Skip to main content
SpringerLink
Log in

Plant-Based Polymeric Nanomaterials for Biomedical Applications

  • Chapter
  • First Online:
Nanomaterial - Based Biomedical Applications in Molecular Imaging, Diagnostics and Therapy

  • 399 Accesses

Abstract

Plant-derived polymeric nanomaterials play an important role as excipients in different biomedical applications ranging from nanomedicine to tissue engineering. These provide versatile biocompatible platforms for controlled drug release with the advantage of being most cost-effective materials. Inorganic nanoparticles have received considerable global interest amongst biomedical researchers, but their toxicity concerns cannot be ignored. In this context, the biomass has been recognized as potential source to obtain different types of functional nanomaterials. These nanomaterials have polysaccharide backbone, which consists of monomer units of carbohydrate and mimic the extracellular matrix of tissues, thus making these biocompatible by nature. Further, the ease of surface functionalization, natural abundance, together with high stability make these ideal biomaterial candidates for next generation health care applications. Here, in this chapter, we have described the biomedical applications of different plant-based nanomaterials, with a major focus towards using these as drug delivery agents, bioprinting materials, wound healing agents, etc.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 129.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 169.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 169.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Abbreviations

[Bmim]PF6:

1-butyl-3-methylimidazolium hexafluorophosphate

AcGGM:

O-acetyl-galactoglucomannan

ATP:

4-aminothiophenol

CMC:

Carboxymethylcellulose

CS:

Chitosan

DSS:

Dentin phospho-phoryn-derived peptide

ECM:

Extracellular matrix

FDA:

Food and Drug Administration

GRA:

Generally recognized as safe

HA:

Hyaluronic acid

HACC:

Hydroxypropyltrimethyl ammonium chloride chitosan

HEC:

Hydroxyethyl cellulose

LLO91–99:

Listeria monocytogenes Listeriolysin

LNP:

Lignin nanoparticles

n- HA:

Nano-hydroxyapatite

PBN:

Plant-based nanomaterials

PCL:

Polycaprolactone

PEG:

Polyethlene glycol

PHB:

Polyhydroxybutyrate

PLLA:

Poly(l-lactide)

PVA:

Polyvinyl alcohol

RCSP:

Rana chensinensis skin peptides

SPI:

Soy protein isolate

SPIONS:

Superparamagnetic iron oxide nanoparticles

TEBAC:

Triethylbenzylammonium chloride

TEMPO:

2,2,6,6-Tetramethylpiperidine-1-oxyl radical

References

  • Ahmed OA (2018) Development and single dose clinical pharmacokinetics investigation of novel zein assisted-alpha lipoic acid nanoencapsulation of vardenafil. Sci Rep 8(1):15802

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Ahn S, Chantre CO, Gannon AR, Lind JU, Campbell PH, Grevesse T, O'Connor BB, Parker KK (2018) Soy protein/cellulose nanofiber scaffolds mimicking skin extracellular matrix for enhanced wound healing. Adv Healthc Mater 7(9):1701175–1701188

    Article  CAS  Google Scholar 

  • Arora V, Sood A, Shah J, Kotnala RK, Jain TK (2017) Synthesis and characterization of pectin-6-aminohexanoic acid-magnetite nanoparticles for drug delivery. Mater Sci Eng C 80:243–251

    Article  CAS  Google Scholar 

  • Ashammakhi N, Ahadian S, Zengjie F, Suthiwanich K, Lorestani F, Orive G, Ostrovidov S, Khademhosseini A (2018) Advances and future perspectives in 4D bioprinting. Biotechnol J 13(12):1800148–1800160

    Article  CAS  Google Scholar 

  • Aswathy RG, Sivakumar B, Brahatheeswaran D, Fukuda T, Yoshida Y, Maekawa T, Kumar DS (2012) Biocompatible fluorescent zein nanoparticles for simultaneous bioimaging and drug delivery application. ANSN 3(2):025006–025013

    Google Scholar 

  • Babitha S, Korrapati PS (2017) Biodegradable zein–polydopamine polymeric scaffold impregnated with TiO2 nanoparticles for skin tissue engineering. Biomed Mater 12(5):055008–550020

    Article  CAS  PubMed  Google Scholar 

  • Basu A, Heitz K, Stromme M, Welch K, Ferraz N (2018a) Ion-crosslinked wood-derived nanocellulose hydrogels with tunable antibacterial properties: Candidate materials for advanced wound care applications. Carbohydr Polym 181:345–350

    Article  CAS  PubMed  Google Scholar 

  • Basu A, Celma G, Stromme M, Ferraz N (2018b) In vitro and in vivo evaluation of the wound healing properties of nanofibrillated cellulose hydrogels. ACS Appl Bio Mater 1(6):1853–1863

    Article  CAS  Google Scholar 

  • Birch NP, Schiffman JD (2014) Characterization of self-assembled polyelectrolyte complex nanoparticles formed from chitosan and pectin. Langmuir 30(12):3441–3447

    Article  CAS  PubMed  Google Scholar 

  • Bush JR, Liang H, Dickinson M, Botchwey EA (2016) Xylan hemicellulose improves chitosan hydrogel for bone tissue regeneration. Polym Adv Technol 27(8):1050–1055

