Skip to main content

Abstracts

Nocturia is a used to define the condition in which the individual has to wake at night one or more times to void, which was frequently complained by more than 60% patients with PD. The pathophysiological mechanisms causing nocturia in patients with PD remains poorly understood. Decreased bladder capacity, nocturnal polyuria, circadian rhythm disturbances, some living habits, and comorbidities are thought to be contributing to nocturia in patients with PD. For the diagnosis of nocturia in PD, detailed medical history and urinary diary are needed. More importantly, ultrasonography and urodynamics also help. Nocturia in PD patients has detrimental impact on patients’ quality of life; therefore, multiple disciplinary managements are needed to ameliorate symptoms. These include pharmacological management, lifestyle change, and urology referral when necessary. Medication for treating nocturia in PD includes dopamine agonists, antimuscarinic agents, desmopressin, and melatonin. Moreover, intermittent catheterization, botulinum toxin injection, deep brain stimulation, and neuromodulation are also efficient for the management of nocturia in PD.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

eBook
USD 16.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 16.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 99.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Similar content being viewed by others

References

  1. Blackett H, Walker R, Wood B. Urinary dysfunction in Parkinson’s disease : a review. Parkinsonism Relat Disord. 2009;15(2):81–7.

    Article  Google Scholar 

  2. Madan A, Ray S, Burdick D, Agarwal P. Management of lower urinary tract symptoms in Parkinson’s disease in the neurology clinic. Int J Neurosci. 2017;127(12):1136–49.

    Article  Google Scholar 

  3. Van KP, Abrams P, Chaikin D, Donovan J, Fonda D, Jackson S, et al. The standardisation of terminology in nocturia : report from the Standardisation Sub-committee of the International Continence Society. BMJ Int. 2002;183(2):179–83.

    Google Scholar 

  4. Rana AQ, Vaid H, Akhter MR, Awan NY, Fattah A, Cader MH, et al. Prevalence of nocturia in Parkinson’s disease patients from various ethnicities. Neurol Res. 2014;36(3):234–8.

    Article  Google Scholar 

  5. Rana AQ, Paul DA, Qureshi AM, Ghazi A, Alenezi S, Rana MA, et al. Association between nocturia and anxiety in Parkinson’s disease. Neurol Res. 2015;37(7):563–7.

    Article  Google Scholar 

  6. Yeo L, Singh R, Gundeti M. Urinary tract dysfunction in Parkinson’s disease : a review. Int Urol Nephrol. 2012;44(2):415–24.

    Article  Google Scholar 

  7. Sakakibara R, Panicker J, Finazzi-agro E, Iacovelli V, Bruschini H. A guideline for the management of bladder dysfunction in Parkinson’s disease and other gait disorders. Neurourol Urodyn. 2016;35(5):551–63.

    Article  Google Scholar 

  8. Batla A, Phe V, De ML, Panicker JN. Nocturia in Parkinson’s disease : why does it occur and how to manage ? Mov Disord Clin Pract. 2016;3(5):443–51.

    Article  Google Scholar 

  9. Sakakibara R, Tateno F, Nagao T, Yamamoto T, Uchiyama T, Yamanishi T, et al. Bladder function of patients with Parkinson’s disease. Int J Urol. 2014;21(7):638–46.

    Article  CAS  Google Scholar 

  10. Easton A, Ph D, Meerlo P, Ph D, Bergmann B, Ph D, et al. The suprachiasmatic nucleus regulates sleep timing and amount in mice. Sleep. 2004;27(7):1307–18.

    Article  Google Scholar 

  11. Kudo T, Loh DH, Truong D, Wu Y, Colwell CS. Circadian dysfunction in a mouse model of Parkinson’s disease. Exp Neurol. 2011;232(1):66–75.

    Article  Google Scholar 

  12. Buser N, Ivic S, Kessler TM, Kessels AGH, Bachmann LM. Efficacy and adverse events of antimuscarinics for treating overactive bladder : network meta-analyses. Eur Urol. 2012;62(6):1040–60.

    Article  CAS  Google Scholar 

  13. Matsuta Y, Yusup A, Tanase K, Ishida H, Akino H. Melatonin increases bladder capacity via GABAergic system and decreases urine volume in rats. J Urol. 2010;184(1):386–91.

