Abstract
Infectious diseases has remained one of the leading causes of morbidity and mortality in the past decade. The problem has further exacerbated due to the lack of newer antibiotics and emergence of antimicrobial drug resistance among the pathogens. Bacteria have evolved diverse mechanisms which make them resistant to many antimicrobials simultaneously. These alarming situations have triggered worldwide initiatives in the direction of developing novel strategies, effective antimicrobial agents, and efficient targeting systems. One of the fields which holds promise to provide solutions as efficient antibacterial agents is nanotechnology. The field of nanotechnology is rapidly evolving with more applications being developed in the pharmaceutical and biomedical domains. Nanoparticles such as metallic and metal-oxide, have gained tremendous attention owing to intrinsic antibacterial properties. These properties have been further enhanced by their surface functionalization approaches. They are being explored as delivery agents to inhibit bacterial population and also to combat drug resistance mechanisms in pathogens. The present chapter summarizes recent scientific advances on metal, metal oxide nanoparticles, and nanocomposites-preparation methods along with their antibacterial potential evaluated in prokaryotic bacterial model systems.
Keywords
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Al-Dhabi NA, Ghilan AKM, Arasu MV, Duraipandiyan V (2018) Green biosynthesis of silver nanoparticles produced from marine Streptomyces sp. Al-Dhabi-89 and their potential applications against wound infection and drug resistant clinical pathogens. J Photochem Photobiol B Biol 189:176–184. https://doi.org/10.1016/j.jphotobiol.2018.09.012
Al-Hazmi F, Alnowaiser F, Al-Ghamdi AA, Al-Ghamdi AA, Aly MM, Al-Tuwirqi RM, El-Tantawy F (2012) A new large-scale synthesis of magnesium oxide nanowires: structural and antibacterial properties. Superlattice Microstruct 52:200–209. https://doi.org/10.1016/j.spmi.2012.04.013
Alavi M, Karimi N (2018) Antiplanktonic, antibiofilm, antiswarming motility and antiquorum sensing activities of green synthesized Ag–TiO2, TiO2–Ag, Ag–Cu and Cu–Ag nanocomposites against multi-drug-resistant bacteria. Artif Cells Nanomed Biotechnol 46:S399–S413. https://doi.org/10.1080/21691401.2018.1496923
Ali K, Dwivedi S, Azam A, Saquib Q, Al-Said MS, Alkhedhairy AA, Musarrat J (2016) Aloe vera extract functionalized zinc oxide nanoparticles as nanoantibiotics against multi-drug resistant clinical bacterial isolates. J Colloid Interface Sci 472:145–156. https://doi.org/10.1016/j.jcis.2016.03.021
Arakha M, Pal S, Samantarrai D, Panigrahi TK, Mallick BC, Pramanik K, Mallick B, Jha S (2015) Antimicrobial activity of iron oxide nanoparticle upon modulation of nanoparticle-bacteria interface. Sci Rep 5:1–12. https://doi.org/10.1038/srep14813
Azam A, Ahmed AS, Oves M, Khan MS, Memic A (2012) Size-dependent antimicrobial properties of CuO nanoparticles against gram-positive and -negative bacterial strains. Int J Nanomedicine 7:3527–3535. https://doi.org/10.2147/IJN.S29020
Bankier C, Cheong Y, Mahalingam S, Edirisinghe M, Ren G, Cloutman-Green E, Ciric L (2018) A comparison of methods to assess the antimicrobial activity of nanoparticle combinations on bacterial cells. PLoS One 13:1–13. https://doi.org/10.1371/journal.pone.0192093
