Skip to main content
SpringerLink
Log in

The Cross-Regulation Between Autophagy and Type I Interferon Signaling in Host Defense

  • Chapter
  • First Online:
Autophagy Regulation of Innate Immunity

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 1209))

Abstract

The production of type I interferons (IFNs) is one of the hallmarks of intracellular antimicrobial program. Typical type I IFN response activates the Janus kinase (JAK)–signal transducer and activator of transcription (STAT) pathway, which results in the transcription of plentiful IFN-stimulated genes (ISGs) to establish the comprehensive antiviral states. Type I IFN signaling should initiate timely to provoke innate and adaptive immune responses for effective elimination of the invading pathogens. Meanwhile, a precise control must come on the stage to restrain the persistent activation of type I IFN responses to avoid attendant toxicity. Autophagy, a conserved eukaryotic degradation system, mediated by a number of autophagy-related (ATG) proteins, plays an essential role in the clearance of invading microorganism and manipulation of type I responses. Autophagy modulates type I IFN responses through regulatory integration with innate immune signaling pathways, and by removing endogenous ligands of innate immune sensors. Moreover, selective autophagy governs the choice of innate immune factors as specific cargoes for degradation, thus tightly monitoring the type I IFN responses. This review will focus on the cross-regulation between autophagy and type I IFN signaling in host defense.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
eBook
USD 16.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 109.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 109.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  1. Adnan M, Malathi SK (2012) RNase L induces autophagy via c-Jun N-terminal kinase and double-stranded RNA-dependent protein kinase signaling pathways. J Biol Chem 287:43651–43664

    Article  CAS  Google Scholar 

  2. Ambjorn M, Ejlerskov P, Liu YW, Lees M, Jaattela M, Issazadeh-Navikas S (2013) IFNB1/interferon-β-induced autophagy in MCF-7 breast cancer cells counteracts its proapoptotic function. Autophagy 9:287–302

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  3. Anding AL, Baehrecke EH (2017) Cleaning house: selective autophagy of organelles. Dev Cell 41:10–22

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  4. Barutcu SA, Girnius N, Vernia S, Davis RJ (2018) Role of the MAPK/cJun NH2-terminal kinase signaling pathway in starvation-induced autophagy. Autophagy 14:1586–1595

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  5. Byun JY, Yoon CH, An S, Park IC, Kang CM, Kim MJ, Lee SJ (2009) The Rac1/MKK7/JNK pathway signals upregulation of Atg5 and subsequent autophagic cell death in response to oncogenic Ras. Carcinogenesis 30:1880–1888

    Article  CAS  PubMed  Google Scholar 

  6. Chakrabarti A, Ghosh PK, Banerjee S, Gaughan C, Silverman RH (2012) RNase L triggers autophagy in response to viral infections. J Virol 86:11311–11321

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  7. Chan YK, Gack MU (2016) Viral evasion of intracellular DNA and RNA sensing. Nat Rev Microbiol 14:360–373

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  8. Chandra PK, Bao LL, Song K, Aboulnasr FM, Baker DP, Shores N, Wimley WC, Liu SH, Hagedorn CH, Fuchs SY et al (2014) HCV infection selectively impairs type I but not type III IFN signaling. Am J Pathol 184:214–229

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  9. Chelbi-Alix MK, Pelicano L, Quignon F, Koken MHM, Venturini L, Stadler M, Pavlovic J, Degos L, De The H (1995) Induction of the PML protein by interferons in normal and APL cells. Leukemia (Basingstoke) 9:2027–2033

    CAS  Google Scholar 

  10. Chen DY, Feng CH, Tian XY, Zheng N, Wu ZW (2018) Promyelocytic leukemia restricts enterovirus 71 replication by inhibiting autophagy. Front Immunol 9:19

    Article  CAS  Google Scholar 

  11. Chen MX, Meng QC, Qin YF, Liang PP, Tan P, He L, Zhou YB, Chen YJ, Huang JJ, Wang RF et al (2016) TRIM14 inhibits cGAS degradation mediated by selective autophagy receptor p62 to promote innate immune responses. Mol Cell 64:105–119