    Article  CAS  Google Scholar 

  14. Panicker JN, Fowler CJ, Kessler TM. Lower urinary tract dysfunction in the neurological patient : clinical assessment and management. Lancet Neurol. 2015;14(7):720–32.

    Article  Google Scholar 

  15. Kuno S, Mizuta E, Yamasaki S, Araki I. Effects of pergolide on nocturia in Parkinson’s disease: three female cases selected from over 400 patients. Parkinsonism Relat Disord. 2004;10(3):181–7.

    Article  Google Scholar 

  16. Rosa-grilo M, Qamar MA, Chaudhuri KR. Rotigotine transdermal patch and sleep in Parkinson’s disease : where are we now? NPJ Parkinson’s Dis. 2017;3:28.

    Google Scholar 

  17. Suchowersky O, Furtado S, Rohs G. Beneficial effect of intranasal desmopressin for nocturnal polyuria in Parkinson’s disease. Mov Disord. 1995;10(3):337–40.

    Article  CAS  Google Scholar 

  18. Marinkovic SP, Gillen LM, Stanton SL. Managing nocturia. BMJ. 2004;328(7447):1063–6.

    Article  Google Scholar 

  19. Giannantoni A, Rossi A, Mearini E, Del ZM, Porena M, Berardelli A. Botulinum toxin A for overactive bladder and detrusor muscle overactivity in patients with Parkinson’s disease and multiple system atrophy. J Urol. 2009;182(4):1453–7.

    Article  Google Scholar 

  20. Giannantoni A, Conte A, Proietti S, Giovannozzi S, Rossi A, Fabbrini G, et al. Botulinum toxin type A in patients with Parkinson’s disease and refractory overactive bladder. J Urol. 2011;186(3):960–4.

    Article  CAS  Google Scholar 

  21. Winge K, Nielsen KK. Bladder dysfunction in advanced Parkinson’s disease. Neurourol Urodyn. 2012;31(8):1279–83.

    Article  Google Scholar 

  22. Witte LP, Odekerken VJJ, Boel JA, Schuurman PR, Gerbrandy-Schreuders LC, de Bie RMA, et al. Does deep brain stimulation improve lower urinary tract symptoms in Parkinson’s disease? Neurourol Urodyn. 2018;37(1):354–9.

    Article  Google Scholar 

  23. Booth J, Lawrence M. The effectiveness of transcutaneous tibial nerve stimulation (TTNS) for adults with overactive bladder syndrome : a systematic review. Neurourol Urodyn. 2018;37(2):528–41.

    Article  Google Scholar 

  24. Carolina M, Carlos P, Levi A, Martins R, Anelyssa C, Lucio A. Transcutaneous tibial nerve stimulation in the treatment of lower urinary tract symptoms and its impact on health-related quality of life in patients with Parkinson disease: a randomized controlled trial. J Wound Ostomy Cont Nurs. 2015;42(1):94–9.

    Article  Google Scholar 

  25. Wallace PA, Lane FL, Noblett KL. Sacral nerve neuromodulation in patients with underlying neurologic disease. Am J Obstet Gynecol. 2007;197(1):96.e1–5.

    Google Scholar 

  26. Griffiths DJ, Mccracken PN, Harrison GM, Ann Gormley E. Relationship of fluid intake to voluntary micturition and urinary incontinence in geriatric patients. Neurourol Urodyn. 1993;12(1):1–7.

    Article  CAS  Google Scholar 

  27. Weiss JP, Blaivas JG. Nocturia. J Urol. 2000;163(1):5–12.

    Article  CAS  Google Scholar 

  28. Batla A, Tayim N, Pakzad M, Panicker JN. Treatment options for urogenital dysfunction in Parkinson’s disease. Curr Treat Options Neurol. 2016;18(10):45.

    Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2020 Springer Nature Singapore Pte Ltd.

About this chapter

Check for updates. Verify currency and authenticity via CrossMark

Cite this chapter

Gu, Xj., Cao, B., Shang, Hf. (2020). Nocturia. In: Liu, CF. (eds) Sleep Disorders in Parkinson’s Disease. Springer, Singapore. https://doi.org/10.1007/978-981-15-2481-3_5

Download citation

  • DOI: https://doi.org/10.1007/978-981-15-2481-3_5

  • Published:

  • Publisher Name: Springer, Singapore

  • Print ISBN: 978-981-15-2480-6

  • Online ISBN: 978-981-15-2481-3

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics