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Protective Effect of Mimusops elengi L. on Renal and Hepatic Markers in STZ-Induced Diabetic Rats

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Medicinal Plants: Biodiversity, Sustainable Utilization and Conservation

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Abstract

The present study was carried out to investigate the effect of ethanolic leaf extract of Mimusops elengi L. on biochemical parameters and enzyme activities in STZ-induced diabetic rats. Leakage of cellular enzymes into the plasma is a clear indication of cell damage. When liver plasma membrane is damaged, a variety of enzymes normally located in the cytosol are released into the bloodstream, and their estimation is a quantitative marker for the extent of damage. The cytoprotective effect of M. elengi was evaluated in rats that were rendered diabetic by administration of streptozotocin at a dose of 40 mg/kg b.w. The activities of the marker enzymes were assayed in the serum, liver and kidney. The indicators of renal damage such as urea, uric acid and creatinine were assayed. Treatment of diabetic rats with the ethanolic leaf extract of M. elengi (100 mg/kg b.w.) was able to reverse the levels of the marker enzymes in the liver and protect the kidney by reverting back to the normal levels of renal markers (urea, uric acid and creatinine). The present results showed that ethanolic leaf extract of M. elengi could alleviate liver and renal damage caused by STZ-induced diabetes.

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Acknowledgements

We thank the Department of Biochemistry, Acharya Nagarjuna University, Guntur, Andhra Pradesh, India, for providing research facilities to carry out this work.

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Authors and Affiliations

  1. Department of Biochemistry, Acharya Nagarjuna University, Guntur, Andhra Pradesh, India

    S. K. Jaffar

  2. Department of Botany and Microbiology, Acharya Nagarjuna University, Guntur, Andhra Pradesh, India

    S. M. Khasim

  3. Department of Biochemistry, Kakatiya University, Warangal, Telangana, India

    M. S. K. Prasad

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  1. S. K. Jaffar
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  2. S. M. Khasim
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Editors and Affiliations

  1. Department of Botany and Microbiology, Acharya Nagarjuna University, Guntur, Andhra Pradesh, India

    Shaik Mahammad Khasim

  2. College of Life and Environmental Sciences, Minzu University of China, Beijing, China

    Chunlin Long

  3. Department of Plant Science, Mahidol University, Thailand, Bangkok, Thailand

    Kanchit Thammasiri

  4. Department of Plant and Environmental Sciences, University of Copenhagen, Taastrup, Denmark

    Henrik Lutken

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Jaffar, S.K., Khasim, S.M., Prasad, M.S.K. (2020). Protective Effect of Mimusops elengi L. on Renal and Hepatic Markers in STZ-Induced Diabetic Rats. In: Khasim, S.M., Long, C., Thammasiri, K., Lutken, H. (eds) Medicinal Plants: Biodiversity, Sustainable Utilization and Conservation. Springer, Singapore. https://doi.org/10.1007/978-981-15-1636-8_28

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