Abstract
Carbon nanotubes (CNTs) are versatile nanomaterials with outstanding properties that can be used in different fields. This chapter reviews the use of single- and multi-walled CNTs in the development of antimicrobial and antifouling surfaces. The performance of CNT-containing surfaces seems to depend on a multiplicity of factors that can be conjugated in order to improve their activity. A substantially higher body of knowledge has accumulated regarding the use of multi-walled CNTs and their composites and exciting developments in CNT modification and combination with different molecules are being reported. Although some of the available results are promising, contradictory findings suggest that further investigation is needed to validate the antimicrobial and antifouling activities of developed surfaces in a wider range of conditions. The existing evidence seems to indicate that CNTs and their composites will remain a promising strategy to delay bacterial adhesion and reduce biofilm formation in very different environments.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
References
Iijima S (1991) Helical microtubules of graphitic carbon. Nature 354(6348):56–58
Upadhyayula VKK, Gadhamshetty V (2010) Appreciating the role of carbon nanotube composites in preventing biofouling and promoting biofilms on material surfaces in environmental engineering: a review. Biotechnol Adv 28(6):802–816
Murugan E, Vimala G (2011) Effective functionalization of multiwalled carbon nanotube with amphiphilic poly(propyleneimine) dendrimer carrying silver nanoparticles for better dispersability and antimicrobial activity. J Colloid Interface Sci 357(2):354–365
Arias LR, Yang L (2009) Inactivation of bacterial pathogens by carbon nanotubes in suspensions. Langmuir 25(5):3003–3012
Akasaka T, Watari F (2009) Capture of bacteria by flexible carbon nanotubes. Acta Biomater 5(2):607–612
Kang S, Herzberg M, Rodrigues DF, Elimelech M (2008) Antibacterial effects of carbon nanotubes: size does matter! Langmuir 24(13):6409–6413
Baughman RH, Zakhidov AA, de Heer WA (2002) Carbon Nanotubes–the Route Toward Applications. Science 297(5582):787
He H et al (2013) Carbon nanotubes: applications in pharmacy and medicine. Biomed Res Int 2013:578290
Aslan S et al (2010) Antimicrobial biomaterials based on carbon nanotubes dispersed in poly(lactic-co-glycolic acid). Nanoscale 2(9):1789–1794
Hirschfeld J et al (2017) Long-term release of antibiotics by carbon nanotube-coated titanium alloy surfaces diminish biofilm formation by Staphylococcus epidermidis. Nanomed: Nanotechnol Biol Med 13(4):1587–1593
Saliev T (2019) The Advances in biomedical applications of carbon nanotubes. C–J Carbon Res 5(2)
Chaudhari AA et al (2019) A three-dimensional human skin model to evaluate the inhibition of Staphylococcus aureus by antimicrobial peptide-functionalized silver carbon nanotubes. J Biomater Appl 33(7):924–934
Mehra NK, Jain K, Jain NK (2015) Pharmaceutical and biomedical applications of surface engineered carbon nanotubes. Drug Discov Today 20(6):750–759
Vashist SK, Zheng D, Al-Rubeaan K, Luong JH, Sheu FS (2011) Advances in carbon nanotube based electrochemical sensors for bioanalytical applications. Biotechnol Adv 29(2):169–188
Vassallo J, Besinis A, Boden R, Handy RD (2018) The minimum inhibitory concentration (MIC) assay with Escherichia coli: an early tier in the environmental hazard assessment of nanomaterials? Ecotoxicol Environ Saf 162:633–646
Beigbeder A et al (2008) Preparation and characterisation of silicone-based coatings filled with carbon nanotubes and natural sepiolite and their application as marine fouling-release coatings. Biofouling 24(4):291–302
