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Model Organisms to Study Biological Activities and Toxicity of Nanoparticles pp 195–216Cite as

Drosophila melanogaster: A Model Organism to Understand Biological Activities of Nanoparticles

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Abstract

Nanoparticles exhibit remarkable physicochemical features not inevitably found in bulk arrangements; their size or coating modifications distinctly alter their physical, chemical, and biological attributes. Owing to these unique properties, there is a general inclination to explore nanoparticles in numerous fields, viz., in medicine and food industry. To that end, our environment and human health are also affected by its toxicity. To study the reaction of nanoparticles with human cells and complex system, a thorough understanding of the parameters is necessary for the nanoparticles to react within the cells. As human-based trials are difficult with ethical barriers, one extensively exploited laboratory model organism, viz., Drosophila melanogaster, is used as an in vivo model organism for the study of developmental biology, genetics, and recently host pathogenicity. D. melanogaster is very much genetically malleable organism with its short life-cycle, clear developmental stages and availability. D. melanogaster, possessing completely the experimental features like inclination of investigational manipulation proportional to vertebrate models, significant gene homology with developed and complex organisms, and simplicity of gaining mutant phenotypes, seems to be an ideal model organism for the study of nanoparticles activities in cells and nanotoxicological trials. The molecular trails with numerous developmental and behavioral factors can be assessed expending this model in different modes of throughput type tests.

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Acknowledgments

Bijayata Patra, Poulomi Ghosh, and Saprativ P. Das are thankful to Brainware University for providing the necessary funding for research. Bijayata Patra and Poulomi Ghosh have contributed equally toward the successful completion of the manuscript. The authors gratefully acknowledge Prof. Subrata Kumar Dey for providing the essential infrastructural facilities.

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  1. Department of Biotechnology, Brainware University, Kolkata, West Bengal, India

    Bijayata Patra, Poulomi Ghosh & Saprativ P. Das

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  1. Bijayata Patra
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  2. Poulomi Ghosh
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  3. Saprativ P. Das
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Correspondence to Saprativ P. Das .

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  1. Department of Microbiology, School of Life Sciences, Pondicherry University, Pondicherry, India

    Busi Siddhardha

  2. Department of Biochemistry and Molecular Biology, School of Life Sciences, Pondicherry University, Pondicherry, India

    Madhu Dyavaiah

  3. Materials Research Group, iThemba LABS-National Research Fond., Cape Town, South Africa

    Kaviyarasu Kasinathan

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Patra, B., Ghosh, P., Das, S.P. (2020). Drosophila melanogaster: A Model Organism to Understand Biological Activities of Nanoparticles. In: Siddhardha, B., Dyavaiah, M., Kasinathan, K. (eds) Model Organisms to Study Biological Activities and Toxicity of Nanoparticles. Springer, Singapore. https://doi.org/10.1007/978-981-15-1702-0_10

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