Decellularized Extracellular Matrices for Tissue Engineering and Regeneration

  • Fang Ge
  • Yuhe Lu
  • Qian Li
  • Xing ZhangEmail author
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 1250)


Decellularized extracellular matrices (dECMs) from mammalian tissues and organs are particularly interesting as scaffolds for tissue engineering and regeneration when considering their ability to retain chemical compositions and three-dimensional (3D) microstructures that are similar to native ECMs. This review discusses the advantages and disadvantages of different decellularization methods that use various agents, such as ionic and nonionic detergents and biological enzymes. The applications of dECMs as scaffolds or hydrogels for tissue engineering of specific tissues including heart valves, blood vessels, and skin, as well as their performance in vitro and in vivo, are also discussed. In addition, whole organ regeneration (i.e., the heart, kidney, liver) using dECM scaffolds has been explored, which are able to recapitulate partial functions of native organs.


Decellularization Recellularization Extracellular matrices Microstructure Tissue engineering Organ regeneration 


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Copyright information

© Springer Nature Singapore Pte Ltd. 2020

Authors and Affiliations

  1. 1.Institute of Metal ResearchChinese Academy of SciencesShenyangChina
  2. 2.Department of ChemistryNortheastern UniversityShenyangChina
  3. 3.School of Materials Science and EngineeringNortheastern UniversityShenyangChina
  4. 4.School of Materials Science and EngineeringUniversity of Science and Technology of ChinaHefeiChina

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