Abstract
Since time immemorial, essential oils (EOs) have been utilized for their therapeutic properties. However, during recent decades, a renewed interest has been experienced in EOs and their individual constituents due to their remarkable pharmacological potentials evidenced by various experimental studies. For instance, they are broadly acknowledged for their antimicrobial, antidiabetic, anti-inflammatory, antispasmodic and anticancer properties. Also, EOs have demonstrated to improve conditions associated with brain and cardiovascular diseases amongst others. Multiple studies have identified and isolated EOs phytocomponents possessing therapeutic activities. In addition, studies have elucidated their underlying mechanisms of actions involved in the treatment and management of several ailments. Thus, given the wide spectrum of biological activities exhibited by these active compounds, this chapter endeavours to provide a mechanistic overview of some common EOs constituents with regard to their pharmacological properties.
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References
Amato A, Liotta R, Mulè F (2014) Effects of menthol on circular smooth muscle of human colon: analysis of the mechanism of action. Eur J Pharmacol 740:295–301
Andrade LN (2015) Sesquiterpenes from essential oils and anti-inflammatory activity. Nat Prod Commun 10:1767–1774
Arab HA, Fathi M, Mortezai E, Hosseinimehr SJ (2015) Chemoprotective effect of thymol against genotoxicity induced by bleomycin in human lymphocytes. Pharm Biomed Res 1(1):26–31. https://doi.org/10.18869/acadpub.pbr.1.1.26
Arafa ESA, Zhu Q, Shah ZI, Wani G, Barakat BM, Racoma I, El-Mahdy MA, Wani AA (2011) Thymoquinone up-regulates PTEN expression and induces apoptosis in doxorubicin-resistant human breast cancer cells. Fund Mol Mech Mut 706:28–35
Azanchi T, Shafaroodi H, Asgarpanah J (2014) Anticonvulsant activity of Citrus aurantium blossom essential oil (neroli): involvement of the GABAergic system. Nat Prod Res 6:1615–1618
Babukumar S, Vinothkumar V, Sankaranarayanan C, Srinivasan S (2017) Geraniol, a natural monoterpene, ameliorates hyperglycemia by attenuating the key enzymes of carbohydrate metabolism in streptozotocin-induced diabetic rats. Pharm Biol 55:1442–1449
Bakkali F, Averbeck S, Averbeck D, Idaomar M (2008) Biological effects of essential oils—a review. Food Chem Toxicol 46:446–475
Baser KHC, Buchbauer G (2010) Handbook of essential oils: science, technology, and applications. CRC Press, Boca Raton, FL
Baser KHC, Buchbauer G (2015) Handbook of essential oils: science, technology, and applications. CRC Press, USA
Bassolé IHN, Juliani HR (2012) Essential oils in combination and their antimicrobial properties. Molecules 17:3989–4006. https://doi.org/10.3390/molecules17043989
Baud V, Karin M (2009) Is NF-κB a good target for cancer therapy? Hopes and pitfalls. Nat Rev Drug Discov 8:33
Bernstein N, Akram M, Daniyal M, Koltai H, Fridlender M, Gorelick J (2018) Antiinflammatory potential of medicinal plants: a source for therapeutic secondary metabolites. In: Sparks D (ed) Advances in agronomy, vol 150. Academic Press, USA, pp 131–183
Burt S (2004) Essential oils: their antibacterial properties and potential applications in foods—a review. Int J Food Microbiol 94:223–253
Carnesecchi S, Langley K, Exinger F, Gosse F, Raul F (2002) Geraniol, a component of plant essential oils, sensitizes human colonic cancer cells to 5-fluorouracil treatment. J Pharmacol Exp Ther 301:625–630
Carnesecchi S, Bras-Gonçalves R, Bradaia A, Zeisel M, Gossé F, Poupon MF, Raul F (2004) Geraniol, a component of plant essential oils, modulates DNA synthesis and potentiates 5-fluorouracil efficacy on human colon tumor xenografts. Cancer Lett 215:53–59