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Capecchi E, Piccinino D, Bizzarri BM, Avitabile D, Pelosi C, Colantonio C, Calabro G, Saladino R (2019) Enzyme-lignin Nanocapsules are sustainable catalysts and vehicles for the preparation of unique polyvalent bioinks. Biomacromolecules 20(5):1975–1988

    Article  CAS  PubMed  Google Scholar 

  • Cauley AN, Wilson JN (2017) Functionalized lignin biomaterials for enhancing optical properties and cellular interactions of dyes. Biomater Sci 5(10):2114–2121

    Article  CAS  PubMed  Google Scholar 

  • Chan SY, Chan BQY, Liu Z, Parikh BH, Zhang K, Lin Q, Su X, Kai D, Choo WS, Young DJ, Loh XJ (2017) Electrospun pectin-polyhydroxybutyrate nanofibers for retinal tissue engineering. ACS Omega 2(12):8959–8968

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Chauhan NPS, Gholipourmalekabadi M, Mozafari M (2017) Fabrication of newly developed pectin–GeO2 nanocomposite using extreme biomimetics route and its antibacterial activities. J Macromol Sci A 54(10):655–661

    Article  CAS  Google Scholar 

  • Chen GG, Qi XM, Li MP, Guan Y, Bian J, Peng F, Yao CL, Sun RC (2015) Hemicelluloses/montmorillonite hybrid films with improved mechanical and barrier properties. Sci Rep 5:16405

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Chen F, Ni Y, Liu B, Zhou T, Yu C, Su Y, Zhu X, Yu X, Zhou Y (2017) Self-crosslinking and injectable hyaluronic acid/RGD-functionalized pectin hydrogel for cartilage tissue engineering. Carbohydr Polym 166:31–44

    Article  CAS  PubMed  Google Scholar 

  • Cheng HT, Hsieh SY, Chen TH, Hung PF, Pan SH (2016) Sorafenib-fortified zein–chondroitin sulphate biopolymer nanoparticles as a novel therapeutic system in gastric cancer treatment. RSC Adv 6(62):57266–57274

    Article  CAS  Google Scholar 

  • Cheng X, Wang X, Cao Z, Yao W, Wang J, Tang R (2017) Folic acid-modified soy protein nanoparticles for enhanced targeting and inhibitory. Mater Sci Eng C 71:298–307

    Article  CAS  Google Scholar 

  • Chien KB, Makridakis E, Shah RN (2012) Three-dimensional printing of soy protein scaffolds for tissue regeneration. Tissue Eng Part C Methods 19(6):417–426

    Article  PubMed  CAS  Google Scholar 

  • Chittasupho C, Jaturanpinyo M, Mangmool S (2013) Pectin nanoparticle enhances cytotoxicity of methotrexate against hepG2 cells. Drug Deliv 20(1):1–9

    Article  CAS  PubMed  Google Scholar 

  • Curvello R, Raghuwanshi VS, Garnier G (2019) Engineering nanocellulose hydrogels for biomedical applications. Adv Colloid Interface Sci 267:47–61

    Article  CAS  PubMed  Google Scholar 

  • Dashdorj U, Reyes MK, Unnithan AR, Tiwari AP, Tumurbaatar B, Park CH, Kim CS (2015) Fabrication and characterization of electrospun zein/Ag nanocomposite mats for wound dressing applications. Int J Biol Macromol 80:1–7

    Article  CAS  PubMed  Google Scholar 

  • Dias SFL, Nogueira SS, De França DF, Guimaraes MA, De Oliveira Pitombeira NA, Gobbo GG, Primo FL, De Paula RCM, Feitosa JPA, Tedesco AC, LCC N (2016) Acetylated cashew gum-based nanoparticles for transdermal delivery of diclofenac diethyl amine. Carbohydr Polym 143:254–261

    Article  CAS  PubMed  Google Scholar 

  • Elumalai R, Patil S, Maliyakkal N, Rangarajan A, Kondaiah P, Raichur AM (2015) Protamine-carboxymethyl cellulose magnetic nanocapsules for enhanced delivery of anticancer drugs against drug resistant cancers. Nanomedicine: NBM 11(4):969–981

    Article  CAS  Google Scholar 

  • Elzoghby A, Freag M, Mamdouh H, Elkhodairy K (2017) Zein-based nanocarriers as potential natural alternatives for drug and gene delivery: focus on cancer therapy. Curr Pharm Des 23(35):5261–5271

    CAS  PubMed  Google Scholar 

  • Fakhri A, Tahami S, Nejad PA (2017) Preparation and characterization of Fe3O4-Ag2O quantum dots decorated cellulose nanofibers as a carrier of anticancer drugs for skin cancer. J Photoch Photobio B 175:83–88

    Article  CAS  Google Scholar 

  • Fares MM, Sani ES, Lara RP, Oliveira RB, Khademhosseini A, Annabi N (2018) Interpenetrating network gelatin methacryloyl (GelMA) and pectin-g-PCL hydrogels with tunable properties for tissue engineering. Biomater Sci 6(11):2938–2950

