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Targeted Delivery with Carbon Nanotubes

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Abstract

Functionalized nanotubes have been frequently used to provide their corresponding areas of action with drugs, proteins, antibodies, nucleic acids other therapeutic agents. CNTs are primarily used in the therapy of malignant diseases like Burkitt’s lymphoma, choriocarcinoma, breast cancer, cervical carcinoma and testicular tumors (Thakare et al., Nanomedicine 5, 1277–1301 2010).

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References

  • S. Aggarwal, Targeted Cancer Therapies (Nature Publishing Group, 2010)

    Google Scholar 

  • A. Al Faraj, A.S. Shaik, E. Ratemi, R. Halwani, Combination of drug-conjugated SWCNT nanocarriers for efficient therapy of cancer stem cells in a breast cancer animal model. J. Controlled Release 225, 240–251 (2016)

    Article  CAS  Google Scholar 

  • T. Anderson, R. Hu, C. Yang, H.S. Yoon, K.-T. Yong, Pancreatic cancer gene therapy using an siRNA-functionalized single walled carbon nanotubes (SWNTs) nanoplex. Biomater. Sci. 2, 1244–1253 (2014)

    Article  CAS  Google Scholar 

  • S. Arora, R. Kumar, H. Kaur, C.S. Rayat, I. Kaur, S.K. Arora, J. Srivastava, L.M. Bharadwaj, Translocation and toxicity of docetaxel multi-walled carbon nanotube conjugates in mammalian breast cancer cells. J. Biomed. Nanotechnol. 10, 3601–3609 (2014)

    Article  CAS  Google Scholar 

  • N. Arya, A. Arora, K. Vasu, A.K. Sood, D.S. Katti, Combination of single walled carbon nanotubes/graphene oxide with paclitaxel: a reactive oxygen species mediated synergism for treatment of lung cancer. Nanoscale 5, 2818–2829 (2013)

    Article  CAS  Google Scholar 

  • C. Bao, F. Tian, G. Estrada, Improved visualisation of internalised carbon nanotubes by maximising cell spreading on nanostructured substrates. Nano Biomed. Eng. 2, 201–207 (2010)

    Article  CAS  Google Scholar 

  • M. Bhattacharya, S. Hong, D. Lee, T. Cui, S.M. Goyal, Carbon nanotube based sensors for the detection of viruses. Sens. Actuat. B: Chem. 155, 67–74 (2011)

    Article  CAS  Google Scholar 

  • M. Bottini, N. Rosato, N. Bottini, PEG-modified carbon nanotubes in biomedicine: current status and challenges ahead. Biomacromol 12, 3381–3393 (2011)

    Article  CAS  Google Scholar 

  • G. Chen, Y. He, X. Wu, Y. Zhang, C. Luo, P. Jing, In vitro and in vivo studies of pirarubicin-loaded SWNT for the treatment of bladder cancer. Braz. J. Med. Biol. Res. 45, 771–776 (2012)

    Article  Google Scholar 

  • P.K. Chopdey, R.K. Tekade, N.K. Mehra, N. Mody, N.K. Jain, Glycyrrhizin conjugated dendrimer and multi-walled carbon nanotubes for liver specific delivery of doxorubicin. J. Nanosci. Nanotechnol. 15, 1088–1100 (2015)

    Article  CAS  Google Scholar 

  • D. Cui, H. Zhang, J. Sheng, Z. Wang, A. Toru, R. He, O. Tetsuya, F. Gao, H. Cho, S. Cho, Effects of CdSe/ZnS quantum dots covered multi-walled carbon nanotubes on murine embryonic stem cells. Nano Biomed. Eng. 2, 236–244 (2010)

    Article  CAS  Google Scholar 

  • S. Dhar, Z. Liu, J. Thomale, H.J. Dai, S.J. Lippard,  Targeted single walled carbon nanotubes-mediated Pt(iv) prodrug delivery using folate as a homing device. J. Am. Chem. Soc. 130, 11467–11476 (2018)

    Article  CAS  Google Scholar 

  • Z. Fan, P.P. Fu, H. Yu, P.C. Ray, Theranostic nanomedicine for cancer detection and treatment. J. Food Drug Anal. 22, 3–17 (2014)