Baptista PV, McCusker MP, Carvalho A, Ferreira DA, Mohan NM, Martins M, Fernandes AR (2018) Nano-strategies to fight multidrug resistant bacteria-“a Battle of the titans”. Front Microbiol 9:1–26. https://doi.org/10.3389/fmicb.2018.01441
Baranwal A, Srivastava A, Kumar P, Bajpai VK, Maurya PK, Chandra P (2018) Prospects of nanostructure materials and their composites as antimicrobial agents. Front Microbiol 9:422. https://doi.org/10.3389/fmicb.2018.00422
Bharathan S, Sundaramoorthy NS, Chandrasekaran H, Rangappa G, ArunKumar G, Subramaniyan SB, Veerappan A, Nagarajan S (2019) Sub lethal levels of platinum nanoparticle cures plasmid and in combination with carbapenem, curtails carbapenem resistant Escherichia coli. Sci Rep 9:1–13. https://doi.org/10.1038/s41598-019-41489-3
Bhardwaj N, Pandey SK, Mehta J, Bhardwaj SK, Kim KH, Deep A (2018) Bioactive nano-metal-organic frameworks as antimicrobials against gram-positive and gram-negative bacteria. Toxicol Res (Camb) 7:931–941. https://doi.org/10.1039/c8tx00087e
Bogdanović U, Lazić V, Vodnik V, Budimir M, Marković Z, Dimitrijević S (2014) Copper nanoparticles with high antimicrobial activity. Mater Lett 128:75–78. https://doi.org/10.1016/j.matlet.2014.04.106
Bui VKH, Park D, Lee YC (2017) Chitosan combined with ZnO, TiO2 and Ag nanoparticles for antimicrobialwound healing applications: a mini review of the research trends. Polymers (Basel) 9:21. https://doi.org/10.3390/polym9010021
Chang TY, Chen CC, Cheng KM, Chin CY, Chen YH, Chen XA, Sun JR, Young JJ, Chiueh TS (2017) Trimethyl chitosan-capped silver nanoparticles with positive surface charge: their catalytic activity and antibacterial spectrum including multidrug-resistant strains of Acinetobacter baumannii. Colloids Surf B Biointerfaces 155:61–70
Chatterjee AK, Chakraborty R, Basu T (2014) Mechanism of antibacterial activity of copper nanoparticles. Nanotechnology 25:135101. https://doi.org/10.1088/0957-4484/25/13/135101
Chen Q, Shah KN, Zhang F, Salazar AJ, Shah PN, Li R, Sacchettini JC, Wooley KL, Cannon CL (2019) Minocycline and silver dual-loaded polyphosphoester-based nanoparticles for treatment of resistant Pseudomonas aeruginosa. Mol Pharm 16:1606–1619. https://doi.org/10.1021/acs.molpharmaceut.8b01288
Cioffi N, Rai M (2012) Nano-antimicrobials: progress and prospects. Springer, Berlin
Duffy LL, Osmond-McLeod MJ, Judy J, King T (2018) Investigation into the antibacterial activity of silver, zinc oxide and copper oxide nanoparticles against poultry-relevant isolates of Salmonella and Campylobacter. Food Control 92:293–300. https://doi.org/10.1016/j.foodcont.2018.05.008
Foster HA, Ditta IB, Varghese S, Steele A (2011) Photocatalytic disinfection using titanium dioxide: spectrum and mechanism of antimicrobial activity. Appl Microbiol Biotechnol 90:1847–1868. https://doi.org/10.1007/s00253-011-3213-7
Girase B, Depan D, Shah JS, Xu W, Misra RDK (2011) Silver-clay nanohybrid structure for effective and diffusion-controlled antimicrobial activity. Mater Sci Eng C 31:1759–1766. https://doi.org/10.1016/j.msec.2011.08.007
Gu H, Ho PL, Tong E, Wang L, Xu B (2003) Presenting vancomycin on nanoparticles to enhance antimicrobial activities. Nano Lett 3:1261–1263. https://doi.org/10.1021/nl034396z
