Abstract
Cell death is a biological process that results in old cells dying and being replaced by new ones or maybe a result of pathological disorders, localized injury, or trauma resulting in the death of cells. There are many cell death pathways so far reported in various kinds of literature, and many are continuously being discovered and reported having regulatory functions. Even though there are many cell death pathways activated in various diseases here in this chapter, we focus on only those cell death pathways that are activated during cerebral ischemia and are regulated by microRNAs.
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References
Kroemer G et al (2009) Classification of cell death: recommendations of the nomenclature committee on cell death 2009. Cell Death Differ 16(1):3–11
Park HH et al (2007) The death domain superfamily in intracellular signaling of apoptosis and inflammation. Annu Rev Immunol 25:561–586
Yuan J, Yankner BA (2000) Apoptosis in the nervous system. Nature 407(6805):802–809
Nafis S et al (2015) Apoptosis regulatory protein-protein interaction demonstrates hierarchical scale-free fractal network. Brief Bioinform 16(4):675–699
Yip KW, Reed JC (2008) Bcl-2 family proteins and cancer. Oncogene 27(50):6398–6406
Tsujimoto Y, Shimizu S (2005) Another way to die: autophagic programmed cell death. Cell Death Differ 12(Suppl 2):1528–1534
Tait SW, Ichim G, Green DR (2014) Die another way--non-apoptotic mechanisms of cell death. J Cell Sci 127(Pt 10):2135–2144
Green DR, Levine B (2014) To be or not to be? How selective autophagy and cell death govern cell fate. Cell 157(1):65–75
Zhao F et al (2017) miR-30d-5p plays an important role in autophagy and apoptosis in developing rat brains after hypoxic-ischemic injury. J Neuropathol Exp Neurol 76(8):709–719
Wang P et al (2014) Down-regulation of miRNA-30a alleviates cerebral ischemic injury through enhancing beclin 1-mediated autophagy. Neurochem Res 39(7):1279–1291
Jiang M et al (2018) Exosomes from MiR-30d-5p-ADSCs reverse acute ischemic stroke-induced, autophagy-mediated brain injury by promoting M2 microglial/macrophage polarization. Cell Physiol Biochem 47(2):864–878
Wang N et al (2018) MicroRNA-9a-5p alleviates ischemia injury after focal cerebral ischemia of the rat by targeting ATG5-mediated autophagy. Cell Physiol Biochem 45(1):78–87
Sun H et al (2018) MiR-298 exacerbates ischemia/reperfusion injury following ischemic stroke by targeting act1. Cell Physiol Biochem 48(2):528–539
Yi H et al (2017) MicroRNA-182 aggravates cerebral ischemia injury by targeting inhibitory member of the ASPP family (iASPP). Arch Biochem Biophys 620:52–58
Wang R et al (2018) miR-186-5p promotes apoptosis by targeting IGF-1 in SH-SY5Y OGD/R model. Int J Biol Sci 14(13):1791–1799
Zhou X et al (2016) MicroRNA-146a down-regulation correlates with neuroprotection and targets pro-apoptotic genes in cerebral ischemic injury in vitro. Brain Res 1648(Pt A):136–143
Liu W, Chen X, Zhang Y (2016) Effects of microRNA-21 and microRNA-24 inhibitors on neuronal apoptosis in ischemic stroke. Am J Transl Res 8(7):3179–3187
Xu LJ et al (2015) Post-stroke treatment with miR-181 antagomir reduces injury and improves long-term behavioral recovery in mice after focal cerebral ischemia. Exp Neurol 264:1–7
Sun H et al (2018) Upregulation of miR-215 exerts neuroprotection effects against ischemic injury via negative regulation of Act1/IL-17RA signaling. Neurosci Lett 662:233–241
Tao J et al (2015) MiR-207/352 regulate lysosomal-associated membrane proteins and enzymes following ischemic stroke. Neuroscience 305:1–14
Liu X et al (2013) MicroRNA-124-mediated regulation of inhibitory member of apoptosis-stimulating protein of p53 family in experimental stroke. Stroke 44(7):1973–1980
Fu F, Wu D, Qian C (2016) The MicroRNA-224 inhibitor prevents neuronal apoptosis via targeting spastic paraplegia 7 after cerebral ischemia. J Mol Neurosci 59(3):421–429
Moon JM, Xu L, Giffard RG (2013) Inhibition of microRNA-181 reduces forebrain ischemia-induced neuronal loss. J Cereb Blood Flow Metab 33(12):1976–1982
Yang X et al (2017) MicroRNA-15a/16-1 antagomir ameliorates ischemic brain injury in experimental stroke. Stroke 48(7):1941–1947
Ouyang YB, Giffard RG (2014) MicroRNAs affect BCL-2 family proteins in the setting of cerebral ischemia. Neurochem Int 77:2–8
Sun Y et al (2013) MicroRNA-124 protects neurons against apoptosis in cerebral ischemic stroke. CNS Neurosci Ther 19(10):813–819
Zhang R et al (2019) miR-1247-3p mediates apoptosis of cerebral neurons by targeting caspase-2 in stroke. Brain Res 1714:18–26
Wei N et al (2016) MicroRNA-9 mediates the cell apoptosis by targeting Bcl2l11 in ischemic stroke. Mol Neurobiol 53(10):6809–6817
Li G et al (2018) Impact of microRNAs on ischemic stroke: from pre- to post-disease. Prog Neurobiol 163–164:59–78
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G. K., R., Gressens, P., Nampoothiri, S.S., Surendran, G., Bokobza, C. (2020). Regulatory Role of microRNAs in Ischemic Cell Death. In: IschemiRs: MicroRNAs in Ischemic Stroke. Springer, Singapore. https://doi.org/10.1007/978-981-15-4798-0_5
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DOI: https://doi.org/10.1007/978-981-15-4798-0_5
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