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Insect Sex Pheromone Research and Beyond pp 111–150Cite as

A Sexy Moth Model – The Molecular Basis of Sex Pheromone Biosynthesis in the Silkmoth Bombyx mori

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Part of the book series: Entomology Monographs ((ENTMON))

Abstract

The reproductive behaviors of many insects are coordinated by the synthesis and release of species-specific volatiles that communicate the location of potential mates. Given their biological importance, structural elucidation of these compounds (i.e., sex pheromones) and molecular determination of the underlying biosynthetic pathways have been the focus of numerous studies. Among the various model species that have been examined, the silkmoth (Bombyx mori) has had an outsized impact on the research field. Indeed, it was Adolf Butenandt’s pioneering publication in 1959 on chemical characterization of the silkmoth sex pheromone (E,Z)-10,12-hexadecadien-1-ol (i.e., bombykol) that ushered in a new era of chemical ecology. Since then, B. mori has been at the forefront of each new advancement in our understanding of the pre- and postadult eclosion processes that culminate in pheromone production – from demonstration of hormonal regulation by a neuropeptide to identification of the cognate receptors and characterization of the genes comprising the biosynthetic and regulatory pathways. In honor of the 60th anniversary of bombykol’s elucidation, we provide a perspective on the spectrum of studies that have made Butenandt’s “sexy” moth one of the principal models for sex pheromone biosynthesis.

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Acknowledgments

We are grateful to Dr. József Fodor for critical reading of the text and insightful comments. We also thank Dr. Shogo Matsumoto (retired; RIKEN Advanced Science Institute) for his support of the Japan Society for the Promotion of Science which played a pivotal role in our respective careers. In addition, we thank the many members of the former Molecular Entomology Laboratory at the RIKEN Advanced Science Institute and the numerous colleagues and peers who have contributed to advancing our understanding of the cellular processes that govern biosynthesis of the pheromone that first piqued Butenstadt’s interest 60 years ago. Mention of trade names or commercial products in this article is solely for the purpose of providing specific information and does not imply recommendation or endorsement by the United States Department of Agriculture (USDA). USDA is an equal opportunity provider and employer.

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  1. USDA-ARS, US Arid Land Agricultural Research Center, Maricopa, AZ, USA

    J. Joe Hull

  2. Plant Protection Institute, Centre for Agricultural Research of Hungarian Academy of Sciences, Budapest, Hungary

    Adrien Fónagy

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  1. J. Joe Hull
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  2. Adrien Fónagy
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Correspondence to J. Joe Hull .

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  1. Laboratory of Applied Entomology, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Tokyo, Japan, Laboratory of Applied Entomology, Faculty of Agriculture, Setsunan University, Osaka, Japan

    Yukio Ishikawa

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Hull, J.J., Fónagy, A. (2020). A Sexy Moth Model – The Molecular Basis of Sex Pheromone Biosynthesis in the Silkmoth Bombyx mori. In: Ishikawa, Y. (eds) Insect Sex Pheromone Research and Beyond. Entomology Monographs. Springer, Singapore. https://doi.org/10.1007/978-981-15-3082-1_6

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