Skip to main content

The Role of Epigenetics in Shaping the Foundations of Children’s Learning

  • Chapter
  • First Online:
Health and Education Interdependence
  • 3636 Accesses

Abstract

Since the mapping of the human genome there has been an exponential growth of research investigating the way in which environmental factors influence the expression of genes and how this shapes the course of human development. This research has identified some of the underlying molecular mechanisms which regulate cellular processes over the life of all organisms. Findings from these epigenetic studies provide a molecular explanation of how environmental influences can affect gene expression—both in early life and throughout the entire lifespan. This has significant implications for many aspects of human development—including health, behaviour and learning. These new scientific insights help to explain what decades of child development research and large-scale longitudinal studies have shown concerning the heightened sensitivity of children to environmental influences—especially those experienced in utero, infancy and the preschool years. They also provide a biological explanation for social gradients, observed in children’s health and learning outcomes which increase or decrease as a function of socio-economic advantage or disadvantage. Together with recent advances in neuroscience, epigenetic research is bringing a new understanding of the biological processes underpinning key aspects of brain functioning relevant to children’s learning. These include memory consolidation and long-term memory storage as well as stress responsiveness and attention. For these reasons it will be useful for school educators to become familiar with key concepts in epigenetics as an integral part of their scientific literacy. This chapter describes the emerging science of epigenetics and some of the insights it is affording to aspects of brain development and functioning of relevance to children’s learning.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 84.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 109.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 109.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  • Abel, J. L., & Rissman, E. F. (2013). Running-induced epigenetic and gene expression changes in the adolescent brain. International Journal of Developmental Neuroscience, 31(6), 382–390.

    Article  Google Scholar 

  • Barker, D. J. (1995). Foetal origins of coronary heart disease. British Medical Journal, 311(6998), 171–174.

    Article  Google Scholar 

  • Boyce, W. T., & Kobor, M. S. (2015). Development and the epigenome: The ‘Synapse’ of gene-environment interplay. Development Science, 18, 1–23.

    Article  Google Scholar 

  • Bygren, L. O., Kaati, G., & Edvinsson, S. (2001). Longevity determined by paternal ancestors’ nutrition during their slow growth period. Acta Biotheoretica, 49, 53–59.

    Article  Google Scholar 

  • Bygren, L. O., Tinghög, P., Carstensen, J., Edvinsson, S., Kaati, G., Pembrey, M. E., Sjöström, M. (2014). Change in paternal grandmothers’ early food supply influenced cardiovascular mortality of the female grandchildren. BMC Genetics, 15(12).

    Article  Google Scholar 

  • Center on the Developing Child at Harvard University. (2010). A Science-based framework for early childhood policy using evidence to improve outcomes in learning, behavior, and health for vulnerable children. Cambridge, MA: Center on the Developing Child at Harvard University.

    Google Scholar 

  • Chen, E., Miller, G. E., Kobor, M. S., & Cole, S. W. (2010). Maternal warmth buffers the effects of low early-life socioeconomic status on pro-inflammatory signalling in adulthood. Molecular Psychiatry, 16, 729–737.

    Article  Google Scholar 

  • Chen, L., Pan, H., Tuan, T. A., Teh, A. L., MacIsaac, J. L., Mah, S. M., et al. (2015). Brain-derived neurotrophic factor (BDNF) polymorphism influences the association of the methylome with maternal anxiety and neonatal brain volumes. Developmental Psychopathology, 271, 137–150.

    Article  Google Scholar 

  • Chomitz, V. R., Slining, M. M., McGowan, R. J., Mitchell, S. E., Dawson, G. F., & Hacker, K. A. (2009). Is there a relationship between physical fitness and academic achievement? Positive results from public school children in the north-eastern United States. Journal of School Health, 79(1), 30–37.

    Article  Google Scholar 

  • Day, J. J., & Sweatt, J. D. (2010). DNA methylation and memory formation. Nature Neuroscience, 13, 1319–1323.

    Article  Google Scholar 

  • Essex, M. J., Boyce, W. T., Hertzman, C., Lam, L. L., Armstrong, J. M., Neumann, S. M. A., & Kobor, M. S. (2013). Epigenetic vestiges of early developmental adversity: Childhood stress exposure and DNA methylation in adolescence. Child Development, 84(1), 58–75.

    Article  Google Scholar 

  • Joubert, B. R., Haberg, S. E., Nilsen, R. M., & Wang, X. (2012). 50K Epigenome-wide scan identifies differential DNA methylation in newborns related to maternal smoking during pregnancy. Environmental Health Perspectives, 120(10), 1425–1431.