    Article  CAS  PubMed  Google Scholar 

  • Feese E, Sadeghifar H, Gracz HS, Argyropoulos DS, Ghiladi RA (2011) Photobactericidal porphyrin-cellulose nanocrystals: synthesis, characterization, and antimicrobial properties. Biomacromolecules 12(10):3528–3539

    Article  CAS  PubMed  Google Scholar 

  • Figueiredo P, Ferro C, Kemell M, Liu Z, Kiriazis A, Lintinen K, Florindo HF, Yli-Kauhaluoma J, Hirvonen J, Kostiainen MA, Santos HA (2017) Functionalization of carboxylated lignin nanoparticles for targeted and pH-responsive delivery of anticancer drugs. Nanomedicine 12(21):2581–2596

    Article  CAS  PubMed  Google Scholar 

  • Figueiredo P, Sipponen MH, Lintinen K, Correia A, Kiriazis A, Yli-Kauhaluoma J, Osterberg M, George A, Hirvonen J, Kostiainen MA, Santos HA (2019) Preparation and characterization of dentin Phosphophoryn-derived peptide-functionalized lignin nanoparticles for enhanced cellular uptake. Small 15(24):1901427

    Article  CAS  Google Scholar 

  • Furnari M, Parodi A, Gemignani L, Giannini EG, Marenco S, Savarino E, Assandri L, Fazio V, Bonfanti D, Inferrera S, Savarino V (2010) Clinical trial: the combination of rifaximin with partially hydrolysed guar gum is more effective than rifaximin alone in eradicating small intestinal bacterial overgrowth. Aliment Pharmacol Ther 32(8):1000–1006

    Article  CAS  PubMed  Google Scholar 

  • Gagliardi A, Bonacci S, Paolino D, Celia C, Procopio A, Fresta M, Cosco D (2019) Paclitaxel-loaded sodium deoxycholate-stabilized zein nanoparticles: characterization and in vitro cytotoxicity. Heliyon 5(9):e02422–e02432

    Article  PubMed  PubMed Central  Google Scholar 

  • Gan D, Xing W, Jiang L, Fang J, Zhao C, Ren F, Fang L, Wang K, Lu X (2019) Plant-inspired adhesive and tough hydrogel based on Ag-lignin nanoparticles-triggered dynamic redox catechol chemistry. Nat Commun 10(1):1487–1497

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Gershlak JR, Hernandez S, Fontana G, Perreault LR, Hansen KJ, Larson SA, Binder BY, Dolivo DM, Yang T, Dominko T, Rolle MW (2017) Crossing kingdoms: using decellularized plants as perfusable tissue engineering scaffolds. Biomaterials 125:13–22

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Gerstenhaber JA, Brodsky R, Huneke RB, Lelkes PI (2014) Electrospun soy protein scaffolds as wound dressings: Enhanced re-epithelialization in a porcine model of wound healing. Wound Medicine 5:9–15

    Article  Google Scholar 

  • Ghafari R, Jonoobi M, Amirabad LM, Oksman K, Taheri AR (2019) Fabrication and characterization of novel bilayer scaffold from nanocellulose based aerogel for skin tissue engineering applications. Int J Biol Macromol 136:796–803

    Article  CAS  PubMed  Google Scholar 

  • Guo J, Liu D, Filpponen I, Johansson LS, Malho JM, Quraishi S, Liebner F, Santos HA, Rojas OJ (2017) Photoluminescent hybrids of cellulose nanocrystals and carbon quantum dots as cytocompatible probes for in vitro bioimaging. Biomacromolecules 18(7):2045–2055

    Article  CAS  PubMed  Google Scholar 

  • Hakkarainen T, Koivuniemi R, Kosonen M, Escobedo-Lucea C, Sanz-Garcia A, Vuola J, Valtonen J, Tammela P, Makitie A, Luukko K, Yliperttula M (2016) Nanofibrillar cellulose wound dressing in skin graft donor site treatment. JCR 244:292–301

    Article  CAS  Google Scholar 

  • Henriksson I, Gatenholm P, Hagg DA (2017) Increased lipid accumulation and adipogenic gene expression of adipocytes in 3D bioprinted nanocellulose scaffolds. Biofabrication 9(1):015022–015032

    Article  CAS  PubMed  Google Scholar 

  • Iravani S, Varma RS (2019) Plant-derived edible nanoparticles and miRNAs: emerging frontier for therapeutics and targeted drug-delivery. ACS Sustain Chem Eng 7(9):8055–8069

    Article  CAS  Google Scholar 

  • Javanbakht S, Namazi H (2018) Doxorubicin loaded carboxymethyl cellulose/graphene quantum dot nanocomposite hydrogel films as a potential anticancer drug delivery system. Mater Sci Eng C 87:50–59

    Article  CAS  Google Scholar 

  • Jiang H, Zhao P, Zhu K (2007) Fabrication and characterization of zein-based nanofibrous scaffolds by an electrospinning method. Macromol Biosci 7(4):517–525

    Article  CAS  PubMed  Google Scholar 

  • Khabibullin A, Alizadehgiashi M, Khuu N, Prince E, Tebbe M, Kumacheva E (2017) Injectable shear-thinning fluorescent hydrogel formed by cellulose nanocrystals and graphene quantum dots. Langmuir 33(43):12344–12350

