Skip to main content
SpringerLink
Log in

Carbon Nanotubes in Vaccine Delivery

  • Chapter
  • First Online:
Carbon Nanotubes for Targeted Drug Delivery

Part of the book series: SpringerBriefs in Applied Sciences and Technology ((BRIEFSAPPLSCIENCES))

Abstract

Vaccines are medicines intended to produce a definite, active immune reaction in a host that will halt the onset of a disease or reduce the impact of a disease once it has instigated. In infectious illnesses state, almost every vaccine is given prophylactically. These techniques have offered a few of the most imperative improvements in human healthcare over the past century.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 39.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 54.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  • A. Bianco, K. Kostarelos, M. Prato, Applications of carbon nanotubes in drug delivery. Curr. Opin. Chem. Biol. 9, 674–679 (2005)

    Article  CAS  Google Scholar 

  • M. Carbone, F. Valentini, R. Caminiti, A. Petrinca, D. Donia, M. Divizia, G. Palleschi, Are PEI-coated SWCNTs conjugated with hepatitis a virus? A Chemical study with SEM, Z-potential, EDXD and RT-PCR. Biomed. Mater. 5, 035001 (2010)

    Article  CAS  Google Scholar 

  • H. Dumortier, S. Lacotte, G. Pastorin, R. Marega, W. Wu, D. Bonifazi, J.-P. Briand, M. Prato, S. Muller, A. Bianco, Functionalized carbon nanotubes are non-cytotoxic and preserve the functionality of primary immune cells. Nano Lett. 6, 1522–1528 (2006)

    Article  CAS  Google Scholar 

  • R. Dyall, W.B. Bowne, L.W. Weber, J. LeMaoult, P. Szabo, Y. Moroi, G. Piskun, J.J. Lewis, A.N. Houghton, J. Nikolić-Žugić, Heteroclitic immunization induces tumor immunity. J. Exp. Med. 188, 1553–1561 (1998)

    Article  CAS  Google Scholar 

  • A.M. Farkas, O.J. Finn, Vaccines based on abnormal self-antigens as tumor-associated antigens: immune regulation, in Seminars in Immunology (Elsevier, Amsterdam, 2010), pp 125–131

    Article  CAS  Google Scholar 

  • T. Fifis, A. Gamvrellis, B. Crimeen-Irwin, G.A. Pietersz, J. Li, P.L. Mottram, I.F. McKenzie, M. Plebanski, Size-dependent immunogenicity: therapeutic and protective properties of nano-vaccines against tumors. J. Immunol. 173, 3148–3154 (2004)

    Article  CAS  Google Scholar 

  • V. Georgakilas, N. Tagmatarchis, D. Pantarotto, A. Bianco, J-P. Briand, M. Prato, Amino acid functionalisation of water soluble carbon nanotubes. Chem. Commun. 3050–3051 (2002)

    Google Scholar 

  • A. Heath, J. Playfair, Cytokines as immunological adjuvants. Vaccine 10, 427–434 (1992)

    Article  CAS  Google Scholar 

  • A.N. Houghton, J.A. Guevara-Patiño, Immune recognition of self in immunity against cancer. J. Clin. Investig. 114, 468–471 (2004)

    Article  CAS  Google Scholar 

  • N.W.S. Kam, M. O’Connell, J.A. Wisdom, H. Dai, Carbon nanotubes as multifunctional biological transporters and near-infrared agents for selective cancer cell destruction. Proc. Natl. Acad. Sci. 102, 11600–11605 (2005)

    Article  CAS  Google Scholar 

  • C. Kojima, Design of stimuli-responsive dendrimers. Expert Opin. Drug Deliv. 7, 307–319 (2010)

    Article  CAS  Google Scholar 

  • N.V. Konduru, Y.Y. Tyurina, W. Feng, L.V. Basova, N.A. Belikova, H. Bayir, K. Clark, M. Rubin, D. Stolz, H. Vallhov, Phosphatidylserine targets single-walled carbon nanotubes to professional phagocytes in vitro and in vivo. Plos One 4, e4398 (2009)

    Article  Google Scholar 

  • K. Kostarelos, A. Bianco, M. Prato, Promises, facts and challenges for carbon nanotubes in imaging and therapeutics. Nat. Nanotechnol. 4, 627 (2009)

    Article  CAS  Google Scholar 

  • K. Kostarelos, L. Lacerda, G. Pastorin, W. Wu, S. Wieckowski, J. Luangsivilay, S. Godefroy, D. Pantarotto, J.-P. Briand, S. Muller, Cellular uptake of functionalized carbon nanotubes is independent of functional group and cell type. Nat. Nanotechnol. 2, 108 (2007)

    Article  CAS  Google Scholar 

  • P.O. Livingston, G. Ragupathi, Cancer vaccines targeting carbohydrate antigens. Hum. Vaccines 2, 137–143 (2006)

    Article  CAS  Google Scholar 

  • C.L. Mackall, Spreading the wealth: antigen discovery in adult tumors can help hone the search for pediatric tumor antigens. J. Immunother. 24, 281–282 (2001)

    Article  CAS  Google Scholar 

  • C.J. Melief, Cancer immunotherapy by dendritic cells. Immunity 29, 372–383 (2008)

    Article  CAS  Google Scholar 

  • J. Meng, J. Duan, H. Kong, L. Li, C. Wang, S. Xie, S. Chen, N. Gu, H. Xu, Carbon nanotubes conjugated to tumor lysate protein enhance the efficacy of an antitumor immunotherapy. Small 4, 1364–1370 (2008)

