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Book cover Autophagy Regulation of Innate Immunity

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 1209))

Abstract

Innate immunity plays an important role in the host defense of a variety of different pathogens, and its responses must be tightly regulated to effectively eliminate microbial invasion and avoid immune-related diseases. Autophagy is a homeostatic process that is critical for the bulk degradation of cellular constituents. Recently, accumulating evidence demonstrates the emerging role of the autophagy in the regulation of innate immune responses. In this chapter, we will have a broad overview of the function of autophagy in innate immunity, and briefly introduce the composition of this book and the content of each chapter.

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References

  1. Alissafi T, Banos A, Boon L, Sparwasser T, Ghigo A, Wing K, Vassilopoulos D, Boumpas D, Chavakis T, Cadwell K et al (2017) Tregs restrain dendritic cell autophagy to ameliorate autoimmunity. J Clin Invest 127:2789–2804

    Article  Google Scholar 

  2. Anding AL, Baehrecke EH (2017) Cleaning house: selective autophagy of organelles. Dev Cell 41:10–22

    Article  CAS  Google Scholar 

  3. Cao XT (2016) Self-regulation and cross-regulation of pattern-recognition receptor signalling in health and disease. Nat Rev Immunol 16:35–50

    Article  CAS  Google Scholar 

  4. Chan YK, Gack MU (2016) Viral evasion of intracellular DNA and RNA sensing. Nat Rev Microbiol 14:360–373

    Article  CAS  Google Scholar 

  5. Chen K, Liu J, Cao XT (2017) Regulation of type I interferon signaling in immunity and inflammation: a comprehensive review. J Autoimmun 83:1–11

    Article  Google Scholar 

  6. Chiang C, Gack MU (2017) Post-translational control of intracellular pathogen sensing pathways. Trends Immunol 38:39–52

    Article  CAS  Google Scholar 

  7. Choi AMK, Ryter SW, Levine B (2013) Autophagy in human health and disease. N Engl J Med 368:651–662

    Article  CAS  Google Scholar 

  8. Choi Y, Bowman JW, Jung JU (2018) Autophagy during viral infection—a double-edged sword. Nat Rev Microbiol 16:340–353

    Article  Google Scholar 

  9. Clarke AJ, Simon AK (2018) Autophagy in the renewal, differentiation and homeostasis of immune cells. Nat Rev Immunol

    Google Scholar 

  10. Deretic V, Kimura T, Timmins G, Moseley P, Chauhan S, Mandell M (2015) Immunologic manifestations of autophagy. J Clin Invest 125:75–84

    Article  Google Scholar 

  11. Deretic V, Levine B (2018) Autophagy balances inflammation in innate immunity. Autophagy 14:243–251

    Article  CAS  Google Scholar 

  12. Deretic V, Saitoh T, Akira S (2013) Autophagy in infection, inflammation and immunity. Nat Rev Immunol 13:722–737

    Article  CAS  Google Scholar 

  13. Du Y, Duan TH, Feng YC, Liu QX, Lin M, Cui J, Wang RF (2018) LRRC25 inhibits type I IFN signaling by targeting ISG15-associated RIG-I for autophagic degradation. EMBO J 37:351–366

    Article  CAS  Google Scholar 

  14. Gapin L (2016) Development of invariant natural killer T cells. Curr Opin Immunol 39:68–74

    Article  CAS  Google Scholar 

  15. Gatica D, Lahiri V, Klionsky DJ (2018) Cargo recognition and degradation by selective autophagy. Nat Cell Biol 20:233–242

    Article  CAS  Google Scholar 

  16. Ivashkiv LB, Donlin LT (2014) Regulation of type I interferon responses. Nat Rev Immunol 14:36–49

    Article  CAS  Google Scholar 

  17. Jin SH, Tian S, Chen YM, Zhang CX, Xie WH, Xia XJ, Cui J, Wang RF (2016) USP19 modulates autophagy and antiviral immune responses by deubiquitinating Beclin-1. EMBO J 35:866–880

    Article  CAS  Google Scholar 

  18. Jin SH, Tian S, Luo M, Xie WH, Liu T, Duan TH, Wu YX, Cui J (2017) Tetherin suppresses type I interferon signaling by targeting MAVS for NDP52-mediated selective autophagic degradation in human cells. Mol Cell 68:308–322

    Article  CAS  Google Scholar 

  19. Jounai N, Takeshita F, Kobiyama K, Sawano A, Miyawaki A, Xin KQ, Ishii KJ, Kawaii T, Akira S, Suzuki K et al (2007) The Atg5–Atg12 conjugate associates with innate antiviral immune responses. Proc Natl Acad Sci USA 104:14050–14055

    Article  CAS  Google Scholar 

  20. Konno H, Konno K, Barber GN (2013) Cyclic dinucleotides trigger ULK1 (ATG1) phosphorylation of STING to prevent sustained innate immune signaling. Cell 155:688–698