    Article  Google Scholar 

  • Lipsky, R. H. (2013). Epigenetic mechanisms regulating learning and long-term memory. International Journal of Developmental Neuroscience, 31, 353–358.

    Article  Google Scholar 

  • Lupien, S. J., McEwen, B. S., Gunnar, M. R., & Heim, C. (2009). Effects of stress throughout the lifespan on brain, behavior and cognition. Nature Neuroscience, 10, 434–445.

    Article  Google Scholar 

  • McEwan, B. (2015). Epigenetics and learning. Trends in Neuroscience and Education, 4, 108–111.

    Article  Google Scholar 

  • McCain, M. N., Mustard, J. F., & McCuaig, K. (2011). Early years study 3: Making decisions, taking action. Toronto, ON: Margaret & Wallace McCain Family Foundation.

    Google Scholar 

  • Molfese, D. L. (2011). Advancing neuroscience through epigenetics: Molecular mechanisms of learning and memory. Developmental Neuropsychology, 36(7), 810–827.

    Article  Google Scholar 

  • O’Connell, M. E., Boat, T., & Warner, K. E. (Eds.). (2009). Preventing mental, emotional, and behavioral disorders among young people: progress and possibilities: Research advances and promising interventions. Washington, DC: The National Academies Press.

    Google Scholar 

  • Perera, F., & Herbstman, J. (2011). Prenatal environmental exposures, epigenetics, and disease. Reproductive Toxicology, 31(3), 363–373.

    Article  Google Scholar 

  • Rasberry, C. N., Lee, S. M., Robin, L., Laris, B. A., Russell, L. A., Coyle, K. K., & Nihiser, A. J. (2011). The association between school-based physical activity, including physical education, and academic performance: a systematic review of the literature. Preventive Medicine, 52, 510–520.

    Article  Google Scholar 

  • Shonkoff, J. P., & Phillips, D. A. (2000). From neurons to neighborhoods: The science of early childhood development. Washington, DC: National Academy Press.

    Google Scholar 

  • Spitzer, U. S., & Hollmann, W. (2013). Experimental observations of the effects of physical exercise on attention, academic and prosocial performance in school settings. Trends in Neuroscience and Education, 2, 1–6.

    Article  Google Scholar 

  • Szyf, M., McGowan, P., & Meaney, M. J. (2008). The social environment and the epigenome. Environmental and Molecular Mutagenesis, 49, 46–60.

    Article  Google Scholar 

  • Tamis-LeMonda, C. S., & Bornstein, M. H. (2002). Maternal responsiveness and early language acquisition. Advances in Child Development and Behavior, 29, 89–127.

    Article  Google Scholar 

  • Ungerer, J., Knezovich, J., Ramsay, M. (2018). In utero alcohol exposure, epigenetic changes, and their consequences. Alcohol Research: Current Reviews, 35(1). NIH National Institute on Alcohol and Alcoholism: US Department of Health and Human Services.

    Google Scholar 

  • Van Dusen, D. P., Kelde, S. H., Kohl, H. W., Ranjit, N., & Perry, C. L. (2011). Associations of physical fitness and academic performance among schoolchildren. Journal of School Health, 81(12), 733–740.

    Article  Google Scholar 

  • Waddington, C. H. (1969). Towards a theoretical biology. Nature, 218(5141), 525–527.

    Article  Google Scholar 

  • Waldfogel, J. (2004). Social mobility, life chances, and the early years. London, UK: London School of Economics.

    Google Scholar 

  • Zovkic, I. B., Guzman-Karlsson, M. C., & Sweatt, J. D. (2019). Epigenetic regulation of memory formation and maintenance. Memory and Learning, 26(2), 61–74.

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Sven Silburn .

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2020 Springer Nature Singapore Pte Ltd.

About this chapter

Check for updates. Verify currency and authenticity via CrossMark

Cite this chapter

Silburn, S. (2020). The Role of Epigenetics in Shaping the Foundations of Children’s Learning. In: Midford, R., Nutton, G., Hyndman, B., Silburn, S. (eds) Health and Education Interdependence. Springer, Singapore. https://doi.org/10.1007/978-981-15-3959-6_16

Download citation

  • DOI: https://doi.org/10.1007/978-981-15-3959-6_16

  • Published:

  • Publisher Name: Springer, Singapore

  • Print ISBN: 978-981-15-3958-9

  • Online ISBN: 978-981-15-3959-6

  • eBook Packages: EducationEducation (R0)

Publish with us

Policies and ethics