Carson CF, Hammer KA, Riley TV (2006) Melaleuca alternifolia (tea tree) oil: a review of antimicrobial and other medicinal properties. Clin Microbiol Rev 19:50–62
Chaillot J, Tebbji F, Remmal A, Boone C, Brown GW, Bellaoui M, Sellam A (2015) The monoterpene carvacrol generates endoplasmic reticulum stress in the pathogenic fungus Candida albicans. Antimicrob Agents Chemother 59:4584–4592
Chang HT, Hsu SS, Chou CT, Cheng JS, Wang JL, Lin KL, Fang YC, Chen WC, Chien JM, Lu T, Pan CC (2011). Effect of thymol on Ca2+ homeostasis and viability in MG63 human osteosarcoma cells. Pharmacology 88:201–212
Chauhan AK, Bahuguna A, Paul S, Kang SC (2017) Thymol elicits HCT-116 colorectal carcinoma cell death through induction of oxidative stress. Anticancer Agents Med Chem 17:1942–1950
Chen Y, Ba L, Huang W, Liu Y, Pan H, Mingyao E, Shi P, Wang Y, Li S, Qi H, Sun H (2017) Role of carvacrol in cardioprotection against myocardial ischemia/reperfusion injury in rats through activation of MAPK/ERK and Akt/eNOS signaling pathways. Eur J Pharmacol 796:90–100
Davidson PM (1997) Chemical preservatives and natural antimicrobial compounds. In: Doyle MP, Beuchat LR, Montville TJ (eds) Food microbiology: fundamental and Frontiers. ASM Publications, Washington, DC, pp 520–556
De Sousa DP, Junior GA, Andrade LN, Calasans FR, Nunes XP, Barbosa-Filho JM, Batista JS (2008) Structure and spasmolytic activity relationships of monoterpene analogues found in many aromatic plants. Zeitschrift für Naturforschung C 63:808–812
Deb DD, Parimala G, Devi SS, Chakraborty T (2011) Effect of thymol on peripheral blood mononuclear cell PBMC and acute promyelotic cancer cell line HL-60. Chemico-biological interactions 193:97–106
Denyer SP, Hugo WB (1991) Biocide-induced damage to the bacterial cytoplasmic membrane. In: Denyer SP, Hugo WB (eds) Mechanisms of action of chemical biocides, the Society for Applied Bacteriology, technical series no 27. Oxford Blackwell Scientific Publication, Oxford, pp 171–188
Devi KP, Nisha SA, Sakthivel R, Pandian SK (2010) Eugenol (an essential oil of clove) acts as an antibacterial agent against Salmonella typhi by disrupting the cellular membrane. J Ethnopharmacol 130:107–115
Dorman HJD, Deans SG (2000) Antimicrobial agents from plants: antibacterial activity of plant volatile oils. J Appl Microbiol 88:308–316
Edris AE (2007) Pharmaceutical and therapeutic potentials of essential oils and their individual volatile constituents: a review. Phytother Res 21:308–323
Edris AE, Farrag E (2003) Antifungal activity of peppermint and sweet basil essential oils and their major aroma constituents on some plant pathogenic fungi from the vapor phase. Food Nahrung 47:117–121
El-Bassossy HM, Ghaleb H, Elberry AA, Balamash KS, Ghareib SA, Azhar A, Banjar Z (2017) Geraniol alleviates diabetic cardiac complications: effect on cardiac ischemia and oxidative stress. Biomed Pharmacother 88:1025–1030
El-Sayed ESM, Mansour AM, Abdul-Hameed MS (2016) Thymol and carvacrol prevent doxorubicin-induced cardiotoxicity by abrogation of oxidative stress, inflammation, and apoptosis in rats. J Biochem Mol Toxicol 30:37–44
Elshafie HS, Mancini E, Sakr S, De Martino L, Mattia CA, De Feo V, Camele I (2015) Antifungal activity of some constituents of Origanum vulgare L. essential oil against postharvest disease of peach fruit. J Med Food 18:929–934
Ezhumalai M, Radhiga T, Pugalendi KV (2014) Antihyperglycemic effect of carvacrol in combination with rosiglitazone in high-fat diet-induced type 2 diabetic C57BL/6J mice. Mol Cell Biochem 385:23–31