Martinelli E et al (2011) Amphiphilic block copolymer/poly(dimethylsiloxane) (PDMS) blends and nanocomposites for improved fouling-release. Biofouling 27(5):529–541
Sun Y, Zhang Z (2016) Anti-biofouling property studies on carboxyl-modified multi-walled carbon nanotubes filled PDMS nanocomposites. World J Microbiol Biotechnol 32(9):148
Fan X, Liu Y, Wang X, Quan X, Chen S (2019) Improvement of antifouling and antimicrobial abilities on silver–carbon nanotube based membranes under electrochemical assistance. Environ Sci Technol 53(9):5292–5300
Cruz-Silva R et al (2019) New insights in the natural organic matter fouling mechanism of polyamide and nanocomposite multiwalled carbon nanotubes-polyamide membranes. Environ Sci Technol 53(11):6255–6263
Hassouna MEM, ElBably MA, Mohammed AN, Nasser MAG (2016) Assessment of carbon nanotubes and silver nanoparticles loaded clays as adsorbents for removal of bacterial contaminants from water sources. J Water Health 15(1):133–144
Smith SC, Rodrigues DF (2015) Carbon-based nanomaterials for removal of chemical and biological contaminants from water: a review of mechanisms and applications. Carbon 91:122–143
Wick P et al (2007) The degree and kind of agglomeration affect carbon nanotube cytotoxicity. Toxicol Lett 168(2):121–131
Chen H et al (2013) Broad-spectrum antibacterial activity of carbon nanotubes to human gut bacteria. Small 9(16):2735–2746
Kang S, Pinault M, Pfefferle LD, Elimelech M (2007) Single-Walled carbon nanotubes exhibit strong antimicrobial activity. Langmuir 23(17):8670–8673
Nagai H, Toyokuni S (2012) Differences and similarities between carbon nanotubes and asbestos fibers during mesothelial carcinogenesis: Shedding light on fiber entry mechanism. Cancer Sci 103(8):1378–1390
Al-Jumaili A, Alancherry S, Bazaka K, Jacob MV (2017) Review on the antimicrobial properties of carbon nanostructures. Materials (Basel, Switzerland) 10(9):1066
Johnston HJ et al (2010) A critical review of the biological mechanisms underlying the in vivo and in vitro toxicity of carbon nanotubes: The contribution of physico-chemical characteristics. Nanotoxicology 4(2):207–246
Liu S et al (2010) Antibacterial action of dispersed single-walled carbon nanotubes on Escherichia coli and Bacillus subtilis investigated by atomic force microscopy. Nanoscale 2(12):2744–2750
Olivi M et al (2013) Inhibition of microbial growth by carbon nanotube networks. Nanoscale 5(19):9023–9029
Young Y-F et al (2012) Toxicity mechanism of carbon nanotubes on Escherichia coli. Mater Chem Phys 134(1):279–286
Zhang Q, Nghiem J, Silverberg GJ, Vecitis CD (2015) Semiquantitative performance and mechanism evaluation of carbon nanomaterials as cathode coatings for microbial fouling reduction. Appl Environ Microbiol 81(14):4744–4755
Hartono MR, Kushmaro A, Chen X, Marks RS (2018) Probing the toxicity mechanism of multiwalled carbon nanotubes on bacteria. Environ Sci Pollut Res 25(5):5003–5012
Malek I et al (2016) Vertically aligned multi walled carbon nanotubes prevent biofilm formation of medically relevant bacteria. J Mater Chem B 4(31):5228–5235
Wang H et al (2006) Unique aggregation of anthrax (Bacillus anthracis) spores by sugar-coated single-walled carbon nanotubes. J Am Chem Soc 128(41):13364–13365
Zhu Z, Wang Z, Li S, Yuan X (2019) Antimicrobial strategies for urinary catheters. J Biomed Mater Res Part A 107(2):445–467
Prabhu S, Poulose EK (2012) Silver nanoparticles: mechanism of antimicrobial action, synthesis, medical applications, and toxicity effects. Int Nano Lett 2(1):32
