Injectable In Situ-Forming Hydrogels for Protein and Peptide Delivery

  • Seung Hun Park
  • Yun Bae Ji
  • Joon Yeong Park
  • Hyeon Jin Ju
  • Mijeong Lee
  • Surha Lee
  • Jae Ho Kim
  • Byoung Hyun Min
  • Moon Suk KimEmail author
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 1250)


Injectable in situ-forming hydrogels have been used clinically in diverse biomedical applications. These hydrogels have distinct advantages such as easy management and minimal invasiveness. The hydrogels are aqueous formulations, and a simple injection at the target site replaces a traditional surgical procedure. Here, we review injectable in situ-forming hydrogels that are formulated by physical and chemical methods to deliver proteins and peptides. Prospects for using in situ-forming hydrogels for several specific applications are also discussed.


Injectable in situ forming hydrogels Protein and peptide Drug depot Crosslinking Physical interaction Electrostatic interaction Biomedical application of hydrogel Drug delivery system Click reaction Covalent and non-covalent bonding Protein and peptide loading 



This study was supported by a grant from Creative Materials Discovery Program through the National Research Foundation (2019M3D1A1078938) and Priority Research Centers Program (2019R1A6A1A11051471) funded by the National Research Foundation of Korea (NRF).


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Copyright information

© Springer Nature Singapore Pte Ltd. 2020

Authors and Affiliations

  • Seung Hun Park
    • 1
  • Yun Bae Ji
    • 1
  • Joon Yeong Park
    • 1
  • Hyeon Jin Ju
    • 1
  • Mijeong Lee
    • 1
  • Surha Lee
    • 1
  • Jae Ho Kim
    • 1
  • Byoung Hyun Min
    • 1
  • Moon Suk Kim
    • 1
    Email author
  1. 1.Department of Molecular Science and TechnologyAjou UniversitySuwonSouth Korea

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