    Article  CAS  Google Scholar 

  • R.P. Feazell, N. Nakayama-Ratchford, H. Dai, S.J. Lippard, Soluble single-walled carbon nanotubes as longboat delivery systems for platinum (IV) anticancer drug design. J. Am. Chem. Soc. 129, 8438–8439 (2007)

    Article  CAS  Google Scholar 

  • M. Ferrari, Cancer nanotechnology: opportunities and challenges. Nat. Revi. Cancer 5, 161 (2005)

    Article  CAS  Google Scholar 

  • C. Guo, W.T. Al-Jamal, F.M. Toma, A. Bianco, M. Prato, K.T. Al-Jamal, K. Kostarelos, Design of cationic multiwalled carbon nanotubes as efficient siRNA vectors for lung cancer xenograft eradication. Bioconjug. Chem. 26, 1370–1379 (2015)

    Article  CAS  Google Scholar 

  • M.S. Hasnain, S.A. Ahmad, M.N. Hoda, S. Rishishwar, P. Rishishwar, A.K. Nayak. Stimuli-responsive carbon nanotubes for targeted drug delivery, in Stimuli Responsive Polymeric Nanocarriers for Drug Delivery Applications: Vol. 2: Advanced Nanocarriers for Therapeutics (Elsevier, 2019), pp. 321–344

    Google Scholar 

  • E. Heister, V. Neves, C. Tîlmaciu, K. Lipert, V.S. Beltrán, H.M. Coley, S.R.P. Silva, J. McFadden, Triple functionalisation of single-walled carbon nanotubes with doxorubicin, a monoclonal antibody, and a fluorescent marker for targeted cancer therapy. Carbon 47, 2152–2160 (2009)

    Article  CAS  Google Scholar 

  • B. Hormozi, Application of nanoparticles in cancer treatment, in Advanced Theranostic Materials (Wiley, 2015), pp. 37–65

    Google Scholar 

  • P. Huang, C. Zhang, C. Xu, L. Bao, Z. Li, Preparation and characterization of near-infrared region absorption enhancer carbon nanotubes hybridmaterials. Nano Biomed. Eng. 2, 225–230 (2010)

    Article  CAS  Google Scholar 

  • G.T. Javan, S.J. Finley, I. Can, A. Salhotra, A. Malhotra, S. Soni, Aberrant signaling pathways: hallmark of cancer cells and target for nanotherapeutics. Adv. Theranostic Mater. 2015, 1–35 (2015)

    Google Scholar 

  • J. Ji, M. Liu, Y. Meng, R. Liu, Y. Yan, J. Dong, Z. Guo, C. Ye, Experimental study of magnetic multi-walled carbon nanotube-doxorubicin conjugate in a lymph node metastatic model of breast cancer. Med. Sci. Monit. 22, 2363–2373 (2016)

    Article  CAS  Google Scholar 

  • N.W.S. Kam, M. O’Connell, J.A. Wisdom, H. Dai, Carbon nanotubes as multifunctional biological transporters and near-infrared agents for selective cancer cell destruction. Proc. Natl. Acad. Sci. 102, 11600–11605 (2005)

    Article  CAS  Google Scholar 

  • A. Karmakar, S.M. Bratton, E. Dervishi, A. Ghosh, M. Mahmood, Y. Xu, L.M. Saeed, T. Mustafa, D. Casciano, A. Radominska-Pandya, Ethylenediamine functionalized-single-walled nanotube (f-SWNT)-assisted in vitro delivery of the oncogene suppressor p53 gene to breast cancer MCF-7 cells. Int. J. Nnanomed. 6, 1045 (2011)

    CAS  Google Scholar 

  • P.-C. Lee, Y.-C. Chiou, J.-M. Wong, C.-L. Peng, M.-J. Shieh, Targeting colorectal cancer cells with single-walled carbon nanotubes conjugated to anticancer agent SN-38 and EGFR antibody. Biomaterials 34, 8756–8765 (2013)

    Article  CAS  Google Scholar 

  • J. Li, F. Yang, G. Guo, D. Yang, J. Long, D. Fu, J. Lu, C. Wang, Preparation of biocompatible multi-walled carbon nanotubes as potential tracers for sentinel lymph nodes. Polymer Int. 59, 169–174 (2010)