    Article  CAS  PubMed  Google Scholar 

  12. Chiang C, Gack MU (2017) Post-translational control of intracellular pathogen sensing pathways. Trends Immunol 38:39–52

    Article  CAS  PubMed  Google Scholar 

  13. Choi AMK, Ryter SW, Levine B (2013) Autophagy in human health and disease. N Engl J Med 368:651–662

    Article  CAS  PubMed  Google Scholar 

  14. Choi Y, Bowman JW, Jung JU (2018) Autophagy during viral infection—a double-edged sword. Nat Rev Microbiol 16:340–353

    Article  CAS  Google Scholar 

  15. Clarke AJ, Simon AK (2019) Autophagy in the renewal, differentiation and homeostasis of immune cells. Nat Rev Immunol 19:170–183

    Article  CAS  Google Scholar 

  16. Deretic V, Levine B (2018) Autophagy balances inflammation in innate immunity. Autophagy 14:243–251

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  17. Deretic V, Saitoh T, Akira S (2013) Autophagy in infection, inflammation and immunity. Nat Rev Immunol 13:722–737

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  18. Desai MM, Gong B, Chan TS, Davey RA, Soong L, Kolokoltsov AA, Sun JR (2011) Differential, type I interferon-mediated autophagic trafficking of hepatitis C virus proteins in mouse liver. Gastroenterology 141:674–685

    Article  CAS  PubMed  Google Scholar 

  19. Dikic I, Elazar Z (2018) Mechanism and medical implications of mammalian autophagy. Nat Rev Mol Cell Biol 19:349–364

    Article  CAS  PubMed  Google Scholar 

  20. Diner EJ, Burdette DL, Wilson SC, Monroe KM, Kellenberger CA, Hyodo M, Hayakawa Y, Hammond MC, Vance RE (2013) The innate immune DNA sensor cGAS produces a noncanonical cyclic dinucleotide that activates human STING. Cell Rep 3:1355–1361

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  21. Ding BB, Zhang LL, Li ZF, Zhong Y, Tang QP, Qin YL, Chen MZ (2017) The matrix protein of human parainfluenza virus type 3 induces mitophagy that suppresses interferon responses. Cell Host Microbe 21:538–547

    Article  CAS  PubMed  Google Scholar 

  22. Du Y, Duan TH, Feng YC, Liu QX, Lin M, Cui J, Wang RF (2018) LRRC25 inhibits type I IFN signaling by targeting ISG15-associated RIG-I for autophagic degradation. EMBO J 37:351–366

    Article  CAS  PubMed  Google Scholar 

  23. Egan DF, Shackelford DB, Mihaylova MM, Gelino S, Kohnz RA, Mair W, Vasquez DS, Joshi A, Gwinn DM, Taylor R et al (2011) Phosphorylation of ULK1 (hATG1) by AMP-activated protein kinase connects energy sensing to mitophagy. Science 331:456–461

    Article  CAS  PubMed  Google Scholar 

  24. Frenz T, Graalmann L, Detje CN, Doring M, Grabski E, Scheu S, Kalinke U (2014) Independent of plasmacytoid dendritic cell (pDC) infection, pDC triggered by virus-infected cells mount enhanced type I IFN responses of different composition as opposed to pDC stimulated with free virus. J Immunol 193:2496–2503

    Article  CAS  PubMed  Google Scholar 

  25. Gao DX, Wu JX, Wu YT, Du FH, Aroh C, Yan N, Sun LJ, Chen ZJJ (2013) Cyclic GMP-AMP synthase is an innate immune sensor of HIV and other retroviruses. Science 341:903–906

    Article  CAS  PubMed  Google Scholar 

  26. Gatica D, Lahiri V, Klionsky DJ (2018) Cargo recognition and degradation by selective autophagy. Nat Cell Biol 20:233–242

