Abstract
The increase of aged population in the twenty-first century is not only due to the advancement in medical science, but also several other factors such as education, industrialization, nutritive foods, hygienic practices, and stable income. Global population growth rate is rapid at one billion per decade and it is expected that the world population count will surpass 10 billion by 2040 (Figdor and Gulabivala 2008). An increase in geriatric population is the major trend accounted for the global population. However, growing socioeconomic, emotional, and health issues are greatly affecting the quality of the geriatric population (Allaband et al. 2019). Other factors, including nature of the disease, race, income, and health-related beliefs can contribute to the use of multiple drugs (Rossi et al. 2007). Several government agencies and research institutes are working constantly to improve the quality and wellbeing of the geriatric population. Healthcare is the primary and foremost important aspect that improves quality of life, in which drug therapies play an important role. On the other hand, modern sedentary lifestyle habits result in various metabolic, cardiovascular, and psychological disorders that lead to consumption of numerous medicines.
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References
Ai R, Wei J, Ma D, Jiang L, Dan H, Zhou Y et al (2017) A meta-analysis of randomized trials assessing the effects of probiotic preparations on oral candidiasis in the elderly. Arch Oral Biol 83:187–192. https://doi.org/10.1016/j.archoralbio.2017.04.030
Alghamdi F, Chan M (2017) Management of heart failure in the elderly. Curr Opin Cardiol 32:217–223. https://doi.org/10.1097/HCO.0000000000000375
Allaband C, McDonald D, Vázquez-Baeza Y, Minich JJ, Tripathi A, Brenner DA, Knight R (2019) Microbiome 101: studying, analyzing, and interpreting gut microbiome data for clinicians. Clin Gastroenterol Hepatol 17:218–230. https://doi.org/10.1016/j.cgh.2018.09.017
Amrane S, Hocquart M, Afouda P, Kuete E, Pham TP, Dione N et al (2019) Metagenomic and culturomic analysis of gut microbiota dysbiosis during Clostridium difficile infection. Sci Rep 9:12807. https://doi.org/10.1038/s41598-019-49189-8
Arcavi L, Benowitz NL (2004) Cigarette smoking and infection. Arch Intern Med 164:2206–2216. https://doi.org/10.1001/archinte.164.20.2206
Bajaj JS, Idilman R, Mabudian L, Hood M, Fagan A, Turan D et al (2018) Diet affects gut microbiota and modulates hospitalization risk differentially in an international cirrhosis cohort. Hepatology 68:234–247. https://doi.org/10.1002/hep.29791
Bedarf JR, Hildebrand F, Coelho LP, Sunagawa S, Bahram M, Goeser F et al (2017) Functional implications of microbial and viral gut metagenome changes in early stage L-DOPA-naïve Parkinson’s disease patients. Genome Med 9:39. https://doi.org/10.1186/s13073-017-0428-y
Besanko LK, Burgstad CM, Cock C, Heddle R, Fraser A, Fraser RJ (2014) Changes in esophageal and lower esophageal sphincter motility with healthy ageing. J Gastrointestin Liver Dis 23:243–248. https://doi.org/10.15403/jgld.2014.1121.233.lkb
Besselink MG, van Santvoort HC, Buskens E, Boermeester MA, van Goor H, Timmerman HM et al (2008) Dutch acute pancreatitis study group. Probiotic prophylaxis in predicted severe acute pancreatitis: a randomised, double-blind, placebo-controlled trial. Lancet 371:651–659. https://doi.org/10.1016/S0140-6736(08)60207-X
