Abstract
Since the mapping of the human genome there has been an exponential growth of research investigating the way in which environmental factors influence the expression of genes and how this shapes the course of human development. This research has identified some of the underlying molecular mechanisms which regulate cellular processes over the life of all organisms. Findings from these epigenetic studies provide a molecular explanation of how environmental influences can affect gene expression—both in early life and throughout the entire lifespan. This has significant implications for many aspects of human development—including health, behaviour and learning. These new scientific insights help to explain what decades of child development research and large-scale longitudinal studies have shown concerning the heightened sensitivity of children to environmental influences—especially those experienced in utero, infancy and the preschool years. They also provide a biological explanation for social gradients, observed in children’s health and learning outcomes which increase or decrease as a function of socio-economic advantage or disadvantage. Together with recent advances in neuroscience, epigenetic research is bringing a new understanding of the biological processes underpinning key aspects of brain functioning relevant to children’s learning. These include memory consolidation and long-term memory storage as well as stress responsiveness and attention. For these reasons it will be useful for school educators to become familiar with key concepts in epigenetics as an integral part of their scientific literacy. This chapter describes the emerging science of epigenetics and some of the insights it is affording to aspects of brain development and functioning of relevance to children’s learning.
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References
Abel, J. L., & Rissman, E. F. (2013). Running-induced epigenetic and gene expression changes in the adolescent brain. International Journal of Developmental Neuroscience, 31(6), 382–390.
Barker, D. J. (1995). Foetal origins of coronary heart disease. British Medical Journal, 311(6998), 171–174.
Boyce, W. T., & Kobor, M. S. (2015). Development and the epigenome: The ‘Synapse’ of gene-environment interplay. Development Science, 18, 1–23.
Bygren, L. O., Kaati, G., & Edvinsson, S. (2001). Longevity determined by paternal ancestors’ nutrition during their slow growth period. Acta Biotheoretica, 49, 53–59.
Bygren, L. O., Tinghög, P., Carstensen, J., Edvinsson, S., Kaati, G., Pembrey, M. E., Sjöström, M. (2014). Change in paternal grandmothers’ early food supply influenced cardiovascular mortality of the female grandchildren. BMC Genetics, 15(12).
Center on the Developing Child at Harvard University. (2010). A Science-based framework for early childhood policy using evidence to improve outcomes in learning, behavior, and health for vulnerable children. Cambridge, MA: Center on the Developing Child at Harvard University.
Chen, E., Miller, G. E., Kobor, M. S., & Cole, S. W. (2010). Maternal warmth buffers the effects of low early-life socioeconomic status on pro-inflammatory signalling in adulthood. Molecular Psychiatry, 16, 729–737.
Chen, L., Pan, H., Tuan, T. A., Teh, A. L., MacIsaac, J. L., Mah, S. M., et al. (2015). Brain-derived neurotrophic factor (BDNF) polymorphism influences the association of the methylome with maternal anxiety and neonatal brain volumes. Developmental Psychopathology, 271, 137–150.
Chomitz, V. R., Slining, M. M., McGowan, R. J., Mitchell, S. E., Dawson, G. F., & Hacker, K. A. (2009). Is there a relationship between physical fitness and academic achievement? Positive results from public school children in the north-eastern United States. Journal of School Health, 79(1), 30–37.
Day, J. J., & Sweatt, J. D. (2010). DNA methylation and memory formation. Nature Neuroscience, 13, 1319–1323.
Essex, M. J., Boyce, W. T., Hertzman, C., Lam, L. L., Armstrong, J. M., Neumann, S. M. A., & Kobor, M. S. (2013). Epigenetic vestiges of early developmental adversity: Childhood stress exposure and DNA methylation in adolescence. Child Development, 84(1), 58–75.
Joubert, B. R., Haberg, S. E., Nilsen, R. M., & Wang, X. (2012). 50K Epigenome-wide scan identifies differential DNA methylation in newborns related to maternal smoking during pregnancy. Environmental Health Perspectives, 120(10), 1425–1431.
Lipsky, R. H. (2013). Epigenetic mechanisms regulating learning and long-term memory. International Journal of Developmental Neuroscience, 31, 353–358.
Lupien, S. J., McEwen, B. S., Gunnar, M. R., & Heim, C. (2009). Effects of stress throughout the lifespan on brain, behavior and cognition. Nature Neuroscience, 10, 434–445.
McEwan, B. (2015). Epigenetics and learning. Trends in Neuroscience and Education, 4, 108–111.
McCain, M. N., Mustard, J. F., & McCuaig, K. (2011). Early years study 3: Making decisions, taking action. Toronto, ON: Margaret & Wallace McCain Family Foundation.
Molfese, D. L. (2011). Advancing neuroscience through epigenetics: Molecular mechanisms of learning and memory. Developmental Neuropsychology, 36(7), 810–827.
O’Connell, M. E., Boat, T., & Warner, K. E. (Eds.). (2009). Preventing mental, emotional, and behavioral disorders among young people: progress and possibilities: Research advances and promising interventions. Washington, DC: The National Academies Press.
Perera, F., & Herbstman, J. (2011). Prenatal environmental exposures, epigenetics, and disease. Reproductive Toxicology, 31(3), 363–373.
Rasberry, C. N., Lee, S. M., Robin, L., Laris, B. A., Russell, L. A., Coyle, K. K., & Nihiser, A. J. (2011). The association between school-based physical activity, including physical education, and academic performance: a systematic review of the literature. Preventive Medicine, 52, 510–520.
Shonkoff, J. P., & Phillips, D. A. (2000). From neurons to neighborhoods: The science of early childhood development. Washington, DC: National Academy Press.
Spitzer, U. S., & Hollmann, W. (2013). Experimental observations of the effects of physical exercise on attention, academic and prosocial performance in school settings. Trends in Neuroscience and Education, 2, 1–6.
Szyf, M., McGowan, P., & Meaney, M. J. (2008). The social environment and the epigenome. Environmental and Molecular Mutagenesis, 49, 46–60.
Tamis-LeMonda, C. S., & Bornstein, M. H. (2002). Maternal responsiveness and early language acquisition. Advances in Child Development and Behavior, 29, 89–127.
Ungerer, J., Knezovich, J., Ramsay, M. (2018). In utero alcohol exposure, epigenetic changes, and their consequences. Alcohol Research: Current Reviews, 35(1). NIH National Institute on Alcohol and Alcoholism: US Department of Health and Human Services.
Van Dusen, D. P., Kelde, S. H., Kohl, H. W., Ranjit, N., & Perry, C. L. (2011). Associations of physical fitness and academic performance among schoolchildren. Journal of School Health, 81(12), 733–740.
Waddington, C. H. (1969). Towards a theoretical biology. Nature, 218(5141), 525–527.
Waldfogel, J. (2004). Social mobility, life chances, and the early years. London, UK: London School of Economics.
Zovkic, I. B., Guzman-Karlsson, M. C., & Sweatt, J. D. (2019). Epigenetic regulation of memory formation and maintenance. Memory and Learning, 26(2), 61–74.
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Silburn, S. (2020). The Role of Epigenetics in Shaping the Foundations of Children’s Learning. In: Midford, R., Nutton, G., Hyndman, B., Silburn, S. (eds) Health and Education Interdependence. Springer, Singapore. https://doi.org/10.1007/978-981-15-3959-6_16
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