Abstract
Memory B cells are a key cellular component of the protective humoral responses to infectious pathogens. Most of our knowledge of memory B-cell responses comes from studies using mono-epitopic model antigens that elicit systemic humoral responses dominated by canonical B-cell antigen receptors. This approach successfully dissected the systemic responses of memory B cells and greatly advanced our understanding of memory B-cell formation, maintenance, and reactivation to re-invading antigens in the secondary lymphoid organs. However, the canonical memory B-cell responses fail to fully recapitulate the heterogeneity of the protective memory responses. Indeed, accumulating studies using “natural” antigens and live pathogens have uncovered new aspects of memory B-cell responses, which are achieved by memory B cells with different phenotypes, tissue residence, and responsiveness to antigen stimulation. Such non-canonical memory B-cell responses are frequently observed in local sites where live pathogens initially infect and replicate. Importantly, the local memory B-cell responses often serve as the first line of defense against re-infecting pathogens, thereby playing an essential role in controlling the pathogens. Here, we provide a comprehensive overview of the systemic and local memory B-cell responses in the humoral protective immunity against pathogens.
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Acknowledgements
The laboratory is funded by the Ministry of Education, Culture, Sports, Science, and Technology in Japan under JP19K17656 (to YA) and the Japan Agency for Medical Research and Development under JP19fk0108051, 19fk0108035, and 19fk0310120 (all to YT).
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Moriyama, S., Adachi, Y., Tonouchi, K., Takahashi, Y. (2020). Memory B Cells in Local and Systemic Sites. In: Wang, JY. (eds) B Cells in Immunity and Tolerance. Advances in Experimental Medicine and Biology, vol 1254. Springer, Singapore. https://doi.org/10.1007/978-981-15-3532-1_5
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DOI: https://doi.org/10.1007/978-981-15-3532-1_5
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