Fernandes ES, Passos GF, Medeiros R, da Cunha FM, Ferreira J, Campos MM, Pianowski LF, Calixto JB (2007) Anti-inflammatory effects of compounds alpha-humulene and (−)-trans-caryophyllene isolated from the essential oil of Cordia verbenacea. Eur J Pharmacol 569:228–236
File SE, Pellow S (1986) Intrinsic actions of the benzodiazepine receptor antagonist Ro 15-1788. Psychopharmacology 88:1–11
Freires IA, Denny C, Benso B, De Alencar SM, Rosalen PL (2015) Antibacterial activity of essential oils and their isolated constituents against cariogenic bacteria: a systematic review. Molecules 20:7329–7358
García DA, Bujons J, Vale C, Suñol C (2006) Allosteric positive interaction of thymol with the GABAA receptor in primary cultures of mouse cortical neurons. Neuropharmacology 50:25–35
Gibson SB, Oyer R, Spalding AC, Anderson SM, Johnson GL (2000) Increased expression of death receptors 4 and 5 synergizes the apoptosis response to combined treatment with etoposide and TRAIL. Mol Cell Biol 20:205–212
Gill AO, Holley RA (2006) Disruption of Escherichia coli, Listeria monocytogenes and Lactobacillus sakei cellular membranes by plant oil aromatics. Int J Food Microbiol 108:1–9
Goossens A, Merckx L (1997) Allergic contact dermatitis from farnesol in a deodorant. Contact Dermatitis 37:179–180
Guimarães AC, Meireles LM, Lemos MF, Guimarães MCC, Endringer DC, Fronza M, Scherer R (2019) Antibacterial activity of terpenes and Terpenoids present in essential oils. Molecules 24:2471
Haberland M, Montgomery RL, Olson EN (2009) The many roles of histone deacetylases in development and physiology: implications for disease and therapy. Nat Rev Gen 10:32
Haeseler G, Maue D, Grosskreutz J, Bufler J, Nentwig B, Piepenbrock S, Dengler R, Leuwer M (2002) Voltage-dependent block of neuronal and skeletal muscle sodium channels by thymol and menthol. Eur J Anaesthesiol 19:571–579
Hirota R, Roger NN, Nakamura H, Song HS, Sawamura M, Suganuma N (2010) Anti-inflammatory effects of limonene from yuzu (Citrus junos Tanaka) essential oil on eosinophils. J Food Sci 75:H87–H92
Hoffmeyer K, Raggioli A, Rudloff S, Anton R, Hierholzer A, Del Valle I, Hein K, Vogt R, Kemler R (2012) Wnt/β-catenin signaling regulates telomerase in stem cells and cancer cells. Science 336:1549–1554. https://doi.org/10.1126/science.1218370
Hsu SS, Lin KL, Chou CT, Chiang AJ, Liang WZ, Chang HT (2011) Effect of thymol on Ca2+ homeostasis and viability in human glioblastoma cells. Eur J Pharmacol 670:85–91. https://doi.org/10.1016/j.ejphar.2011.08.017
Jaafari A, Tilaoui M, Mouse HA, M’bark LA, Aboufatima R, Chait A, Lepoivre M, Zyad A (2012) Comparative study of the antitumor effect of natural monoterpenes: relationship to cell cycle analysis. Rev Bras 22:534–540. https://doi.org/10.1590/s0102-695x2012005000021
Jeong JB, Choi J, Lou Z, Jiang X, Lee SH (2013) Patchouli alcohol, an essential oil of Pogostemon cablin, exhibits anti-tumorigenic activity in human colorectal cancer cells. Int Immunopharmacol 16:184–190
Joo JH, Liao G, Collins JB, Grissom SF, Jetten AM (2007) Farnesol-induced apoptosis in human lung carcinoma cells is coupled to the endoplasmic reticulum stress response. Cancer Res 67:7929–7936
Kalemba D, Kunicka A (2003) Antibacterial and antifungal properties of essential oils. Curr Med Chem 10:813–829
Kang SH, Kim YS, Kim EK, Hwang JW, Jeong JH, Dong X, Lee JW, Moon SH, Jeon BT, Park PJ (2016) Anticancer effect of thymol on AGS human gastric carcinoma cells. J Microbiol Biotechnol 26:28–37
Kannappan A, Balasubramaniam B, Ranjitha R, Srinivasan R, Packiavathy IASV, Balamurugan K, Pandian SK, Ravi AV (2019) In vitro and in vivo biofilm inhibitory efficacy of geraniol-cefotaxime combination against Staphylococcus spp. Food Chem Toxicol 125:322–332