    Article  CAS  Google Scholar 

  • R. Li, Wu Ra, L. Zhao, Z. Hu, S. Guo, X. Pan, H. Zou, Folate and iron difunctionalized multiwall carbon nanotubes as dual-targeted drug nanocarrier to cancer cells. Carbon 49, 1797–1805 (2011)

    Article  CAS  Google Scholar 

  • F. Liang, B. Chen, A review on biomedical applications of single-walled carbon nanotubes. Curr. Med. Chem. 17, 10–24 (2010)

    Article  CAS  Google Scholar 

  • L. Liu, X. Ye, K. Wu, R. Han, Z. Zhou, T. Cui, Humidity sensitivity of multi-walled carbon nanotube networks deposited by dielectrophoresis. Sensors 9, 1714–1721 (2009a)

    Article  CAS  Google Scholar 

  • Z. Liu, C. Davis, W. Cai, L. He, X. Chen, H. Dai, Circulation and long-term fate of functionalized, biocompatible single-walled carbon nanotubes in mice probed by Raman spectroscopy. Proc. Natl. Acad. Sci. 105, 1410–1415 (2008)

    Article  CAS  Google Scholar 

  • Z. Liu, S. Tabakman, K. Welsher, H. Dai, Carbon nanotubes in biology and medicine: in vitro and in vivo detection, imaging and drug delivery. Nano Res. 2, 85–120 (2009b)

    Article  CAS  Google Scholar 

  • Y.-J. Lu, K.-C. Wei, C.-C.M. Ma, S.-Y. Yang, J.-P. Chen, Dual targeted delivery of doxorubicin to cancer cells using folate-conjugated magnetic multi-walled carbon nanotubes. Colloids Surf. B: Biointerfaces 89, 1–9 (2012)

    Article  CAS  Google Scholar 

  • S. Mahajan, A. Patharkar, K. Kuche, R. Maheshwari, P.K. Deb, K. Kalia, R.K. Tekade, Functionalized carbon nanotubes as emerging delivery system for the treatment of cancer. Int. J. Pharm. 548, 540–558 (2018)

    Article  CAS  Google Scholar 

  • L. Meng, Z. Ji, G. Lin, et al., Targeted therapy of SMMC-7721 liver cancer in vitro and in vivo with carbon nanotubes based drug delivery systems. J. Colloids. Interaf. Sci. 365, 143–149 (2012)

    Google Scholar 

  • M.R. McDevitt, D. Chattopadhyay, J.S. Jaggi, R.D. Finn, P.B. Zanzonico, C. Villa, D. Rey, J. Mendenhall, C.A. Batt, J.T. Njardarson, PET imaging of soluble yttrium-86-labeled carbon nanotubes in mice. PLoS ONE 2, e907 (2007)

    Article  CAS  Google Scholar 

  • J. Meng, J. Meng, J. Duan, H. Kong, L. Li, C. Wang, S. Xie, S. Chen, N. Gu, H. Xu, Carbon nanotubes conjugated to tumor lysate protein enhance the efficacy of an antitumor immunotherapy. Small 4, 1364–1370 (2008)

    Article  CAS  Google Scholar 

  • M. Mohammadi, Z. Salmasi, M. Hashemi, F. Mosaffa, K. Abnous, M. Ramezani, Single-walled carbon nanotubes functionalized with aptamer and piperazine–polyethylenimine derivative for targeted siRNA delivery into breast cancer cells. Int. J. Pharm. 485, 50–60 (2015)

    Article  CAS  Google Scholar 

  • C.L. Morgan, D.J. Newman, C. Price, Immunosensors: technology and opportunities in laboratory medicine. Clin. Chem. 42, 193–209 (1996)

    CAS  Google Scholar 

  • T. Murakami, J. Fan, M. Yudasaka, S. Iijima, K. Shiba, Solubilization of single-wall carbon nanohorns using a PEG—doxorubicin conjugate. Mol. Pharm. 3, 407–414 (2006)

    Article  CAS  Google Scholar 

  • S. Nimesh, N. Gupta, R. Chandra, Cationic polymer based nanocarriers for delivery of therapeutic nucleic acids. J. Biomed. Nanotechnol. 7, 504–520 (2011)

    Article  CAS  Google Scholar 

  • Y. Oh, J.-O. Jin, J. Oh, Photothermal-triggered control of sub-cellular drug accumulation using doxorubicin-loaded single-walled carbon nanotubes for the effective killing of human breast cancer cells. Nanotechnology 28, 125101 (2017)