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  27. Goldberg AA, Nkengfac B, Sanchez AMJ, Moroz N, Qureshi ST, Koromilas AE, Wang S, Burelle Y, Hussain SN, Kristof AS (2017) Regulation of ULK1 expression and autophagy by STAT1. J Biol Chem 292:1899–1909

    Article  CAS  PubMed  Google Scholar 

  28. Grutter MG, Luban J (2012) TRIM5 structure, HIV-1 capsid recognition, and innate immune signaling. Curr Opin Virol 2:142–150

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  29. Gui X, Yang H, Li T, Tan XJ, Shi PQ, Li MH, Du FH, Chen ZJJ (2019) Autophagy induction via STING trafficking is a primordial function of the cGAS pathway. Nature 567:262–266

    Article  CAS  PubMed  Google Scholar 

  30. Gunduz F, Aboulnasr FM, Chandra PK, Hazari S, Poat B, Baker DP, Balart LA, Dash S (2012) Free fatty acids induce ER stress and block antiviral activity of interferon alpha against hepatitis C virus in cell culture. Virol J 9:12

    Article  CAS  Google Scholar 

  31. Hansen M, Rubinsztein DC, Walker DW (2018) Autophagy as a promoter of longevity: insights from model organisms. Nat Rev Mol Cell Biol 19:579–593

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  32. Hayashi K, Taura M, Iwasaki A (2018) The interaction between IKKα and LC3 promotes type I interferon production through the TLR9-containing LAPosome. Sci Signal 11:10

    Google Scholar 

  33. He YL, She H, Zhang T, Xu HD, Cheng LH, Yepes M, Zhao YR, Mao ZX (2018) p38 MAPK inhibits autophagy and promotes microglial inflammatory responses by phosphorylating ULK1. J Cell Biol 217:315–328

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  34. Henault J, Martinez J, Riggs JM, Tian J, Mehta P, Clarke L, Sasai M, Latz E, Brinkmann MM, Iwasaki A et al (2012) Noncanonical autophagy is required for type I interferon secretion in response to DNA-immune complexes. Immunity 37:986–997

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  35. Hoyer-Hansen M, Bastholm L, Szyniarowski P, Campanella M, Szabadkai G, Farkas T, Bianchi K, Fehrenbacher N, Elling F, Rizzuto R et al (2007) Control of macroautophagy by calcium, calmodulin-dependent kinase kinase-β, and Bcl-2. Mol Cell 25:193–205

    Article  PubMed  CAS  Google Scholar 

  36. Hu MM, Yang Q, Xie XQ, Liao CY, Lin H, Liu TT, Yin L, Shu HB (2016) Sumoylation promotes the stability of the DNA sensor cGAS and the adaptor STING to regulate the kinetics of response to DNA virus. Immunity 45:555–569

    Article  CAS  PubMed  Google Scholar 

  37. Huang TZ, Kim CK, Alvarez AA, Pangeni RP, Wan XC, Song X, Shi TP, Yang YY, Sastry N, Horbinski CM et al (2017) MST4 phosphorylation of ATG4B regulates autophagic activity, tumorigenicity, and radioresistance in glioblastoma. Cancer Cell 32:840–855

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  38. Inomata M, Niida S, Shibata K, Into T (2012) Regulation of Toll-like receptor signaling by NDP52-mediated selective autophagy is normally inactivated by A20. Cell Mol Life Sci 69:963–979

    Article  CAS  PubMed  Google Scholar 

  39. Ivashkiv LB, Donlin LT (2014) Regulation of type I interferon responses. Nat Rev Immunol 14:36–49

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  40. Jin SH, Tian S, Luo M, Xie WH, Liu T, Duan TH, Wu YX, Cui J (2017) Tetherin suppresses type I interferon signaling by targeting MAVS for NDP52-mediated selective autophagic degradation in human cells. Mol Cell 68:308–322