Kim JR, Kang P, Lee HS, Kim KY, Seol GH (2017) Cardiovascular effects of linalyl acetate in acute nicotine exposure. Env Health Prevent Med 22:42
Knobloch K, Weigand H, Weis N, Schwarm HM, Vigenschow H (eds) (1986) Action of terpenoids on energy metabolism. Walter de Gruyter, Berlin, Germany
Koto R, Imamura M, Watanabe C, Obayashi S, Shiraishi M, Sasaki Y, Azuma H (2006) Linalyl acetate as a major ingredient of lavender essential oil relaxes the rabbit vascular smooth muscle through dephosphorylation of myosin light chain. J Cardiovasc Pharmacol 48:850–856
Kovač J, Šimunović K, Wu Z, Klančnik A, Bucar F, Zhang Q, Možina SS (2015) Antibiotic resistance modulation and modes of action of (−)-α-pinene in campylobacter jejuni. PLoS One 10:e0122871
Krupčík J, Gorovenko R, Špánik I, Sandra P, Armstrong DW (2015) Enantioselective comprehensive two-dimensional gas chromatography. A route to elucidate the authenticity and origin of Rosa damascena Miller essential oils. J Sep Sci 38:3397–3403
Lahlou S, Figueiredo AF, Magalhães PJC, Leal-Cardoso JH (2002) Cardiovascular effects of 1, 8-cineole, a terpenoid oxide present in many plant essential oils, in normotensive rats. Can J Physiol Pharmacol 80:1125–1131
Lambert RJW, Skandamis PN, Coote PJ, Nychas GJ (2001) A study of the minimum inhibitory concentration and mode of action of oregano essential oil, thymol and carvacrol. J Appl Microbiol 91:453–462
Leal-Cardoso JH, Lahlou S, Coelho-de-Souza AN, Criddle DN, Pinto Duarte GI, Santo MA, Magalhães PJ (2002) Inhibitory actions of eugenol on rat isolated ileum. Can J Physiol Pharmacol 80:901–906
Lee JH, Kim C, Kim SH, Sethi G, Ahn KS (2015) Farnesol inhibits tumor growth and enhances the anticancer effects of bortezomib in multiple myeloma xenograft mouse model through the modulation of STAT3 signaling pathway. Cancer Lett 360:280–293
Legault J, Pichette A (2007) Potentiating effect of β-caryophyllene on anticancer activity of α-humulene, isocaryophyllene and paclitaxel. J Pharm Pharmacol 59:1643–1647
Liang D, Yang M, Guo B, Yang L, Cao J, Zhang X (2012) HIF-1α induced by β-elemene protects human osteosarcoma cells from undergoing apoptosis. J Cancer Res Clin Oncol 138:1865–1877
Liang D, Li F, Fu Y, Cao Y, Song X, Wang T, Wang W, Guo M, Zhou E, Li D, Yang Z (2014) Thymol inhibits LPS-stimulated inflammatory response via down-regulation of NF-κB and MAPK signaling pathways in mouse mammary epithelial cells. Inflammation 37:214–222
Lima CC, Criddle DN, Coelho-de-Souza AN, Monte FJ, Jaffar M, Leal-Cardoso JH (2000) Relaxant and antispasmodic actions of methyleugenol on Guinea-pig isolated ileum. Planta Med 66:408–411
Lüthy R, Münch R, Blaser J, Bhend H, Siegenthaler W (1979) Human pharmacology of cefotaxime (HR 756), a new cephalosporin. Antimicrob Agents Chemother 16:127–133
Maeda K, Ito T, Shioda S (2012) Medical aromatherapy practice in Japan. Essence 10:14–16
Magalhães Pedro JC, Criddle DN, Tavares RA, Melo EM, Mota TL, Leal-Cardoso JH (1998) Intestinal myorelaxant and antispasmodic effects of the essential oil of Croton nepetaefolius and its constituents cineole, methyl-eugenol and terpineol. Phytother Res 12:172–177
Magalhães PJ, Lahlou S, Leal-Cardoso JH (2004) Antispasmodic effects of the essential oil of Croton nepetaefolius on Guinea-pig ileum: a myogenic activity. Fund Clin Pharmacol 18(5):539–546
Marcu BK, Otero M, Olivotto E, Maria Borzi R, Goldring BM (2010) NF-κB signaling: multiple angles to target OA. Curr Drug Targ 11:599–613
