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Natural Sources and Applications of Demineralized Bone Matrix in the Field of Bone and Cartilage Tissue Engineering

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Bioinspired Biomaterials

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 1249 ))

Abstract

Demineralized bone matrix (DBM) is one of the most widely used materials for bone repair. Recently, different strategies in tissue engineering have been used to improve preparation of biomaterials from natural sources suitable for the use in bone regeneration. However, the application of DBM in tissue engineering is still a challenge, because the mechanical properties which are essential to bear tensile and load and the risk of transmission of disease by donor are still a matter of homework. A solution to this problem is to blend natural and synthetic polymers to complement defects and make them ideal biomaterials. An ideal biomaterial improves survival, adhesion, proliferation, induction, and differentiation of cells in the biomaterial after in vivo transplantation. In this review, we will look at the study of DBM made of natural and synthetic materials giving a direction for future research.

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Authors and Affiliations

  1. Department of BIN Convergence Technology, Department of Polymer Nano Science & Technology and Polymer BIN Research Center, Jeonbuk National University, Jeonju, South Korea

    Hunhwi Cho, Wonkyung Kim, Yongwoon Jeong, Namyeong Kim, Junjae Jung & Gilson Khang

  2. Microsystem Technology Group, Fondazione Bruno Kessler, Trento, Italy

    Alessio Bucciarelli

  3. Department of Industrial Engineering and BIOtech Research Center, Trento, Italy

    Alessio Bucciarelli

  4. Department of Orthopedic Surgery, Medical School, Chonbuk National University Hospital, Jeonju, Republic of Korea

    Sunjung Yoon

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  1. Hunhwi Cho
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  6. Junjae Jung
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  7. Sunjung Yoon
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  8. Gilson Khang
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Correspondence to Gilson Khang .

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Editors and Affiliations

  1. Institute of Cell & Tissue Engineering and College of Medicine, Catholic University of Korea, Seoul, Korea (Republic of)

    Heung Jae Chun

  2. 3B’s Research Group, I3Bs – Research Institute on Biomaterials, Biodegradables and Biomimetics, Headquarters of the European Institute of Excellence on Tissue Engineering and Regenerative Medicine, University of Minho, Guimarães, Portugal

    Rui L. Reis

  3. Department of Industrial Engineering and BIOtech Research Center, University of Trento, Trento, Italy

    Antonella Motta

  4. Department of BIN Convergence Technology, Department of Polymer Nano Science & Technology and Polymer BIN Research Center, Jeonbuk National University, Jeonju, Korea (Republic of)

    Gilson Khang

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Cho, H. et al. (2020). Natural Sources and Applications of Demineralized Bone Matrix in the Field of Bone and Cartilage Tissue Engineering. In: Chun, H.J., Reis, R.L., Motta, A., Khang, G. (eds) Bioinspired Biomaterials. Advances in Experimental Medicine and Biology, vol 1249 . Springer, Singapore. https://doi.org/10.1007/978-981-15-3258-0_1

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