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Autophagy and Immune-Related Diseases

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Autophagy Regulation of Innate Immunity

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 1209))

Abstract

Autophagy is an intracellular degradation and recycling machinery by which cellular materials are delivered to the lysosome for disposal. Beyond lysosomal degradation, autophagy genes play additional roles in secretion and membrane-trafficking pathways. Ranging from cell-intrinsic and cell-type-specific regulation of innate inflammatory signaling pathways to intercellular cross talk through secretion of soluble factors (e.g., shaping the MHC immunopeptidome for T cell response, etc.), autophagy exerts multiple functions in driving inflammation and modulating the pathological progression of immune-related disorders such as neurodegenerative diseases, inflammatory bowel diseases, autoimmunity, and metabolic diseases. Notably, owing to the complexity of autophagy process involving multiple proteins and stepwise assembly of protein complexes, noncanonical forms of autophagy or autophagic proteins, which function beyond autophagy, are equally important in the maintenance of cellular homeostasis and pathogenesis. This chapter summarizes the most up-to-date findings of autophagy proteins in the regulation of immune-related diseases. Understanding of the autophagy machinery offers therapeutic strategies for treating inflammatory diseases.

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Authors and Affiliations

  1. Institute of Biosciences and Technology, College of Medicine, Texas A&M University, Houston, TX, 77030, USA

    Peng Tan & Lian He

  2. Department of Biochemistry and Molecular Biology, University of Texas Health Science Center at Houston McGovern Medical School, Houston, TX, 77030, USA

    Youqiong Ye

  3. Xiangya Hospital, Central South University, Changsha, 410008, People’s Republic of China

    Jingrong Mao

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  1. Peng Tan
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  2. Youqiong Ye
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  4. Lian He
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Correspondence to Peng Tan or Youqiong Ye .

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  1. School of Life Sciences, Sun Yat-sen University, Guangzhou, Guangdong, China

    Jun Cui

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Tan, P., Ye, Y., Mao, J., He, L. (2019). Autophagy and Immune-Related Diseases. In: Cui, J. (eds) Autophagy Regulation of Innate Immunity. Advances in Experimental Medicine and Biology, vol 1209. Springer, Singapore. https://doi.org/10.1007/978-981-15-0606-2_10

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