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Enhancing Osteochondral Tissue Regeneration of Gellan Gum by Incorporating Gallus gallus var Domesticus-Derived Demineralized Bone Particle

  • Muthukumar Thangavelu
  • David Kim
  • Young Woon Jeong
  • Wonchan Lee
  • Jun Jae Jung
  • Jeong Eun Song
  • Rui L. Reis
  • Gilson KhangEmail author
Chapter
  • 73 Downloads
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 1250)

Abstract

Treatment for the osteochondral defects (ODs) is more challenging nowadays that needs to be addressed by developing alternative bone tissue engineering materials. Gellan gum (GG) is a widely used natural polysaccharide in the field of tissue engineering (TE) and regenerative medicine due to its versatile properties. There are many reports about the successful application of GG in cartilage tissue engineering and guiding bone formation. Functional coatings and porous composite materials have been introduced in next-generation materials for treating OD, whereas osteoconductive materials, such as demineralized bone particle (DBP) or bone derivatives, are used. However, modification of porosity, biocompatibility, cell proliferation, and mechanical properties is needed. DBP can activate human mesenchymal stem cells to differentiate into osteoblast cells. In this chapter, the potential application of GG with DBP in different combinations was reviewed, and the best suitable combinations were selected and further studied in small animal models for the soft and hard tissue engineering applications; also its application in the osteochondral integration fields were briefly discussed.

Keywords

Osteochondral defect Gellan gum Demineralized bone particle Osteoarthritis Biomaterial Scaffold Osteochondral defects Tissue engineering Hydrogel 

Notes

Acknowledgment

This research was supported by a grant of the Korea Health Technology R&D Project through the Korea Health Industry Development Institute (KHIDI), funded by the Ministry of Health and Welfare, Republic of Korea (grant number: HI15C2996), and the International Research and Development Program of the National Research Foundation of Korea (NRF) funded by the Ministry of Science, ICT and Future Planning (NRF-2017K1A3A7A03089427).

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Copyright information

© Springer Nature Singapore Pte Ltd. 2020

Authors and Affiliations

  • Muthukumar Thangavelu
    • 1
  • David Kim
    • 1
  • Young Woon Jeong
    • 1
  • Wonchan Lee
    • 1
  • Jun Jae Jung
    • 1
  • Jeong Eun Song
    • 1
  • Rui L. Reis
    • 2
  • Gilson Khang
    • 1
    Email author
  1. 1.Department of BIN Convergence Technology, Department of Polymer Nano Science & Technology and Polymer BIN Research CenterJeonbuk National UniversityJeonjuSouth Korea
  2. 2.3B’s Research Group, I3Bs – Research Institute on Biomaterials, Biodegradables and Biomimetics, Headquarters of the European Institute of Excellence on Tissue Engineering and Regenerative MedicineUniversity of MinhoGuimarãesPortugal

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