    Article  CAS  PubMed  Google Scholar 

  41. Jounai N, Takeshita F, Kobiyama K, Sawano A, Miyawaki A, Xin KQ, Ishii KJ, Kawaii T, Akira S, Suzuki K et al (2007) The Atg5–Atg12 conjugate associates with innate antiviral immune responses. Proc Natl Acad Sci USA 104:14050–14055

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  42. Kawai T, Akira S (2011) Toll-like receptors and their crosstalk with other innate receptors in infection and immunity. Immunity 34:637–650

    Article  CAS  PubMed  Google Scholar 

  43. Kim JH, Kim TH, Lee HC, Nikapitiya C, Uddina MB, Park ME, Pathinayake P, Lee ES, Chathuranga K, Herath TUB et al (2017) Rubicon modulates antiviral type I interferon (IFN) signaling by targeting IFN regulatory factor 3 dimerization. J Virol 91:14

    Google Scholar 

  44. Kim N, Kim MJ, Sung PS, Bae YC, Shin EC, Yoo JY (2016) Interferon-inducible protein SCOTIN interferes with HCV replication through the autolysosomal degradation of NS5A. Nat Commun 7:12

    Google Scholar 

  45. Kimura T, Jain A, Choi SW, Mandell MA, Schroder K, Johansen T, Deretic V (2015) TRIM-mediated precision autophagy targets cytoplasmic regulators of innate immunity. J Cell Biol 210:973–989

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  46. Konno H, Konno K, Barber GN (2013) Cyclic dinucleotides trigger ULK1 (ATG1) phosphorylation of STING to prevent sustained innate immune signaling. Cell 155:688–698

    Article  CAS  PubMed  Google Scholar 

  47. Kumar H, Kawai T, Akira S (2011) Pathogen recognition by the innate immune system. Int Rev Immunol 30:16–34

    Article  CAS  PubMed  Google Scholar 

  48. Kumar KGS, Barriere H, Carbone CJ, Liu JH, Swaminathan G, Xu P, Li Y, Baker DP, Peng JM, Lukacs GL et al (2007) Site-specific ubiquitination exposes a linear motif to promote interferon-alpha receptor endocytosis. J Cell Biol 179:935–950

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  49. Kumar KGS, Tang W, Ravindranath AK, Clark WA, Croze E, Fuchs SY (2003) SCFHOS ubiquitin ligase mediates the ligand-induced down-regulation of the interferon-alpha receptor. EMBO J 22:5480–5490

    Article  CAS  PubMed  Google Scholar 

  50. Kurt R, Chandra PK, Aboulnasr F, Panigrahi R, Ferraris P, Aydin Y, Reiss K, Wu T, Balart LA, Dash S (2015) Chaperone-mediated autophagy targets IFNAR1 for lysosomal degradation in free fatty acid treated HCV cell culture. PLoS One 10:21

    Article  CAS  Google Scholar 

  51. Lazear HM, Schoggins JW, Diamond MS (2019) Shared and distinct functions of type I and type III interferons. Immunity 50:907–923

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  52. Lee HK, Lund JM, Ramanathan B, Mizushima N, Iwasaki A (2007) Autophagy-dependent viral recognition by plasmacytoid dendritic cells. Science 315:1398–1401

    Article  CAS  PubMed  Google Scholar 

  53. Lee NR, Ban J, Lee NJ, Yi CM, Choi JY, Kim H, Lee JK, Seong J, Cho NH, Jung JU et al (2018) Activation of RIG-I-mediated antiviral signaling triggers autophagy through the MAVS-TRAF6-Beclin-1 signaling axis. Front Immunol 9:14

    Article  CAS  Google Scholar 

  54. Lei Y, Wen HT, Yu YB, Taxman DJ, Zhang L, Widman DG, Swanson KV, Wen KW, Damania B, Moore CB et al (2012) The mitochondrial proteins NLRX1 and TUFM form a complex that regulates type I interferon and autophagy. Immunity 36:933–946

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  55. Levine B, Kroemer G (2019) Biological functions of autophagy genes: a disease perspective. Cell 176:11–42