Hamilton WL, Wenlock R (2016) Antimicrobial resistance: a major threat to public health. Cambridge Med J. https://doi.org/10.7244/cmj.2016.01.001
Hasani A, Madhi M, Gholizadeh P, Mojarrad JS, Rezaee MA, Zarrini G, Kafil HS (2019) Metal nanoparticles and consequences on multi-drug resistant bacteria: reviving their role. SN Appl Sci 1:1–13. https://doi.org/10.1007/s42452-019-0344-4
Hazan R, Beyth N, Khan W, Khan W, Hazan R (2015) Alternative antimicrobial approach: nano-antimicrobial materials. Evid Based Complement Alternat Med 2015:1–16. https://doi.org/10.1155/2015/246012
He Y, Ingudam S, Reed S, Gehring A, Strobaugh TP Jr, Irwin P (2016) Study on the mechanism of antibacterial action of magnesium oxide nanoparticles against foodborne pathogens. J Nanobiotechnol 14:1–9. https://doi.org/10.1186/s12951-016-0202-0
Huma ZE, Gupta A, Javed I, Das R, Hussain SZ, Mumtaz S, Hussain I, Rotello VM (2018) Cationic silver nanoclusters as potent antimicrobials against multidrug-resistant bacteria. ACS Omega 3:16721–16727. https://doi.org/10.1021/acsomega.8b02438
Jesline A, John NP, Narayanan PM et al (2015) Antimicrobial activity of zinc and titanium dioxide nanoparticles against biofilm-producing methicillin-resistant Staphylococcus aureus. Appl Nanosci 5:157–162. https://doi.org/10.1007/s13204-014-0301-x
Jeyaraj Pandian C, Palanivel R, Dhanasekaran S (2016) Screening antimicrobial activity of nickel nanoparticles synthesized using Ocimum sanctum leaf extract. J Nanopart 2016:1–13. https://doi.org/10.1155/2016/4694367
Jha D, Thiruveedula PK, Pathak R, Kumar B, Gautam HK, Agnihotri S, Sharma AK, Kumar P (2017) Multifunctional biosynthesized silver nanoparticles exhibiting excellent antimicrobial potential against multi-drug resistant microbes along with remarkable anticancerous properties. Mater Sci Eng C 80:659–669. https://doi.org/10.1016/j.msec.2017.07.011
Jin T, He Y (2011) Antibacterial activities of magnesium oxide (MgO) nanoparticles against foodborne pathogens. J Nanopart Res 13:6877–6885. https://doi.org/10.1007/s11051-011-0595-5
Jin T, Sun D, Su JY, Zhang H, Sue HJ (2009) Antimicrobial efficacy of zinc oxide quantum dots against Listeria monocytogenes, Salmonella enteritidis, and Escherichia coli O157:H7. J Food Sci 74:M46–M52. https://doi.org/10.1111/j.1750-3841.2008.01013.x
Kanmani P, Lim ST (2013) Synthesis and structural characterization of silver nanoparticles using bacterial exopolysaccharide and its antimicrobial activity against food and multidrug resistant pathogens. Process Biochem 48:1099–1106. https://doi.org/10.1016/j.procbio.2013.05.011
Karlsson HL, Cronholm P, Gustafsson J, Möller L (2008) Copper oxide nanoparticles are highly toxic: a comparison between metal oxide nanoparticles and carbon nanotubes. Chem Res Toxicol 21:1726–1732. https://doi.org/10.1021/tx800064j
Khalid HF, Tehseen B, Sarwar Y, Hussain SZ, Khan WS, Raza ZA, Bajwa SZ, Kanaras AG, Hussain I, Rehman A (2019) Biosurfactant coated silver and iron oxide nanoparticles with enhanced anti-biofilm and anti-adhesive properties. J Hazard Mater 364:441–448. https://doi.org/10.1016/j.jhazmat.2018.10.049
