death in adult and children. The most challenging complex heterogeneous group of conditions is prevalent in developing countries as well as the western world is T II DM. Rise in upcoming cases of diabetes has posed it as a global health problem. The predisposition factors are responsible for identifying at risk individuals for this polygenic disorder. Several controllable and non-controllable predisposition factors are responsible for identification of at-risk individuals to T II DM. The complex interactions between genetic and environmental and biochemical predisposition factors unmask the advancement of the disease. This review gives brief description and table form of the work done by the researchers for predisposition of Type II diabetes and some of the related complications among Asian Indian phenotypes and world wide.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 39.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 54.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  1. Himsworth HP (1936) Diabetes mellitus: its differentiation into insulin-sensitive and insulin-insensitive types. Lancet 227(5864):127–130

    Article  Google Scholar 

  2. International Diabetes Federation (2011) IDF Diabetes Atlas, 5th edn. Brussels, International Diabetes Federation, Belgium

    Google Scholar 

  3. Sicree R, Shaw J, Zimmet P (2006) Diabetes and impaired glucose tolerance. In: Gan D (ed) Diabetes atlas, 3rd edn. International Diabetes Federation, Belgium, pp 15–103

    Google Scholar 

  4. Wild S et al (2004) Global prevalence of diabetes estimates for the year 2000 and projections for 2030. Diabetes Care 27(5):1047–1053

    Article  Google Scholar 

  5. Chakravarthy A (1938) A study of diabetes and its treatment with special reference to Bengalis and their diet. Indian Med Rec 58:65

    Google Scholar 

  6. Patel JC, Dhirawani MK (1959) Incidence of diabetes in Bombay: analysis of 8 years’ case records of a general hospital. Indian J Med Sci 12:10

    Google Scholar 

  7. Jaya Rao KS et al (1972) A survey of diabetes mellitus in a rural population of India. Diabetes 21:1192–1196

    Google Scholar 

  8. Rao PV et al (1989) The Eluru survey: prevalence of known diabetes in a rural Indian population. Diabetes Res Clin Pract 7(1):29–31

    Article  CAS  Google Scholar 

  9. Blots ML et al (1994) Impaired glucose tolerance and diabetes mellitus in a rural population in South India. Diabetes Clin Pract 24(1):47–53

    Article  Google Scholar 

  10. Ramachandran A, Dharmaraj D, Snehlatha C, Viswanathan M (1992) Prevalence of glucose intolerance in Asian Indians: urban–rural difference and significance of upper body adiposity. Diabetes Care 15:1348–1355

    Article  CAS  Google Scholar 

  11. Fagot-Campagna A et al (2000) Type 2 diabetes among North American children and adolescents: an epidemiologic review and a public health perspective. J Pediatr 136(5):664–672

    Article  CAS  Google Scholar 

  12. Pinhas-Hamiel O (1996) Increased incidence of non-insulin-dependent diabetes mellitus among adolescents. J Pediatr 128(5 Pt 1):608–615

    Article  CAS  Google Scholar 

  13. Bennett PH, Burch TA, Miller M (1971) Diabetes mellitus in American (Pima) Indians. Lancet 2:125–128

    Article  CAS  Google Scholar 

  14. McKeigue PM, Miller GJ, Marmot MG (1989) Coronary heart disease in South Asians overseas—a review. J Clin Epidemiol 42:597–609

    Article  CAS  Google Scholar 

  15. Abate N, Chandalia M (2007) Ethnicity, type 2 diabetes and migrant Asian Indians. Indian J Med Res 125:251–258

    Google Scholar 

  16. Haffner S, Temprosa M, Crandall J et al (2005) Intensive lifestyle intervention or metformin on inflammation and coagulation in participants with impaired glucose tolerance. Diabetes 54:1566–1572

    Article  Google Scholar 

  17. Rosenwaike I, Hempstead K, Rogers RG (1987) Mortality differentials among persons born in Cuba, Mexico, and Puerto Rico residing in the United States, 1979–81. Am J Public Health 77:603–606

    Article  CAS  Google Scholar 

  18. Østergård T et al (2006) Endothelial function and biochemical vascular markers in first-degree relatives of type 2 diabetic patients: the effect of exercise training. Metabolism 55(11):1508–1515

    Article  Google Scholar 

  19. Klein R et al (1998) Relation of glycemic control to diabetic complications and health outcomes. Diabetes Care 21(3):c39–c43