Nepal D, Balasubramanian S, Simonian AL, Davis VA (2008) Strong Antimicrobial coatings: single-walled carbon nanotubes armored with biopolymers. Nano Lett 8(7):1896–1901
Levashov PA, Sedov SA, Shipovskov S, Belogurova NG, Levashov AV (2010) Quantitative turbidimetric assay of enzymatic gram-negative bacteria lysis. Anal Chem 82(5):2161–2163
Wild P et al (1997) Reevaluation of the effect of lysoyzme on Escherichia coli employing ultrarapid freezing followed by cryoelectronmicroscopy or freeze substitution. Microsc Res Tech 39(3):297–304
Ahmed F et al (2012) Antimicrobial applications of electroactive PVK-SWNT nanocomposites. Environ Sci Technol 46(3):1804–1810
Aslan S et al (2012) Carbon nanotube-based antimicrobial biomaterials formed via layer-by-layer assembly with polypeptides. J Colloid Interface Sci 388(1):268–273
Goodwin DG et al (2015) Interactions of microorganisms with polymer nanocomposite surfaces containing oxidized carbon nanotubes. Environ Sci Technol 49(9):5484–5492
Sah U, Sharma K, Chaudhri N, Sankar M, Gopinath P (2018) Antimicrobial photodynamic therapy: single-walled carbon nanotube (SWCNT)-Porphyrin conjugate for visible light mediated inactivation of Staphylococcus aureus. Colloids Surf B 162:108–117
Cajero-Zul LR et al (2019) Evaluation of the resistance to bacterial growth of star-shaped poly(epsilon-caprolactone)-co-poly(ethylene glycol) grafted onto functionalized carbon nanotubes nanocomposites. J Biomater Sci-Polym Edn 30(3):163–189
Tiraferri A, Vecitis CD, Elimelech M (2011) Covalent binding of single-walled carbon nanotubes to polyamide membranes for antimicrobial surface properties. ACS Appl Mater Interfaces 3(8):2869–2877
Neelgund GM, Oki A (2011) Deposition of silver nanoparticles on dendrimer functionalized multiwalled carbon nanotubes: synthesis, characterization and antimicrobial activity. J Nanosci Nanotechnol 11(4):3621–3629
Neelgund GM, Oki A, Luo Z (2012) Antimicrobial activity of CdS and Ag2S quantum dots immobilized on poly(amidoamine) grafted carbon nanotubes. Colloids Surf B Biointerfaces 100:215–221
Ding L, Wang H, Liu D, Zeng X-A, Mao Y (2020) Bacteria capture and inactivation with functionalized multi-walled carbon nanotubes (MWCNTs). J Nanosci Nanotechnol 20(4):2055–2062
Zardini HZ et al (2014) Microbial toxicity of ethanolamines—multiwalled carbon nanotubes. J Biomed Mater Res Part A 102(6):1774–1781
Gilbertson LM, Goodwin DG, Taylor AD, Pfefferle L, Zimmerman JB (2014) Toward tailored functional design of multi-walled carbon nanotubes (MWNTs): electrochemical and antimicrobial activity enhancement via oxidation and selective reduction. Environ Sci Technol 48(10):5938–5945
Jung JH, Hwang GB, Lee JE, Bae GN (2011) Preparation of airborne Ag/CNT hybrid nanoparticles using an aerosol process and their application to antimicrobial air filtration. Langmuir 27(16):10256–10264
Mohan R, Shanmugharaj AM, Sung Hun R (2011) An efficient growth of silver and copper nanoparticles on multiwalled carbon nanotube with enhanced antimicrobial activity. J Biomed Mater Res B Appl Biomater 96B(1):119–126
Seo Y et al (2014) Antibacterial activity and cytotoxicity of multi-walled carbon nanotubes decorated with silver nanoparticles. Int J Nanomedicine 9:4621–4629
Rusen E et al (2014) Design of antimicrobial membrane based on polymer colloids/multiwall carbon nanotubes hybrid material with silver nanoparticles. ACS Appl Mater Interfaces 6(20):17384–17393
Sui M, Zhang L, Sheng L, Huang S, She L (2013) Synthesis of ZnO coated multi-walled carbon nanotubes and their antibacterial activities. Sci Total Environ 452–453:148–154
Karthika V, Arumugam A (2017) Synthesis and characterization of MWCNT/TiO2/Au nanocomposite for photocatalytic and antimicrobial activity. IET Nanobiotechnol 11(1):113–118