Khan MH, Unnikrishnan S, Ramalingam K (2019) Bactericidal potential of silver-tolerant bacteria derived silver nanoparticles against multi drug resistant ESKAPE pathogens. Biocatal Agric Biotechnol 18:100939. https://doi.org/10.1016/j.bcab.2018.12.004
Khan ST, Musarrat J, Al-Khedhairy AA (2016) Countering drug resistance, infectious diseases, and sepsis using metal and metal oxides nanoparticles: current status. Colloids Surf B Biointerfaces 146:70–83. https://doi.org/10.1016/j.colsurfb.2016.05.046
Kirui DK, Weber G, Talackine J, Millenbaugh NJ (2019) Targeted laser therapy synergistically enhances efficacy of antibiotics against multi-drug resistant Staphylococcus aureus and Pseudomonas aeruginosa biofilms. Nanomed Nanotechnol Biol Med 20:102018. https://doi.org/10.1016/j.nano.2019.102018
Lallo da Silva B, Caetano BL, Chiari-Andréo BG et al (2019) Increased antibacterial activity of ZnO nanoparticles: influence of size and surface modification. Colloids Surf B Biointerfaces 177:440–447. https://doi.org/10.1016/j.colsurfb.2019.02.013
Lee JH, Kim YG, Cho MH, Lee J (2014) ZnO nanoparticles inhibit Pseudomonas aeruginosa biofilm formation and virulence factor production. Microbiol Res 169(12):888–896
Linlin W, Chen H, Longquan S (2017) The antimicrobial activity of nanoparticles: present situation and prospects for the future. Int J Nanomedicine 12:1227–1249. https://doi.org/10.2147/IJN.S121956
Liu L, Yang J, Xie J, Luo Z, Jiang J, Yang YY, Liu S (2013) The potent antimicrobial properties of cell penetrating peptide-conjugated silver nanoparticles with excellent selectivity for gram-positive bacteria over erythrocytes. Nanoscale 5:3834–3840. https://doi.org/10.1039/c3nr34254a
Liu Y, He L, Mustapha A, Li H, Hu ZQ, Lin M (2009) Antibacterial activities of zinc oxide nanoparticles against Escherichia coli O157:H7. J Appl Microbiol 107:1193–1201. https://doi.org/10.1111/j.1365-2672.2009.04303.x
Lu B, Lu F, Ran L, Yu K, Xiao Y, Li Z, Dai F, Wu D, Lan G (2018) Self-assembly of natural protein and imidazole molecules on gold nanoparticles: applications in wound healing against multi-drug resistant bacteria. Int J Biol Macromol 119:505–516. https://doi.org/10.1016/j.ijbiomac.2018.07.167
Lungu M, Gavriliu Ş, Enescu E, Ion L, Brătulescu A, Mihăescu G, Măruţescu L, Chifiriuc MC (2014) Silver-titanium dioxide nanocomposites as effective antimicrobial and antibiofilm agents. J Nanopart Res 16:2203. https://doi.org/10.1007/s11051-013-2203-3
Marega C, Maculan J, Andrea Rizzi G, Saini R, Cavaliere E, Gavioli L, Cattelan M, Giallongo G, Marigo A, Granozzi G (2015) Polyvinyl alcohol electrospun nanofibers containing Ag nanoparticles used as sensors for the detection of biogenic amines. Nanotechnology 26:75501. https://doi.org/10.1088/0957-4484/26/7/075501
Martinez-Gutierrez F, Olive PL, Banuelos A, Orrantia E, Nino N, Sanchez EM, Ruiz F, Bach H, Av-Gay Y (2010) Synthesis, characterization, and evaluation of antimicrobial and cytotoxic effect of silver and titanium nanoparticles. Nanomed Nanotechnol Biol Med 6:681–688. https://doi.org/10.1016/j.nano.2010.02.001
Mehta M, Allen-Gipson D, Mohapatra S, Kindy M, Limayem A (2019) Study on the therapeutic index and synergistic effect of chitosan-zinc oxide nanomicellar composites for drug-resistant bacterial biofilm inhibition. Int J Pharm 565:472–480. https://doi.org/10.1016/j.ijpharm.2019.05.003