    Google Scholar 

  20. Petrovic BD et al (2005) Gly482Ser polymorphism of the peroxisome proliferator-activated receptor-gamma coactivator-1 gene might be a risk factor for diabetic retinopathy in Slovene population (Caucasians) with type 2 diabetes and the Pro12Ala polymorphism of the PPARgamma gene is not. Diabetes Metab Res Rev 21(5):470–474

    Article  CAS  Google Scholar 

  21. Altshuler David (2000) The common PPARγ Pro12Ala polymorphism is associated with decreased risk of type 2 diabetes. Nat Genet 26:76–80

    Article  CAS  Google Scholar 

  22. Cheyssac C (2006) Analysis of common PTPN1 gene variants in type 2 diabetes, obesity and associated phenotypes in the French population. BMC Med Genet 7:44

    Article  Google Scholar 

  23. Bento JL (2004) Association of protein tyrosine phosphatase 1B gene polymorphisms with type 2 diabetes. Diabetes 53:3007–3012

    Article  CAS  Google Scholar 

  24. Wang RQ (2011) ENPP1/PC-1 gene K121Q polymorphism is associated with obesity in European adult populations: evidence from a meta-analysis involving 24324 subject. Biomed Environ Sci 24(2):200–206

    Google Scholar 

  25. Fu D, Cong X, Ma Y et al (2013) Genetic polymorphism of glucokinase on the risk of type 2 diabetes and impaired glucose regulation: evidence based on 298, 468 subjects. PloS ONE 8(2):e55727

    Google Scholar 

  26. Florez JC, Jablonski KA, Kahn SE et al (2007) Type 2 diabetes-associated missense polymorphisms KCNJ11 E23K and ABCC8 A1369S influence progression to diabetes and response to interventions in the diabetes prevention program. Diabetes 56:531–536

    Google Scholar 

  27. Sakamoto Y et al (2007) SNPs in the KCNJ11-ABCC8 gene locus are associated with type 2 diabetes and blood pressure levels in the Japanese population. J Hum Genet 52:781–793

    Article  CAS  Google Scholar 

  28. Glyon AL (2003) Large-scale association studies of variants in genes encoding the pancreatic beta-cell KATP channel subunits Kir6.2 (KCNJ11) and SUR1 (ABCC8) confirm that the KCNJ11 E23K variant is associated with type 2 diabetes. Diabetes 52(2):568–572

    Article  Google Scholar 

  29. Horikawa Y (2000) Genetic variation in the gene encoding calpain-10 is associated with type 2 diabetes mellitus. Nat Genet 26:163–175

    Article  CAS  Google Scholar 

  30. Gloyn AL, Braun M, Rorsman P (2009) Type 2 diabetes susceptibility gene TCF7L2 and its role in beta-cell function. Diabetes 58:800–802

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Biochemistry, Acharya Nagarjuna University, Guntur, 522 510, Andhra Pradesh, India

    Alice Jayapradha Cheekurthy

  2. Acharya Nagarjuna University, Guntur, 522 510, Andhra Pradesh, India

    C. Ram Babu

  3. BioAxis DNA Research Centre (P) Limited, Hyderabad, 500 068, Andhra Pradesh, India

    Amit Kumar & K. Surendrababu

Authors
  1. Alice Jayapradha Cheekurthy
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. C. Ram Babu
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Amit Kumar
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. K. Surendrababu
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Alice Jayapradha Cheekurthy .

Rights and permissions

Reprints and permissions

Copyright information

© 2015 The Author(s)

About this chapter

Cite this chapter

Cheekurthy, A.J., Ram Babu, C., Kumar, A., Surendrababu, K. (2015). Predisposition Factors of Type II Diabetes Mellitus and Related Complications. In: Biotechnology and Bioforensics. SpringerBriefs in Applied Sciences and Technology(). Springer, Singapore. https://doi.org/10.1007/978-981-287-050-6_5

Download citation

  • DOI: https://doi.org/10.1007/978-981-287-050-6_5

  • Published:

  • Publisher Name: Springer, Singapore

  • Print ISBN: 978-981-287-049-0

  • Online ISBN: 978-981-287-050-6

  • eBook Packages: EngineeringEngineering (R0)

Publish with us

Policies and ethics

Search

Navigation