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Extracellular Vesicles: The Next Frontier in Regenerative Medicine and Drug Delivery

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Bioinspired Biomaterials

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 1249 ))

Abstract

Extracellular vesicles (EVs) are nanosized membrane particles secreted by cells to convey intercellular information. In recent years, EVs have enticed scientists owing to their prevalent distribution, enormous possibility as therapeutic aspirants, and probable roles as disease biomarkers. As natural transporters in the endogenous communication system, they play a role in protein, lipid, miRNA, mRNA, and DNA transport. In this chapter, we recapitulate the roles of EVs in the vast field of regenerative medicine. This summary mainly describes the potential roles of EVs in the regeneration of extensively studied organs or tissues, such as the heart, kidney, lung, liver, skin, and hair. Furthermore, EV can also transport drugs and corroborate their uptake by target cells through endocytosis; therefore, this chapter also highlights the use of EVs in the field of drug delivery.

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Abbreviations

ALIX:

ALG-2-interacting protein X

APP:

Amyloid precursor protein

ARF6:

ADP-ribosylation factor 6

ARMMs:

Arrestin domain-containing protein 1-mediated microvesicles

CXCR4:

CXC chemokine receptor 4

GAPDH:

Glyceraldehyde 3-phosphate dehydrogenase

HSP70:

Heat shock 70 kDa protein

HSPG:

Heparan sulfate proteoglycan

ICAM:

Intercellular adhesion molecule

LBPA:

Lyso-bis-phosphatidyl acid

LFA1:

Lymphocyte function-associated antigen 1

MHC:

Major histocompatibility complex

PECAM1:

Platelet-endothelial cell adhesion molecule

PLD:

Phospholipase D

PrP:

Prion protein

ROCK:

RHO-associated protein kinase

TCR:

T cell receptor

TDP43:

TAR DNA-binding protein 43

TFR:

Transferrin receptor

TSG101:

Tumor susceptibility gene 101 protein

TSPAN:

Tetraspanin

VPS:

Vacuolar protein sorting

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Acknowledgments

This work was supported by the Basic Science Research Program of the National Research Foundation of Korea (NRF) funded by the Ministry of Education (NRF-2018R1D1A1B07045240).

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Author notes

  1. Authors Md. Asadujjaman and Dong-Jin Jang have equally contributed to this chapter

Authors and Affiliations

  1. College of Pharmacy, Chosun University, Gwangju, Republic of Korea

    Md. Asadujjaman, Seung Rim Hwang & Jun-Pil Jee

  2. Department of Pharmaceutical Engineering, Inje University, Gimhae, Republic of Korea

    Dong-Jin Jang

  3. Department of Pharmacy, College of Pharmacy, Inje University, Gimhae, Republic of Korea

    Kwan Hyung Cho

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Correspondence to Jun-Pil Jee .

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Editors and Affiliations

  1. Institute of Cell & Tissue Engineering and College of Medicine, Catholic University of Korea, Seoul, Korea (Republic of)

    Heung Jae Chun

  2. 3B’s Research Group, I3Bs – Research Institute on Biomaterials, Biodegradables and Biomimetics, Headquarters of the European Institute of Excellence on Tissue Engineering and Regenerative Medicine, University of Minho, Guimarães, Portugal

    Rui L. Reis

  3. Department of Industrial Engineering and BIOtech Research Center, University of Trento, Trento, Italy

    Antonella Motta

  4. Department of BIN Convergence Technology, Department of Polymer Nano Science & Technology and Polymer BIN Research Center, Jeonbuk National University, Jeonju, Korea (Republic of)

    Gilson Khang

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Asadujjaman, M., Jang, DJ., Cho, K.H., Hwang, S.R., Jee, JP. (2020). Extracellular Vesicles: The Next Frontier in Regenerative Medicine and Drug Delivery. In: Chun, H.J., Reis, R.L., Motta, A., Khang, G. (eds) Bioinspired Biomaterials. Advances in Experimental Medicine and Biology, vol 1249 . Springer, Singapore. https://doi.org/10.1007/978-981-15-3258-0_10

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