    Article  CAS  Google Scholar 

  • Z. Ou, B. Wu, D. Xing, F. Zhou, H. Wang, Y. Tang, Functional single-walled carbon nanotubes based on an integrin αvβ3 monoclonal antibody for highly efficient cancer cell targeting. Nanotechnology 20, 105102 (2009)

    Article  CAS  Google Scholar 

  • B. Pan, D. Cui, P. Xu, C. Ozkan, G. Feng, M. Ozkan, T. Huang, B. Chu, Q. Li, R. He, Synthesis and characterization of polyamidoamine dendrimer-coated multi-walled carbon nanotubes and their application in gene delivery systems. Nanotechnology 20, 125101 (2009)

    Article  CAS  Google Scholar 

  • S. Prakash, A.G. Kulamarva, Recent advances in drug delivery: potential and limitations of carbon nanotubes. Recent Pat. Drug Deliv. Formulation 1, 214–221 (2007)

    Article  CAS  Google Scholar 

  • S. Prakash, M. Malhotra, W. Shao, C. Tomaro-Duchesneau, S. Abbasi, Polymeric nanohybrids and functionalized carbon nanotubes as drug delivery carriers for cancer therapy. Adv. Drug Deliv. Rev. 63, 1340–1351 (2011)

    Article  CAS  Google Scholar 

  • G. Prencipe, S.M. Tabakman, K. Welsher, Z. Liu, A.P. Goodwin, L. Zhang, J. Henry, H. Dai, PEG branched polymer for functionalization of nanomaterials with ultralong blood circulation. J. Am. Chem. Soc. 131, 4783–4787 (2009)

    Article  CAS  Google Scholar 

  • G. Qu, Y. Bai, Y. Zhang, Q. Jia, W. Zhang, B. Yan, The effect of multiwalled carbon nanotube agglomeration on their accumulation in and damage to organs in mice. Carbon 47, 2060–2069 (2009)

    Article  CAS  Google Scholar 

  • J. Ren, S. Shen, D. Wang, Z. Xi, L. Guo, Z. Pang, Y. Qian, X. Sun, X. Jiang, The targeted delivery of anticancer drugs to brain glioma by PEGylated oxidized multi-walled carbon nanotubes modified with angiopep-2. Biomaterials 33, 3324–3333 (2012)

    Article  CAS  Google Scholar 

  • G. Risi, N. Bloise, D. Merli, A. Icaro-Cornaglia, A. Profumo, M. Fagnoni, E. Quartarone, M. Imbriani, L. Visai, In vitro study of multiwall carbon nanotubes (MWCNTs) with adsorbed mitoxantrone (MTO) as a drug delivery system to treat breast cancer. Rsc Advances 4, 18683–18693 (2014)

    Article  CAS  Google Scholar 

  • P.C. Rodriguez, M.S. Ernstoff, C. Hernandez, M. Atkins, J. Zabaleta, R. Sierra, A.C. Ochoa, Arginase I—producing myeloid-derived suppressor cells in renal cell carcinoma are a subpopulation of activated granulocytes. Cancer Res. 69, 1553–1560 (2009)

    Article  CAS  Google Scholar 

  • A. Romano, C. Conticello, M. Cavalli, C. Vetro, A. La Fauci, N.L. Parrinello, F. Di Raimondo, Immunological dysregulation in multiple myeloma microenvironment. BioMed. Res. Int. 2014 (2014a)

    Google Scholar 

  • A. Romano, C. Vetro, G. Caocci, M. Greco, N.L. Parrinello, F. Di Raimondo, G. La Nasa, Immunological deregulation in classic Hodgkin lymphoma. Mediterr. J. Hematol. Infect. Dis. 6 (2014b)

    Google Scholar 

  • L.M. Saeed, M. Mahmood, S.J. Pyrek, T. Fahmi, Y. Xu, T. Mustafa, Z.A. Nima, S.M. Bratton, D. Casciano, E. Dervishi, Single-walled carbon nanotube and graphene nanodelivery of gambogic acid increases its cytotoxicity in breast and pancreatic cancer cells. J. Appl. Toxicol. 34, 1188–1199 (2014)