    Article  CAS  PubMed  Google Scholar 

  • Khorasani AC, Shojaosadati SA (2017) Pectin-non-starch nanofibers biocomposites as novel gastrointestinal-resistant prebiotics. Int J Biol Macromol 94(Part A):131–144

    Article  CAS  PubMed  Google Scholar 

  • Kozlova EA, Atkin VS, Zakharevich AM, Markin AV, Skaptsov AA (2017) Synthesis and investigation of rosin nanoparticles. In Saratov Fall Meeting 2016: optical technologies in biophysics and medicine XVIII (vol 10336). International Society for Optics and Photonics, p 1033615

    Google Scholar 

  • Kumar NS, Santhosh C, Sudakaran SV, Deb A, Raghavan V, Venugopal V, Bhatnagar A, Bhat S, Andrews NG (2017) Electrospun polyurethane and soy protein nanofibres for wound dressing applications. IET Nanobiotechnol 12(2):94–98

    Article  Google Scholar 

  • Larranneta E, Imizcoz M, Toh JX, Irwin NJ, Ripolin A, Perminova A, Dominguez-Robles J, Rodríguez A, Donnelly RF (2018) Synthesis and characterization of lignin hydrogels for potential applications as drug eluting antimicrobial coatings for medical materials. ACS Sustain Chem Eng 6(7):9037–9046

    Article  CAS  Google Scholar 

  • Lee CM, Lim S, Kim GY, Kim DW, Rhee JH, Lee KY (2005) Rosin nanoparticles as a drug delivery carrier for the controlled release of hydrocortisone. Biotechnol Lett 27(19):1487–1490

    Article  CAS  PubMed  Google Scholar 

  • Leppiniemi J, Lahtinen P, Paajanen A, Mahlberg R, Metsaa Kortelainen S, Pinomaa T, Pajari H, Vikholm Lundin I, Pursula P, Hytonen VP (2017) 3D-printable bioactivated nanocellulose–alginate hydrogels. ACS Appl Mater Interfaces 9(26):21959–21970

    Article  CAS  PubMed  Google Scholar 

  • Li X, Gong Y, Zhou X, Jin H, Yan H, Wang S, Liu J (2016) Facile synthesis of soybean phospholipid-encapsulated MoS2 nanosheets for efficient in vitro and in vivo photothermal regression of breast tumor. Int J Nanomedicine 11:1819–1833

    CAS  PubMed  PubMed Central  Google Scholar 

  • Li J, Wang Y, Zhang L, Xu Z, Dai H, Wu W (2019) Nanocellulose/gelatin composite cryogels for controlled drug release. ACS Sustain Chem Eng 7(6):6381–6389

    Article  CAS  Google Scholar 

  • Licciardi M, Volsi AL, Sardo C, Mauro N, Cavallaro G, Giammona G (2015) Inulin-ethylenediamine coated SPIONs magnetoplexes: a promising tool for improving siRNA delivery. Pharm Res 32(11):3674–3687

    Article  CAS  PubMed  Google Scholar 

  • Licciardi M, Li Volsi A, Mauro N, Scialabba C, Cavallaro G, Giammona G (2016) Preparation and characterization of inulin coated gold nanoparticles for selective delivery of doxorubicin to breast cancer cells. J Nanomater 2078315:9–21

    Google Scholar 

  • Lin J, Li C, Zhao Y, Hu J, Zhang LM (2012) Co-electrospun nanofibrous membranes of collagen and zein for wound healing. ACS Appl Mater Interfaces 4(2):1050–1057

    Article  CAS  PubMed  Google Scholar 

  • Lin N, Geze A, Wouessidjewe D, Huang J, Dufresne A (2016) Biocompatible double-membrane hydrogels from cationic cellulose nanocrystals and anionic alginate as complexing drugs codelivery. ACS Appl Mater Interfaces 8(11):6880–6889

    Article  CAS  PubMed  Google Scholar 

  • Liu J, Chinga Carrasco G, Cheng F, Xu W, Willfor S, Syverud K, Xu C (2016) Hemicellulose-reinforced nanocellulose hydrogels for wound healing application. Cellulose 23(5):3129–3143

    Article  CAS  Google Scholar 

  • Lopez BSG, Yamamoto M, Utsumi K, Aratsu C, Sakagami H (2009) A clinical pilot study of lignin-ascorbic acid combination treatment of herpes simplex virus. In Vivo 23(6):1011–1016

    CAS  PubMed  Google Scholar 

  • Lucio D, Martínez Oharriz MC, Jaras G, Aranaz P, Gonzalez-Navarro CJ, Radulescu A, Irache JM (2017) Optimization and evaluation of zein nanoparticles to improve the oral delivery of glibenclamide In vivo study using C elegans. Eur J Pharm Biopharm 121:104–112

    Article  CAS  PubMed  Google Scholar 

  • Luo Y, Teng Z, Wang Q (2012) Development of zein nanoparticles coated with carboxymethyl chitosan for encapsulation and controlled release of vitamin D3. J Agric Food Chem 60(3):836–843

