Abstract
Colorectal cancer (CRC) is one of the leading malignancies that result in high morbidity and mortality among both the genders, though the incidence is higher in females. It is a multifactorial and multistage disease. One of the major progenitors of colorectal cancer is the reactive oxygen species. A disturbance in the prooxidant-antioxidant balance in the cells leads to compromise in DNA repair mechanism, protein denaturation, lipid peroxidation, and apoptosis leading finally to tumor proliferation. Dysbiosis in the colon is a known cause of oxidative stress. This chapter aims to elucidate the role played by oxidative stress in colorectal oncogenesis. The potential palliative role of probiotics against CRC is also discussed. Probiotics have been known for possessing potent antioxidant attributes and preventing colorectal carcinogenesis. However, mechanism of action of probiotics in amelioration of oxidative stress is not very clear. Thus, the aim of the present chapter is also to review the antioxidant mechanisms of probiotics, choice of species specific to colorectal disease, and role of prebiotics in potentiating the effect of probiotics by balancing the microbiota and physicochemical conditions of colorectal milieu, in the production of anti-cancer compounds and in decreasing oxidative stress. Synbiotics, i.e., the combination of probiotics and prebiotics, are known to be an effective potential strategy in combating CRC.
Keywords
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Gulati, M., Singh, S.K., Singh, A. (2020). The Role of Synbiotics in Alleviating Oxidative Stress in Colorectal Cancer. In: Maurya, P., Dua, K. (eds) Role of Oxidative Stress in Pathophysiology of Diseases. Springer, Singapore. https://doi.org/10.1007/978-981-15-1568-2_6
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DOI: https://doi.org/10.1007/978-981-15-1568-2_6
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