    Article  CAS  Google Scholar 

  • N. Sanoj Rejinold, M. Muthunarayanan, K. Chennazhi, S. Nair, R. Jayakumar, Curcumin loaded fibrinogen nanoparticles for cancer drug delivery. J. Biomed. Nanotechnol. 7, 521–534 (2011)

    Article  CAS  Google Scholar 

  • D.J. Shirale, M.A. Bangar, M. Park, M.V. Yates, W. Chen, N.V. Myung, A. Mulchandani, Label-free chemiresistive immunosensors for viruses. Environ. Sci. Technol. 44, 9030–9035 (2010)

    Article  CAS  Google Scholar 

  • N. Sinha, J.-W. Yeow, Carbon nanotubes for biomedical applications. IEEE Trans. Nanobiosci. 4, 180–195 (2005)

    Article  Google Scholar 

  • S.M. Taghdisi, P. Lavaee, M. Ramezani, K. Abnous, Reversible targeting and controlled release delivery of daunorubicin to cancer cells by aptamer-wrapped carbon nanotubes. Eur. J. Pharm. Biopharm. 77, 200–206 (2011)

    Article  CAS  Google Scholar 

  • V.S. Thakare, M. Das, A.K. Jain, S. Patil, S. Jain, Carbon nanotubes in cancer theragnosis. Nanomedicine 5, 1277–1301 (2010)

    Article  CAS  Google Scholar 

  • S.V. Torti, F. Byrne, O. Whelan, N. Levi, B. Ucer, M. Schmid, F.M. Torti, S. Akman, J. Liu, P.M. Ajayan, Thermal ablation therapeutics based on CNx multi-walled nanotubes. Int. J. Nanomed. 2, 707 (2007)

    CAS  Google Scholar 

  • J.V. Veetil, K. Ye, Development of immunosensors using carbon nanotubes. Biotechnol. Prog. 23, 517–531 (2007)

    Article  CAS  Google Scholar 

  • Y. Xiao, X. Gao, O. Taratula, S. Treado, A. Urbas, R.D. Holbrook, R.E. Cavicchi, C.T. Avedisian, S. Mitra, R. Savla, Anti-HER2 IgY antibody-functionalized single-walled carbon nanotubes for detection and selective destruction of breast cancer cells. BMC Cancer 9, 351 (2009)

    Article  CAS  Google Scholar 

  • F. Yang, C. Jin, D. Yang, Y. Jiang, J. Li, Y. Di, J. Hu, C. Wang, Q. Ni, D. Fu, Magnetic functionalised carbon nanotubes as drug vehicles for cancer lymph node metastasis treatment. Eur. J. Cancer 47, 1873–1882 (2011)

    Article  CAS  Google Scholar 

  • Z. Yang, Y. Zhang, Y. Yang, L. Sun, D. Han, H. Li, C. Wang, Pharmacological and toxicological target organelles and safe use of single-walled carbon nanotubes as drug carriers in treating Alzheimer disease. Nanomed.: Nanotechnol. Biolo. Med. 6, 427–441 (2010)

    Article  CAS  Google Scholar 

  • B. Yu, L. Tan, R. Zheng, H. Tan, L. Zheng, Targeted delivery and controlled release of Paclitaxel for the treatment of lung cancer using single-walled carbon nanotubes. Mater. Sci. Eng., C 68, 579–584 (2016)

    Article  CAS  Google Scholar 

  • X. Zhang, L. Meng, Q. Lu, Z. Fei, P.J. Dyson, Targeted delivery and controlled release of doxorubicin to cancer cells using modified single wall carbon nanotubes. Biomaterials 30, 6041–6047 (2009)

    Article  CAS  Google Scholar 

  • F. Zhou, X. Da, Z. Ou, B. Wu, D.E. Resasco, W.R. Chen, Cancer photothermal therapy in the near-infrared region by using single-walled carbon nanotubes. J. Biomed. Opt. 14, 021009 (2009)

    Article  CAS  Google Scholar 

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Correspondence to Md Saquib Hasnain .

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Hasnain, M.S., Nayak, A.K. (2019). Targeted Delivery with Carbon Nanotubes. In: Carbon Nanotubes for Targeted Drug Delivery. SpringerBriefs in Applied Sciences and Technology. Springer, Singapore. https://doi.org/10.1007/978-981-15-0910-0_7

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