    Article  CAS  PubMed  Google Scholar 

  • Mandracchia D, Tripodo G, Trapani A, Ruggieri S, Annese T, Chlapanidas T, Trapani G, Ribatti D (2016) Inulin based micelles loaded with curcumin or celecoxib with effective anti-angiogenic activity. Eur J Pharm Sci 93:141–146

    Article  CAS  PubMed  Google Scholar 

  • Mansur AA, De Carvalho FG, Mansur RL, Carvalho SM, De Oliveira LC, Mansur HS (2017) Carboxymethylcellulose/ZnCdS fluorescent quantum dot nanoconjugates for cancer cell bioimaging. Int J Biol Macromol 96:675–686

    Article  CAS  PubMed  Google Scholar 

  • Markstedt K, Mantas A, Tournier I, Martinez Avila H, Haagg D, Gatenholm P (2015) 3D bioprinting human chondrocytes with nanocellulose–alginate bioink for cartilage tissue engineering applications. Biomacromolecules 16(5):1489–1496

    Article  CAS  PubMed  Google Scholar 

  • Markstedt K, Escalante A, Toriz G, Gatenholm P (2017) Biomimetic inks based on cellulose nanofibrils and cross-linkable xylans for 3D printing. ACS Appl Mater Interfaces 9(46):40878–40886

    Article  CAS  PubMed  Google Scholar 

  • Mertaniemi H, Escobedo-Lucea C, Sanz-Garcia A, Gandia C, Makitie A, Partanen J, Ikkala O, Yliperttula M (2016) Human stem cell decorated nanocellulose threads for biomedical applications. Biomaterials 82:208–220

    Article  CAS  PubMed  Google Scholar 

  • Mikani M, Torabizadeh H, Rahmanian R (2018) Magnetic soy protein isolate–bovine serum albumin nanoparticles preparation as a carrier for inulinase immobilisation. IET Nanobiotechnol 12(5):633–639

    Article  PubMed  Google Scholar 

  • Mirza S, Zia I, Jolly R, Kazmi S, Owais M, Shakir M (2018) Synergistic combination of natural bioadhesive bael fruit gum and chitosan/nano-hydroxyapatite: A ternary bioactive nanohybrid for bone tissue engineering. Int J Biol Macromol 119:215–224

    Article  CAS  PubMed  Google Scholar 

  • Mitchell CM, Davy BM, Halliday TM, Hulver MW, Neilson AP, Ponder MA, Davy KP (2015) The effect of prebiotic supplementation with inulin on cardiometabolic health: rationale, design, and methods of a controlled feeding efficacy trial in adults at risk of type 2 diabetes. Contemp Clin Trials 45(Part B):328–337

    Article  PubMed  PubMed Central  Google Scholar 

  • Naguib GH, Hosny KM, Hassan AH, Al Hazmi F, Al Dharrab A, Alkhalidi HM, Hamed MT, Alnowaiser AM, Pashley DH (2018) Zein based magnesium oxide nanoparticles: assessment of antimicrobial activity for dental implications. Pak J Pharm Sci 31(1):245–250

    CAS  PubMed  Google Scholar 

  • Najafi SHM, Baghaie M, Ashori A (2016) Preparation and characterization of acetylated starch nanoparticles as drug carrier: Ciprofloxacin as a model. Int J Biol Macromol 87:48–54

    Article  CAS  Google Scholar 

  • Nguyen D, Hagg DA, Forsman A, Ekholm J, Nimkingratana P, Brantsing C, Kalogeropoulos T, Zaunz S, Concaro S, Brittberg M, Lindahl A (2017) Cartilage tissue engineering by the 3D bioprinting of iPS cells in a nanocellulose/alginate bioink. Sci Rep 7(1):658

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Nirmala R, Woo-il B, Navamathavan R, Kalpana D, Lee YS, Kim HY (2013) Influence of antimicrobial additives on the formation of rosin nanofibers via electrospinning. Colloids Surf B Biointerfaces 104:262–267

    Article  CAS  PubMed  Google Scholar 

  • Ntoutoume GMN, Granet R, Mbakidi JP, Bregier F, Leger DY, Fidanzi-Dugas C, Lequart V, Joly N, Liagre B, Chaleix V, Sol V (2016) Development of curcumin–cyclodextrin/cellulose nanocrystals complexes: new anticancer drug delivery systems. Bioorg Med Chem 26(3):941–945

    Article  CAS  Google Scholar 

  • Pallavicini P, Arciola CR, Bertoglio F, Curtosi S, Dacarro G, Agostino A, Ferrari F, Merli D, Milanese C, Rossi S, Taglietti A (2017) Silver nanoparticles synthesized and coated with pectin: An ideal compromise for anti-bacterial and anti-biofilm action combined with wound-healing properties. J Colloid Interface Sci 498:271–281

    Article  CAS  PubMed  Google Scholar 

  • Park JY, Lee YK, Lee DS, Yoo JE, Shin MS, Yamabe N, Kim SN, Lee S, Kim KH, Lee HJ, Roh SS (2017) Abietic acid isolated from pine resin (Resina Pini) enhances angiogenesis in HUVECs and accelerates cutaneous wound healing in mice. J Ethnopharmacol 203:279–287