Brown GC (2015) Living too long: the current focus of medical research on increasing the quantity, rather than the quality, of life is damaging our health and harming the economy. EMBO Rep 16:137–141. https://doi.org/10.15252/embr.201439518
Browne HP, Forster SC, Anonye BO, Kumar N, Neville BA, Stares MD, Lawley TD (2016) Culturing of ‘unculturable’ human microbiota reveals novel taxa and extensive sporulation. Nature 533:543–546. https://doi.org/10.1038/nature1764
Buch A, Carmeli E, Boker LK, Marcus Y, Shefer G, Kis O et al (2016) Muscle function and fat content in relation to sarcopenia, obesity and frailty of old age–An overview. Exp Gerontol 76:25–32. https://doi.org/10.1016/j.exger.2016.01.008
Cappello M, Morreale GC, Licata A (2016) Elderly onset celiac disease: a narrative review. Clin Med Insights Gastroenterol 9:41–49. https://doi.org/10.4137/CGast.S38454
Carson TL, Wang F, Cui X, Jackson BE, Van Der Pol WJ, Lefkowitz EJ et al (2018) Associations between race, perceived psychological stress, and the gut microbiota in a sample of generally healthy black and white women: a pilot study on the role of race and perceived psychological stress. Psychosom Med 80:640–648. https://doi.org/10.1097/PSY.0000000000000614
Commisso A, Lim F (2019) Lifestyle modifications in adults and older adults with chronic gastroesophageal reflux disease (GERD). Crit Care Nurs Q 42:64–74. https://doi.org/10.1097/CNQ.0000000000000239
Costello SP, Hughes PA, Waters O, Bryant RV, Vincent AD, Blatchford P et al (2019) Effect of fecal microbiota transplantation on 8-week remission in patients with ulcerative colitis: a randomized clinical trial. JAMA 321:156–164. https://doi.org/10.1001/jama.2018.20046
Coutts L, Ibrahim K, Tan QY, Lim SER, Cox NJ, Roberts HC (2020) Can probiotics, prebiotics and synbiotics improve functional outcomes for older people: a systematic review. Eur Geriatr Med 11:975–993. https://doi.org/10.1007/s41999-020-00396-x
Deluche E, Girault S, Jesus P, Monzat S, Turlure P, Leobon S et al (2017) Assessment of the nutritional status of adult patients with acute myeloid leukemia during induction chemotherapy. Nutrition 41:120–125. https://doi.org/10.1016/j.nut.2017.04.011
Doestzada M, Vila AV, Zhernakova A, Koonen DPY, Weersma RK, Touw DJ et al (2018) Pharmacomicrobiomics: a novel route towards personalized medicine? Protein Cell 9:432–445. https://doi.org/10.1007/s13238-018-0547-2
Fabian E, Bogner M, Kickinger A, Wagner KH, Elmadfa I (2011) Intake of medication and vitamin status in the elderly. Ann Nutr Metab 58(2):118–125. https://doi.org/10.1159/000327351
Fali T, Vallet H, Sauce D (2018) Impact of stress on aged immune system compartments: overview from fundamental to clinical data. Exp Gerontol 105:19–26. https://doi.org/10.1016/j.exger.2018.02.007
FarioliVecchioli S, Sacchetti S, Nicolis di Robilant V, Cutuli D (2018) The role of physical exercise and Omega-3 fatty acids in depressive illness in the elderly. Curr Neuropharmacol 16:308–326. https://doi.org/10.2174/1570159X15666170912113852
Farré R, Vicario M (2017) Abnormal barrier function in gastrointestinal disorders. Handb Exp Pharmacol 239:193–217. https://doi.org/10.1007/164_2016_107
Fávaro-Moreira NC, Krausch-Hofmann S, Matthys C, Vereecken C, Vanhauwaert E, Declercq A et al (2016) Risk factors for malnutrition in older adults: a systematic review of the literature based on longitudinal data. Adv Nutr 7:507–522. https://doi.org/10.3945/an.115.011254
Feldblum I, German L, Castel H, Harman-Boehm I, Bilenko N, Eisinger M, Fraser D, Shahar DR (2007) Characteristics of undernourished older medical patients and the identification of predictors for undernutrition status. Nutr J 2(6):37. https://doi.org/10.1186/1475-2891-6-37
