Bone Regeneration Using Duck’s Feet-Derived Collagen Scaffold as an Alternative Collagen Source

  • Jeong Eun Song
  • Muthukumar Thangavelu
  • Joohee Choi
  • Hunhwi Cho
  • Byung Kwan Moon
  • Sun Jung Yoon
  • Nuno M. Neves
  • Gilson KhangEmail author
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 1250)


Collagen is an important component that makes 25–35% of our body proteins. Over the past decades, tissue engineers have been designing collagen-based biocompatible materials and studying their applications in different fields. Collagen obtained from cattle and pigs has been mainly used until now, but collagen derived from fish and other livestock has attracted more attention since the outbreak of mad cow disease, and they are also used as a raw material for cosmetics and foods. Due to the zoonotic infection using collagen derived from pigs and cattle, their application in developing biomaterials is limited; hence, the development of new animal-derived collagen is required. In addition, there is a religion (Islam, Hinduism, and Judaism) limited to export raw materials and products derived from cattle and pig. Hence, high-value collagen that is universally accessible in the world market is required. Therefore, in this review, we have dealt with the use of duck’s feet-derived collagen (DC) as an emerging alternative to solve this problem and also presenting few original investigated bone regeneration results performed using DC.


Duck’s feet Collagen Extraction Biomaterial Scaffold Bone marrow stem cell Differentiation Bone Regeneration Tissue engineering 



This research was supported by a grant of the Korea Health Technology R&D Project through the Korea Health Industry Development Institute (KHIDI), funded by the Ministry of Health &Welfare, Republic of Korea (HI15C2996) and the International Research & Development Program of the National Research Foundation of Korea (NRF) funded by the Ministry of Science, ICT & Future Planning (NRF-2017K1A3A7A03089427).


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Copyright information

© Springer Nature Singapore Pte Ltd. 2020

Authors and Affiliations

  • Jeong Eun Song
    • 1
  • Muthukumar Thangavelu
    • 1
  • Joohee Choi
    • 1
  • Hunhwi Cho
    • 1
  • Byung Kwan Moon
    • 1
  • Sun Jung Yoon
    • 2
  • Nuno M. Neves
    • 3
  • Gilson Khang
    • 1
    Email author
  1. 1.Department of BIN Convergence Technology, Department of Polymer Nano Science & Technology and Polymer BIN Research CenterJeonbuk National UniversityJeonjuSouth Korea
  2. 2.Department of orthopedic surgery, Medical SchoolJeonbuk National UniversityJeonjuRepublic of Korea
  3. 3.3B’s Research Group—Biomaterials, Biodegradables and Biomimetics, Headquarters of the European Institute of Excellence on Tissue Engineering and Regenerative MedicineGuimarãesPortugal

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