Abstract
Humans and the microbiome inhabiting them in varied body niches have co-evolved mutually, constituting a super-meta organism. Neonatal microbiota primarily structured by maternal microbiome during delivery, and subsequently diet and environment play an imperative role in giving them sustainable richness and diversity. The ecologically stable and healthy microbiome of an organism including both bacterial and non-bacterial communities possess site specific diversity and relative abundance. However, both the diversity and relative abundance is greatly influenced by plethora of factors like age, nutrition, lifestyle, environmental factors and even the geography. As the microbial communities and their metabolites greatly influence the host immune system, dysbiosis with age and diet is attributed with unregulated immune responses like autoimmunity, inflammation and tumour progression. In consideration with this, it is quite intriguing to discuss these factors affecting the functionality of microbiota, so here we are overviewing the role of age and extrinsic factors in the makeover of a healthy microbiota of human host. The evocative role of these microbial niches and switch in their constitution with age and nutrition could definitely entrench a platform for formulation of probiotics to retrench age related and nutritional impairments.
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Bashir, H., Bawa, A., Kumar, R. (2022). Human Microbiome: Implication of Age and External Factors. In: Thomas, S. (eds) Human Microbiome . Springer, Singapore. https://doi.org/10.1007/978-981-16-7672-7_1
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