Figdor D, Gulabivala K (2008) Survival against the odds: microbiology of root canals associated with post-treatment disease: microbiology of post-treatment disease. Endod Top 18:62–77. https://doi.org/10.1111/j.1601-1546.2011.00259.x
Garza-González E, Mendoza-Olazarán S, Morfin-Otero R, RamÃrez-Fontes A, RodrÃguez-Zulueta P, Flores-Treviño S, Bocanegra-Ibarias P, Maldonado-Garza H, Camacho-Ortiz A (2019) Intestinal microbiome changes in fecal microbiota transplant (FMT) vs. FMT enriched with lactobacillus in the treatment of recurrent Clostridioides difficile infection. Can. J Gastroenterol Hepatol 4549298. https://doi.org/10.1155/2019/4549298
Grosicki GJ, Fielding RA, Lustgarten MS (2018) Gut microbiota contribute to age-related changes in skeletal muscle size, composition, and function: biological basis for a gut-muscle Axis. Calcif Tissue Int 102:433–442. https://doi.org/10.1007/s00223-017-0345-5
Gras-Miralles B, Cremonini F (2013) A critical appraisal of lubiprostone in the treatment of chronic constipation in the elderly. Clin Interv Ageing 8:191–200. https://doi.org/10.2147/CIA.S30729
Gustavsson J, Jernbro C, Nilson F (2018) There is more to life than risk avoidance–elderly people's experiences of falls, fall-injuries and compliant flooring. Int J Qual Stud Health Well-being 13:1479586. https://doi.org/10.1080/17482631.2018.1479586
Hanewinckel R, van Oijen M, Ikram MA, van Doorn PA (2016) The epidemiology and risk factors of chronic polyneuropathy. Eur J Epidemiol 31:5–20. https://doi.org/10.1007/s10654-015-0094-6
Heuberger RA, Caudell K (2011) Polypharmacy and nutritional status in older adults. Drugs Ageing 28:315–323. https://doi.org/10.2165/11587670-000000000-00000
Hsu DW, Suh JD (2018) Rhinitis and sinusitis in the geriatric population. Otolaryngol Clin North Am 51:803–813. doi: https://doi.org/10.1016/j.otc.2018.03.008. https://www.infoplease.com/world/health-and-social-statistics/life-expectancy-countries. Accessed on January 01, 2021
Huang YC, Chang HH, Huang SC, Cheng CH, Lee BJ, Cheng SY, Su KH (2005) Plasma pyridoxal 5′-phosphate is a significant indicator of immune responses in the mechanically ventilated critically ill. Nutrition 21:779–785. https://doi.org/10.1016/j.nut.2004.11.013
Jones CI (2016) Platelet function and ageing. Mamm Genome 27:358–366. https://doi.org/10.1007/s00335-016-9629-8
Kato K, Odamaki T, Mitsuyama E, Sugahara H, Xiao JZ, Osawa R (2017) Age-related changes in the composition of gut Bifidobacterium species. Curr Microbiol 74:987–995. https://doi.org/10.1007/s00284-017-1272-4
Kazemi A, Noorbala AA, Azam K, Eskandari MH, Djafarian K (2019) Effect of probiotic and prebiotic vs placebo on psychological outcomes in patients with major depressive disorder: a randomized clinical trial. Clin Nutr 38:522–528. https://doi.org/10.1016/j.clnu.2018.04.010
Kim J, Parish AL (2017) Polypharmacy and medication management in older adults. Nurs Clin North Am 52:457–468. https://doi.org/10.1016/j.cnur.2017.04.007
Lahaye C, Tatar Z, Dubost JJ, Soubrier M (2015) Overview of biologic treatments in the elderly. Joint Bone Spine 82:154–160. https://doi.org/10.1016/j.jbspin.2014.10.012
Lahaye C, Tatar Z, Dubost JJ, Tournadre A, Soubrier M (2019) Management of inflammatory rheumatic conditions in the elderly. Rheumatology (Oxford) 58:748–764. https://doi.org/10.1093/rheumatology/key165