    Article  CAS  PubMed  Google Scholar 

  • Patil SN, Paradeshi JS, Chaudhari PB, Mishra SJ, Chaudhari BL (2016) Bio-therapeutic potential and cytotoxicity assessment of pectin-mediated synthesized nanostructured cerium oxide. Appl Biochem Biotechnol 180(4):638–654

    Article  CAS  PubMed  Google Scholar 

  • Penalva R, Esparza I, Larraneta E, Gonzalez Navarro CJ, Gamazo C, Irache JM (2015) Zein-based nanoparticles improve the oral bioavailability of resveratrol and its anti-inflammatory effects in a mouse model of endotoxic shock. J Agr Food Chem 63(23):5603–5611

    Article  CAS  Google Scholar 

  • Pereira RF, Sousa A, Barrias CC, Bartolo PJ, Granja PL (2018) A single-component hydrogel bioink for bioprinting of bioengineered 3D constructs for dermal tissue engineering. Mater Horiz 5(6):1100–1111

    Article  CAS  Google Scholar 

  • Posadowska U, Brzychczy Wloch M, Pamula E (2016) Injectable gellan gum-based nanoparticles-loaded system for the local delivery of vancomycin in osteomyelitis treatment. J Mater Sci: Mater 27(1):9–18

    Google Scholar 

  • Raguvaran R, Manuja BK, Chopra M, Thakur R, Anand T, Kalia A, Manuja A (2017) Sodium alginate and gum acacia hydrogels of ZnO nanoparticles show wound healing effect on fibroblast cells. Int J Biol Macromol 96:185–191

    Article  CAS  PubMed  Google Scholar 

  • Ranjbar Mohammadi M, Rabbani S, Bahrami SH, Joghataei MT, Moayer F (2016) Antibacterial performance and in vivo diabetic wound healing of curcumin loaded gum tragacanth/poly (ε-caprolactone) electrospun nanofibers. Mater Sci Eng C 69:1183–1191

    Article  CAS  Google Scholar 

  • Rashad A, Mohamed Ahmed S, Ojansivu M, Berstad K, Yassin MA, Kivijaarvi T, Heggset EB, Syverud K, Mustafa K (2018) Coating 3D printed polycaprolactone scaffolds with nanocellulose promotes growth and differentiation of mesenchymal stem cells. Biomacromolecules 19(11):4307–4319

    Article  CAS  PubMed  Google Scholar 

  • Reesi F, Minaiyan M, Taheri A (2018) A novel lignin-based nanofibrous dressing containing arginine for wound-healing applications. J Drug Deliv Sci Technol 8(1):111–122

    CAS  Google Scholar 

  • Richter AP, Brown JS, Bharti B, Wang A, Gangwal S, Houck K, Hubal EAC, Paunov VN, Stoyanov SD, Velev OD (2015) An environmentally benign antimicrobial nanoparticle based on a silver-infused lignin core. Nat Nanotechnol 10(9):817–823

    Article  CAS  PubMed  Google Scholar 

  • Rodriguez Del Rio E, Marradi M, Calderon Gonzalez R, Frande Cabanes E, Penades S, Petrovsky N, Alvarez-Dominguez C (2015) A gold glyco-nanoparticle carrying a listeriolysin O peptide and formulated with Advaxâ„¢ delta inulin adjuvant induces robust T-cell protection against listeria infection. Vaccine 33(12):1465–1473

    Article  CAS  PubMed  Google Scholar 

  • Salami MA, Kaveian F, Rafienia M, Saber-Samandari S, Khandan A, Naeimi M (2017) Electrospun polycaprolactone/lignin-based nanocomposite as a novel tissue scaffold for biomedical applications. JMSS 7(4):228–238

    PubMed  Google Scholar 

  • Sengupta S, Bhattacharyya DK, Goswami R, Bhowal J (2019) Emulsions stabilized by soy protein nanoparticles as potential functional non-dairy yogurts. J Sci Food Agric 99(13):5808–5818

    Article  CAS  PubMed  Google Scholar 

  • Sharma G, Pathania D, Naushad M (2014) Preparation, characterization and antimicrobial activity of biopolymer based nanocomposite ion exchanger pectin zirconium (IV) selenotungstophosphate: application for removal of toxic metals. J Ind Eng Chem 20(6):4482–4490

    Article  CAS  Google Scholar 

  • Siddiqui L, Mishra H, Mishra PK, Iqbal Z, Talegaonkar S (2018) Novel 4-in-1 strategy to combat colon cancer, drug resistance and cancer relapse utilizing functionalized bioinspiring lignin nanoparticle. Med Hypotheses 121:10–14

    Article  CAS  PubMed  Google Scholar 

  • Singla R, Soni S, Padwad YS, Acharya A, Yadav SK (2017) Sustained delivery of BSA/HSA from biocompatible plant cellulose nanocrystals for in vitro cholesterol release from endothelial cells. Int J Biol Macromol 104:748–757