Grover N, Borkar IV, Dinu CZ, Kane RS, Dordick JS (2012) Laccase- and chloroperoxidase-nanotube paint composites with bactericidal and sporicidal activity. Enzyme Microbial Technology 50(6):271–279
Venkatesan J, Jayakumar R, Mohandas A, Bhatnagar I, Kim SK (2014) Antimicrobial activity of chitosan–carbon nanotube hydrogels. Materials (Basel) 7(5):3946–3955
Mohamed NA, Al-Harby NF, Almarshed MS (2019) Synthesis and characterization of novel trimellitic anhydride isothiocyanate-cross linked chitosan hydrogels modified with multi-walled carbon nanotubes for enhancement of antimicrobial activity. Int J Biol Macromol 132:416–428
Kong M, Chen XG, Xing K, Park HJ (2010) Antimicrobial properties of chitosan and mode of action: a state of the art review. Int J Food Microbiol 144(1):51–63
Rabea EI, Badawy MET, Stevens CV, Smagghe G, Steurbaut W (2003) Chitosan as antimicrobial agent: applications and mode of action. Biomacromol 4(6):1457–1465
Ji Y et al (2018) Effect of CNT/PDMS nanocomposites on the dynamics of pioneer bacterial communities in the natural biofilms of seawater. Materials (Basel, Switzerland) 11(6):902
Kim K-I et al (2019) Carbon nanotube incorporation in PMMA to prevent microbial adhesion. Sci Rep 9(1):4921
Jing H, Sahle-Demessie E, Sorial GA (2018) Inhibition of biofilm growth on polymer-MWCNTs composites and metal surfaces. Sci Total Environ 633:167–178
Zhang Q et al (2017) Interlaced CNT electrodes for bacterial fouling reduction of microfiltration membranes. Environ Sci Technol 51(16):9176–9183
Lin C-W et al (2019) Direct grafting of tetraaniline via perfluorophenylazide photochemistry to create antifouling, low bio-adhesion surfaces. Chem Sci 10(16):4445–4457
Liu Y-L, Chang Y, Chang Y-H, Shih Y-J (2010) Preparation of amphiphilic polymer-functionalized carbon nanotubes for low-protein-adsorption surfaces and protein-resistant membranes. ACS Appl Mater Interfaces 2(12):3642–3647
Celik E, Park H, Choi H, Choi H (2011) Carbon nanotube blended polyethersulfone membranes for fouling control in water treatment. Water Res 45(1):274–282
Feng Y, Wang K, Davies CHJ, Wang H (2015) Carbon nanotube/alumina/polyethersulfone hybrid hollow fiber membranes with enhanced mechanical and anti-fouling properties. Nanomaterials (Basel, Switzerland) 5(3):1366–1378
Abidin MNZ et al (2016) Antifouling polyethersulfone hemodialysis membranes incorporated with poly (citric acid) polymerized multi-walled carbon nanotubes. Mater Sci Eng C Mater Biol Appl 68:540–550
Takizawa Y et al (2017) Antiorganic fouling and low-protein adhesion on reverse-osmosis membranes made of carbon nanotubes and polyamide nanocomposite. ACS Appl Mater Interfaces 9(37):32192–32201
Liu Y et al (2017) Synergy of the mechanical, antifouling and permeation properties of a carbon nanotube nanohybrid membrane for efficient oil/water separation. Nanoscale 9(22):7508–7518
Kitano H et al (2019) Enhanced antifouling feed spacer made from a carbon nanotube-polypropylene nanocomposite. ACS Omega 4(13):15496–15503
Vatanpour V, Ghadimi A, Karimi A, Khataee A, Yekavalangi ME (2018) Antifouling polyvinylidene fluoride ultrafiltration membrane fabricated from embedding polypyrrole coated multiwalled carbon nanotubes. Mater Sci Eng, C 89:41–51
Yaghoubi Z, Parsa JB (2019) Preparation of thermo-responsive PNIPAAm-MWCNT membranes and evaluation of its antifouling properties in dairy wastewater. Mater Sci Eng C 103:109779
Gunawan P et al (2011) Hollow fiber membrane decorated with Ag/MWNTs: toward effective water disinfection and biofouling control. ACS Nano 5(12):10033–10040
