Abstract
Researchers have demonstrated that breath acetone is an effective biomarker of type 2 diabetes which a habitual form of diabetes. Conventional way for the detection of glucose levels is through invasive technique which involves pricking the finger and collecting blood samples. This is not only painful and blood consuming but also time-consuming and expensive. Therefore, there has been a great demand for the non-invasive techniques of blood glucose determinations in the commercial market. Researchers have been attempting to develop a number of non-invasive techniques where the diabetes is detected by different methods outside the body, without puncturing the skin or without taking the blood sample.
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References
World Health Organization, Diabetes action now: an initiative of the World Health Organization and the International Diabetes Federation (2004)
Diabetes Prevention Trial-Type 1 Diabetes Study Group, Effects of insulin in relatives of patients with type 1 diabetes mellitus. N. Engl. J. Med. 346(22), 1685–1691 (2002)
J. Tuomilehto, J. Lindström, J.G. Eriksson, T.T. Valle, H. Hämäläinen, P. Ilanne-Parikka, S. Keinänen-Kiukaanniemi, M. Laakso, A. Louheranta, M. Rastas, V. Salminen, Prevention of type 2 diabetes mellitus by changes in lifestyle among subjects with impaired glucose tolerance. N. Engl. J. Med. 344(18), 1343–1350 (2001)
P.J. Donovan, H.D. McIntyre, Drugs for gestational diabetes. Aust. Prescriber 33(5), (2010)
J. Lindström, P. Ilanne-Parikka, M. Peltonen, S. Aunola, J.G. Eriksson, K. Hemiö, H. Hämäläinen, P. Härkönen, S. Keinänen-Kiukaanniemi, M. Laakso, A. Louheranta, Sustained reduction in the incidence of type 2 diabetes by lifestyle intervention: follow-up of the Finnish Diabetes Prevention Study. The Lancet 368(9548), 1673–1679 (2006)
S. Bolen, L. Feldman, J. Vassy, L. Wilson, H.C. Yeh, S. Marinopoulos, C. Wiley, E. Selvin, R. Wilson, E.B. Bass, F.L. Brancati, Systematic review: comparative effectiveness and safety of oral medications for type 2 diabetes mellitus. Ann. Intern. Med. 147(6), 386–399 (2007)
J.C. Cash, C.A. Glass (eds.), Family practice guidelines (Springer Publishing Company, 2017)
A.H. Romano, T. Conway, Evolution of carbohydrate metabolic pathways. Res. Microbiol. 147(6–7), 448–455 (1996)
P.C. Champe, R.A. Harvey, D.R. Ferrier, Biochemistry (Lippincott Williams & Wilkins, 2005)
D.G. Johnston, A. Pernet, A. McCulloch, G. Blesa-Malpica, J.M. Burrin, K.G. Alberti, Some hormonal influences on glucose and ketone body metabolism in normal human subjects, in Ciba Foundation Symposium, vol. 87 (1982), pp. 168–191
L. Stryer, Biochemistry, 4th edn (1995)
G.F. Cahill Jr., R.L. Veech, Ketoacids? Good medicine? Trans. Am. Clin. Climatol. Assoc. 114, 149 (2003)
J.W. Pelley, Citric acid cycle, electron transport chain, and oxidative phosphorylation. Elsevier’s Integrated Review Biochemistry, 2nd edn (WB Saunders, Philadelphia, PA, 2012), pp. 57–65
T. Fukao, G. Mitchell, J.O. Sass, T. Hori, K. Orii, Y. Aoyama, Ketone body metabolism and its defects. J. Inherit. Metab. Dis. 37(4), 541–551 (2014)
C.R. Barnett, Y.A. Barnett, Ketone Bodies (2003)
S.M. Phinney, J. Volek, The Art And Science Of Low Carbohydrate Performance (Beyond Obesity LLC, 2011)