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  56. Li DD, Wang L, Deng R, Tang J, Shen Y, Guo JF, Wang Y, Xia LP, Feng GK, Liu QQ et al (2009) The pivotal role of c-Jun NH2-terminal kinase-mediated Beclin 1 expression during anticancer agents-induced autophagy in cancer cells. Oncogene 28:886–898

    Article  CAS  PubMed  Google Scholar 

  57. Li YB, Zhu HY, Zeng X, Fan JJ, Qian XL, Wang SF, Wang ZY, Sun Y, Wang XD, Wang WW et al (2013) Suppression of autophagy enhanced growth inhibition and apoptosis of interferon-β in human glioma cells. Mol Neurobiol 47:1000–1010

    Article  CAS  PubMed  Google Scholar 

  58. Li YZ, Sassano A, Majchrzak B, Deb DK, Levy DE, Gaestel M, Nebreda AR, Fish EN, Platanias LC (2004) Role of p38α map kinase in type I interferon signaling. J Biol Chem 279:970–979

    Article  CAS  PubMed  Google Scholar 

  59. Liang QM, Seo GJ, Choi YJ, Kwak MJ, Ge JN, Rodgers MA, Shi MD, Leslie BJ, Hopfner KP, Ha T et al (2014) Crosstalk between the cGAS DNA sensor and Beclin-1 autophagy protein shapes innate antimicrobial immune responses. Cell Host Microbe 15:228–238

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  60. Lin M, Zhao ZY, Yang ZF, Meng QC, Tan P, Xie WH, Qin YF, Wang RF, Cui J (2016) USP38 inhibits type I interferon signaling by editing TBK1 ubiquitination through NLRP4 signalosome. Mol Cell 64:267–281

    Article  CAS  PubMed  Google Scholar 

  61. Liu BY, Zhang M, Chu HL, Zhang HH, Wu HF, Song GH, Wang P, Zhao K, Hou JX, Wang X et al (2017) The ubiquitin E3 ligase TRIM31 promotes aggregation and activation of the signaling adaptor MAVS through Lys63-linked polyubiquitination. Nat Immunol 18:214–224

    Article  CAS  PubMed  Google Scholar 

  62. Liu J, Qian C, Cao XT (2016) Post-translational modification control of innate immunity. Immunity 45:15–30

    Article  PubMed  CAS  Google Scholar 

  63. Liu D, Wu H, Wang C, Li Y, Tian H, Siraj S, Sehgal SA, Wang X, Wang J, Shang Y et al (2019) STING directly activates autophagy to tune the innate immune response. Cell Death Differ 26:1735–1749

    Article  CAS  Google Scholar 

  64. Liu YY, Wang N, Zhang SK, Liang QW (2018). Autophagy protects bone marrow mesenchymal stem cells from palmitate-induced apoptosis through the ROS-JNK/p38 MAPK signaling pathways. Mol Med Rep 18:1485–1494

    Google Scholar 

  65. Lou J, Wang YL, Zheng XM, Qiu WQ (2018) TRIM22 regulates macrophage autophagy and enhances Mycobacterium tuberculosis clearance by targeting the nuclear factor-multiplicity κB/beclin 1 pathway. J Cell Biochem 119:8971–8980

    Article  CAS  PubMed  Google Scholar 

  66. Madjo U, Leymarie O, Fremont S, Kuster A, Nehlich M, Gallois-Montbrun S, Janvier K, Berlioz-Torrent C (2016) LC3C contributes to Vpu-mediated antagonism of BST2/Tetherin restriction on HIV-1 release through a non-canonical autophagy pathway. Cell Reports 17:2221–2233

    Article  CAS  PubMed  Google Scholar 

  67. Martin PK, Marchiando A, Xu RL, Rudensky E, Yeung F, Schuster SL, Kernbauer E, Cadwell K (2018) Autophagy proteins suppress protective type I interferon signalling in response to the murine gut microbiota. Nat Microbiol 3:1131–1141