Mohan Kumar K, Mandal BK, Appala Naidu E, Sinha M, Siva Kumar K, Sreedhara Reddy P (2013) Synthesis and characterisation of flower shaped zinc oxide nanostructures and its antimicrobial activity. Spectrochim Acta A Mol Biomol Spectrosc 104:171–174. https://doi.org/10.1016/j.saa.2012.11.025
Mosaiab T, Jeong CJ, Shin GJ, Choi KH, Lee SK, Lee I, In I, Park SY (2013) Recyclable and stable silver deposited magnetic nanoparticles with poly(vinyl pyrrolidone)-catechol coated iron oxide for antimicrobial activity. Mater Sci Eng C 33:3786–3794. https://doi.org/10.1016/j.msec.2013.05.009
Mukherjee A, Mohammed Sadiq I, Prathna TC, Chandrasekaran N (2011) Antimicrobial activity of aluminium oxide nanoparticles for potential clinical applications. In: Science against microbial pathogens: communicating current research and technological advances. Formatex Research Center, Badajoz, Spain, pp 245–251
Muthukrishnan L, Chellappa M, Nanda A (2019) Bio-engineering and cellular imaging of silver nanoparticles as weaponry against multidrug resistant human pathogens. J Photochem Photobiol B Biol 194:119–127. https://doi.org/10.1016/j.jphotobiol.2019.03.021
Nejabatdoust A, Zamani H, Salehzadeh A (2019) Functionalization of ZnO nanoparticles by glutamic acid and conjugation with thiosemicarbazide alters expression of efflux pump genes in multiple drug-resistant Staphylococcus aureus strains. Microb Drug Resist 25:966–974. https://doi.org/10.1089/mdr.2018.0304
Nombona N, Antunes E, Chidawanyika W, Kleyi P, Tshentu Z, Nyokong T (2012) Synthesis, photophysics and photochemistry of phthalocyanine-ε-polylysine conjugates in the presence of metal nanoparticles against Staphylococcus aureus. J Photochem Photobiol A Chem 233:24–33. https://doi.org/10.1016/j.jphotochem.2012.02.012
Otari SV, Patil RM, Nadaf NH, Ghosh SJ, Pawar SH (2014) Green synthesis of silver nanoparticles by microorganism using organic pollutant: its antimicrobial and catalytic application. Environ Sci Pollut Res 21:1503–1513. https://doi.org/10.1007/s11356-013-1764-0
Ouyang J, Liu RY, Chen W, Liu Z, Xu Q, Zeng K, Deng L, Shen L, Liu Y-N (2018) A black phosphorus based synergistic antibacterial platform against drug resistant bacteria. J Mater Chem B 6:6302–6310. https://doi.org/10.1039/c8tb01669k
Pal I, Bhattacharyya D, Kar RK, Zarena D, Bhunia A, Atreya HS (2019) A peptide-nanoparticle system with improved efficacy against multidrug resistant bacteria. Sci Rep 9:1–11. https://doi.org/10.1038/s41598-019-41005-7
Palza H, Delgado K, Curotto N (2015) Synthesis of copper nanostructures on silica-based particles for antimicrobial organic coatings. Appl Surf Sci 357:86–90. https://doi.org/10.1016/j.apsusc.2015.08.260
Pazos-Ortiz E, Roque-Ruiz JH, Hinojos-Márquez EA, López-Esparza J, Donohué-Cornejo A, Cuevas-González JC, Espinosa-Cristóbal LF, Reyes-López SY (2017) Dose-dependent antimicrobial activity of silver nanoparticles on polycaprolactone fibers against gram-positive and gram-negative bacteria. J Nanomater 2017:1–9. https://doi.org/10.1155/2017/4752314
