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Role of Oxidative Stress in Complexity of Respiratory Diseases

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Role of Oxidative Stress in Pathophysiology of Diseases

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Abstract

Oxidative stress can arise from excess production of endogenous reactive oxygen species (ROS) or from exposure to exogenous ROS. In the lungs, oxidative stress causes lipid, protein and DNA oxidation, changes to histone acetylation, and inflammation. These pathways are thought to underlay the pathophysiology of respiratory diseases such as asthma, chronic obstructive pulmonary disease, cystic fibrosis, acute respiratory distress syndrome, pneumonia, lung cancer, and obstructive sleep apnoea. This chapter discusses the risk factors for respiratory disease, the evidence for the role of oxidative stress in these diseases, and proposed antioxidant therapies for the treatment of respiratory disease.

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Author notes

  1. Maliheh Ghadiri and Amanda Eugenia Yung contributed equally to the work.

Authors and Affiliations

  1. Woolcock Institute of Medical Research, Faculty of Medicine and Health, The University of Sydney, Camperdown, NSW, Australia

    Maliheh Ghadiri

  2. School of Biomedical Engineering, Faculty of Engineering and Internet Technology, University of Technology Sydney, Ultimo, NSW, Australia

    Maliheh Ghadiri

  3. School of Medicine, Faculty of Medicine and Health, The University of Sydney, Camperdown, NSW, Australia

    Amanda Eugenia Yung

  4. Graduate School of Health, University of Technology Sydney, Ultimo, NSW, Australia

    Mehra Haghi

Authors
  1. Maliheh Ghadiri
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  2. Amanda Eugenia Yung
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  3. Mehra Haghi
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Correspondence to Mehra Haghi .

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Editors and Affiliations

  1. Department of Biochemistry, Central University of Haryana, Mahendergarh, Haryana, India

    Pawan K. Maurya

  2. Discipline of Pharmacy, Graduate School of Health, University of Technology Sydney, Sydney, NSW, Australia

    Kamal Dua

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Ghadiri, M., Yung, A.E., Haghi, M. (2020). Role of Oxidative Stress in Complexity of Respiratory Diseases. In: Maurya, P., Dua, K. (eds) Role of Oxidative Stress in Pathophysiology of Diseases. Springer, Singapore. https://doi.org/10.1007/978-981-15-1568-2_5

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