La-Ongkham O, Nakphaichit M, Nakayama J, Keawsompong S, Nitisinprasert S (2020) Age-related changes in the gut microbiota and the core gut microbiome of healthy Thai humans. 3 Biotech 10(6):276. https://doi.org/10.1007/s13205-020-02265-7
Ladanza E, Fabbri R, Bašić-ČiČak D, Amedei A, Telalovic JH (2020) Gut microbiota and artificial intelligence approaches: a scoping review. Heal Technol 10:1343–1358. https://doi.org/10.1007/s12553-020-00486-7
Lee J, Venna VR, Durgan DJ, Shi H, Hudobenko J, Putluri N et al (2020a) Young versus aged microbiota transplants to germ-free mice: increased short-chain fatty acids and improved cognitive performance. Gut Microbes 8:1–14. https://doi.org/10.1080/19490976.2020.1814107
Lee SH, Yoon SH, Jung Y, Kim N, Min U, Chun J, Choi I (2020b) Emotional Well-being and gut microbiome profiles by enterotype. Sci Rep 10:20736. https://doi.org/10.1038/s41598-020-77673-z
Liang SY (2016) Sepsis and other infectious disease emergencies in the elderly. Emerg Med Clin North Am 34:501–522. https://doi.org/10.1016/j.emc.2016.04.005
Lin D, Peters BA, Friedlander C, Freiman HJ, Goedert JJ, Sinha R et al (2018) Association of dietary fibre intake and gut microbiota in adults. Br J Nutr 120:1014–1022. https://doi.org/10.1017/S0007114518002465
Little MO (2018) Updates in nutrition and polypharmacy. Curr Opin Clin Nutr Metab Care 21:4–9. https://doi.org/10.1097/MCO.0000000000000425
Liubakka A, Vaughn BP (2016) Clostridium difficile infection and fecal microbiota transplant. AACN Adv Crit Care 27:324–337. https://doi.org/10.4037/aacnacc2016703
Madhumita P, Gupta N (2011) Clinical and bacteriological spectrum of community-acquired acute bacterial meningitis in adults at a tertiary care hospital in northern India. Int J Nutr Pharmacol Neurol Dis 1:194–200. https://doi.org/10.4103/2231-0738.84214
Maher RL, Hanlon J, Hajjar ER (2014) Clinical consequences of polypharmacy in elderly. Expert Opin Drug Saf 13:57–65. https://doi.org/10.1517/14740338.2013.827660
MartÃnez-MartÃnez MI, Calabuig-Tolsá R, Cauli O (2017) The effect of probiotics as a treatment for constipation in elderly people: a systematic review. Arch Gerontol Geriatr 71:142–149. https://doi.org/10.1016/j.archger.2017.04.004
Maynard C, Weinkove D (2018) The gut microbiota and ageing. Subcell Biochem 90:351–371. https://doi.org/10.1007/978-981-13-2835-0_12
McArthur DB (2019) Emerging infectious diseases. Nurs Clin North Am 54:297–311. https://doi.org/10.1016/j.cnur.2019.02.006
Miller LE, Lehtoranta L, Lehtinen MJ (2019) Short-term probiotic supplementation enhances cellular immune function in healthy elderly: systematic review and meta-analysis of controlled studies. Nutr Res 64:1–8. https://doi.org/10.1016/j.nutres.2018.12.011
Moayyedi P, Surette MG, Kim PT, Libertucci J, Wolfe M, Onischi C et al (2015) Fecal microbiota transplantation induces remission in patients with active ulcerative colitis in a randomized controlled trial. Gastroenterology 149:102–109.e6. https://doi.org/10.1053/j.gastro.2015.04.001
Moser A, Panczak R, Zwahlen M, Clough-Gorr KM, Spoerri A, Stuck AE, Egger M (2014) Swiss National Cohort. What does your neighbourhood say about you? A study of life expectancy in 1.3 million Swiss neighbourhoods. J Epidemiol Community Health 68:1125–1132. https://doi.org/10.1136/jech-2014-204352
Naseribafrouei A, Hestad K, Avershina E, Sekelja M, Linløkken A, Wilson R, Rudi K (2014) Correlation between the human fecal microbiota and depression. Neurogastroenteral Motil 26:1155–1162. https://doi.org/10.1111/nmo.12378
