Abstract
Mesoporous hydroxyapatite (HAP) nanopowders (NPs) with distinct particle morphologies of nanorods (HAP-NR) and hierarchically nanostructured microspheres (HAP-MS) were synthesized. HAP was a major phase in both products. Crystals were nanodimensional and exposed to tensile strain. HAP-NR was more crystalline than HAP-MS NP. Particles of HAP-NR and HAP-MS NPs were nanorod-like (aspect ratio of five to six) and hierarchically nanostructured microspheres in shape, respectively. Average particle size was 88 ± 30 nm (along c-axis) for HAP-NR and 1.5–2 µm for HAP-MS NP. EDX results were in agreement with XRD phase analysis. Specific surface areas of HAP-NR and HAP-MS NPs were 15 m2 g−1 and 22 m2 g1, respectively. HAP-MS NP was more porous than HAP-NR and, therefore, exhibited 45% higher vancomycin loading efficiency than HAP-NR NP. In addition, drug-releasing rate of HAP-MS NP was more than HAP-NR in simulated conditions.
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Singh, R.P., Singh, J. (2020). Influence of Particle Morphologies of Mesoporous Hydroxyapatite Nanopowders on Controlled Delivery of Vancomycin Drug. In: Prakash, C., Singh, S., Krolczyk, G., Pabla, B. (eds) Advances in Materials Science and Engineering. Lecture Notes in Mechanical Engineering. Springer, Singapore. https://doi.org/10.1007/978-981-15-4059-2_7
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