A.E. Kitabchi, G.E. Umpierrez, J.M. Miles, J.N. Fisher, Hyperglycemic crises in adult patients with diabetes. Diab. Care 32(7), 1335–1343 (2009)
K.C. Bilchick, R.A. Wise, Paradoxical physical findings described by Kussmaul: pulsus paradoxus and Kussmaul’s sign. Lancet 359(9321), 1940–1942 (2002)
A. Kußmaul, Zur lehre vom diabetes mellitus. Dtsch. Arch. Klin. Med. 14, 1–46 (1874)
N.H.S. Diabetes, Joint British Diabetes Societies Inpatient Care Group. The Management of Diabetic Ketoacidosis in Adults (2011). www.diabetologists-abcd.org.uk/JBDS_DKA_Management.pdf. Accessed 7 April 2014
S. Misra, N.S. Oliver, Diabetic ketoacidosis in adults. BMJ 351, h5660 (2015)
V. Ruzsányi, M.P. Kalapos, C. Schmidl, D. Karall, S. Scholl-Bürgi, M. Baumann, Breath profiles of children on ketogenic therapy. J. Breath Res. 12(3), 036021 (2018)
A. Kuksis, A. Ravandi, M. Schneider, Covalent binding of acetone to aminophospholipids in vitro and in vivo. Ann. N. Y. Acad. Sci. 1043(1), 417–439 (2005)
S.S. Likhodii, I. Serbanescu, M.A. Cortez, P. Murphy, O.C. Snead III, W.M. Burnham, Anticonvulsant properties of acetone, a brain ketone elevated by the ketogenic diet. Ann. Neurol. 54(2), 219–226 (2003)
R. Davies, Studies on the acetone-butanol fermentation: 4. Acetoacetic acid decarboxylase of Cl. acetobutylicum (BY). Biochem. J. 37(2), 230 (1943)
V. Saasa, T. Malwela, M. Beukes, M. Mokgotho, C.P. Liu, B. Mwakikunga, Sensing technologies for detection of acetone in human breath for diabetes diagnosis and monitoring. Diagnostics 8(1), 12 (2018)
W.H. Hofmann, Vi-Jon Laboratories Inc, Nail polish remover. U.S. Patent 4,824,662 (1989)
G. Mansour, D. El-rafey, Ethyl glucuronide, ethyl sulfate and acetone as biomarkers for alcohol based hand sanitizers chronic exposure in health care workers. Ain Shams J Forensic Med. Clin. Toxicol. 33(2), 80–91 (2019)
I.P. Dick, P.G. Blain, F.M. Williams, The percutaneous absorption and skin distribution of lindane in man: I. in vivo studies. Hum. Exp. Toxicol. 16(11), 645–651 (1997)
S.B. Azam, Comparative study on the antibacterial activities of four commercially available antiseptics-Dettol, Hexisol, Oralon and Betadine against Staphylococcus aureus, Klebsiella pneumoniae, Bacillus cereus, and Pseudomonas aeruginosa. Doctoral dissertation, BRAC Univeristy, 2017
G. Shi, G. Xue, C. Li, S. Jin, Layered poly (naphthalene) films prepared by electrochemical polymerization. Polym. Bull. 33(3), 325–329 (1994)
G. Neri, A. Bonavita, G. Micali, N. Donato, Design and development of a breath acetone MOS sensor for ketogenic diets control. IEEE Sens. J. 10(1), 131–136 (2009)
V. Ruzsányi, M. P. Kalapos, J. Breath Res. 11 024002 (2017)
ElProCus—Electronic Projects for Engineering Students. MQ135 Alcohol Sensor Circuit and Its Working (2019). Available at: https://www.elprocus.com/mq-135-alcohol-sensor-circuit-and-working/. Accessed 14 Sep 2019
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Renumadhavi, C.H. et al. (2020). Microcontroller-Based Detection of Diabetes and Ketosis State Using Breath Sensors. In: Jain, S., Paul, S. (eds) Recent Trends in Image and Signal Processing in Computer Vision. Advances in Intelligent Systems and Computing, vol 1124. Springer, Singapore. https://doi.org/10.1007/978-981-15-2740-1_1
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