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Exercise and Dementia

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Physical Exercise for Human Health

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 1228))

Abstract

Several experimental and human studies documented the preventive and therapeutic effects of exercise on various diseases as well as the normal physiological function of different systems during aging. The findings of several basic animal studies and clinical investigations identified the advantageous effects of exercise as non-pharmaceutical intervention on dementia and Alzheimer’s disease (AD). The main positive effects suggested for exercise are less cognitive and behavioral impairment or decline, development of health-associated conditions (stress, sleep), reduction of dementia risk factors including chronic non-communicable disease (diabetes, cardiovascular disease), increase in neurotrophins, enhancement of brain blood flow, angiogenesis, neurogenesis, synaptogenesis and synaptic plasticity in the brain memory-related region (e.g., hippocampus), and reduction of neuroinflammation and apoptosis. However, regarding the controversial evidence in literature, designing standard clinical and experimental studies to reveal the correlation between physical activity and dementia sign and symptom including biomarker alternation, brain supramolecular and molecular changes, and neuropsychological manifestation is necessary for preparation of effective guidelines and recommendations.

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Acknowledgments

Competing financial interests: The authors declare no competing financial interests.

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Authors and Affiliations

  1. Neurogenic Inflammation Research Center, Mashhad University of Medical Sciences, Mashhad, Iran

    Zahra Gholamnezhad, Mohammad Hossien Boskabady & Zahra Jahangiri

  2. Department of Physiology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran

    Zahra Gholamnezhad, Mohammad Hossien Boskabady & Zahra Jahangiri

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  1. Zahra Gholamnezhad
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  2. Mohammad Hossien Boskabady
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  3. Zahra Jahangiri
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Correspondence to Zahra Gholamnezhad .

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  1. Cardiac Regeneration and Ageing Lab Institute of Cardiovascular Sciences School of Life Science, Shanghai University, Shanghai, China

    Junjie Xiao

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Gholamnezhad, Z., Boskabady, M.H., Jahangiri, Z. (2020). Exercise and Dementia. In: Xiao, J. (eds) Physical Exercise for Human Health. Advances in Experimental Medicine and Biology, vol 1228. Springer, Singapore. https://doi.org/10.1007/978-981-15-1792-1_20

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