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Long-Term Implications of Developmental Programming and Obesity

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Health Impacts of Developmental Exposure to Environmental Chemicals

Abstract

There is a global obesity pandemic. The prevailing theory is that obesity is the result of overeating and lack of exercise. However, the imbalance of calorie consumption and exercise per se cannot explain the reasons for the obesity epidemic. The susceptibility to obesity, like many noncommunicable diseases, has been shown to start during development due to poor nutrition, stress, or exposure to environmental chemicals. The subclass of environmental chemicals that can increase the susceptibility to obesity following exposure in utero or early life are called obesogens. There are now significant animal and human data indicating a role for obesogens in the obesity pandemic. This review presents an overview of the importance of exposure to obesogens in the etiology of obesity. The possibility of reducing exposures to obesogens during development could lead to a focus on prevention of obesity.

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  1. Healthy Environment and Endocrine Disruptor Strategies, Bolinas, CA, USA

    Jerrold J. Heindel

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  1. Center for Environmental and Health Sciences, Hokkaido University, Sapporo, Hokkaido, Japan

    Reiko Kishi

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    Philippe Grandjean

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Heindel, J.J. (2020). Long-Term Implications of Developmental Programming and Obesity. In: Kishi, R., Grandjean, P. (eds) Health Impacts of Developmental Exposure to Environmental Chemicals. Current Topics in Environmental Health and Preventive Medicine. Springer, Singapore. https://doi.org/10.1007/978-981-15-0520-1_9

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