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Graphene Oxide Influences on Mechanical Properties and Drug Release Ability of Hydroxyapatite Based Composite Material

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Nanomaterials in Biomedical Application and Biosensors (NAP-2019)

Part of the book series: Springer Proceedings in Physics ((SPPHY,volume 244))

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Abstract

Bioactive composite material based on hydroxyapatite (HA), sodium alginate (Alg) with different content of graphene oxide (GO) was synthesized by the “wet chemistry” method and characterized by TEM, XRD, FTIR, HPLC analysis. Introduced the GO nanoparticles, as well as Ca2+ ions, as cross-linker of Alg macromolecules by the beads formation, lead to enhancement of the composites mechanical properties. HA–Alg–GO10 sample with GO content of 0.004% in relation to the HA powder has a much higher Young’s modulus (1325 MPa) in comparison with GO-free HA–Alg composite (793 MPa), as well as steel sample of the same size (~706 MPa). The addition of GO reduces the degree of the composites swelling in a phosphate buffered saline for 43% and enhances the beads shape stability. Chlorhexidine bigluconate release from GO containing samples lasts for 48 h longer according to HPLC study. The findings clear demonstrate the potential possibility of applications of the HA–Alg–GO composite material in bioengineering of bone tissue to fill bone defects of various geometries with the function of prolonged release of the drug. It is assumed that HA–Alg–GO composite material can be used in 3D modeling of areas of bone tissue that have to bear a mechanical load.

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References

  1. A. White, S. Best, I. Kinloch, Int. J. Appl. Ceram. Technol. 4(1), 1–13 (2007)

    Article  Google Scholar 

  2. T. Boontheekul, H.J. Kong, D.J. Mooney, Biomaterials 26, 2455–2465 (2005)

    Article  Google Scholar 

  3. K.Y. Lee, D.J. Mooney, Prog. Polym. Sci. 37, 106–126 (2012)

    Article  Google Scholar 

  4. Y.X. Huang, X.C. Dong, Y.X. Liu, L.J. Li, P. Chen, J. Mater. Chem. 21, 12358–12362 (2011)

    Article  Google Scholar 

  5. A.K. Geim, K.S. Novoselov, Nat. Mater. 6, 183–191 (2007)

    Article  ADS  Google Scholar 

  6. M. Ionita, M.A. Pandele, H. Iovu, Carbohyd. Polym. 94(1), 339–344 (2013). https://doi.org/10.1016/j.carbpol.2013.01.065

    Article  Google Scholar 

  7. A.S. Stanislavov, L.F. Sukhodub, L.B. Sukhodub, V.N. Kuznetsov, K.L. Bychkov, M.I. Kravchenko, Ultrasonics—Sonochemistry 42, 84–96 (2018)

    Article  Google Scholar 

  8. H.P. Klug, L.E. Alexander, X-Ray Diffraction Procedures: For Polycrystalline and Amorphous Materials (Wiley, New York, 1974)

    Google Scholar 

  9. V.M. Kuznetsov, L.B. Sukhodub, L.F. Sukhodub, Journal of nano- and electronic physics 6(4), 04039–04043 (2014)

    Google Scholar 

  10. A.T. Palasz, P.B. Breña, J. De-la-Fuente, A. Gutiérrez-Adán, Theriogenology 9, 1461–1470 (2008)

    Article  Google Scholar 

  11. L.F. Sukhodub, L.B. Sukhodub, O. Litsis, Yu. Prylutsky, Mat. Chem. Phys. 217, 228–234 (2018). https://doi.org/10.1016/j.matchemphys.2018.06.071

    Article  Google Scholar 

  12. Y. Han, Q. Zeng, H. Li, J. Chang, Acta Biomater. 9, 9107–9117 (2013). https://doi.org/10.1016/j.actbio.2013.06.022

    Article  Google Scholar 

  13. L. Vovchenko, O. Lazarenko, L. Matzui, Yu. Perets, A. Zhuravkov, V. Fedorets, F. LE Normand, Phys. Status Solidi A 211(2), 336–341 (2014)