Macevele LE, Moganedi KLM, Magadzu T (2017) Investigation of antibacterial and fouling resistance of silver and multi-walled carbon nanotubes doped poly(vinylidene fluoride-co-hexafluoropropylene) composite membrane. Membranes (Basel), 7(3)
Seo Y et al (2018) Engineering copper nanoparticles synthesized on the surface of carbon nanotubes for anti-microbial and anti-biofilm applications. Nanoscale 10(33):15529–15544
Pang WY, Ahmad AL, Zaulkiflee ND (2019) Antifouling and antibacterial evaluation of ZnO/MWCNT dual nanofiller polyethersulfone mixed matrix membrane. J Environ Manage 249:109358
Pangule RC et al (2010) Antistaphylococcal nanocomposite films based on enzyme-nanotube conjugates. ACS Nano 4(7):3993–4000
Qi X et al (2011) Covalent immobilization of nisin on multi-walled carbon nanotubes: superior antimicrobial and anti-biofilm properties. Nanoscale 3(4):1874–1880
Dong X, McCoy E, Zhang M, Yang L (2014) Inhibitory effects of nisin-coated multi-walled carbon nanotube sheet on biofilm formation from Bacillus anthracis spores. J Environ Sci 26(12):2526–2534
Zhou J, Qi X (2011) Multi-walled carbon nanotubes/epilson-polylysine nanocomposite with enhanced antibacterial activity. Lett Appl Microbiol 52(1):76–83
Huang Y-W et al (2017) Versatile polyvinylidene fluoride hybrid ultrafiltration membranes with superior antifouling, antibacterial and self-cleaning properties for water treatment. J Colloid Interface Sci 505:38–48
Alizadeh A, Razmjou A, Ghaedi M, Jannesar R (2019) Nanoporous solid-state membranes modified with multi-wall carbon nanotubes with anti-biofouling property. Int J Nanomed 14:1669–1685
Weinstein MP et al (1997) The clinical significance of positive blood cultures in the 1990s: a prospective comprehensive evaluation of the microbiology, epidemiology, and outcome of bacteremia and fungemia in adults. Clin Infect Dis 24(4):584–602
Control ECfDPa (2008) Report on the state of communicable diseases in the EU and EEA/EFTA countries
Klevens RM et al (2007) Estimating health care-associated infections and deaths in U.S. hospitals, 2002. Public Health Rep 122(2): 160–166
Vagos MR, Moreira JMR, Soares OSGP, Pereira MFR, Mergulhao FJ (2019) Incorporation of Carbon Nanotubes in Polydimethylsiloxane to Control Escherichia coli Adhesion. Polym Compos 40:E1697–E1704
Acknowledgements
This work was financially supported by: Base Funding—UIDB/00511/2020 of the Laboratory for Process Engineering, Environment, Biotechnology and Energy—LEPABE—funded by national funds through the FCT/MCTES (PIDDAC) and by: Project PTDC/BII-BIO/29589/2017—POCI-01-0145-FEDER-029589—funded by FEDER funds through COMPETE2020—Programa Operacional Competitividade e Internacionalização (POCI) and by national funds (PIDDAC) through FCT/MCTES. R. Teixeira-Santos acknowledges the receipt of a junior researcher fellowship from this project.
Author information
Authors and Affiliations
Corresponding author
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2020 Springer Nature Singapore Pte Ltd.
About this chapter
Cite this chapter
Teixeira-Santos, R., Gomes, M., Mergulhão, F.J. (2020). Carbon Nanotube-Based Antimicrobial and Antifouling Surfaces. In: Snigdha, S., Thomas, S., Radhakrishnan, E., Kalarikkal, N. (eds) Engineered Antimicrobial Surfaces. Materials Horizons: From Nature to Nanomaterials. Springer, Singapore. https://doi.org/10.1007/978-981-15-4630-3_4
Download citation
DOI: https://doi.org/10.1007/978-981-15-4630-3_4
Published:
Publisher Name: Springer, Singapore
Print ISBN: 978-981-15-4629-7
Online ISBN: 978-981-15-4630-3
eBook Packages: Chemistry and Materials ScienceChemistry and Material Science (R0)