Prabakar K, Sivalingam P, Mohamed Rabeek SI, Muthuselvam M, Devarajan N, Arjunan A, Karthick R, Suresh MM, Wembonyama JP (2013) Evaluation of antibacterial efficacy of phyto fabricated silver nanoparticles using Mukia scabrella (Musumusukkai) against drug resistance nosocomial gram negative bacterial pathogens. Colloids Surf B Biointerfaces 104:282–288. https://doi.org/10.1016/j.colsurfb.2012.11.041
Prasad R, Pandey R, Barman I (2016) Engineering tailored nanoparticles with microbes: quo vadis? Wiley Interdiscip Rev Nanomed Nanobiotechnol 8:316–330. https://doi.org/10.1002/wnan.1363
Premanathan M, Karthikeyan K, Jeyasubramanian K, Manivannan G (2011) Selective toxicity of ZnO nanoparticles toward gram-positive bacteria and cancer cells by apoptosis through lipid peroxidation. Nanomedicine Nanotechnology, Biol Med 7:184–192. https://doi.org/10.1016/j.nano.2010.10.001
Prucek R, Tuček J, Kilianová M, Panáček A, Kvítek L, Filip J, Kolář M, Tománková K, Zbořil R (2011) The targeted antibacterial and antifungal properties of magnetic nanocomposite of iron oxide and silver nanoparticles. Biomaterials 32:4704–4713. https://doi.org/10.1016/j.biomaterials.2011.03.039
Rajivgandhi G, Maruthupandy M, Muneeswaran T, Anand M, Quero F, Manoharan N, Li W-J (2019a) Biosynthesized silver nanoparticles for inhibition of antibacterial resistance and biofilm formation of methicillin-resistant coagulase negative Staphylococci. Bioorg Chem 89:103008. https://doi.org/10.1016/j.bioorg.2019.103008
Rajivgandhi G, Maruthupandy M, Muneeswaran T, Ramachandran G, Manoharan N, Quero F, Anand M, Song JM (2019b) Biologically synthesized copper oxide nanoparticles enhanced intracellular damage in ciprofloxacin resistant ESBL producing bacteria. Microb Pathog 127:267–276. https://doi.org/10.1016/j.micpath.2018.12.017
Razeeb KM, Podporska-Carroll J, Jamal M, Hasan M, Nolan ME, McCormack DE, Quilty B, Newcomb SB, Pillai SC (2014) Antimicrobial properties of vertically aligned nano-tubular copper. Mater Lett 128:60–63. https://doi.org/10.1016/j.matlet.2014.04.130
Richtera L, Chudobova D, Cihalova K, Kremplova M, Milosavljevic V, Kopel P, Blazkova I, Hynek D, Adam V, Kizek R (2015) The composites of graphene oxide with metal or semimetal nanoparticles and their effect on pathogenic microorganism. Materials (Basel) 8:2994–3011. https://doi.org/10.3390/ma8062994
Rodrigues AG, Romano de Oliveira Gonçalves PJ, Ottoni CA, de Cássia Ruiz R, Morgano MA, de Araújo WL, de Melo IS, De Souza AO (2019) Functional textiles impregnated with biogenic silver nanoparticles from Bionectria ochroleuca and its antimicrobial activity. Biomed Microdevices 21:56. https://doi.org/10.1007/s10544-019-0410-0
Rudramurthy GR, Swamy MK, Sinniah UR, Ghasemzadeh A (2016) Nanoparticles: alternatives against drug-resistant pathogenic microbes. Molecules 21:1–30. https://doi.org/10.3390/molecules21070836
Sánchez-Sanhueza G, Fuentes-Rodríguez D, Bello-Toledo H (2016) Copper nanoparticles as potential antimicrobial agent in disinfecting root canals: a systematic review. Int J Odontostomatol 10:547–554. https://doi.org/10.4067/s0718-381x2016000300024
Schwegmann H, Frimmel FH (2010) Nanoparticles: interaction with microorganisms. In: Frimmel FH, Niessner R (eds) Nanoparticles in the water cycle. Springer Berlin Heidelberg, Berlin, Heidelberg, pp 165–182
Seil JT, Webster TJ (2012) Antimicrobial applications of nanotechnology: methods and literature. Int J Nanomedicine 7:2767–2781. https://doi.org/10.2147/IJN.S24805