    Article  CAS  Google Scholar 

  21. Kumar H, Kawai T, Akira S (2011) Pathogen recognition by the innate immune system. Int Rev Immunol 30:16–34

    Article  CAS  Google Scholar 

  22. Levine B, Kroemer G (2019) Biological functions of autophagy genes: a disease perspective. Cell 176:11–42

    Article  CAS  Google Scholar 

  23. Levy JMM, Towers CG, Thorburn A (2017) Targeting autophagy in cancer. Nat Rev Cancer 17:528–542

    Article  CAS  Google Scholar 

  24. Liu J, Qian C, Cao XT (2016) Post-translational modification control of innate immunity. Immunity 45:15–30

    Article  Google Scholar 

  25. Liu T, Tang Q, Liu KP, Xie WH, Liu X, Wang HS, Wang RF, Cui J (2016) TRIM11 suppresses AIM2 inflammasome by degrading AIM2 via p62-dependent selective autophagy. Cell Rep 16:1988–2002

    Article  CAS  Google Scholar 

  26. Lopez-Soto A, Bravo-San Pedro JM, Kroemer G, Galluzzi L, Gonzalez S (2017) Involvement of autophagy in NK cell development and function. Autophagy 13:633–636

    Article  CAS  Google Scholar 

  27. Maurer K, Reyes-Robles T, Alonzo F, Durbin J, Torres VJ, Cadwell K (2015) Autophagy mediates tolerance to Staphylococcus aureus α-toxin. Cell Host Microbe 17:429–440

    Article  CAS  Google Scholar 

  28. Riffelmacher T, Richter FC, Simon AK (2018) Autophagy dictates metabolism and differentiation of inflammatory immune cells. Autophagy 14:199–206

    Article  CAS  Google Scholar 

  29. Rongvaux A (2018) Innate immunity and tolerance toward mitochondria. Mitochondrion 41:14–20

    Article  CAS  Google Scholar 

  30. Saitoh T, Fujita N, Hayashi T, Takahara K, Satoh T, Lee H, Matsunaga K, Kageyama S, Omori H, Noda T et al (2009) Atg9a controls dsDNA-driven dynamic translocation of STING and the innate immune response. Proc Natl Acad Sci USA 106:20842–20846

    Article  CAS  Google Scholar 

  31. Schlee M, Hartmann G (2016) Discriminating self from non-self in nucleic acid sensing. Nat Rev Immunol 16:566–580

    Article  CAS  Google Scholar 

  32. Shibutani ST, Saitoh T, Nowag H, Munz C, Yoshimori T (2015) Autophagy and autophagy-related proteins in the immune system. Nat Immunol 16:1014–1024

    Article  CAS  Google Scholar 

  33. Stranks AJ, Hansen AL, Panse I, Mortensen M, Ferguson DJP, Puleston DJ, Shenderov K, Watson AS, Veldhoen M, Phadwal K et al (2015) Autophagy controls acquisition of aging features in macrophages. J Innate Immun 7:375–391

    Article  CAS  Google Scholar 

  34. Takahama M, Akira S, Saitoh T (2018) Autophagy limits activation of the inflammasomes. Immunol Rev 281:62–73

    Article  CAS  Google Scholar 

  35. Ushio H, Ueno T, Kojima Y, Komatsu M, Tanaka S, Yamamoto A, Ichimura Y, Ezaki J, Nishida K, Komazawa-Sakon S et al (2011) Crucial role for autophagy in degranulation of mast cells. J Allergy Clin Immunol 127:1267–1282

    Article  CAS  Google Scholar 

  36. Wang WD, Jiang MH, Liu S, Zhang SK, Liu W, Ma YW, Zhang LF, Zhang JY, Cao XT (2016) RNF122 suppresses antiviral type I interferon production by targeting RIG-I CARDs to mediate RIG-I degradation. Proc Natl Acad Sci USA 113:9581–9586

    Article  CAS  Google Scholar 

  37. Wei YJ, Sinha S, Levine B (2008) Dual role of JNK1-mediated phosphorylation of Bcl-2 in autophagy and apoptosis regulation. Autophagy 4:949–951

    Article  CAS  Google Scholar 

  38. Xian HF, Yang S, Jin SH, Zhang YX, Cui J (2019) LRRC59 modulates type I interferon signaling by restraining the SQSTM1/p 62-mediated autophagic degradation of pattern recognition receptor DDX58/RIG-I. Autophagy 1–11

    Google Scholar 

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Acknowledgements

This work was supported by National Natural Science Foundation of China (31870862, 31700760 and 31800751), and Science and Technology Planning Project of Guangzhou, China (201804010385).

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Correspondence to Jun Cui .

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© 2019 Springer Nature Singapore Pte Ltd.

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Cui, J. (2019). Introduction. In: Cui, J. (eds) Autophagy Regulation of Innate Immunity. Advances in Experimental Medicine and Biology, vol 1209. Springer, Singapore. https://doi.org/10.1007/978-981-15-0606-2_1

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