Navarro-López V, MartÃnez-Andrés A, RamÃrez-Boscá A, Ruzafa-Costas B, Núñez-Delegido E, Carrión-Gutiérrez MA et al (2019) Efficacy and safety of Oral Administration of a Mixture of probiotic strains in patients with psoriasis: a randomized controlled clinical trial. Acta Derm Venereol 99:1078–1084. https://doi.org/10.2340/00015555-3305
Nikolakakis N, Dragioti E, Paritsis N, Tsamakis K, Christodoulou NG, Rizos EN (2019) Association between happiness and psychopathology in an elderly regional rural population in Crete. Psychiatriki 30:299–310. https://doi.org/10.22365/jpsych.2019.304.299
Olyaei AJ, Bennett WM (2009) Drug dosing in the elderly patients with chronic kidney disease. Clin Geriatr Med 25:459–527. https://doi.org/10.1016/j.cger.2009.04.004
O'Toole PW, Jeffery IB (2018) Microbiome-health interactions in older people. Cell Mol Life Sci 75:119–128. https://doi.org/10.1007/s00018-017-2673-z
Paalanne N, Husso A, Salo J, Pieviläinen O, Tejesvi MV, Koivusaari P et al (2018) Intestinal microbiome as a risk factor for urinary tract infections in children. Eur J Clin Microbiol Infect Dis 37:1881–1891. https://doi.org/10.1007/s10096-018-3322-7
Przewłócka K, Folwarski M, Kaźmierczak-Siedlecka K, Skonieczna-Żydecka K, Kaczor JJ (2020) Gut-muscle AxisExists and may affect skeletal muscle adaptation to training. Nutrients 125:1451. https://doi.org/10.3390/nu12051451
RamÃrez-Carrillo E, Gaona O, Nieto J, Sánchez-Quinto A, Cerqueda-GarcÃa D, Falcón LI et al (2020) Disturbance in human gut microbiota networks by parasites and its implications in the incidence of depression. Sci Rep 10:3680. https://doi.org/10.1038/s41598-020-60562-w
Rossi MI, Young A, Maher R, Rodriguez KL, Appelt CJ, Perera S, Hajjar ER, Hanlon JT (2007) Polypharmacy and health beliefs in older outpatients. Am J Geriatr Pharmacother 5:317–323. https://doi.org/10.1016/j.amjopharm.2007.12.001
Sachdeva A (2017) Pneumococcal conjugate vaccine introduction in India's universal immunization program. Indian Pediatr 54:445–446. https://doi.org/10.1007/s13312-017-1044-z
Salive ME (2013) Multimorbidity in older adults. Epidemiol Rev 35:75–83. https://doi.org/10.1093/epirev/mxs009
Scher JU, Nayak RR, Ubeda C, Turnbaugh PJ, Abramson SB (2020) Pharmacomicrobiomics in inflammatory arthritis: gut microbiome as modulator of therapeutic response. Nat Rev Rheumatol 16:282–292. https://doi.org/10.1038/s41584-020-0395-3
Sebastiani P, Thyagarajan B, Sun F, Schupf N, Newman AB, Montano M, Perls TT (2017) Biomarker signatures of ageing. Ageing. Cell 16:329–338. https://doi.org/10.1111/acel.12557
Severance EG, Gressitt KL, Stallings CR, Katsafanas E, Schweinfurth LA, Savage CLG et al (2017) Probiotic normalization of Candida albicans in schizophrenia: a randomized, placebo-controlled, longitudinal pilot study. Brain Behav Immun 62:41–45. https://doi.org/10.1016/j.bbi.2016.11.019
Song WJ, Won HK, An J, Kang SY, Jo EJ, Chang YS et al (2019) Chronic cough in the elderly. Pulm Pharmacol Ther 56:63–68. https://doi.org/10.1016/j.pupt.2019.03.010
Sosnowski K, Akarapipad P, Yoon JY (2020) The future of microbiome analysis: biosensor methods for big data collection and clinical diagnostics. Med Devices Sens 3:e1008. https://doi.org/10.1002/mds3.10085
Stewart EJ (2012) Growing unculturable bacteria. J Bacteriol 194(16):4151–4160. https://doi.org/10.1128/JB.00345-12
Strandwitz P, Kim KH, Terekhova D, Liu JK, Sharma A, Levering J et al (2019) GABA-modulating bacteria of the human gut microbiota. Nat Microbiol 4:396–403. https://doi.org/10.1038/s41564-018-0307-3