Mauro M, Catanzaro I, Naselli F, Sciandrello G, Caradonna F (2013) Abnormal mitotic spindle assembly and cytokinesis induced by D-limonene in cultured mammalian cells. Mutagenesis 28:631–635
Maurya AK, Singh M, Dubey V, Srivastava S, Luqman S, Bawankule DU (2014) α-(−)-bisabolol reduces pro-inflammatory cytokine production and ameliorates skin inflammation. Curr Pharm Biotechnol 15:173–181
Mendes SS, Bomfim RR, Jesus HCR, Alves PB, Blank AF, Estevam CS, Antoniolli AR, Thomazzi SM (2010) Evaluation of the analgesic and anti-inflammatory effects of the essential oil of Lippia gracilis leaves. J Ethnopharmacol 129:391–397. https://doi.org/10.1016/j.jep.2010.04.005
Menezes IA, Barreto CM, Antoniolli ÂR, Santos MR, de Sousa DP (2010) Hypotensive activity of terpenes found in essential oils. Zeitschrift für Naturforschung C 65:562–566
Miguel MG (2010) Antioxidant and anti-inflammatory activities of essential oils: a short review. Molecules 15:9252–9287
Mohammadreza VR (2008) Variation in the essential oil composition of Artemisia annua L. of different growth stages cultivated in Iran. Bot Res J 1:33–35
Moon HK, Kang P, Lee HS, Min SS, Seol GH (2014) Effects of 1, 8-cineole on hypertension induced by chronic exposure to nicotine in rats. J Pharm Pharmacol 66:688–693
Muruganathan U, Srinivasan S (2016) Beneficial effect of carvone, a dietary monoterpene ameliorates hyperglycemia by regulating the key enzymes activities of carbohydrate metabolism in streptozotocin-induced diabetic rats. Biomed Pharmacother 84:1558–1567
Nóbrega FF, Salvadori MG, Masson CJ, Mello CF, Nascimento TS, Leal-Cardoso JH, De Sousa DP, Almeida RN (2014) Monoterpenoid terpinen-4-ol exhibits anticonvulsant activity in behavioural and electrophysiological studies. Oxid Medicine Cell Longev 2014:703848. https://doi.org/10.1155/2014/703848
Oguntibeju OO (2018) Medicinal plants with anti-inflammatory activities from selected countries and regions of Africa. J Inflamma Res 11:307
Okoh SO, Iweriebor BC, Okoh OO, Okoh AI (2017) Bioactive constituents, radical scavenging, and antibacterial properties of the leaves and stem essential oils from Peperomia pellucida (L.) Kunth. Pharmacog Mag 13(Suppl 3):S392
Park JS, Kwon JK, Kim HR, Kim HJ, Kim BS, Jung JY (2014) Farnesol induces apoptosis of DU145 prostate cancer cells through the PI3K/Akt and MAPK pathways. Int J Mol Med 33:1169–1176
Parki A, Chaubey P, Prakash O, Kumar R, Pant AK (2017) Seasonal variation in essential oil compositions and antioxidant properties of Acorus calamus L. accessions. Medicines 4:81
Pauli A (2001) Antimicrobial properties of essential oil constituents. Int J Aromather 11:126–133
Pauli A, Schilche H (2009) In vitro antimicrobial activities of essential oils monographed in the European pharmacopoeia. In: Hüsnü K, Baser C, Buchbauer G (eds) Handbook of essential oils: science, technology, and applications. CRC Press, USA, pp 353–547
Peixoto-Neves D, Silva-Alves KS, Gomes MDM, Lima FC, Lahlou S, Magalhães PJC, Ceccatto VM, Coelho-de-Souza AN, Leal-Cardoso JH (2010) Vasorelaxant effects of the monoterpenic phenol isomers, carvacrol and thymol, on rat isolated aorta. Fund Clin Pharmacol 24:341–350
Pérez GS, Zavala SM, Arias GL, Ramos LM (2011) Anti-inflammatory activity of some essential oils. J Essent Oil Res 23:38–44
Pfister C, Pfrommer H, Tatagiba MS, Roser F (2013) Detection and quantification of farnesol-induced apoptosis in difficult primary cell cultures by TaqMan protein assay. Apoptosis 18:452–466
Polakis P (2000) Wnt signaling and cancer. Genes Dev 14:1837–1851
Quintans-Júnior LJ, Guimarães AG, Araújo BE, Oliveira GF, Santana MT, Moreira FV, Santos MR, Cavalcanti SC, Júnior WL, Botelho MA, Ribeiro LA (2010) Carvacrol, (−)-borneol and citral reduce convulsant activity in rodents. Afr J Biotechnol 9:6566–6572