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  68. Mesev EV, LeDesma RA, Ploss A (2019) Decoding type I and III interferon signalling during viral infection. Nat Microbiol 4:914–924

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  69. Nakashima H, Nguyen T, Goins WF, Chiocca EA (2015) Interferon-stimulated gene 15 (ISG15) and ISG15-linked proteins can associate with members of the selective autophagic process, histone deacetylase 6 (HDAC6) and SQSTM1/p62. J Biol Chem 290:1485–1495

    Article  PubMed  CAS  Google Scholar 

  70. Orvedahl A, Sumpter R, Xiao GH, Ng A, Zou ZJ, Tang Y, Narimatsu M, Gilpin C, Sun QH, Roth M et al (2011) Image-based genome-wide siRNA screen identifies selective autophagy factors. Nature 480:113–117

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  71. Prabakaran T, Bodda C, Krapp C, Zhang BC, Christensen MH, Sun CL, Reinert L, Cai YJ, Jensen SB, Skouboe MK et al (2018) Attenuation of cGAS-STING signaling is mediated by a p62/SQSTM1-dependent autophagy pathway activated by TBK1. EMBO J 37:17

    Article  CAS  Google Scholar 

  72. Puissant A, Robert G, Fenouille N, Luciano F, Cassuto JP, Raynaud S, Auberger P (2010) Resveratrol promotes autophagic cell death in chronic myelogenous leukemia cells via JNK-mediated p62/SQSTM1 expression and AMPK activation. Can Res 70:1042–1052

    Article  CAS  Google Scholar 

  73. Saitoh T, Fujita N, Hayashi T, Takahara K, Satoh T, Lee H, Matsunaga K, Kageyama S, Omori H, Noda T et al (2009) Atg9a controls dsDNA-driven dynamic translocation of STING and the innate immune response. Proc Natl Acad Sci USA 106:20842–20846

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  74. Samie M, Lim JH, Verschueren E, Baughman JM, Peng I, Wong A, Kwon YS, Senbabaoglu Y, Hackney JA, Keir M et al (2018) Selective autophagy of the adaptor TRIF regulates innate inflammatory signaling. Nat Immunol 19:246–254

    Article  CAS  PubMed  Google Scholar 

  75. Schmeisser H, Bekisz J, Zoon KC (2014) New function of type I IFN: induction of autophagy. J Interferon Cytokine Res 34:71–78

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  76. Schmeisser H, Fey SB, Horowitz J, Fischer ER, Balinsky CA, Miyake K, Bekisz J, Snow AL, Zoon KC (2013) Type I interferons induce autophagy in certain human cancer cell lines. Autophagy 9:683–696

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  77. Siddiqui MA, Mukherjee S, Manivannan P, Malathi K (2015) RNase L cleavage products promote switch from autophagy to apoptosis by caspase-mediated cleavage of Beclin-1. Int J Mol Sci 16:17611–17636

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  78. Sil P, Muse G, Martinez J (2018) A ravenous defense: canonical and non-canonical autophagy in immunity. Curr Opin Immunol 50:21–31

    Article  CAS  PubMed  Google Scholar 

  79. Snell LM, McGaha TL, Brooks DG (2017) Type I interferon in chronic virus infection and cancer. Trends Immunol 38:542–557

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  80. Song J, Hu YJ, Li JQ, Zheng HW, Wang JJ, Guo L, Shi H, Liu LD (2018) Suppression of the toll-like receptor 7-dependent type I interferon production pathway by autophagy resulting from enterovirus 71 and coxsackievirus A16 infections facilitates their replication. Arch Virol 163:135–144

    Article  CAS  PubMed  Google Scholar 

  81. Sparrer KMJ, Gableske S, Zurenski MA, Parker ZM, Full F, Baumgart GJ, Kato J, Pacheco-Rodriguez G, Liang CY, Pornillos O et al (2017) TRIM23 mediates virus-induced autophagy via activation of TBK1. Nat Microbiol 2:1543–1557

