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Autophagy Regulation of Innate Immunity pp 79–108Cite as

The Interplay Between Pattern Recognition Receptors and Autophagy in Inflammation

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Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 1209))

Abstract

Pattern recognition receptors (PRRs) are sensors of exogenous and endogenous “danger” signals from pathogen-associated molecular patterns (PAMPs), and damage associated molecular patterns (DAMPs), while autophagy can respond to these signals to control homeostasis. Almost all PRRs can induce autophagy directly or indirectly. Toll-like receptors (TLRs), Nod-like receptors (NLRs), retinoic acid-inducible gene-I-like receptors (RLRs), and cyclic guanosine monophosphate–adenosine monophosphate synthase (cGAS)-stimulator of interferon genes (STING) pathway can induce autophagy directly through Beclin-1 or LC3-dependent pathway, while the interactions with the receptor for advanced glycation end products (RAGE)/high mobility group box 1 (HMGB1), CD91/Calreticulin, and TLRs/HSPs are achieved by protein, Ca2+, and mitochondrial homeostasis. Autophagy presents antigens to PRRs and helps to clean the pathogens. In addition, the induced autophagy can form a negative feedback regulation of PRRs-mediated inflammation in cell/disease-specific manner to maintain homeostasis and prevent excessive inflammation. Understanding the interaction between PRRs and autophagy in a specific disease will promote drug development for immunotherapy. Here, we focus on the interactions between PRRs and autophagy and how they affect the inflammatory response.

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Acknowledgements

The P.-H. Wang laboratory was supported by Cheeloo Young Scholar Program of Shandong University.

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Authors and Affiliations

  1. Advanced Medical Research Institute, Shandong University, Jinan, 250012, Shandong, China

    Mei-Ling Nan, Jing Zhang & Pei-Hui Wang

  2. Department of Pediatric Surgery, Guangzhou Women and Children’s Medical Center, Guangzhou Institute of Pediatrics, Guangzhou Medical University, Guangzhou, 510623, Guangdong, China

    Yun Zhu

  3. School of Biomedical Sciences, The University of Hong Kong, Pokfulam, Hong Kong, China

    Yun Zhu, Jian Deng & Pei-Hui Wang

  4. The Postgraduate College, University of Ibadan, Ibadan, 200284, Nigeria

    Akinkunmi Okekunle

  5. Department of Epidemiology and Medical Statistics, College of Medicine, University of Ibadan, Ibadan, 200284, Nigeria

    Akinkunmi Okekunle

  6. Key Laboratory for Cell and Gene Engineering of Zhejiang Province, College of Life Sciences, Zhejiang University, Hangzhou, 310058, People’s Republic of China

    Jiang-Yuan Li

  7. School of Biological Sciences, University of Missouri-Kansas City, Kansas City, MO, 64110-2499, USA

    Xiao-Qiang Yu

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Zhu, Y. et al. (2019). The Interplay Between Pattern Recognition Receptors and Autophagy in Inflammation. In: Cui, J. (eds) Autophagy Regulation of Innate Immunity. Advances in Experimental Medicine and Biology, vol 1209. Springer, Singapore. https://doi.org/10.1007/978-981-15-0606-2_6

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