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Health Impacts of Developmental Exposure to Environmental Chemicals pp 485–512Cite as

Gene–Environment Interactions to Detect Adverse Health Effects on the Next Generation

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Abstract

We reviewed epidemiological studies of gene–environment interactions to detect adverse health effects of environmental chemicals on the next generation in 2008, more than 10 years ago. Since then, researches on gene–environment interactions have continued via small-scale epidemiological studies seeking to elucidate associations between tobacco and environmental chemicals and candidate genes such as those encoding metabolic enzymes. In the last 10 years, extensive innovation in research designs and methods, accompanied by recent rapid advances in analytical technologies, has occurred. Specifically, genome-wide association studies (GWASs) and epigenome-wide association studies (EWASs) have become mainstream in genome cohort studies using advanced genomics and epigenomics. These have made it possible to better understand the genetic basis of diseases. Furthermore, in addition to GWASs and meta-analyses, Mendelian randomization has emerged as a GWAS-based theoretical method for environmental risk assessment that uses genetic factors associated with environmental factors. Although the concept of exposome was initially proposed as an improved tool to quantify total environmental contributions, linking it with genomics is expected to additionally enable the elucidation of the origins of multiple complex diseases. We have reviewed researches on gene–environment interactions and discussed recently developed approaches, such as GWAS, Mendelian randomization, and exposome linked with genomics, for evaluating genetic susceptibility.

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Abbreviations

ADA1:

Adenosine deaminase 1

AHR:

Aromatic hydrocarbon receptor

CBS:

Cystathionine beta-synthase

CHEAR:

Child Health Environmental Analysis Resource

CYP:

Cytochrome P450

DOHaD:

Developmental origins of health and disease

EGG:

Early growth genetics

GST:

Glutathione S-transferase

GSTTP1:

GST theta pseudogene 1

EPHX1:

Epoxide hydrolase 1

EWAS Epigenome-wide association study GWAS:

Genome-wide association study

LHCGR:

Luteinizing hormone/chorionic gonadotropin receptor

INHA:

Inhibinα

IUGR:

Intrauterine growth restriction

LBW:

Low birth weight

MTHFD1:

Methylenetetrahydrofolate dehydrogenase 1

MTHFR:

5,10-Methylenetetrahydrofolate reductase

MTR:

5-Methyltetrahydrofolate-homocysteine methyltransferase

MTRR:

5-Methyltetrahydrofolate-homocysteine methyltransferase reductase

NAT2:

N-acetyltransferase 2

NCD:

Non-communicable disease

NQO1:

NAD(P)H dehydrogenase

OGG1:

8-Oxoguanine glycosylase

PB:

Preterm birth

SGA:

Small-for-gestational-age

SHMT1:

Serine hydroxymethyltransferase 1

SNP:

Single-nucleotide polymorphism

TGFBR1:

Transforming growth factor-β receptor type 1

XRCC1:

X-ray repair cross-complementing gene 1

XRCC3:

X-ray repair cross-complementing gene 3

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Acknowledgements

Our work was supported in part by Grants-in-Aid for Scientific Research from the Japan Society for the Promotion of Science; the Japan Ministry of Health, Labour, and Welfare; and the Japan Agency for Medical Research and Development (AMED) under Grant Number JP18gk0110032.

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  1. Health Center, Chuo University, Tokyo, Japan

    Fumihiro Sata

  2. Center for Environmental and Health Sciences, Hokkaido University, Sapporo, Japan

    Fumihiro Sata, Sumitaka Kobayashi & Reiko Kishi

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  1. Fumihiro Sata
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  2. Sumitaka Kobayashi
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Correspondence to Fumihiro Sata .

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  1. Center for Environmental and Health Sciences, Hokkaido University, Sapporo, Hokkaido, Japan

    Reiko Kishi

  2. Department of Environmental Health Harvard T.H. Chan School of Public Health, Boston, MA, USA

    Philippe Grandjean

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Sata, F., Kobayashi, S., Kishi, R. (2020). Gene–Environment Interactions to Detect Adverse Health Effects on the Next Generation. In: Kishi, R., Grandjean, P. (eds) Health Impacts of Developmental Exposure to Environmental Chemicals. Current Topics in Environmental Health and Preventive Medicine. Springer, Singapore. https://doi.org/10.1007/978-981-15-0520-1_19

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