    Article  ADS  Google Scholar 

  14. C.W. Chen, C.S. Oakes, K. Byrappa, R.E. Riman, K. Brown, K.S. TenHuisen, V.F. Janas, J. Mater. Chem. 14, 2425–2432 (2004)

    Article  Google Scholar 

  15. B.O. Fowler, Inorg. Chem. 13, 194–207 (1974)

    Article  Google Scholar 

  16. J. Arends, J. Christoffersen, M.R. Christoffersen, H. Eckert, B.O. Fowler, J.C. Heughebaert, G.H. Nancollas, J.P. Yesinowski, S.J. Zawacki, J. Cryst. Growth 3, 512–532 (1987)

    Google Scholar 

  17. V.K. Malesu, D. Sahoo, P.L. Nayak, Int. J. Appl. Biol. Pharmaceut. Technol. 2(3), 402–411 (2011)

    Google Scholar 

  18. A. Kovtun, D. Kozlova, K. Ganesan, C. Biewald, N. Seipold, P. Gaengler, W.H. Arnold, M. Epple RSC Adv. 2, 870–875 (2012)

    Article  Google Scholar 

  19. S. Garner, M. Barbour, Oral Dis. 21(5), 641–644 (2015). https://doi.org/10.1111/odi.12328

    Article  Google Scholar 

  20. C. Lee, X. Wei, J.W. Kysar, J. Hone, Science 321, 385–388 (2008)

    Google Scholar 

  21. J. Tucek, P. Błonski, J. Ugolotti, A.K. Swain, T. Enoki, R. Zboril, Chem. Soc. Rev. 47(11), 3899–3990 (2017)

    Article  Google Scholar 

  22. X. Wang, G. Shi, Phys. Chem. Chem. Phys. 17, 28484–28504 (2015)

    Article  Google Scholar 

  23. S. Fu, X. Feng, B. Lauke, Y. Mai, Composites B 39, 933 (2008)

    Article  Google Scholar 

  24. X. Jiang, Y. Ma, J. Li, Q. Fan, W. Huang, J. Phys. Chem. C 114, 22462–22465 (2010)

    Article  Google Scholar 

Download references

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Authors and Affiliations

  1. Sumy State University, Sumy, Ukraine

    L. B. Sukhodub, L. F. Sukhodub & M. A. Kumeda

  2. Taras Shevchenko National University of Kyiv, Kiev, Ukraine

    Yu. I. Prylutskyy

  3. Technical University of Ilmenau, Ilmenau, 98693, Germany

    U. Ritter

Authors
  1. L. B. Sukhodub
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  2. L. F. Sukhodub
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  3. Yu. I. Prylutskyy
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  4. M. A. Kumeda
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  5. U. Ritter
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Corresponding author

Correspondence to L. B. Sukhodub .

Editor information

Editors and Affiliations

  1. Department of Nanoelectronics, Sumy State University, Sumy, Ukraine

    Alexander D. Pogrebnjak

  2. Center of Collective Use of Scientific Equipment, Sumy State University, Sumy, Ukraine

    Maksym Pogorielov

  3. Optical Biosensors and Functional Nanomaterials Laboratory, University of Latvia, Riga, Latvia

    Roman Viter

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Sukhodub, L.B., Sukhodub, L.F., Prylutskyy, Y.I., Kumeda, M.A., Ritter, U. (2020). Graphene Oxide Influences on Mechanical Properties and Drug Release Ability of Hydroxyapatite Based Composite Material. In: Pogrebnjak, A., Pogorielov, M., Viter, R. (eds) Nanomaterials in Biomedical Application and Biosensors (NAP-2019). Springer Proceedings in Physics, vol 244. Springer, Singapore. https://doi.org/10.1007/978-981-15-3996-1_14

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