Shaker MA, Shaaban MI (2017) Formulation of carbapenems loaded gold nanoparticles to combat multi-antibiotic bacterial resistance: In vitro antibacterial study. Int J Pharm 525:71–84. https://doi.org/10.1016/j.ijpharm.2017.04.019
Silvan JM, Zorraquin-Peña I, de Llano DG, Moreno-Arribas MV, Martinez-Rodriguez AJ (2018) Antibacterial activity of glutathione-stabilized silver nanoparticles against Campylobacter multidrug-resistant strains. Front Microbiol 9:1–10. https://doi.org/10.3389/fmicb.2018.00458
Singh S, Bahadur D (2019) Highly efficient and reusable dendritic Fe3O4 magnetic Nanoadsorbent for inhibition of bacterial growth. Surfaces and Interfaces:100348. https://doi.org/10.1016/j.surfin.2019.100348
Sirelkhatim A, Mahmud S, Seeni A, Kaus NHM, Ann LC, Bakhori SKM, Hasan H, Mohamad D (2015) Review on zinc oxide nanoparticles: antibacterial activity and toxicity mechanism. Nano-Micro Lett 7:219–242. https://doi.org/10.1007/s40820-015-0040-x
Sudhakar K, Moloi SJ, Madhusudhana Rao K (2017) Green synthesis and characterization of Halloysite Nanoclay/Curcumin/Ag hybrid Nano materials for antibacterial applications. J Inorg Organomet Polym Mater 27:1450–1456. https://doi.org/10.1007/s10904-017-0600-2
Tang J, Chen Q, Xu L et al (2013) Graphene oxide-silver nanocomposite as a highly effective antibacterial agent with species-specific mechanisms. ACS Appl Mater Interfaces 5:3867–3874. https://doi.org/10.1021/am4005495
Tiwari V, Mishra N, Gadani K et al (2018) Mechanism of anti-bacterial activity of zinc oxide nanoparticle against Carbapenem-resistant Acinetobacter baumannii. Front Microbiol 9:1–10. https://doi.org/10.3389/fmicb.2018.01218
Trouiller B, Reliene R, Westbrook A et al (2009) Titanium dioxide nanoparticles induce DNA damage and genetic instability in vivo in mice. Cancer Res 69:8784–8789. https://doi.org/10.1158/0008-5472.CAN-09-2496
Tsuang YH, Sun JS, Huang YC et al (2008) Studies of photokilling of bacteria using titanium dioxide nanoparticles. Artif Organs 32:167–174. https://doi.org/10.1111/j.1525-1594.2007.00530.x
Willems NIT (2005) Roadmap report on nanoparticles. Methodology:1–57
Wu J, Li F, Hu X et al (2019) Responsive assembly of silver Nanoclusters with a biofilm locally amplified bactericidal effect to enhance treatments against multi-drug-resistant bacterial infections. ACS Cent Sci 5:1366–1376. https://doi.org/10.1021/acscentsci.9b00359
Zare Y, Shabani I (2016) Polymer/metal nanocomposites for biomedical applications. Mater Sci Eng C 60:195–203. https://doi.org/10.1016/j.msec.2015.11.023
Zhang S, Wang Y, Song H et al (2019) Copper nanoparticles and copper ions promote horizontal transfer of plasmid-mediated multi-antibiotic resistance genes across bacterial genera. Environ Int 129:478–487. https://doi.org/10.1016/j.envint.2019.05.054
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Sangave, P.C., Matkar, N.M., Suvarna, V. (2020). Antimicrobial Activity of Metallic Nanoparticles Using Prokaryotic Model Organisms. In: Siddhardha, B., Dyavaiah, M., Kasinathan, K. (eds) Model Organisms to Study Biological Activities and Toxicity of Nanoparticles. Springer, Singapore. https://doi.org/10.1007/978-981-15-1702-0_4
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