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Decellularized Extracellular Matrices for Tissue Engineering and Regeneration

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Biomimicked Biomaterials

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 1250))

Abstract

Decellularized extracellular matrices (dECMs) from mammalian tissues and organs are particularly interesting as scaffolds for tissue engineering and regeneration when considering their ability to retain chemical compositions and three-dimensional (3D) microstructures that are similar to native ECMs. This review discusses the advantages and disadvantages of different decellularization methods that use various agents, such as ionic and nonionic detergents and biological enzymes. The applications of dECMs as scaffolds or hydrogels for tissue engineering of specific tissues including heart valves, blood vessels, and skin, as well as their performance in vitro and in vivo, are also discussed. In addition, whole organ regeneration (i.e., the heart, kidney, liver) using dECM scaffolds has been explored, which are able to recapitulate partial functions of native organs.

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Author information

Author notes

  1. Authors Fang Ge and Yuhe Lu have equally contributed to this chapter.

Authors and Affiliations

  1. Institute of Metal Research, Chinese Academy of Sciences, Shenyang, Liaoning, China

    Fang Ge, Yuhe Lu, Qian Li & Xing Zhang

  2. Department of Chemistry, Northeastern University, Shenyang, Liaoning, China

    Fang Ge & Qian Li

  3. School of Materials Science and Engineering, Northeastern University, Shenyang, Liaoning, China

    Yuhe Lu

  4. School of Materials Science and Engineering, University of Science and Technology of China, Hefei, Anhui, China

    Xing Zhang

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  1. Fang Ge
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  2. Yuhe Lu
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  4. Xing Zhang
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Corresponding author

Correspondence to Xing Zhang .

Editor information

Editors and Affiliations

  1. Institute of Cell & Tissue Engineering and College of Medicine, Catholic University of Korea, Seoul, Korea (Republic of)

    Heung Jae Chun

  2. 3B’s Research Group, I3Bs – Research Institute on Biomaterials, Biodegradables and Biomimetics, Headquarters of the European Institute of Excellence on Tissue Engineering and Regenerative Medicine, University of Minho, Guimarães, Portugal

    Rui L. Reis

  3. Department of Industrial Engineering and BIOtech Research Center, University of Trento, Trento, Italy

    Antonella Motta

  4. Department of BIN Convergence Technology, Department of Polymer Nano Science & Technology and Polymer BIN Research Center, Jeonbuk National University, Jeonju, Korea (Republic of)

    Gilson Khang

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Ge, F., Lu, Y., Li, Q., Zhang, X. (2020). Decellularized Extracellular Matrices for Tissue Engineering and Regeneration. In: Chun, H., Reis, R., Motta, A., Khang, G. (eds) Biomimicked Biomaterials. Advances in Experimental Medicine and Biology, vol 1250. Springer, Singapore. https://doi.org/10.1007/978-981-15-3262-7_2

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