Rabi T, Bishayee A (2009) D-limonene sensitizes docetaxel-induced cytotoxicity in human prostate cancer cells: generation of reactive oxygen species and induction of apoptosis. Mol Carcinog 8. https://doi.org/10.4103/1477-3163.51368
Rathinam A, Pari L, Chandramohan R, Sheikh BA (2014) Histopathological findings of the pancreas, liver, and carbohydrate metabolizing enzymes in STZ-induced diabetic rats improved by administration of myrtenal. J Physiol Biochem 70:935–946
Ravizza R, Gariboldi MB, Molteni R, Monti E (2008) Linalool, a plant-derived monoterpene alcohol, reverses doxorubicin resistance in human breast adenocarcinoma cells. Oncol Rep 20:625–630
Riella KR, Marinho RR, Santos JS, Pereira-Filho RN, Cardoso JC, Albuquerque-Junior RLC, Thomazzi SM (2012) Anti-inflammatory and cicatrizing activities of thymol, a monoterpene of the essential oil from Lippia gracilis, in rodents. J Ethnopharmacol 143:656–663
Sancheti J, Shaikh MF, Chaudhari R, Somani G, Patil S, Jain P, Sathaye S (2014) Characterization of anticonvulsant and antiepileptogenic potential of thymol in various experimental models. Naunyn Schmiedeberg’s Arch Pharmacol 387:59–66
Shiina Y, Funabashi N, Lee K, Toyoda T, Sekine T, Honjo S, Hasegawa R, Kawata T, Wakatsuki Y, Hayashi S, Murakami S (2008) Relaxation effects of lavender aromatherapy improve coronary flow velocity reserve in healthy men evaluated by transthoracic Doppler echocardiography. Int J Cardiol 129:193–197
Sikkema J, de Bont JAM, Poolman B (1994) Interactions of cyclic hydrocarbons with biological membranes. J Biol Chem 269:8022–8028
Silva MIG, Silva MAG, De Aquino Neto MR, Moura BA, De Sousa HL, De Lavor EPH, De Vasconcelos PF, Macêdo DS, De Sousa DP, Vasconcelos SMM, De Sousa FCF (2009) Effects of isopulegol on pentylenetetrazol-induced convulsions in mice: possible involvement of GABAergic system and antioxidant activity. Fitoterapia 80:506–513
Singulani JL, Pedroso RS, Ribeiro AB, Nicolella HD, Freitas KS, Damasceno JL, Vieira TM, Crotti AE, Tavares DC, Martins CH, Mendes-Giannini MJ (2018) Geraniol and linalool anticandidal activity, genotoxic potential and embryotoxic effect on zebrafish. Fut Microbiol 13(15):1637–1646
Sitarek P, Rijo P, Garcia C, Skała E, Kalemba D, Białas AJ, Szemraj J, Pytel D, Toma M, Wysokińska H and Śliwiński T (2017). Antibacterial, anti-inflammatory, antioxidant, and antiproliferative properties of essential oils from hairy and normal roots of Leonurus sibiricus L. and their chemical composition. Oxid Med Cell Longev 2017
Smith DR, Goh HS (1996) Overexpression of the c-myc proto-oncogene in colorectal carcinoma is associated with a reduced mortality that is abrogated by point mutation of the p53 tumor suppressor gene. Clin Cancer Res 2:1049–1053
Souza CM, Pereira Junior SA, Moraes TD, Damasceno JL, Amorim Mendes S, Dias HJ, Stefani R, Tavares DC, Martins CH, Crotti AE, Mendes-Giannini MJ (2016) Antifungal activity of plant-derived essential oils on Candida tropicalis planktonic and biofilms cells. Sabouraudia 54(5):515–523
Speranza B, Corbo MR (2010) Essential oils for preserving perishable foods: possibilities and limitations. Application of alternative food-preservation technologies to enhance food safety and stability 23, pp. 35–37
Srinivasan S, Muruganathan U (2016) Antidiabetic efficacy of citronellol, a citrus monoterpene by ameliorating the hepatic key enzymes of carbohydrate metabolism in streptozotocin-induced diabetic rats. Chem Biol Interact 250:38–46