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  82. Stremlau M, Owens CM, Perron MJ, Kiessling M, Autissier P, Sodroski J (2004) The cytoplasmic body component TRIM5 alpha restricts HIV-1 infection in old world monkeys. Nature 427:848–853

    Article  CAS  PubMed  Google Scholar 

  83. Subramanian G, Kuzmanovic T, Zhang Y, Peter CB, Veleeparambil M, Chakravarti R, Sen GC, Chattopadhyay S (2018) A new mechanism of interferon’s antiviral action: induction of autophagy, essential for paramyxovirus replication, is inhibited by the interferon stimulated gene, TDRD7. PLoS Pathog 14:25

    Article  CAS  Google Scholar 

  84. Sun JR, Desai MM, Soong L, Ou JHJ (2011) IFN α/β and autophagy: tug-of-war between HCV and the host. Autophagy 7:1394–1396

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  85. Tal MC, Sasai M, Lee HK, Yordy B, Shadel GS, Iwasaki A (2009) Absence of autophagy results in reactive oxygen species-dependent amplification of RLR signaling. Proc Natl Acad Sci USA 106:2770–2775

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  86. Talloczy Z, Jiang WX, Virgin HW, Leib DA, Scheuner D, Kaufman RJ, Eskelinen EL, Levine B (2002) Regulation of starvation- and virus-induced autophagy by the eIF2 alpha kinase signaling pathway. Proc Natl Acad Sci USA 99:190–195

    Article  CAS  PubMed  Google Scholar 

  87. Talloczy Z, Virgin HW, Levine B (2006) PKR-dependent autophagic degradation of herpes simplex virus type 1. Autophagy 2:24–29

    Article  CAS  PubMed  Google Scholar 

  88. Wei YJ, Sinha S, Levine B (2008) Dual role of JNK1-mediated phosphorylation of Bcl-2 in autophagy and apoptosis regulation. Autophagy 4:949–951

    Article  CAS  PubMed  Google Scholar 

  89. Winkler R, Gillis E, Lasman L, Safra M, Geula S, Soyris C, Nachshon A, Tai-Schmiedel J, Friedman N, Le-Trilling VTK et al (2019) m6A modification controls the innate immune response to infection by targeting type I interferons. Nat Immunol 20:173–182

    Article  PubMed  CAS  Google Scholar 

  90. Xia C, Anderson P, Hahm B (2018) Viral dedication to vigorous destruction of interferon receptors. Virology 522:19–26

    Article  CAS  PubMed  Google Scholar 

  91. Xia P, Ye BQ, Wang S, Zhu XX, Du Y, Xiong Z, Tian Y, Fan ZS (2016) Glutamylation of the DNA sensor cGAS regulates its binding and synthase activity in antiviral immunity. Nat Immunol 17:369–378

    Article  CAS  PubMed  Google Scholar 

  92. Xian HF, Yang S, Jin SH, Zhang YX, Cui J (2019) LRRC59 modulates type I interferon signaling by restraining the SQSTM1/p62-mediated autophagic degradation of pattern recognition receptor DDX58/RIG-I. Autophagy 1–11

    Google Scholar 

  93. Xu DC, Zhang T, Xiao J, Zhu KZ, Wei R, Wu ZM, Meng HY, Li Y, Yuan JY (2015) Modification of BECN1 by ISG15 plays a crucial role in autophagy regulation by type I IFN/interferon. Autophagy 11:617–628

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  94. Yang Q, Liu TT, Lin H, Zhang M, Wei J, Luo WW, Hu YH, Zhong B, Hu MM, Shu HB (2017) TRIM32-TAX1BP1-dependent selective autophagic degradation of TRIF negatively regulates TLR3/4-mediated innate immune responses. PLoS Pathog 13:21

    Google Scholar 

  95. Yoneyama M, Kikuchi M, Natsukawa T, Shinobu N, Imaizumi T, Miyagishi M, Taira K, Akira S, Fujita T (2004) The RNA helicase RIG-I has an essential function in double-stranded RNA-induced innate antiviral responses. Nat Immunol 5:730–737