    Article  CAS  PubMed  Google Scholar 

  • Singla R, Abidi SMS, Dar AI, Acharya A (2019a) Inhibition of glycation-induced aggregation of human serum albumin by organic–inorganic hybrid nanocomposites of Iron oxide-functionalized Nanocellulose. ACS Omega 4(12):14805–14819

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Singla R, Abidi SMS, Dar AI, Acharya A (2019b) Nanomaterials as potential and versatile platform for next generation tissue engineering applications. J Biomed Mater Res B 019(107B):2433–2449

    Article  CAS  Google Scholar 

  • Sun F, Nordli HR, Pukstad B, Gamstedt EK, Chinga-Carrasco G (2017) Mechanical characteristics of nanocellulose-PEG bionanocomposite wound dressings in wet conditions. Mech Behav Biomed 69:377–384

    Article  CAS  Google Scholar 

  • Sun Q, Luan L, Arif M, Li J, Dong QJ, Gao Y, Chi Z, Liu CG (2018) Redox-sensitive nanoparticles based on 4-aminothiophenol-carboxymethyl inulin conjugate for budesonide delivery in inflammatory bowel diseases. Carbohydr Polym 189:352–359

    Article  CAS  PubMed  Google Scholar 

  • Szu SC, Lin KFY, Hunt S, Chu C, Thinh ND (2014) Phase I clinical trial of O-acetylated pectin conjugate, a plant polysaccharide based typhoid vaccine. Vaccine 32(22):2618–2622

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Tang J, Song Y, Tanvir S, Anderson WA, Berry RM, Tam KC (2015) Polyrhodanine coated cellulose nanocrystals: a sustainable antimicrobial agent. ACS Sustain Chem Eng 3(8):1801–1809

    Article  CAS  Google Scholar 

  • Tansaz S, Boccaccini AR (2016) Biomedical applications of soy protein: a brief overview. J Biomed Mater Res A 104(2):553–569

    Article  CAS  PubMed  Google Scholar 

  • Tavakolian M, Okshevsky M, Van De Ven TG, Tufenkji N (2018) Developing antibacterial nanocrystalline cellulose using natural antibacterial agents. ACS Appl Mater Interfaces 10(40):33827–33838

    Article  CAS  PubMed  Google Scholar 

  • Teng Z, Luo Y, Wang Q (2012) Nanoparticles synthesized from soy protein: preparation, characterization, and application for nutraceutical encapsulation. J Agric Food Chem 60(10):2712–2720

    Article  CAS  PubMed  Google Scholar 

  • Tripodo G, Pasut G, Trapani A, Mero A, Lasorsa FM, Chlapanidas T, Trapani G, Mandracchia D (2015) Inulin-D-α-tocopherol succinate (INVITE) nanomicelles as a platform for effective intravenous administration of curcumin. Biomacromolecules 16(2):550–557

    Article  CAS  PubMed  Google Scholar 

  • Vahedikia N, Garavand F, Tajeddin B, Cacciotti I, Jafari SM, Omidi T, Zahedi Z (2019) Biodegradable zein film composites reinforced with chitosan nanoparticles and cinnamon essential oil: physical, mechanical, structural and antimicrobial attributes. Colloids Surf B: Biointerfaces 177:25–32

    Article  CAS  PubMed  Google Scholar 

  • Visan AI, Popescu-Pelin G, Gherasim O, Grumezescu V, Socol M, Zgura I, Cristescu R (2019) Laser processed antimicrobial nanocomposite based on polyaniline grafted lignin loaded with gentamicin-functionalized magnetite on a silver-infused lignin core. Polymers 11(2):283–305

    Article  PubMed Central  CAS  Google Scholar 

  • Volsi AL, De Aberasturi DJ, Henriksen-Lacey M, Giammona G, Licciardi M, Liz-Marzan LM (2016) Inulin coated plasmonic gold nanoparticles as a tumor-selective tool for cancer therapy. J Mater Chem B 4(6):1150–1155

    Article  CAS  Google Scholar 

  • Wang J, Tian L, Luo B, Ramakrishna S, Kai D, Loh XJ, Meo X (2018) Engineering PCL/lignin nanofibers as an antioxidant scaffold for the growth of neuron and Schwann cell. Colloids Surf B Biointerfaces 169:356–365

    Article  CAS  PubMed  Google Scholar 

  • Weeks BS, Perez PP (2009) The hemicellulose preparation, Natramune (PDS-2865), increases macrophage phagocytosis and nitric oxide production and increases circulating human lymphocytes levels. Med Sci Monit Basic Res 15(2):43–46

    Google Scholar 

  • Xue Y, Liang W, Li Y, Wu Y, Peng X, Qiu X, Liu J, Sun R (2016) Fluorescent pH-sensing probe based on biorefinery wood lignosulfonate and its application in human cancer cell bioimaging. J Agric Food Chem 64(51):9592–9600

    Article  CAS  PubMed  Google Scholar 

  • Xue Y, Mou Z, Xiao H (2017) Nanocellulose as a sustainable biomass material: structure, properties, present status and future prospects in biomedical applications. Nanoscale 9(39):14758–14781