Srinivasan S, Sathish G, Jayanthi M, Muthukumaran J, Muruganathan U, Ramachandran V (2014) Ameliorating effect of eugenol on hyperglycemia by attenuating the key enzymes of glucose metabolism in streptozotocin-induced diabetic rats. Mol Cell Biochem 385:159–168
Swamy MK, Akhtar MS, Sinniah UR (2016) Antimicrobial properties of plant essential oils against human pathogens and their mode of action: an updated review. Evid Based Complement Alternat Med 2016:21. https://doi.org/10.1155/2016/3012462
Tahir HU, Sarfraz RA, Ashraf A, Adil S (2016) Chemical composition and antidiabetic activity of essential oils obtained from two spices (Syzygium aromaticum and Cuminum cyminum). Int J Food Prop 19:2156–2164
Tisserand R, Young R (eds) (2013) Essential oil safety: a guide for health care professionals. Elsevier Health Sciences, United Kingdom
Vieira A, Heidor R, Cardozo MT, Scolastici C, Purgatto E, Shiga TM, Barbisan LF, Ong TP, Moreno FS (2011) Efficacy of geraniol but not of β-ionone or their combination for the chemoprevention of rat colon carcinogenesis. Braz J Med Biol 44:538–545
Wang YL, Liu HF, Shi XJ, Wang Y (2018a) Antiproliferative activity of Farnesol in HeLa cervical cancer cells is mediated via apoptosis induction, loss of mitochondrial membrane potential (ΛΨm) and PI3K/Akt signalling pathway. J BUON 23:752–757
Wang L, Zhao Y, Wu Q, Guan Y, Wu X (2018b) Therapeutic effects of β-elemene via attenuation of the Wnt/β-catenin signaling pathway in cervical cancer cells. Mol Med Rep 17:4299–4306
Xia Z, Mao X, Luo Y (1999) Study on antifungal mechanism of alpha-pinene. Hunan yi ke da xue xue bao= Hunan yike daxue xuebao= Bullet Hum Med Univ 24:507–509
Xia T, Gao R, Zhou G, Liu J, Li J, Shen J (2019) Trans-Cinnamaldehyde inhibits IL-1β-stimulated inflammation in chondrocytes by suppressing NF-κB and p38-JNK pathways and exerts chondrocyte protective effects in a rat model of osteoarthritis. Biomed Res Int 2019, 1
Ya’ni AA, Eldahshan OA, Hassan SA, Elwan ZA, Ibrahim HM (2018) Antidiabetic effects of essential oils of some selected medicinal Lamiaceae plants from Yemen against α-glucosidase enzyme. J Phytochem Biochem 2:2
Yadav DK, Mudgal V, Agrawal J, Maurya AK, Bawankule DU, Chanotiya CS, Khan F, Thul ST (2013) Molecular docking and ADME studies of natural compounds of agarwood oil for topical anti-inflammatory activity. Curr Comput-Aid Drug 9:360–370
Yang H, Woo J, Pae AN, Um MY, Cho NC, Park KD, Yoon M, Kim J, Lee CJ, Cho S (2016) α-Pinene, a major constituent of pine tree oils, enhances non-rapid eye movement sleep in mice through GABAA-benzodiazepine receptors. Mol Pharmacol 90:530–539
Yeo SK, Ali AY, Hayward OA, Turnham D, Jackson T, Bowen ID, Clarkson R (2016) β-Bisabolene, a Sesquiterpene from the essential oil extract of Opoponax (Commiphora guidottii), exhibits cytotoxicity in breast Cancer cell lines. Phytother Res 30:418–425
Yuan W, Yuk HG (2019) Effect of sublethal thymol, carvacrol and trans-cinnamaldehyde adaptation on virulence properties of Escherichia coli O157: H7. Appl Environ Microbiol AEM-00271. https://doi.org/10.1128/AEM.00271-19
Zhu T, Zhao Y, Zhang J, Li L, Zou L, Yao Y, Xu Y (2011) β-Elemene inhibits proliferation of human glioblastoma cells and causes cell-cycle G0/G1 arrest via mutually compensatory activation of MKK3 and MKK6. Int J Oncol 38:419–426
Zuzarte M, Salgueiro L (eds) (2015) Essential oils chemistry. Springer, Switzerland
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Jugreet, B.S., Mahomoodally, M.F. (2020). Pharmacological Properties of Essential Oil Constituents and their Mechanisms of Action. In: Swamy, M. (eds) Plant-derived Bioactives. Springer, Singapore. https://doi.org/10.1007/978-981-15-2361-8_18
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