    Article  CAS  PubMed  Google Scholar 

  96. Zhang Y, Wang X, Zhang X, Wang J, Ma Y, Zhang L, Cao X (2019) RNA-binding protein YTHDF3 suppresses interferon-dependent antiviral responses by promoting FOXO3 translation. Proc Natl Acad Sci USA 116:976–981

    Article  CAS  PubMed  Google Scholar 

  97. Zhao YY, Sun XF, Nie XL, Sun LW, Tang TS, Chen DH, Sun QM (2012) COX5B regulates MAVS-mediated antiviral signaling through interaction with ATG5 and repressing ROS production. PLoS Pathog 8:16

    Article  CAS  Google Scholar 

  98. Zhong ZY, Sanchez-Lopez E, Karin M (2016) Autophagy, inflammation, and immunity: a troika governing cancer and its treatment. Cell 166:288–298

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  99. Zhou DJ, Kang KH, Spector SA (2012) Production of interferon α by human immunodeficiency virus type 1 in human plasmacytoid dendritic cells is dependent on induction of autophagy. J Infect Dis 205:1258–1267

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  100. Zhou YL, He CX, Wang L, Ge BX (2017) Post-translational regulation of antiviral innate signaling. Eur J Immunol 47:1414–1426

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  101. Zhou YY, Li Y, Jiang WQ, Zhou LF (2015) MAPK/JNK signalling: a potential autophagy regulation pathway. Biosci Rep 35:10

    Article  CAS  Google Scholar 

  102. Zhu S, Cao LZ, Yu Y, Yang LC, Yang MH, Liu K, Huang J, Kang R, Livesey KM, Tang DL (2013) Inhibiting autophagy potentiates the anticancer activity of IFN1@/IFN α in chronic myeloid leukemia cells. Autophagy 9:317–327

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  103. Zitvogel L, Galluzzi L, Kepp O, Smyth MJ, Kroemer G (2015) Type I interferons in anticancer immunity. Nat Rev Immunol 15:405–414

    Article  CAS  PubMed  Google Scholar 

  104. Zou J, Li WJ, Misra A, Yue F, Song K, Chen Q, Guo GH, Yi JL, Kimata JT, Liu LY (2015) The viral restriction factor Tetherin prevents leucine-rich pentatricopeptide repeat-containing protein (LRPPRC) from association with Beclin 1 and B-cell CLL/lymphoma 2 (Bcl-2) and enhances autophagy and mitophagy. J Biol Chem 290:7269–7279

    Article  CAS  PubMed  PubMed Central  Google Scholar 

Download references

Acknowledgements

This work was supported by the National Natural Science Foundation of China (31970700 and 31700760) and the Fundamental Research Funds for the Central Universities (18lgpy49).

Author information

Authors and Affiliations

  1. MOE Key Laboratory of Gene Function and Regulation, State Key Laboratory of Biocontrol, School of Life Sciences, Sun Yat-sen University, Guangzhou, 510006, Guangdong, China

    Shouheng Jin

Authors
  1. Shouheng Jin
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Shouheng Jin .

Editor information

Editors and Affiliations

  1. School of Life Sciences, Sun Yat-sen University, Guangzhou, Guangdong, China

    Jun Cui

Rights and permissions

Reprints and permissions

Copyright information

© 2019 Springer Nature Singapore Pte Ltd.

About this chapter

Check for updates. Verify currency and authenticity via CrossMark

Cite this chapter

Jin, S. (2019). The Cross-Regulation Between Autophagy and Type I Interferon Signaling in Host Defense. In: Cui, J. (eds) Autophagy Regulation of Innate Immunity. Advances in Experimental Medicine and Biology, vol 1209. Springer, Singapore. https://doi.org/10.1007/978-981-15-0606-2_8

Download citation

Publish with us

Policies and ethics

Search

Navigation