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Brain Imaging of Ketamine Abusers

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Abstract

In this chapter, we highlight the role of brain imaging techniques (e.g., magnetic resonance imaging [MRI]) in studying ketamine abuse. In the past two to three decades, brain imaging studies demonstrated deficits in brain circuits related to drug addiction and drug abuse. This chapter begins with a brief introduction of structural and functional brain imaging techniques such as computed tomography (CT) and electroencephalogram (EEG). Then, we give a brief introduction of ketamine abuse in mainland China before introducing structural MRI and functional MRI and reviewing the application of structural MRI study for ketamine abusers (including reduction of gray matter volume and disruption of white matter integrity) and functional MRI study for ketamine abusers (including alternation of regional homogeneity (ReHo) of resting-state brain activity, functional connectivity by resting-state fMRI, task-based fMRI). Finally, we discuss the implication for medical use of ketamine by brain imaging study, especially its rapid-acting glutamatergic antidepressant effects and the “ketamine model” of psychosis.

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Authors and Affiliations

  1. Department of Psychiatry, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, China

    Yanhui Liao

  2. Key Laboratory of Medical Neurobiology of Zhejiang Province, Hangzhou, Zhejiang, China

    Yanhui Liao

  3. Department of Psychiatry, The Second Xiangya Hospital, Central South University, Changsha, Hunan, China

    Yanhui Liao & Wei Hao

  4. National Clinical Research Center on Mental Disorders, Changsha, Hunan, China

    Yanhui Liao & Wei Hao

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  1. Yanhui Liao
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  2. Wei Hao
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Editors and Affiliations

  1. Division of Clinical Neuroscience, Chiba University, Chiba, Japan

    Kenji Hashimoto

  2. Tokyo Metropolitan Institute of Medical, Tokyo, Japan

    Soichiro Ide

  3. Tokyo Metropolitan Institute of Medical, Tokyo, Japan

    Kazutaka Ikeda

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Liao, Y., Hao, W. (2020). Brain Imaging of Ketamine Abusers. In: Hashimoto, K., Ide, S., Ikeda, K. (eds) Ketamine. Springer, Singapore. https://doi.org/10.1007/978-981-15-2902-3_2

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