    Article  CAS  Google Scholar 

  • T. Mocan, C. Iancu, Effective colon cancer prophylaxis in mice using embryonic stem cells and carbon nanotubes. Int. J. Nanomed. 6, 1945 (2011)

    Article  CAS  Google Scholar 

  • P.L. Mottram, D. Leong, B. Crimeen-Irwin, S. Gloster, S.D. Xiang, J. Meanger, R. Ghildyal, N. Vardaxis, M. Plebanski, Type 1 and 2 immunity following vaccination is influenced by nanoparticle size: formulation of a model vaccine for respiratory syncytial virus. Mol. Pharm. 4, 73–84 (2007)

    Article  CAS  Google Scholar 

  • G.M. Mutlu, G.S. Budinger, A.A. Green, D. Urich, S. Soberanes, S.E. Chiarella, G.F. Alheid, D.R. McCrimmon, I. Szleifer, M.C. Hersam, Biocompatible nanoscale dispersion of single-walled carbon nanotubes minimizes in vivo pulmonary toxicity. Nano Lett. 10, 1664–1670 (2010)

    Article  CAS  Google Scholar 

  • D.T. O’Hagan, M.L. MacKichan, M. Singh, Recent developments in adjuvants for vaccines against infectious diseases. Biomol. Eng. 18, 69–85 (2001)

    Article  Google Scholar 

  • D. Pantarotto, C.D. Partidos, R. Graff, J. Hoebeke, J.-P. Briand, M. Prato, A. Bianco, Synthesis, structural characterization, and immunological properties of carbon nanotubes functionalized with peptides. J. Am. Chem. Soc. 125, 6160–6164 (2003a)

    Article  CAS  Google Scholar 

  • D. Pantarotto, C.D. Partidos, J. Hoebeke, F. Brown, E. Kramer, J.-P. Briand, S. Muller, M. Prato, A. Bianco, Immunization with peptide-functionalized carbon nanotubes enhances virus-specific neutralizing antibody responses. Chem. Biol. 10, 961–966 (2003b)

    Article  CAS  Google Scholar 

  • D.A. Scheinberg, C.H. Villa, F.E. Escorcia, M.R. McDevitt, Conscripts of the infinite armada: systemic cancer therapy using nanomaterials. Nat. Rev. Clin. Oncol. 7, 266 (2010)

    Article  CAS  Google Scholar 

  • P. Singh, S. Campidelli, S. Giordani, D. Bonifazi, A. Bianco, M. Prato, Organic functionalisation and characterisation of single-walled carbon nanotubes. Chem. Soc. Rev. 38, 2214–2230 (2009)

    Article  CAS  Google Scholar 

  • P.K. Srivastava, A. Menoret, S. Basu, R.J. Binder, K.L. McQuade, Heat shock proteins come of age: primitive functions acquire new roles in an adaptive world. Immunity 8, 657–665 (1998)

    Article  CAS  Google Scholar 

  • R.M. Steinman, J. Banchereau, Taking dendritic cells into medicine. Nature 449, 419 (2007)

    Article  CAS  Google Scholar 

  • C.H. Villa, T. Dao, I. Ahearn, N. Fehrenbacher, E. Casey, D.A. Rey, T. Korontsvit, V. Zakhaleva, C.A. Batt, M.R. Philips, Single-walled carbon nanotubes deliver peptide antigen into dendritic cells and enhance IgG responses to tumor-associated antigens. ACS Nano 5, 5300–5311 (2011)

    Article  CAS  Google Scholar 

  • S.D. Xiang, K. Scalzo-Inguanti, G. Minigo, A. Park, C.L. Hardy, M. Plebanski, Promising particle-based vaccines in cancer therapy. Expert. Rev. Vaccines 7, 1103–1119 (2008)

    Article  Google Scholar 

  • N. Yandar, G. Pastorin, M. Prato, A. Bianco, M.E. Patarroyo, J.M. Lozano, Immunological profile of a Plasmodium vivax AMA-1 N-terminus peptide-carbon nanotube conjugate in an infected Plasmodium berghei mouse model. Vaccine 26, 5864–5873 (2008)

    Article  CAS  Google Scholar 

  • M. Zeinali, M. Jammalan, S.K. Ardestani, N. Mosaveri, Immunological and cytotoxicological characterization of tuberculin purified protein derivative (PPD) conjugated to single-walled carbon nanotubes. Immunol. Lett. 126, 48–53 (2009)

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Pharmacy, Shri Venkateshwara University, Amroha, Uttar Pradesh, India

    Md Saquib Hasnain

  2. Department of Pharmaceutics, Seemanta Institute of Pharmaceutical Science, Mayurbhanj, Odisha, India

    Amit Kumar Nayak

Authors
  1. Md Saquib Hasnain
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Amit Kumar Nayak
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Md Saquib Hasnain .

Rights and permissions

Reprints and permissions

Copyright information

© 2019 The Author(s), under exclusive license to Springer Nature Singapore Pte Ltd.

About this chapter

Check for updates. Verify currency and authenticity via CrossMark

Cite this chapter

Hasnain, M.S., Nayak, A.K. (2019). Carbon Nanotubes in Vaccine Delivery. In: Carbon Nanotubes for Targeted Drug Delivery. SpringerBriefs in Applied Sciences and Technology. Springer, Singapore. https://doi.org/10.1007/978-981-15-0910-0_12

Download citation

Publish with us

Policies and ethics

Search

Navigation