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3D Bioprinting of Tissue Models with Customized Bioinks

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Bioinspired Biomaterials

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 1249 ))

Abstract

The ordered assembly of multicellular structures mimicking native tissues has lately come into prominence for various applications of biomedicine. In this respect, three-dimensional bioprinting (3DP) of cells and other biologics through additive manufacturing techniques has brought the possibility to develop functional in vitro tissue models and perhaps creating de novo transplantable tissues or organs in time. Bioinks, which can be defined as the printable analogues of the extracellular matrix, represent the foremost component of 3DP. In this chapter, we attempt to elaborate the major classes of bioinks which are prevalently being evaluated for the 3DP of a wide range of tissue models.

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Abbreviations

3DP:

Three-dimensional bioprinting

A1AT:

Alpha-1 antitrypsin

ACCs:

Articular cartilage chondrocytes

AChR:

Acetylcholine receptor

Alg:

Calcium alginate

ALI:

Air-liquid interface

ALP:

Alkaline phosphatase

APAP:

Acetaminophen

ASCs:

Adipose stem cells

BaCl2:

Barium chloride

BM-MSCs:

Bone marrow-derived mesenchymal stem cells

CaCl2:

Calcium chloride

CECs:

Corneal epithelial cells

CKCs:

Corneal keratocytes

CMA:

Collagen methacrylamide

CMPCs:

Cardiac-derived cardiomyocyte progenitor cells

CMs:

Cardiomyocytes

CYP:

Cytochrome P450

dECM:

Decellularized extracellular matrix

DLP:

Digital light processing

DVS:

Divinyl sulfone

EBB:

Extrusion-based bioprinting

EDC:

1-Ethyl-(3-3-dimethylaminopropyl) hydrochloride

ESC-LESCs:

Embryonic stem cell-derived limbal epithelial stem cells

FBs:

Fibroblasts

FDM:

Fused deposition modeling

Gel-MA:

Gelatin methacrylate

Gel-AGE:

Allylated gelatin

GRGDS:

Cell binding domain of osteopontin

HA:

Hyaluronic acid

HAGM:

Hyaluronic acid glycidyl methacrylate

HUVECs:

Human umbilical vein endothelial cells

iPSCs:

Induced pluripotent stem cells

LAB:

Laser-assisted bioprinting

LAP:

Lithium phenyl-2,4,6-trimethylbenzoylphosphinate

LBB:

Laser-based bioprinting

MBB:

Microvalve-based bioprinting

MCs:

Melanocytes

MMP:

Matrix metalloproteinase

MPCs:

Muscle progenitor cells

MRI:

Magnetic resonance imaging

MSCs:

Mesenchymal stem cells

NaHCO3:

Sodium bicarbonate

nHAp:

Nanohydroxyapatite

NSCs:

Neural stem cells

PCL:

Poly(caprolactone)

PCNs:

Primary cortical neurons

PDMS:

Poly(dimethylsiloxane)

PEGDE:

Poly(ethylene glycol) diglycidyl ether

PEGDMA:

Poly(ethylene glycol) dimethacrylate

PEGDVS:

Poly(ethylene glycol) divinyl sulfone

PHCs:

Primary hepatocytes

PMMA:

Poly(methyl methacrylate)

PU:

Poly(urethane)

RGD:

Arginylglycylaspartic acid peptide

RT:

Room temperature

s.c.:

Subcutaneous

sGAGs:

Sulfated glycosaminoglycans

TA:

Tibialis anterior

μCOP:

Micro-continuous optical printing

μCT:

X-ray micro-tomography

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Acknowledgments

The work was supported by grants from TUBITAK, the Scientific and Technological Research Council of Turkey (117M281 and 216S575).

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Authors and Affiliations

  1. Biovalda Health Technologies, Inc., Ankara, Turkey

    Murat Taner Vurat, Can Ergun & Yaşar Murat Elçin

  2. Tissue Engineering, Biomaterials and Nanobiotechnology Laboratory, Ankara University Faculty of Science, Ankara, Turkey

    Murat Taner Vurat, Can Ergun & Yaşar Murat Elçin

  3. Tissue Engineering, Biomaterials and Nanobiotechnology Laboratory, Ankara University Faculty of Science, and Ankara University Stem Cell Institute, Ankara, Turkey

    Ayşe Eser Elçin

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  1. Murat Taner Vurat
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  2. Can Ergun
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  3. Ayşe Eser Elçin
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  4. Yaşar Murat Elçin
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Editors and Affiliations

  1. Institute of Cell & Tissue Engineering and College of Medicine, Catholic University of Korea, Seoul, Korea (Republic of)

    Heung Jae Chun

  2. 3B’s Research Group, I3Bs – Research Institute on Biomaterials, Biodegradables and Biomimetics, Headquarters of the European Institute of Excellence on Tissue Engineering and Regenerative Medicine, University of Minho, Guimarães, Portugal

    Rui L. Reis

  3. Department of Industrial Engineering and BIOtech Research Center, University of Trento, Trento, Italy

    Antonella Motta

  4. Department of BIN Convergence Technology, Department of Polymer Nano Science & Technology and Polymer BIN Research Center, Jeonbuk National University, Jeonju, Korea (Republic of)

    Gilson Khang

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Vurat, M.T., Ergun, C., Elçin, A.E., Elçin, Y.M. (2020). 3D Bioprinting of Tissue Models with Customized Bioinks. In: Chun, H.J., Reis, R.L., Motta, A., Khang, G. (eds) Bioinspired Biomaterials. Advances in Experimental Medicine and Biology, vol 1249 . Springer, Singapore. https://doi.org/10.1007/978-981-15-3258-0_5

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