    Article  CAS  PubMed  Google Scholar 

  • Yanamala N, Farcas MT, Hatfield MK, Kisin ER, Kagan VE, Geraci CL, Shvedova AA (2014) In vivo evaluation of the pulmonary toxicity of cellulose nanocrystals: a renewable and sustainable nanomaterial of the future. ACS Sustain Chem Eng 2(7):1691–1698

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Yao W, Zha Q, Cheng X, Wang X, Wang J, Tang R (2017) Folic acid-conjugated soybean protein-based nanoparticles mediate efficient antitumor ability in vitro. J Biomater Appl 31(6):832–843

    Article  CAS  PubMed  Google Scholar 

  • Yin K, Divakar P, Wegst UG (2019) Plant-derived Nanocellulose as structural and mechanical reinforcement of freeze-cast chitosan scaffolds for biomedical applications. Biomacromolecules 20(10):3733–3745

    Article  CAS  PubMed  Google Scholar 

  • Zhang Y, Chen T, Yuan P, Tian R, Hu W, Tang Y, Jia Y, Zhang L (2015) Encapsulation of honokiol into self-assembled pectin nanoparticles for drug delivery to HepG2 cells. Carbohydr Polym 133:31–38

    Article  CAS  PubMed  Google Scholar 

  • Zhang Y, Jiang M, Zhang Y, Cao Q, Wang X, Han Y, Sun G, Li Y, Zhou J (2016a) Epichlorohydrin-cross-linked hydroxyethyl cellulose/soy protein isolate composite films as biocompatible and biodegradable implants for tissue engineering. ACS Appl Mater Interfaces 8(4):2781–2795

    Article  CAS  Google Scholar 

  • Zhang M, Li X, Li S, Liu Y, Hao L (2016b) Electrospun poly (l-lactide)/zein nanofiber mats loaded with Rana chensinensis skin peptides for wound dressing. J Mater Sci: Mater 27(9):136–148

    Google Scholar 

  • Zhang Y, Jiang M, Zhang Y, Cao Q, Wang X, Han Y, Sun G, Li Y, Zhou J (2019) Novel lignin–chitosan–PVA composite hydrogel for wound dressing. Mat Sci Eng C-Mater 104:110002–110012

    Article  CAS  Google Scholar 

  • Zhao XJ, Zhang WL, Zhou ZQ (2014) Sodium hydroxide-mediated hydrogel of citrus pectin for preparation of fluorescent carbon dots for bioimaging. Colloids Surf B Biointerfaces 123:493–497

    Article  CAS  PubMed  Google Scholar 

  • Zhao W, Odelius K, Edlund U, Zhao C, Albertsson AC (2015) In situ synthesis of magnetic field-responsive hemicellulose hydrogels for drug delivery. Biomacromolecules 16(8):2522–2528

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Zhou G, Luo Z, Fu X (2014a) Preparation of starch nanoparticles in a water-in-ionic liquid microemulsion system and their drug loading and releasing properties. J Agric Food Chem 62(32):8214–8220

    Article  CAS  PubMed  Google Scholar 

  • Zhou P, Xia Y, Cheng X, Wang P, Xie Y, Xu S (2014b) Enhanced bone tissue regeneration by antibacterial and osteoinductive silica-HACC-zein composite scaffolds loaded with rhBMP-2. Biomaterials 35(38):10033–10045

    Article  CAS  PubMed  Google Scholar 

Download references

Acknowledgements

The authors would like to thank Director, CSIR- IHBT for his constant support and encouragement. AA acknowledges the financial support from CSIR (MLP-201) and DST (GAP-0214; EMR/2016/003027). SMSA and AID thank DBT and DST, respectively, for providing SRF. Academy of Scientific and Innovative Research, New Delhi is duly acknowledged. The CSIR-IHBT communication number of this manuscript is 4499.

Author information

Authors and Affiliations

  1. Biotechnology Division, CSIR-Institute of Himalayan Bioresource Technology, Palampur, H.P, India

    Syed M. S. Abidi, Aqib Iqbal Dar & Amitabha Acharya

  2. Academy of Scientific & Innovative Research (AcSIR), CSIR-Institute of Himalayan Bioresource Technology, Palampur, H.P, India

    Syed M. S. Abidi, Aqib Iqbal Dar & Amitabha Acharya

Authors
  1. Syed M. S. Abidi
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Aqib Iqbal Dar
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Amitabha Acharya
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Amitabha Acharya .

Editor information

Editors and Affiliations

  1. Biotechnology Division, Institute of Himalayan Bioresource Technology, Palampur, Himachal Pradesh, India

    Amitabha Acharya

Rights and permissions

Reprints and permissions

Copyright information

© 2020 Springer Nature Singapore Pte Ltd.

About this chapter

Check for updates. Verify currency and authenticity via CrossMark

Cite this chapter

Abidi, S.M.S., Dar, A.I., Acharya, A. (2020). Plant-Based Polymeric Nanomaterials for Biomedical Applications. In: Acharya, A. (eds) Nanomaterial - Based Biomedical Applications in Molecular Imaging, Diagnostics and Therapy. Springer, Singapore. https://doi.org/10.1007/978-981-15-4280-0_7

Download citation

Publish with us

Policies and ethics

Search

Navigation