Takahasi MK, Tan X, Dy AJ, Braff D, Akana RT, Furuta Y et al (2018) A low-cost paper-based synthetic biology platform for analyzing gut microbiota and host biomarkers. Nat Commun 3347:1–12
Tamtaji OR, Heidari-Soureshjani R, Mirhosseini N, Kouchaki E, Bahmani F, Aghadavod E et al (2019a) Probiotic and selenium co-supplementation, and the effects on clinical, metabolic and genetic status in Alzheimer's disease: a randomized, double-blind, controlled trial. Clin Nutr 38:2569–2575. https://doi.org/10.1016/j.clnu.2018.11.034
Tamtaji OR, Taghizadeh M, DaneshvarKakhaki R, Kouchaki E, Bahmani F, Borzabadi S et al (2019b) Clinical and metabolic response to probiotic administration in people with Parkinson's disease: a randomized, double-blind, placebo-controlled trial. Clin Nutr 38:1031–1035. https://doi.org/10.1016/j.clnu.2018.05.018
Templier V, Roux A, Roupioz Y, Livache T (2016) Ligands for label-free detection of whole bacteria on biosensors: a review. TrAC 79:71–79. https://doi.org/10.1016/j.trac.2015.10.015
Thigpen MC, Whitney CG, Messonnier NE, Zell ER, Lynfield R, Hadler JL et al (2011) Emerging infections programs network. Bacterial meningitis in the United States, 1998-2007. N Engl J Med 364:2016–2025. https://doi.org/10.1056/NEJMoa1005384
Ticinesi A, Milani C, Lauretani F, Nouvenne A, Mancabelli L, Lugli GA et al (2017) Gut microbiota composition is associated with polypharmacy in elderly hospitalized patients. Sci Rep 7(1):11102. https://doi.org/10.1038/s41598-017-10734-y
Tiihonen K, Ouwehand AC, Rautonen N (2009) Human intestinal microbiota and healthy ageing. Ageing Res Rev 9:107–116. https://doi.org/10.1016/j.arr.2009.10.004
Tillisch K, Mayer EA, Gupta A, Gill Z, Brazeilles R, Le Nevé B et al (2017) Brain structure and response to emotional stimuli as related to gut microbial profiles in healthy women. Psychosom Med 79:905–913. https://doi.org/10.1097/PSY.0000000000000493
Valdes-Rodriguez R, Stull C, Yosipovitch G (2015) Chronic pruritus in the elderly: pathophysiology, diagnosis and management. Drugs Ageing 32:201–215. https://doi.org/10.1007/s40266-015-0246-0
Velasquez MT, Ramezani A, Manal A, Raj DS (2016) Trimethylamine N-oxide: the good, the bad and the unknown. Toxins (Basel) 8:326. https://doi.org/10.3390/toxins8110326
Violi F, Loffredo L, Carnevale R, Pignatelli P, Pastori D (2017) Atherothrombosis and oxidative stress: mechanisms and management in elderly. Antioxid Redox Signal 27:1083–1124. https://doi.org/10.1089/ars.2016.6963
Wilson ID, Nicholson JK (2017) Gut microbiome interactions with drug metabolism, efficacy, and toxicity. Transl Res 179:204–222. https://doi.org/10.1016/j.trsl.2016.08.002
Wu GD, Chen J, Hoffmann C, Bittinger K, Chen YY, Keilbaugh SA et al (2011) Linking long-term dietary patterns with gut microbial enterotypes. Science 334:105–108. https://doi.org/10.1126/science.1208344
Zeppa SD, Agostini D, Piccoli G, StocchiV SP (2020) Gut microbiota status in COVID-19: an unrecognized player? Front Cell Infect Microbiol 10:742. https://doi.org/10.3389/fcimb.2020.576551
Zhuang ZQ, Shen LL, Li WW, Fu X, Zeng F, Gui L et al (2018) Gut microbiota is altered in patients with Alzheimer's disease. J Alzheimers Dis 63:1337–1346. https://doi.org/10.3233/JAD-180176
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Pazhani, G.P., Veerapandian, M., Malayandi, R., Ramamurthy, T. (2022). Microbiome Association of Polypharmacy in Geriatric Population. In: Thomas, S. (eds) Human Microbiome . Springer, Singapore. https://doi.org/10.1007/978-981-16-7672-7_9
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