Abstract
The novel bioactive Fullerene C60-containing apatite/polymer polyelectrolyte composite for dental applications based on hydroxyapatite (HA), sodium alginate (Alg) and chitosan (CS) in form of thing membrane was synthesized by the “wet chemistry” method and investigated by various experimental techniques. XRD data indicate the formation under influence of MW irradiation of only one phase of HA (JCPDS 9-432) with average crystallites size of 20 nm and small carbonate content. The including of fullerene to the samples leads to a decrease in the liquid absorption degree for of about 60% and liquid retention ability for of about 50%. The fullerene-containing samples have higher shape stability after oscillations for 10 days in the shaker (rpm 80) at 37 °C. HPLC studies have shown the ability to use the material as a system for prolonged drug release. The addition of C60 accelerates and equals the kinetics of chlorhexidine (CHX) release during 48 h. The components ratio in the composite affects the thickness and mechanical properties of the film, its solubility and release of the antibacterial agent. The biodegradable and biocompatible with native surroundings material can be used in surgical and conservative dentistry for the treatment of periodontal diseases. Material can stimulate the bone tissue repair as an additional source of calcium and phosphorus ions, do not cause side effects, have antimicrobial properties and act as a system for prolonged drug release.
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Sukhodub, L.B., Kumeda, M.A., Sukhodub, L.F., Prylutskyy, Y.I. (2020). Fullerene C60-Containing Hydroxyapatite/Polymer Polyelectrolyte Composite for Dental Applications. In: Pogrebnjak, A., Pogorielov, M., Viter, R. (eds) Nanomaterials in Biomedical Application and Biosensors (NAP-2019). Springer Proceedings in Physics, vol 244. Springer, Singapore. https://doi.org/10.1007/978-981-15-3996-1_13
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